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Fusion gene ID: 39391 |
FusionGeneSummary for TRAPPC11_KCNN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRAPPC11_KCNN4 | Fusion gene ID: 39391 | Hgene | Tgene | Gene symbol | TRAPPC11 | KCNN4 | Gene ID | 60684 | 3783 |
| Gene name | trafficking protein particle complex 11 | potassium calcium-activated channel subfamily N member 4 | |
| Synonyms | C4orf41|FOIGR|GRY|LGMD2S | DHS2|IK|IK1|IKCA1|KCA4|KCa3.1|SK4|hIKCa1|hKCa4|hSK4 | |
| Cytomap | 4q35.1 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trafficking protein particle complex subunit 11foie gras homologgryzun homolog | intermediate conductance calcium-activated potassium channel protein 4SKCa 4SKCa4potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4potassium intermediate/small conductance calcium-activated channel, subfami | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q7Z392 | O15554 | |
| Ensembl transtripts involved in fusion gene | ENST00000334690, ENST00000357207, ENST00000511409, ENST00000512476, | ENST00000262888, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 4 X 4 X 4=64 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRAPPC11 [Title/Abstract] AND KCNN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRAPPC11 | GO:0051259 | protein complex oligomerization | 21525244 |
| Tgene | KCNN4 | GO:0006816 | calcium ion transport | 18796614 |
| Tgene | KCNN4 | GO:0030322 | stabilization of membrane potential | 18796614 |
| Tgene | KCNN4 | GO:0050862 | positive regulation of T cell receptor signaling pathway | 18796614 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-EY-A4KR-01A | TRAPPC11 | chr4 | 184589270 | + | KCNN4 | chr19 | 44276287 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000334690 | ENST00000262888 | TRAPPC11 | chr4 | 184589270 | + | KCNN4 | chr19 | 44276287 | - |
| In-frame | ENST00000357207 | ENST00000262888 | TRAPPC11 | chr4 | 184589270 | + | KCNN4 | chr19 | 44276287 | - |
| 3UTR-3CDS | ENST00000511409 | ENST00000262888 | TRAPPC11 | chr4 | 184589270 | + | KCNN4 | chr19 | 44276287 | - |
| intron-3CDS | ENST00000512476 | ENST00000262888 | TRAPPC11 | chr4 | 184589270 | + | KCNN4 | chr19 | 44276287 | - |
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FusionProtFeatures for TRAPPC11_KCNN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRAPPC11 | KCNN4 |
| Forms a voltage-independent potassium channel that isactivated by intracellular calcium (PubMed:26148990). Activationis followed by membrane hyperpolarization which promotes calciuminflux. Required for maximal calcium influx and proliferationduring the reactivation of naive T-cells. The channel is blockedby clotrimazole and charybdotoxin but is insensitive to apamin(PubMed:17157250, PubMed:18796614). {ECO:0000269|PubMed:17157250,ECO:0000269|PubMed:18796614, ECO:0000269|PubMed:26148990}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 241_261 | 227 | 452 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
| Tgene | >KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 286_347 | 227 | 452 | Region | Note=Calmodulin-binding |
| Tgene | >KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 265_285 | 227 | 452 | Transmembrane | Helical%3B Name%3DSegment S6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 108_128 | 227 | 452 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Tgene | KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 143_163 | 227 | 452 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Tgene | KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 207_227 | 227 | 452 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Tgene | KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 29_49 | 227 | 452 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Tgene | KCNN4 | chr4:184589270 | chr19:44276287 | ENST00000262888 | - | 2 | 9 | 59_79 | 227 | 452 | Transmembrane | Helical%3B Name%3DSegment S2 |
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FusionGeneSequence for TRAPPC11_KCNN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRAPPC11_ENST00000334690_chr4_184589270_+_KCNN4_ENST00000262888_chr19_44276287_-_387aa MSPTQWDFPVELCCRPMAFVTLTGLDVVYNAVHRAVWDAFCANRRADRVPISFKVLPGDHEYPKCRPKRTSYEWYIPKGILKTGWMNKHL NLVPALVVVFYELDWDEPQWKEKQSECATRVEIVRQSLQGRNTKVAVVLIQKKTPLPPGEDVIASERAAALCNACELSGKSLFVLPHTDH LVGYIIRQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEM KESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAG >In-frame_TRAPPC11_ENST00000357207_chr4_184589270_+_KCNN4_ENST00000262888_chr19_44276287_-_387aa MSPTQWDFPVELCCRPMAFVTLTGLDVVYNAVHRAVWDAFCANRRADRVPISFKVLPGDHEYPKCRPKRTSYEWYIPKGILKTGWMNKHL NLVPALVVVFYELDWDEPQWKEKQSECATRVEIVRQSLQGRNTKVAVVLIQKKTPLPPGEDVIASERAAALCNACELSGKSLFVLPHTDH LVGYIIRQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEM KESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRAPPC11_ENST00000334690_chr4_184589270_+_KCNN4_ENST00000262888_chr19_44276287_-_1161nt ATGAGCCCCACACAGTGGGACTTCCCTGTGGAATTATGTTGCCGGCCTATGGCCTTTGTTACTCTAACGGGCCTGGATGTAGTTTATAAT GCAGTCCATCGAGCTGTCTGGGACGCCTTCTGTGCAAATCGGAGAGCTGATCGAGTACCAATTTCTTTCAAGGTGCTCCCAGGTGACCAT GAGTATCCCAAATGTAGACCCAAGAGAACTTCATATGAGTGGTACATTCCTAAAGGGATCTTAAAGACTGGCTGGATGAATAAGCATCTG AATCTGGTGCCAGCCCTGGTGGTTGTGTTCTATGAACTGGACTGGGATGAGCCTCAGTGGAAAGAAAAGCAGTCTGAGTGCGCCACCAGA GTGGAAATAGTCAGGCAAAGTTTACAAGGAAGAAACACAAAAGTTGCAGTGGTTCTGATTCAGAAGAAAACCCCTTTGCCCCCAGGAGAA GATGTCATTGCTTCAGAAAGGGCTGCAGCTTTATGCAATGCATGTGAACTCTCAGGAAAGTCTTTGTTTGTACTGCCGCACACTGACCAC CTTGTGGGTTATATTATAAGGCAGGCTGTTAATGCCACTGGGCACCTTTCAGACACACTTTGGCTGATCCCCATCACATTCCTGACCATC GGCTATGGTGACGTGGTGCCGGGCACCATGTGGGGCAAGATCGTCTGCCTGTGCACTGGAGTCATGGGTGTCTGCTGCACAGCCCTGCTG GTGGCCGTGGTGGCCCGGAAGCTGGAGTTTAACAAGGCAGAGAAGCACGTGCACAACTTCATGATGGATATCCAGTATACCAAAGAGATG AAGGAGTCCGCTGCCCGAGTGCTACAAGAAGCCTGGATGTTCTACAAACATACTCGCAGGAAGGAGTCTCATGCTGCCCGCAGGCATCAG CGCAAGCTGCTGGCCGCCATCAACGCGTTCCGCCAGGTGCGGCTGAAACACCGGAAGCTCCGGGAACAAGTGAACTCCATGGTGGACATC TCCAAGATGCACATGATCCTGTATGACCTGCAGCAGAATCTGAGCAGCTCACACCGGGCCCTGGAGAAACAGATTGACACGCTGGCGGGG >In-frame_TRAPPC11_ENST00000357207_chr4_184589270_+_KCNN4_ENST00000262888_chr19_44276287_-_1161nt ATGAGCCCCACACAGTGGGACTTCCCTGTGGAATTATGTTGCCGGCCTATGGCCTTTGTTACTCTAACGGGCCTGGATGTAGTTTATAAT GCAGTCCATCGAGCTGTCTGGGACGCCTTCTGTGCAAATCGGAGAGCTGATCGAGTACCAATTTCTTTCAAGGTGCTCCCAGGTGACCAT GAGTATCCCAAATGTAGACCCAAGAGAACTTCATATGAGTGGTACATTCCTAAAGGGATCTTAAAGACTGGCTGGATGAATAAGCATCTG AATCTGGTGCCAGCCCTGGTGGTTGTGTTCTATGAACTGGACTGGGATGAGCCTCAGTGGAAAGAAAAGCAGTCTGAGTGCGCCACCAGA GTGGAAATAGTCAGGCAAAGTTTACAAGGAAGAAACACAAAAGTTGCAGTGGTTCTGATTCAGAAGAAAACCCCTTTGCCCCCAGGAGAA GATGTCATTGCTTCAGAAAGGGCTGCAGCTTTATGCAATGCATGTGAACTCTCAGGAAAGTCTTTGTTTGTACTGCCGCACACTGACCAC CTTGTGGGTTATATTATAAGGCAGGCTGTTAATGCCACTGGGCACCTTTCAGACACACTTTGGCTGATCCCCATCACATTCCTGACCATC GGCTATGGTGACGTGGTGCCGGGCACCATGTGGGGCAAGATCGTCTGCCTGTGCACTGGAGTCATGGGTGTCTGCTGCACAGCCCTGCTG GTGGCCGTGGTGGCCCGGAAGCTGGAGTTTAACAAGGCAGAGAAGCACGTGCACAACTTCATGATGGATATCCAGTATACCAAAGAGATG AAGGAGTCCGCTGCCCGAGTGCTACAAGAAGCCTGGATGTTCTACAAACATACTCGCAGGAAGGAGTCTCATGCTGCCCGCAGGCATCAG CGCAAGCTGCTGGCCGCCATCAACGCGTTCCGCCAGGTGCGGCTGAAACACCGGAAGCTCCGGGAACAAGTGAACTCCATGGTGGACATC TCCAAGATGCACATGATCCTGTATGACCTGCAGCAGAATCTGAGCAGCTCACACCGGGCCCTGGAGAAACAGATTGACACGCTGGCGGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRAPPC11_ENST00000334690_chr4_184589270_+_KCNN4_ENST00000262888_chr19_44276287_-_1923nt AAAGTGCTTCCTGTGCCGGGGGAGGTGGGTACAGGGAAGTCTCGCCTGTTGGAACTGGCTGTGGGGCTGCGGCGGTGGGGACGGGCCACG GCGTTCTGTGACATCCCCCCGCCTCCCCTCGTCTTCTCCCGGCTGGCGGCGACCGGCCTCAGCTGCAGCGGGCCCGGGGCGTGGGGCCTG GGTTTTTTGTGACATCGTAAACATGAGCCCCACACAGTGGGACTTCCCTGTGGAATTATGTTGCCGGCCTATGGCCTTTGTTACTCTAAC GGGCCTGGATGTAGTTTATAATGCAGTCCATCGAGCTGTCTGGGACGCCTTCTGTGCAAATCGGAGAGCTGATCGAGTACCAATTTCTTT CAAGGTGCTCCCAGGTGACCATGAGTATCCCAAATGTAGACCCAAGAGAACTTCATATGAGTGGTACATTCCTAAAGGGATCTTAAAGAC TGGCTGGATGAATAAGCATCTGAATCTGGTGCCAGCCCTGGTGGTTGTGTTCTATGAACTGGACTGGGATGAGCCTCAGTGGAAAGAAAA GCAGTCTGAGTGCGCCACCAGAGTGGAAATAGTCAGGCAAAGTTTACAAGGAAGAAACACAAAAGTTGCAGTGGTTCTGATTCAGAAGAA AACCCCTTTGCCCCCAGGAGAAGATGTCATTGCTTCAGAAAGGGCTGCAGCTTTATGCAATGCATGTGAACTCTCAGGAAAGTCTTTGTT TGTACTGCCGCACACTGACCACCTTGTGGGTTATATTATAAGGCAGGCTGTTAATGCCACTGGGCACCTTTCAGACACACTTTGGCTGAT CCCCATCACATTCCTGACCATCGGCTATGGTGACGTGGTGCCGGGCACCATGTGGGGCAAGATCGTCTGCCTGTGCACTGGAGTCATGGG TGTCTGCTGCACAGCCCTGCTGGTGGCCGTGGTGGCCCGGAAGCTGGAGTTTAACAAGGCAGAGAAGCACGTGCACAACTTCATGATGGA TATCCAGTATACCAAAGAGATGAAGGAGTCCGCTGCCCGAGTGCTACAAGAAGCCTGGATGTTCTACAAACATACTCGCAGGAAGGAGTC TCATGCTGCCCGCAGGCATCAGCGCAAGCTGCTGGCCGCCATCAACGCGTTCCGCCAGGTGCGGCTGAAACACCGGAAGCTCCGGGAACA AGTGAACTCCATGGTGGACATCTCCAAGATGCACATGATCCTGTATGACCTGCAGCAGAATCTGAGCAGCTCACACCGGGCCCTGGAGAA ACAGATTGACACGCTGGCGGGGAAGCTGGATGCCCTGACTGAGCTGCTTAGCACTGCCCTGGGGCCGAGGCAGCTTCCAGAACCCAGCCA GCAGTCCAAGTAGCTGGACCCACGAGGAGGAACCAGGCTACTTTCCCCAGTACTGAGGTGGTGGACATCGTCTCTGCCACTCCTGACCCA GCCCTGAACAAAGCACCTCAAGTGCAAGGACCAAAGGGGGCCCTGGCTTGGAGTGGGTTGGCTTGCTGATGGCTGCTGGAGGGGACGCTG GCTAAAGTGGGTAGGCCTTGGCCCACCTGAGGCCCCAGGTGGGAACATGGTCACCCCCACTCTGCATACCCTCATCAAAAACACTCTCAC TATGCTGCTATGGACGACCTCCAGCTCTCAGTTACAAGTGCAGGCGACTGGAGGCAGGACTCCTGGGTCCCTGGGAAAGAGGGTACTAGG GGCCCGGATCCAGGATTCTGGGAGGCTTCAGTTACCGCTGGCCGAGCTGAAGAACTGGGTATGAGGCTGGGGCGGGGCTGGAGGTGGCGC CCCCTGGTGGGACAACAAAGAGGACACCATTTTTCCAGAGCTGCAGAGAGCACCTGGTGGGGAGGAAGAAGTGTAACTCACCAGCCTCTG >In-frame_TRAPPC11_ENST00000357207_chr4_184589270_+_KCNN4_ENST00000262888_chr19_44276287_-_1897nt GGGTACAGGGAAGTCTCGCCTGTTGGAACTGGCTGTGGGGCTGCGGCGGTGGGGACGGGCCACGGCGTTCTGTGACATCCCCCCGCCTCC CCTCGTCTTCTCCCGGCTGGCGGCGACCGGCCTCAGCTGCAGCGGGCCCGGGGCGTGGGGCCTGGGTTTTTTGTGACATCGTAAACATGA GCCCCACACAGTGGGACTTCCCTGTGGAATTATGTTGCCGGCCTATGGCCTTTGTTACTCTAACGGGCCTGGATGTAGTTTATAATGCAG TCCATCGAGCTGTCTGGGACGCCTTCTGTGCAAATCGGAGAGCTGATCGAGTACCAATTTCTTTCAAGGTGCTCCCAGGTGACCATGAGT ATCCCAAATGTAGACCCAAGAGAACTTCATATGAGTGGTACATTCCTAAAGGGATCTTAAAGACTGGCTGGATGAATAAGCATCTGAATC TGGTGCCAGCCCTGGTGGTTGTGTTCTATGAACTGGACTGGGATGAGCCTCAGTGGAAAGAAAAGCAGTCTGAGTGCGCCACCAGAGTGG AAATAGTCAGGCAAAGTTTACAAGGAAGAAACACAAAAGTTGCAGTGGTTCTGATTCAGAAGAAAACCCCTTTGCCCCCAGGAGAAGATG TCATTGCTTCAGAAAGGGCTGCAGCTTTATGCAATGCATGTGAACTCTCAGGAAAGTCTTTGTTTGTACTGCCGCACACTGACCACCTTG TGGGTTATATTATAAGGCAGGCTGTTAATGCCACTGGGCACCTTTCAGACACACTTTGGCTGATCCCCATCACATTCCTGACCATCGGCT ATGGTGACGTGGTGCCGGGCACCATGTGGGGCAAGATCGTCTGCCTGTGCACTGGAGTCATGGGTGTCTGCTGCACAGCCCTGCTGGTGG CCGTGGTGGCCCGGAAGCTGGAGTTTAACAAGGCAGAGAAGCACGTGCACAACTTCATGATGGATATCCAGTATACCAAAGAGATGAAGG AGTCCGCTGCCCGAGTGCTACAAGAAGCCTGGATGTTCTACAAACATACTCGCAGGAAGGAGTCTCATGCTGCCCGCAGGCATCAGCGCA AGCTGCTGGCCGCCATCAACGCGTTCCGCCAGGTGCGGCTGAAACACCGGAAGCTCCGGGAACAAGTGAACTCCATGGTGGACATCTCCA AGATGCACATGATCCTGTATGACCTGCAGCAGAATCTGAGCAGCTCACACCGGGCCCTGGAGAAACAGATTGACACGCTGGCGGGGAAGC TGGATGCCCTGACTGAGCTGCTTAGCACTGCCCTGGGGCCGAGGCAGCTTCCAGAACCCAGCCAGCAGTCCAAGTAGCTGGACCCACGAG GAGGAACCAGGCTACTTTCCCCAGTACTGAGGTGGTGGACATCGTCTCTGCCACTCCTGACCCAGCCCTGAACAAAGCACCTCAAGTGCA AGGACCAAAGGGGGCCCTGGCTTGGAGTGGGTTGGCTTGCTGATGGCTGCTGGAGGGGACGCTGGCTAAAGTGGGTAGGCCTTGGCCCAC CTGAGGCCCCAGGTGGGAACATGGTCACCCCCACTCTGCATACCCTCATCAAAAACACTCTCACTATGCTGCTATGGACGACCTCCAGCT CTCAGTTACAAGTGCAGGCGACTGGAGGCAGGACTCCTGGGTCCCTGGGAAAGAGGGTACTAGGGGCCCGGATCCAGGATTCTGGGAGGC TTCAGTTACCGCTGGCCGAGCTGAAGAACTGGGTATGAGGCTGGGGCGGGGCTGGAGGTGGCGCCCCCTGGTGGGACAACAAAGAGGACA CCATTTTTCCAGAGCTGCAGAGAGCACCTGGTGGGGAGGAAGAAGTGTAACTCACCAGCCTCTGCTCTTATCTTTGTAATAAATGTTAAA |
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FusionGenePPI for TRAPPC11_KCNN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRAPPC11 | TP53, TP63, TP73, TECPR1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC12, TRAPPC8, TRAPPC1, TRAPPC3L, TRAPPC4, TRAPPC11, BARD1, ALB, NTRK1, RACGAP1, PTAR1, TRAPPC5, TBC1D14 | KCNN4 | USP8, CALM1, RAB7A, TSG101, CDH1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAPPC11_KCNN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | KCNN4 | O15554 | DB00468 | Quinine | Intermediate conductance calcium-activated potassium channel protein 4 | small molecule | approved |
| Tgene | KCNN4 | O15554 | DB00228 | Enflurane | Intermediate conductance calcium-activated potassium channel protein 4 | small molecule | approved|investigational|vet_approved |
| Tgene | KCNN4 | O15554 | DB01110 | Miconazole | Intermediate conductance calcium-activated potassium channel protein 4 | small molecule | approved|investigational|vet_approved |
| Tgene | KCNN4 | O15554 | DB00257 | Clotrimazole | Intermediate conductance calcium-activated potassium channel protein 4 | small molecule | approved|vet_approved |
| Tgene | KCNN4 | O15554 | DB01159 | Halothane | Intermediate conductance calcium-activated potassium channel protein 4 | small molecule | approved|vet_approved |
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RelatedDiseases for TRAPPC11_KCNN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRAPPC11 | C3809236 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2S | 1 | ORPHANET;UNIPROT |
| Tgene | KCNN4 | C4225242 | DEHYDRATED HEREDITARY STOMATOCYTOSIS 2 | 2 | UNIPROT |
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