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Fusion gene ID: 39316 |
FusionGeneSummary for TRABD2B_PSMD13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRABD2B_PSMD13 | Fusion gene ID: 39316 | Hgene | Tgene | Gene symbol | TRABD2B | PSMD13 | Gene ID | 388630 | 5719 |
| Gene name | TraB domain containing 2B | proteasome 26S subunit, non-ATPase 13 | |
| Synonyms | TIKI2 | HSPC027|Rpn9|S11|p40.5 | |
| Cytomap | 1p33 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metalloprotease TIKI2TRAB domain-containing protein 2BUPF0632 protein Aheart, kidney and adipose-enriched transmembrane protein homolog | 26S proteasome non-ATPase regulatory subunit 1326S proteasome regulatory subunit RPN926S proteasome regulatory subunit S1126S proteasome regulatory subunit p40.526S proteasome subunit p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | |
| Modification date | 20180403 | 20180523 | |
| UniProtAcc | A6NFA1 | Q9UNM6 | |
| Ensembl transtripts involved in fusion gene | ENST00000606738, ENST00000435576, | ENST00000532097, ENST00000431206, ENST00000352303, ENST00000532025, | |
| Fusion gene scores | * DoF score | 7 X 3 X 5=105 | 4 X 3 X 4=48 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRABD2B [Title/Abstract] AND PSMD13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRABD2B | GO:0006508 | proteolysis | 22726442 |
| Hgene | TRABD2B | GO:0030178 | negative regulation of Wnt signaling pathway | 22726442 |
| Hgene | TRABD2B | GO:0032461 | positive regulation of protein oligomerization | 22726442 |
| Hgene | TRABD2B | GO:1904808 | positive regulation of protein oxidation | 22726442 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-ND-A4WF-01A | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000606738 | ENST00000532097 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| Frame-shift | ENST00000606738 | ENST00000431206 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| In-frame | ENST00000606738 | ENST00000352303 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| 5CDS-intron | ENST00000606738 | ENST00000532025 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000532097 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000431206 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000352303 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
| 5UTR-intron | ENST00000435576 | ENST00000532025 | TRABD2B | chr1 | 48459706 | - | PSMD13 | chr11 | 244041 | + |
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FusionProtFeatures for TRABD2B_PSMD13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRABD2B | PSMD13 |
| Metalloprotease that acts as a negative regulator of theWnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage,Wnt proteins become oxidized and form large disulfide-bondoligomers, leading to their inactivation. Able to cleave WNT3A,WNT5, but not WNT11. Required for head formation.{ECO:0000269|PubMed:22726442}. | Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair.{ECO:0000269|PubMed:1317798}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PSMD13 | chr1:48459706 | chr11:244041 | ENST00000431206 | + | 0 | 11 | 171_338 | 31 | 379 | Domain | PCI |
| Tgene | >PSMD13 | chr1:48459706 | chr11:244041 | ENST00000532097 | + | 1 | 13 | 171_338 | 58 | 377 | Domain | PCI |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TRABD2B | chr1:48459706 | chr11:244041 | ENST00000606738 | - | 2 | 7 | 20_494 | 222 | 518 | Topological domain | Extracellular |
| Hgene | >TRABD2B | chr1:48459706 | chr11:244041 | ENST00000606738 | - | 2 | 7 | 516_517 | 222 | 518 | Topological domain | Cytoplasmic |
| Hgene | >TRABD2B | chr1:48459706 | chr11:244041 | ENST00000606738 | - | 2 | 7 | 495_515 | 222 | 518 | Transmembrane | Helical |
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FusionGeneSequence for TRABD2B_PSMD13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PSMD13_ENST00000532097_chr11_244041_+_541aa MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTD PYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRF RGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKS SDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQER AFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPA NHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDILT >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PSMD13_ENST00000352303_chr11_244041_+_514aa MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTD PYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRF RGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKS SDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQER AFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEVELLVMK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PSMD13_ENST00000532097_chr11_244041_+_1623nt ATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGACGGAGGACAGTGCCGG CCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGGCACTATTCACGTCCCC TACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGAGCTGGACCTTACAGAC CCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCACGAGCTTTACTGGCGC TTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCTCTATGCTGACTACCTA TTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGAGAGGGACGTGCGCTTC CGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGAGCAGGTGGAGGAGCAG TGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGCTTTATGAAAACTTTATCAGTGAATTTGAACACAGGGTGAACCCTTTGTCCCTC GTGGAAATCATTCTTCATGTAGTTAGACAGATGACTGATCCTAATGTGGCTCTTACTTTTCTGGAAAAGACTCGTGAGAAGGTGAAAAGT AGTGATGAGGCAGTGATCCTGTGTAAAACAGCAATTGGAGCTCTAAAATTAAACATCGGGGACCTACAGGTTACAAAGGAAACAATTGAA GATGTTGAAGAAATGCTCAACAACCTTCCTGGTGTGACATCGGTTCACAGTCGTTTCTATGATCTCTCCAGTAAATACTATCAAACAATC GGAAACCACGCGTCCTACTACAAAGATGCTCTGCGGTTTTTGGGCTGTGTTGACATCAAGGATCTACCAGTGTCTGAGCAGCAGGAGAGA GCCTTCACGCTGGGGCTAGCAGGACTTCTCGGCGAGGGAGTTTTTAACTTTGGAGAACTCCTCATGCACCCTGTGCTGGAGTCCCTGAGG AATACTGACCGGCAGTGGCTGATTGACACCCTCTATGCCTTCAACAGTGGCAACGTAGAGCGGTTCCAGACTCTGAAGACTGCCTGGGGC CAGCAGCCTGATTTAGCAGCTAATGAAGCCCAGCTTCTGAGGAAAATTCAGTTGTTGTGCCTCATGGAGATGACTTTCACACGACCTGCC AATCACAGACAACTCACTTTTGAAGAAATTGCCAAAAGTGCTAAAATCACAGTGAATGAGGTGGAGCTTCTGGTGATGAAGGCCCTTTCG GTGGGGCTGGTGAAAGGCAGTATAGACGAGGTGGACAAACGAGTCCACATGACCTGGGTGCAGCCCCGAGTGTTGGATTTGCAACAGATC AAGGGAATGAAGGACCGCCTGGAGTTCTGGTGCACGGATGTGAAGAGCATGGAGATGCTGGTGGAGCACCAGGCCCATGACATCCTCACC >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PSMD13_ENST00000352303_chr11_244041_+_1542nt ATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGACGGAGGACAGTGCCGG CCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGGCACTATTCACGTCCCC TACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGAGCTGGACCTTACAGAC CCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCACGAGCTTTACTGGCGC TTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCTCTATGCTGACTACCTA TTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGAGAGGGACGTGCGCTTC CGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGAGCAGGTGGAGGAGCAG TGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGCTTTATGAAAACTTTATCAGTGAATTTGAACACAGGGTGAACCCTTTGTCCCTC GTGGAAATCATTCTTCATGTAGTTAGACAGATGACTGATCCTAATGTGGCTCTTACTTTTCTGGAAAAGACTCGTGAGAAGGTGAAAAGT AGTGATGAGGCAGTGATCCTGTGTAAAACAGCAATTGGAGCTCTAAAATTAAACATCGGGGACCTACAGGTTACAAAGGAAACAATTGAA GATGTTGAAGAAATGCTCAACAACCTTCCTGGTGTGACATCGGTTCACAGTCGTTTCTATGATCTCTCCAGTAAATACTATCAAACAATC GGAAACCACGCGTCCTACTACAAAGATGCTCTGCGGTTTTTGGGCTGTGTTGACATCAAGGATCTACCAGTGTCTGAGCAGCAGGAGAGA GCCTTCACGCTGGGGCTAGCAGGACTTCTCGGCGAGGGAGTTTTTAACTTTGGAGAACTCCTCATGCACCCTGTGCTGGAGTCCCTGAGG AATACTGACCGGCAGTGGCTGATTGACACCCTCTATGCCTTCAACAGTGGCAACGTAGAGCGGTTCCAGACTCTGAAGACTGCCTGGGGC CAGCAGCCTGATTTAGCAGCTAATGAAGCCCAGCTTCTGAGGAAAATTCAGTTGTTGTGCCTCATGGAGGTGGAGCTTCTGGTGATGAAG GCCCTTTCGGTGGGGCTGGTGAAAGGCAGTATAGACGAGGTGGACAAACGAGTCCACATGACCTGGGTGCAGCCCCGAGTGTTGGATTTG CAACAGATCAAGGGAATGAAGGACCGCCTGGAGTTCTGGTGCACGGATGTGAAGAGCATGGAGATGCTGGTGGAGCACCAGGCCCATGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PSMD13_ENST00000532097_chr11_244041_+_2085nt TGGAGCCCCGTGCTCCAGAGGAAACTCCGTGCCCAACTGGGGGCTCCCCGCCCCGCTGAGGGGCGCCGCCCAGGAGGGTCCCCCGCGCCC CGCGGGCCCTGGCAGGATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGA CGGAGGACAGTGCCGGCCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGG CACTATTCACGTCCCCTACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGA GCTGGACCTTACAGACCCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCA CGAGCTTTACTGGCGCTTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCT CTATGCTGACTACCTATTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGA GAGGGACGTGCGCTTCCGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGA GCAGGTGGAGGAGCAGTGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGCTTTATGAAAACTTTATCAGTGAATTTGAACACAGGGT GAACCCTTTGTCCCTCGTGGAAATCATTCTTCATGTAGTTAGACAGATGACTGATCCTAATGTGGCTCTTACTTTTCTGGAAAAGACTCG TGAGAAGGTGAAAAGTAGTGATGAGGCAGTGATCCTGTGTAAAACAGCAATTGGAGCTCTAAAATTAAACATCGGGGACCTACAGGTTAC AAAGGAAACAATTGAAGATGTTGAAGAAATGCTCAACAACCTTCCTGGTGTGACATCGGTTCACAGTCGTTTCTATGATCTCTCCAGTAA ATACTATCAAACAATCGGAAACCACGCGTCCTACTACAAAGATGCTCTGCGGTTTTTGGGCTGTGTTGACATCAAGGATCTACCAGTGTC TGAGCAGCAGGAGAGAGCCTTCACGCTGGGGCTAGCAGGACTTCTCGGCGAGGGAGTTTTTAACTTTGGAGAACTCCTCATGCACCCTGT GCTGGAGTCCCTGAGGAATACTGACCGGCAGTGGCTGATTGACACCCTCTATGCCTTCAACAGTGGCAACGTAGAGCGGTTCCAGACTCT GAAGACTGCCTGGGGCCAGCAGCCTGATTTAGCAGCTAATGAAGCCCAGCTTCTGAGGAAAATTCAGTTGTTGTGCCTCATGGAGATGAC TTTCACACGACCTGCCAATCACAGACAACTCACTTTTGAAGAAATTGCCAAAAGTGCTAAAATCACAGTGAATGAGGTGGAGCTTCTGGT GATGAAGGCCCTTTCGGTGGGGCTGGTGAAAGGCAGTATAGACGAGGTGGACAAACGAGTCCACATGACCTGGGTGCAGCCCCGAGTGTT GGATTTGCAACAGATCAAGGGAATGAAGGACCGCCTGGAGTTCTGGTGCACGGATGTGAAGAGCATGGAGATGCTGGTGGAGCACCAGGC CCATGACATCCTCACCTAGGGCCCCCTGGTTCCCCGTCGTGTCTCCTTTGACTCACCTGAGAGAGGCGTTTGCAGCCAATGAAGCTGGCT GCTCAGACGGTCGACATTGAATTTGGGTGGGGGTTGGGATCCTGTCTGAAGTACAGACTGTTCTTGCTCTAAAAACAGGACTGTCCCTGA TGGGAGCCAGGCCACAGGGAGGAGGCTTCTTTGTGGGTCTCTCCTGCAGAGGGTGGGGGTCTCAGGGTCTTAGGTGATACGGGAGAGAAA GAACGTGCCAGGCAGGAGGCCCCCTGAAGTCTGTGTACTCCGAGGTGGATCTCCATCCCCATCCACCTGTACGGACATCTTTTCCGTTGC >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PSMD13_ENST00000352303_chr11_244041_+_2001nt TGGAGCCCCGTGCTCCAGAGGAAACTCCGTGCCCAACTGGGGGCTCCCCGCCCCGCTGAGGGGCGCCGCCCAGGAGGGTCCCCCGCGCCC CGCGGGCCCTGGCAGGATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGA CGGAGGACAGTGCCGGCCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGG CACTATTCACGTCCCCTACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGA GCTGGACCTTACAGACCCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCA CGAGCTTTACTGGCGCTTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCT CTATGCTGACTACCTATTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGA GAGGGACGTGCGCTTCCGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGA GCAGGTGGAGGAGCAGTGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGCTTTATGAAAACTTTATCAGTGAATTTGAACACAGGGT GAACCCTTTGTCCCTCGTGGAAATCATTCTTCATGTAGTTAGACAGATGACTGATCCTAATGTGGCTCTTACTTTTCTGGAAAAGACTCG TGAGAAGGTGAAAAGTAGTGATGAGGCAGTGATCCTGTGTAAAACAGCAATTGGAGCTCTAAAATTAAACATCGGGGACCTACAGGTTAC AAAGGAAACAATTGAAGATGTTGAAGAAATGCTCAACAACCTTCCTGGTGTGACATCGGTTCACAGTCGTTTCTATGATCTCTCCAGTAA ATACTATCAAACAATCGGAAACCACGCGTCCTACTACAAAGATGCTCTGCGGTTTTTGGGCTGTGTTGACATCAAGGATCTACCAGTGTC TGAGCAGCAGGAGAGAGCCTTCACGCTGGGGCTAGCAGGACTTCTCGGCGAGGGAGTTTTTAACTTTGGAGAACTCCTCATGCACCCTGT GCTGGAGTCCCTGAGGAATACTGACCGGCAGTGGCTGATTGACACCCTCTATGCCTTCAACAGTGGCAACGTAGAGCGGTTCCAGACTCT GAAGACTGCCTGGGGCCAGCAGCCTGATTTAGCAGCTAATGAAGCCCAGCTTCTGAGGAAAATTCAGTTGTTGTGCCTCATGGAGGTGGA GCTTCTGGTGATGAAGGCCCTTTCGGTGGGGCTGGTGAAAGGCAGTATAGACGAGGTGGACAAACGAGTCCACATGACCTGGGTGCAGCC CCGAGTGTTGGATTTGCAACAGATCAAGGGAATGAAGGACCGCCTGGAGTTCTGGTGCACGGATGTGAAGAGCATGGAGATGCTGGTGGA GCACCAGGCCCATGACATCCTCACCTAGGGCCCCCTGGTTCCCCGTCGTGTCTCCTTTGACTCACCTGAGAGAGGCGTTTGCAGCCAATG AAGCTGGCTGCTCAGACGGTCGACATTGAATTTGGGTGGGGGTTGGGATCCTGTCTGAAGTACAGACTGTTCTTGCTCTAAAAACAGGAC TGTCCCTGATGGGAGCCAGGCCACAGGGAGGAGGCTTCTTTGTGGGTCTCTCCTGCAGAGGGTGGGGGTCTCAGGGTCTTAGGTGATACG GGAGAGAAAGAACGTGCCAGGCAGGAGGCCCCCTGAAGTCTGTGTACTCCGAGGTGGATCTCCATCCCCATCCACCTGTACGGACATCTT |
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FusionGenePPI for TRABD2B_PSMD13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRABD2B | PSMD13 | PSMD2, PSMD12, PSMD1, PSMD11, PSMC3, PSMD3, PSMD6, PSMC1, PSMC4, PSMC2, PSMC5, PSMD14, PSMD7, PSMD8, PSMD4, PSMA3, MTHFD2, PSMC6, PSMA1, VHL, PSMA6, SLC25A22, PSMA7, CRB1, FES, TRAF6, UCHL5, USP14, INSIG2, SHFM1, RAD23A, FKBP8, PSMA2, GRB2, PSMD10, PSMD5, PSMB1, PSMB5, PSMB7, PSMA5, PSMB3, PSMB2, PSMA4, PSMB4, PSMB6, RAD23B, PSMA8, UNC45A, ZCCHC8, RBBP4, FN1, NOS2, PARK2, RNF11, ADRM1, HNRNPA2B1, PPFIA1, PPP1R2P4, ABCF1, DHX9, KIAA0368, FLNC, HNRNPA0, KCMF1, MAP2, STRN3, RANBP9, RPS21, RPS8, STRN4, TXNL1, UBR4, RPE65, HUWE1, ABCE1, DKK1, CCDC74B, CCDC92, PSMB9, AMBRA1, PSMB8, PSMD9, PSMG2, ZFYVE19, NTRK1, SRPK2, SNW1, CDC5L, POU5F1, UBLCP1, PTPN2, UBC, INTU, CYLD, DLD, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRABD2B_PSMD13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRABD2B_PSMD13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PSMD13 | C0019693 | HIV Infections | 1 | CTD_human |
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