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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39338

FusionGeneSummary for TRAF3_KLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF3_KLC1
Fusion gene ID: 39338
HgeneTgene
Gene symbol

TRAF3

KLC1

Gene ID

7187

3831

Gene nameTNF receptor associated factor 3kinesin light chain 1
SynonymsCAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118KLC|KNS2|KNS2A
Cytomap

14q32.32

14q32.33

Type of geneprotein-codingprotein-coding
DescriptionTNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50
Modification date2018052720180522
UniProtAcc

Q13114

Q07866

Ensembl transtripts involved in fusion geneENST00000560371, ENST00000347662, 
ENST00000392745, ENST00000539721, 
ENST00000351691, 		ENST00000348520, 
ENST00000380038, ENST00000389744, 
ENST00000557575, ENST00000553286, 
ENST00000347839, ENST00000555836, 
ENST00000334553, ENST00000246489, 
ENST00000557450, ENST00000554280, 
ENST00000452929, ENST00000445352, 
Fusion gene scores* DoF score12 X 6 X 10=7206 X 7 X 2=84
# samples 137
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAF3 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-OL-A5RW-01ATRAF3chr14

103296809

+KLC1chr14

104120901

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000560371ENST00000348520TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000380038TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000389744TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000557575TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000553286TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000347839TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000555836TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000334553TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000246489TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000557450TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000554280TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000452929TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000560371ENST00000445352TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000348520TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000380038TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000389744TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000557575TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000553286TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000347839TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000555836TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000334553TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000246489TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000557450TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000554280TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000452929TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000347662ENST00000445352TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000348520TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000380038TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000389744TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000557575TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000553286TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000347839TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000555836TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000334553TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000246489TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000557450TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000554280TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000452929TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000392745ENST00000445352TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000348520TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000380038TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000389744TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000557575TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000553286TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000347839TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000555836TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000334553TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000246489TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000557450TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000554280TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000452929TRAF3chr14

103296809

+KLC1chr14

104120901

+
intron-5UTRENST00000539721ENST00000445352TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000348520TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000380038TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000389744TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000557575TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000553286TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000347839TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000555836TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000334553TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000246489TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000557450TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000554280TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000452929TRAF3chr14

103296809

+KLC1chr14

104120901

+
5UTR-5UTRENST00000351691ENST00000445352TRAF3chr14

103296809

+KLC1chr14

104120901

+

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FusionProtFeatures for TRAF3_KLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF3

Q13114

KLC1

Q07866

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAF3_KLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAF3_KLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAF3TANK, CASP3, SRC, MAP3K5, CD40, TNFSF14, TNFRSF9, TDP2, LTBR, NGFR, TNFRSF18, CD27, CFLAR, EDA2R, TNFRSF17, TRAF3IP2, TNFRSF14, RIPK1, TNFRSF11A, NUP62, TRAF3, TRAF3IP1, MAP3K14, TRIM37, USP7, OTUD5, TBK1, SMURF1, TRAIP, BIRC2, BIRC3, OTUB1, OTUB2, RNF216, MAVS, ZBP1, IRF1, AZI2, TLR3, TLR4, TLR9, TRAF2, USO1, TRAF5, WDR5, NLRX1, TNIP1, TAX1BP1, TICAM1, OPTN, CBLB, MYD88, TNFRSF1B, TNFRSF1A, FAS, TNFRSF8, PDLIM7, TRAF3IP3, TNAP, TNFRSF13C, TNFRSF13B, TRAF1, TNFRSF4, IKBKE, IRF3, NFATC2IP, ZMYND11, PPP3CA, PPP3R1, UBE2O, SNAP29, TFG, SEC16A, RBM14, DCAF7, GALC, DYRK1A, ETV6, TROAP, MYT1, UCHL1, SYK, SAR1A, DAXX, EWSR1, IL15, ABCC1, APOBEC3C, IKBKG, UBE2I, PPP1CC, TMEM173, NMRAL1, RIPK2, ECH1, FAM53C, IFIT3, RNF166, ESR1, CREB1, MAP3K7, TRIM14, CSNK1E, FOSL1, DDX3X, VAV3, SPP1, TSKS, SHPK, CELF2, HNRNPCKLC1MAPK8IP3, YWHAG, YWHAB, YWHAZ, SFN, LRSAM1, KIF5B, KIF5C, KIF5A, APP, MAPK6, SNCA, KLC2, KLC4, SKP1, BSDC1, FAM63B, LDLRAP1, PRKAG3, RASSF8, RIC3, YWHAE, ARCN1, COPB1, COPZ1, DIAPH1, TLE3, PTPN23, SMEK2, BNIP2, KRT31, CCDC114, EZH2, TRAK2, SYNE4, DTNBP1, KPTN, AZIN1, TRIP6, USP7, HSPB1, NTRK1, OFD1, FGFR1OP, CLK1, CSNK1D, RAP1B, SORT1, KLC3, POLR2C, PIAS1, NOLC1, RAB11FIP2, AVL9, ORC3, RBFOX1, RAB11FIP1, CEP44, DPY30, ZNF503, COG6, KIF2B, MYCL, ARHGAP17, SNAPIN, EXOC3, TRPC4AP, RABEP2, USF1, CCDC83, CBY1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAF3_KLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAF3_KLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRAF3C3553868HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 31UNIPROT