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Fusion gene ID: 39406 |
FusionGeneSummary for TRAPPC8_GREB1L |
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Fusion gene information | Fusion gene name: TRAPPC8_GREB1L | Fusion gene ID: 39406 | Hgene | Tgene | Gene symbol | TRAPPC8 | GREB1L | Gene ID | 22878 | 80000 |
Gene name | trafficking protein particle complex 8 | GREB1 like retinoic acid receptor coactivator | |
Synonyms | GSG1|HsT2706|KIAA1012|TRS85 | C18orf6|KIAA1772|RHDA3 | |
Cytomap | 18q12.1 | 18q11.1-q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | trafficking protein particle complex subunit 8general sporulation gene 1 homologprotein TRS85 homolog | GREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9Y2L5 | Q9C091 | |
Ensembl transtripts involved in fusion gene | ENST00000283351, ENST00000582539, ENST00000582513, ENST00000584876, | ENST00000431264, ENST00000424526, ENST00000400483, ENST00000269218, ENST00000580732, ENST00000578368, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 4 X 4=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRAPPC8 [Title/Abstract] AND GREB1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GREB1L | GO:0001822 | kidney development | 29100091 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-55-8511-01A | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000283351 | ENST00000431264 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000283351 | ENST00000424526 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000283351 | ENST00000400483 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000283351 | ENST00000269218 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000283351 | ENST00000580732 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000283351 | ENST00000578368 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582539 | ENST00000431264 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582539 | ENST00000424526 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582539 | ENST00000400483 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582539 | ENST00000269218 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582539 | ENST00000580732 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582539 | ENST00000578368 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582513 | ENST00000431264 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582513 | ENST00000424526 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582513 | ENST00000400483 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582513 | ENST00000269218 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582513 | ENST00000580732 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
5CDS-intron | ENST00000582513 | ENST00000578368 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
intron-intron | ENST00000584876 | ENST00000431264 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
intron-intron | ENST00000584876 | ENST00000424526 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
intron-intron | ENST00000584876 | ENST00000400483 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
intron-intron | ENST00000584876 | ENST00000269218 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
intron-intron | ENST00000584876 | ENST00000580732 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
intron-intron | ENST00000584876 | ENST00000578368 | TRAPPC8 | chr18 | 29470698 | - | GREB1L | chr18 | 19014908 | + |
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FusionProtFeatures for TRAPPC8_GREB1L |
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Hgene | Tgene |
TRAPPC8 | GREB1L |
May be involved in endoplasmic reticulum to Golgiapparatus trafficking at a very early stage.{ECO:0000269|PubMed:21525244}. | Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAPPC8_GREB1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRAPPC8_GREB1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRAPPC8 | TECPR1, TRAPPC3, TRAPPC13, TRAPPC2L, TRAPPC2, TRAPPC11, TRAPPC12, TRAPPC10, TRAPPC3L, TRAPPC4, TRAPPC8, TRAPPC9, TRAPPC6B, BARD1, PAXIP1, ACAT2, UNK, NTRK1, TRAPPC1, TRAPPC5, TBC1D14, TPCN2, SSRP1, TKT | GREB1L | MOV10, NXF1, TSEN2, LYPD4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAPPC8_GREB1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAPPC8_GREB1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |