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Fusion gene ID: 39343 |
FusionGeneSummary for TRAF3_SIVA1 |
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Fusion gene information | Fusion gene name: TRAF3_SIVA1 | Fusion gene ID: 39343 | Hgene | Tgene | Gene symbol | TRAF3 | SIVA1 | Gene ID | 7187 | 10572 |
Gene name | TNF receptor associated factor 3 | SIVA1 apoptosis inducing factor | |
Synonyms | CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118 | CD27BP|SIVA|Siva-1|Siva-2 | |
Cytomap | 14q32.32 | 14q32.33 | |
Type of gene | protein-coding | protein-coding | |
Description | TNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3 | apoptosis regulatory protein SivaCD27-binding (Siva) protein | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q13114 | O15304 | |
Ensembl transtripts involved in fusion gene | ENST00000560371, ENST00000347662, ENST00000392745, ENST00000539721, ENST00000351691, | ENST00000329967, ENST00000347067, | |
Fusion gene scores | * DoF score | 12 X 6 X 10=720 | 5 X 3 X 5=75 |
# samples | 13 | 5 | |
** MAII score | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRAF3 [Title/Abstract] AND SIVA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SIVA1 | GO:0097191 | extrinsic apoptotic signaling pathway | 9177220 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-8677-01A | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000560371 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000560371 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000347662 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000347662 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000392745 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000392745 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000539721 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
5UTR-intron | ENST00000539721 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
intron-intron | ENST00000351691 | ENST00000329967 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
intron-intron | ENST00000351691 | ENST00000347067 | TRAF3 | chr14 | 103244012 | + | SIVA1 | chr14 | 105233127 | + |
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FusionProtFeatures for TRAF3_SIVA1 |
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Hgene | Tgene |
TRAF3 | SIVA1 |
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}. | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoformBcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.{ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602,ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577,ECO:0000269|PubMed:16491128}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAF3_SIVA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRAF3_SIVA1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRAF3 | TANK, CASP3, SRC, MAP3K5, CD40, TNFSF14, TNFRSF9, TDP2, LTBR, NGFR, TNFRSF18, CD27, CFLAR, EDA2R, TNFRSF17, TRAF3IP2, TNFRSF14, RIPK1, TNFRSF11A, NUP62, TRAF3, TRAF3IP1, MAP3K14, TRIM37, USP7, OTUD5, TBK1, SMURF1, TRAIP, BIRC2, BIRC3, OTUB1, OTUB2, RNF216, MAVS, ZBP1, IRF1, AZI2, TLR3, TLR4, TLR9, TRAF2, USO1, TRAF5, WDR5, NLRX1, TNIP1, TAX1BP1, TICAM1, OPTN, CBLB, MYD88, TNFRSF1B, TNFRSF1A, FAS, TNFRSF8, PDLIM7, TRAF3IP3, TNAP, TNFRSF13C, TNFRSF13B, TRAF1, TNFRSF4, IKBKE, IRF3, NFATC2IP, ZMYND11, PPP3CA, PPP3R1, UBE2O, SNAP29, TFG, SEC16A, RBM14, DCAF7, GALC, DYRK1A, ETV6, TROAP, MYT1, UCHL1, SYK, SAR1A, DAXX, EWSR1, IL15, ABCC1, APOBEC3C, IKBKG, UBE2I, PPP1CC, TMEM173, NMRAL1, RIPK2, ECH1, FAM53C, IFIT3, RNF166, ESR1, CREB1, MAP3K7, TRIM14, CSNK1E, FOSL1, DDX3X, VAV3, SPP1, TSKS, SHPK, CELF2, HNRNPC | SIVA1 | CD27, LPAR2, S1PR4, PXMP2, TP53, MDM2, NEDD4, NEDD4L, XIAP, MAP3K7, APP, CDKN2A, UBE2D1, NGFRAP1, PCNA, TBXA2R, TRAF2, RAD18, TYK2, FOXP3, CD4, TCAP, MEFV, STMN1, CAMK2G, RHOU |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAF3_SIVA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SIVA1 | O15304 | DB01593 | Zinc | Apoptosis regulatory protein Siva | small molecule | approved|investigational |
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RelatedDiseases for TRAF3_SIVA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRAF3 | C3553868 | HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 3 | 1 | UNIPROT |
Tgene | SIVA1 | C0010246 | Coxsackievirus Infections | 1 | CTD_human |