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Fusion gene ID: 39343 |
FusionGeneSummary for TRAF3_SIVA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRAF3_SIVA1 | Fusion gene ID: 39343 | Hgene | Tgene | Gene symbol | TRAF3 | SIVA1 | Gene ID | 7187 | 10572 |
| Gene name | TNF receptor associated factor 3 | SIVA1 apoptosis inducing factor | |
| Synonyms | CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118 | CD27BP|SIVA|Siva-1|Siva-2 | |
| Cytomap | 14q32.32 | 14q32.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3 | apoptosis regulatory protein SivaCD27-binding (Siva) protein | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q13114 | O15304 | |
| Ensembl transtripts involved in fusion gene | ENST00000560371, ENST00000347662, ENST00000392745, ENST00000539721, ENST00000351691, | ENST00000329967, ENST00000347067, | |
| Fusion gene scores | * DoF score | 12 X 6 X 10=720 | 5 X 3 X 5=75 |
| # samples | 13 | 5 | |
| ** MAII score | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRAF3 [Title/Abstract] AND SIVA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SIVA1 | GO:0097191 | extrinsic apoptotic signaling pathway | 9177220 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-BR-8677-01A | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000560371 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000560371 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000347662 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000347662 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000392745 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000392745 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000539721 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| 5UTR-intron | ENST00000539721 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| intron-intron | ENST00000351691 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
| intron-intron | ENST00000351691 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
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FusionProtFeatures for TRAF3_SIVA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRAF3 | SIVA1 |
| Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}. | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoformBcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.{ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602,ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577,ECO:0000269|PubMed:16491128}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAF3_SIVA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRAF3_SIVA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRAF3 | TANK, CASP3, SRC, MAP3K5, CD40, TNFSF14, TNFRSF9, TDP2, LTBR, NGFR, TNFRSF18, CD27, CFLAR, EDA2R, TNFRSF17, TRAF3IP2, TNFRSF14, RIPK1, TNFRSF11A, NUP62, TRAF3, TRAF3IP1, MAP3K14, TRIM37, USP7, OTUD5, TBK1, SMURF1, TRAIP, BIRC2, BIRC3, OTUB1, OTUB2, RNF216, MAVS, ZBP1, IRF1, AZI2, TLR3, TLR4, TLR9, TRAF2, USO1, TRAF5, WDR5, NLRX1, TNIP1, TAX1BP1, TICAM1, OPTN, CBLB, MYD88, TNFRSF1B, TNFRSF1A, FAS, TNFRSF8, PDLIM7, TRAF3IP3, TNAP, TNFRSF13C, TNFRSF13B, TRAF1, TNFRSF4, IKBKE, IRF3, NFATC2IP, ZMYND11, PPP3CA, PPP3R1, UBE2O, SNAP29, TFG, SEC16A, RBM14, DCAF7, GALC, DYRK1A, ETV6, TROAP, MYT1, UCHL1, SYK, SAR1A, DAXX, EWSR1, IL15, ABCC1, APOBEC3C, IKBKG, UBE2I, PPP1CC, TMEM173, NMRAL1, RIPK2, ECH1, FAM53C, IFIT3, RNF166, ESR1, CREB1, MAP3K7, TRIM14, CSNK1E, FOSL1, DDX3X, VAV3, SPP1, TSKS, SHPK, CELF2, HNRNPC | SIVA1 | CD27, LPAR2, S1PR4, PXMP2, TP53, MDM2, NEDD4, NEDD4L, XIAP, MAP3K7, APP, CDKN2A, UBE2D1, NGFRAP1, PCNA, TBXA2R, TRAF2, RAD18, TYK2, FOXP3, CD4, TCAP, MEFV, STMN1, CAMK2G, RHOU |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAF3_SIVA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SIVA1 | O15304 | DB01593 | Zinc | Apoptosis regulatory protein Siva | small molecule | approved|investigational |
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RelatedDiseases for TRAF3_SIVA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRAF3 | C3553868 | HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 3 | 1 | UNIPROT |
| Tgene | SIVA1 | C0010246 | Coxsackievirus Infections | 1 | CTD_human |
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