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Fusion gene ID: 39457 |
FusionGeneSummary for TRIB1_SAE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRIB1_SAE1 | Fusion gene ID: 39457 | Hgene | Tgene | Gene symbol | TRIB1 | SAE1 | Gene ID | 10221 | 10055 |
| Gene name | tribbles pseudokinase 1 | SUMO1 activating enzyme subunit 1 | |
| Synonyms | C8FW|GIG-2|GIG2|SKIP1|TRB-1|TRB1 | AOS1|HSPC140|SUA1|UBLE1A | |
| Cytomap | 8q24.13 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tribbles homolog 1G-protein-coupled receptor induced proteinG-protein-coupled receptor-induced gene 2 proteinG-protein-coupled receptor-induced protein 2phosphoprotein regulated by mitogenic pathwaystribbles-like protein 1 | SUMO-activating enzyme subunit 1SUMO-1 activating enzyme E1 N subunitSUMO-1 activating enzyme subunit 1activator of SUMO1sentrin/SUMO-activating protein AOS1ubiquitin-like 1-activating enzyme E1Aubiquitin-like protein SUMO-1 activating enzyme | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96RU8 | Q9UBE0 | |
| Ensembl transtripts involved in fusion gene | ENST00000311922, ENST00000520847, ENST00000521778, ENST00000519576, | ENST00000413379, ENST00000540850, ENST00000598840, ENST00000270225, ENST00000392776, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 4 X 7=168 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRIB1 [Title/Abstract] AND SAE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRIB1 | GO:0043405 | regulation of MAP kinase activity | 15299019 |
| Tgene | SAE1 | GO:0016925 | protein sumoylation | 15660128|20164921 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAN0-01A | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000311922 | ENST00000413379 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| 5CDS-intron | ENST00000311922 | ENST00000540850 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| 5CDS-intron | ENST00000311922 | ENST00000598840 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| 5CDS-intron | ENST00000311922 | ENST00000270225 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| 5CDS-intron | ENST00000311922 | ENST00000392776 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000520847 | ENST00000413379 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000520847 | ENST00000540850 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000520847 | ENST00000598840 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000520847 | ENST00000270225 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000520847 | ENST00000392776 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000521778 | ENST00000413379 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000521778 | ENST00000540850 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000521778 | ENST00000598840 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000521778 | ENST00000270225 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000521778 | ENST00000392776 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000519576 | ENST00000413379 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000519576 | ENST00000540850 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000519576 | ENST00000598840 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000519576 | ENST00000270225 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
| intron-intron | ENST00000519576 | ENST00000392776 | TRIB1 | chr8 | 126443504 | + | SAE1 | chr19 | 47706928 | + |
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FusionProtFeatures for TRIB1_SAE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIB1 | SAE1 |
| Adapter protein involved in protein degradation byinteracting with COP1 ubiquitin ligase (PubMed:27041596). TheCOP1-binding motif is masked by autoinhibitory interactions withthe protein kinase domain (PubMed:26455797). Serves to alter COP1substrate specificity by directing the activity of COP1 towardCEBPA (PubMed:27041596). Binds selectively the recognitionsequence of CEBPA (PubMed:26455797). Regulates myeloid celldifferentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophiland neutrophil differentiation via the COP1-binding domain (Bysimilarity). Interacts with MAPK kinases and regulates activationof MAP kinases, but has no kinase activity (PubMed:15299019,PubMed:26455797). {ECO:0000250|UniProtKB:Q8K4K4,ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797,ECO:0000305|PubMed:27041596}. | The heterodimer acts as an E1 ligase for SUMO1, SUMO2,SUMO3, and probably SUMO4. It mediates ATP-dependent activation ofSUMO proteins followed by formation of a thioester bond between aSUMO protein and a conserved active site cysteine residue onUBA2/SAE2. {ECO:0000269|PubMed:10187858,ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954,ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128,ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRIB1_SAE1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRIB1_SAE1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRIB1 | ALOX12, ELAVL1, MYC, RFWD2, STK40, FOSL2, LLGL1, PCDH1, BECN1, STK17B, RASSF8, MORC3, SLAIN2, HNRNPA1L2, FOS, MALT1, PECR, DET1, ISCA1, TRIB2, UBE2E1, JUNB | SAE1 | UBA2, UBE2I, FKBP4, SUMO3, UNC79, CYP1B1, SUMO1, SUMO2, BCL6, ETV4, APP, BAG3, IL3RA, PTK2, AARS, ADSL, DHPS, LPP, PDE12, RANGAP1, CALU, CUL5, DPP9, MCM3, NPLOC4, OSGEP, PANK4, PPP2R5E, TRMT10A, RPRD1B, SRP14, TP53RK, TPD52L2, WDR4, USP39, HSPA1A, HSPA2, FUS, FAF2, ABCE1, FRG1B, PSMB6, UBE2M, TYMS, NTRK1, KRAS, MYC, EWSR1, OFD1, CTSC, GDF15, PQBP1, WAS, DNM1L, SOD1, EDEM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRIB1_SAE1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIB1_SAE1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRIB1 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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