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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39331

FusionGeneSummary for TRAF3IP2_KIAA1324

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF3IP2_KIAA1324
Fusion gene ID: 39331
HgeneTgene
Gene symbol

TRAF3IP2

KIAA1324

Gene ID

10758

57535

Gene nameTRAF3 interacting protein 2KIAA1324
SynonymsACT1|C6orf2|C6orf4|C6orf5|C6orf6|CANDF8|CIKS|PSORS13EIG121
Cytomap

6q21

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionadapter protein CIKSNFkB-activating protein ACT1connection to IKK and SAPK/JNKnuclear factor NF-kappa-B activator 1UPF0577 protein KIAA1324estrogen-induced gene 121 proteinmaba1
Modification date2018052320180527
UniProtAcc

O43734

Q6UXG2

Ensembl transtripts involved in fusion geneENST00000368761, ENST00000359831, 
ENST00000392556, ENST00000340026, 
ENST00000368731, ENST00000368735, 
ENST00000369939, ENST00000529753, 
ENST00000369938, 
Fusion gene scores* DoF score3 X 4 X 4=485 X 5 X 5=125
# samples 49
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/125*10)=-0.473931188332412
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAF3IP2 [Title/Abstract] AND KIAA1324 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRAF3IP2

GO:0002230

positive regulation of defense response to virus by host

23066157


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A8I4-01ATRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000368761ENST00000369939TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5CDS-intronENST00000368761ENST00000529753TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5CDS-intronENST00000368761ENST00000369938TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
Frame-shiftENST00000359831ENST00000369939TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5CDS-intronENST00000359831ENST00000529753TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5CDS-intronENST00000359831ENST00000369938TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5UTR-3CDSENST00000392556ENST00000369939TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5UTR-intronENST00000392556ENST00000529753TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5UTR-intronENST00000392556ENST00000369938TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
Frame-shiftENST00000340026ENST00000369939TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5CDS-intronENST00000340026ENST00000529753TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
5CDS-intronENST00000340026ENST00000369938TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
intron-3CDSENST00000368731ENST00000369939TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
intron-intronENST00000368731ENST00000529753TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
intron-intronENST00000368731ENST00000369938TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
intron-3CDSENST00000368735ENST00000369939TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
intron-intronENST00000368735ENST00000529753TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+
intron-intronENST00000368735ENST00000369938TRAF3IP2chr6

111896846

-KIAA1324chr1

109727667

+

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FusionProtFeatures for TRAF3IP2_KIAA1324


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF3IP2

O43734

KIAA1324

Q6UXG2

May protect cells from cell death by inducing cytosolicvacuolization and upregulating the autophagy pathway.{ECO:0000269|PubMed:21072319}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAF3IP2_KIAA1324


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAF3IP2_KIAA1324


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAF3IP2TRAF2, MDFI, TRAF3, CD40, IKBKG, CHUK, IKBKB, UBC, IL17A, TRAF6, TRAF3IP2, IL17RA, MAP3K7, TNFRSF13C, TBK1, IKBKE, SYK, UBE2V1, ELAVL1, SRSF1, FHL3, TRIP6, STK16, MRPL28, RIMBP3, HSP90AA1, IL17RB, IL17RC, HSPA4, IRF3, QPRT, TRAF5, GOLGA2, MMGT1, HSD17B10, INVSKIAA1324


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAF3IP2_KIAA1324


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAF3IP2_KIAA1324


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRAF3IP2C0033860Psoriasis3CTD_human
HgeneTRAF3IP2C0003872Arthritis, Psoriatic2CTD_human
HgeneTRAF3IP2C3279754PSORIASIS 13, SUSCEPTIBILITY TO2UNIPROT
HgeneTRAF3IP2C3714992CANDIDIASIS, FAMILIAL, 81UNIPROT