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Fusion gene ID: 39390 |
FusionGeneSummary for TRAPPC11_ING2 |
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Fusion gene information | Fusion gene name: TRAPPC11_ING2 | Fusion gene ID: 39390 | Hgene | Tgene | Gene symbol | TRAPPC11 | ING2 | Gene ID | 60684 | 54556 |
Gene name | trafficking protein particle complex 11 | inhibitor of growth family member 3 | |
Synonyms | C4orf41|FOIGR|GRY|LGMD2S | Eaf4|ING2|MEAF4|p47ING3 | |
Cytomap | 4q35.1 | 7q31.31 | |
Type of gene | protein-coding | protein-coding | |
Description | trafficking protein particle complex subunit 11foie gras homologgryzun homolog | inhibitor of growth protein 3 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q7Z392 | Q9H160 | |
Ensembl transtripts involved in fusion gene | ENST00000334690, ENST00000357207, ENST00000511409, ENST00000512476, | ENST00000302327, ENST00000434682, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TRAPPC11 [Title/Abstract] AND ING2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TRAPPC11 | GO:0051259 | protein complex oligomerization | 21525244 |
Tgene | ING2 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
Tgene | ING2 | GO:0043967 | histone H4 acetylation | 14966270|16387653 |
Tgene | ING2 | GO:0043968 | histone H2A acetylation | 14966270|16387653 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-UF-A7JA-01A | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000334690 | ENST00000302327 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
Frame-shift | ENST00000334690 | ENST00000434682 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
Frame-shift | ENST00000357207 | ENST00000302327 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
Frame-shift | ENST00000357207 | ENST00000434682 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
intron-3CDS | ENST00000511409 | ENST00000302327 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
intron-3CDS | ENST00000511409 | ENST00000434682 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
intron-3CDS | ENST00000512476 | ENST00000302327 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
intron-3CDS | ENST00000512476 | ENST00000434682 | TRAPPC11 | chr4 | 184600639 | + | ING2 | chr4 | 184431435 | + |
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FusionProtFeatures for TRAPPC11_ING2 |
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Hgene | Tgene |
TRAPPC11 | ING2 |
Seems to be involved in p53/TP53 activation andp53/TP53-dependent apoptotic pathways, probably by enhancingacetylation of p53/TP53. Component of a mSin3A-like corepressorcomplex, which is probably involved in deacetylation ofnucleosomal histones. ING2 activity seems to be modulated bybinding to phosphoinositides (PtdInsPs).{ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAPPC11_ING2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRAPPC11_ING2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRAPPC11 | TP53, TP63, TP73, TECPR1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC12, TRAPPC8, TRAPPC1, TRAPPC3L, TRAPPC4, TRAPPC11, BARD1, ALB, NTRK1, RACGAP1, PTAR1, TRAPPC5, TBC1D14 | ING2 | SIN3A, HDAC1, HDAC2, SUDS3, RBBP7, RBBP4, ARID4A, ARID4B, SAP130, BRMS1L, SAP30, SMARCC2, SMARCC1, ACTL6A, SMARCB1, PCNA, EP300, TP53, SKIL, SMAD2, SIRT1, COPS2, SMURF1, APP, HIST3H3, WDR5, PRMT5, FOXK1, FOXK2, NANOG, GATAD1, FAM60A, SIN3B, CENPH, SAP30L, TARSL2, BRMS1, ZNF704, MXD3, BAHCC1, PCM1, AHNAK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAPPC11_ING2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAPPC11_ING2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRAPPC11 | C3809236 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2S | 1 | ORPHANET;UNIPROT |