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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39406

FusionGeneSummary for TRAPPC8_GREB1L

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAPPC8_GREB1L
Fusion gene ID: 39406
HgeneTgene
Gene symbol

TRAPPC8

GREB1L

Gene ID

22878

80000

Gene nametrafficking protein particle complex 8GREB1 like retinoic acid receptor coactivator
SynonymsGSG1|HsT2706|KIAA1012|TRS85C18orf6|KIAA1772|RHDA3
Cytomap

18q12.1

18q11.1-q11.2

Type of geneprotein-codingprotein-coding
Descriptiontrafficking protein particle complex subunit 8general sporulation gene 1 homologprotein TRS85 homologGREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like
Modification date2018052320180519
UniProtAcc

Q9Y2L5

Q9C091

Ensembl transtripts involved in fusion geneENST00000283351, ENST00000582539, 
ENST00000582513, ENST00000584876, 
ENST00000431264, ENST00000424526, 
ENST00000400483, ENST00000269218, 
ENST00000580732, ENST00000578368, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 4 X 4=48
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAPPC8 [Title/Abstract] AND GREB1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGREB1L

GO:0001822

kidney development

29100091


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-8511-01ATRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283351ENST00000431264TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000283351ENST00000424526TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000283351ENST00000400483TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000283351ENST00000269218TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000283351ENST00000580732TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000283351ENST00000578368TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582539ENST00000431264TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582539ENST00000424526TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582539ENST00000400483TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582539ENST00000269218TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582539ENST00000580732TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582539ENST00000578368TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582513ENST00000431264TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582513ENST00000424526TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582513ENST00000400483TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582513ENST00000269218TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582513ENST00000580732TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
5CDS-intronENST00000582513ENST00000578368TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
intron-intronENST00000584876ENST00000431264TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
intron-intronENST00000584876ENST00000424526TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
intron-intronENST00000584876ENST00000400483TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
intron-intronENST00000584876ENST00000269218TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
intron-intronENST00000584876ENST00000580732TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+
intron-intronENST00000584876ENST00000578368TRAPPC8chr18

29470698

-GREB1Lchr18

19014908

+

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FusionProtFeatures for TRAPPC8_GREB1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAPPC8

Q9Y2L5

GREB1L

Q9C091

May be involved in endoplasmic reticulum to Golgiapparatus trafficking at a very early stage.{ECO:0000269|PubMed:21525244}. Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAPPC8_GREB1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAPPC8_GREB1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAPPC8TECPR1, TRAPPC3, TRAPPC13, TRAPPC2L, TRAPPC2, TRAPPC11, TRAPPC12, TRAPPC10, TRAPPC3L, TRAPPC4, TRAPPC8, TRAPPC9, TRAPPC6B, BARD1, PAXIP1, ACAT2, UNK, NTRK1, TRAPPC1, TRAPPC5, TBC1D14, TPCN2, SSRP1, TKTGREB1LMOV10, NXF1, TSEN2, LYPD4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAPPC8_GREB1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAPPC8_GREB1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource