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Fusion gene ID: 39315 |
FusionGeneSummary for TRABD2B_PKN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRABD2B_PKN2 | Fusion gene ID: 39315 | Hgene | Tgene | Gene symbol | TRABD2B | PKN2 | Gene ID | 388630 | 5586 |
| Gene name | TraB domain containing 2B | protein kinase N2 | |
| Synonyms | TIKI2 | PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7 | |
| Cytomap | 1p33 | 1p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metalloprotease TIKI2TRAB domain-containing protein 2BUPF0632 protein Aheart, kidney and adipose-enriched transmembrane protein homolog | serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2 | |
| Modification date | 20180403 | 20180523 | |
| UniProtAcc | A6NFA1 | Q16513 | |
| Ensembl transtripts involved in fusion gene | ENST00000606738, ENST00000435576, | ENST00000316005, ENST00000370521, ENST00000370505, ENST00000370513, ENST00000544045, ENST00000495119, | |
| Fusion gene scores | * DoF score | 7 X 3 X 5=105 | 4 X 2 X 3=24 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TRABD2B [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRABD2B | GO:0006508 | proteolysis | 22726442 |
| Hgene | TRABD2B | GO:0030178 | negative regulation of Wnt signaling pathway | 22726442 |
| Hgene | TRABD2B | GO:0032461 | positive regulation of protein oligomerization | 22726442 |
| Hgene | TRABD2B | GO:1904808 | positive regulation of protein oxidation | 22726442 |
| Tgene | PKN2 | GO:0006468 | protein phosphorylation | 17332740 |
| Tgene | PKN2 | GO:0010631 | epithelial cell migration | 21754995 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A5ZV-01A | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000606738 | ENST00000316005 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| In-frame | ENST00000606738 | ENST00000370521 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000370505 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000370513 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000544045 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5CDS-intron | ENST00000606738 | ENST00000495119 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000316005 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-3CDS | ENST00000435576 | ENST00000370521 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000370505 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000370513 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000544045 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
| 5UTR-intron | ENST00000435576 | ENST00000495119 | TRABD2B | chr1 | 48459706 | - | PKN2 | chr1 | 89206671 | + |
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FusionProtFeatures for TRABD2B_PKN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRABD2B | PKN2 |
| Metalloprotease that acts as a negative regulator of theWnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage,Wnt proteins become oxidized and form large disulfide-bondoligomers, leading to their inactivation. Able to cleave WNT3A,WNT5, but not WNT11. Required for head formation.{ECO:0000269|PubMed:22726442}. | PKC-related serine/threonine-protein kinase and Rho/Raceffector protein that participates in specific signal transductionresponses in the cell. Plays a role in the regulation of cellcycle progression, actin cytoskeleton assembly, cell migration,cell adhesion, tumor cell invasion and transcription activationsignaling processes. Phosphorylates CTTN in hyaluronan-inducedastrocytes and hence decreases CTTN ability to associate withfilamentous actin. Phosphorylates HDAC5, therefore lead to impairHDAC5 import. Direct RhoA target required for the regulation ofthe maturation of primordial junctions into apical junctionformation in bronchial epithelial cells. Required for G2/M phasesof the cell cycle progression and abscission during cytokinesis ina ECT2-dependent manner. Stimulates FYN kinase activity that isrequired for establishment of skin cell-cell adhesion duringkeratinocytes differentiation. Regulates epithelial bladder cellsspeed and direction of movement during cell migration and tumorcell invasion. Inhibits Akt pro-survival-induced kinase activity.Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leadingto stimulation of HCV RNA replication. Involved in the negativeregulation of ciliogenesis (PubMed:27104747).{ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925,ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095,ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740,ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804,ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747,ECO:0000269|PubMed:9121475}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 121_203 | -147 | 828 | Domain | REM-1 2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 204_284 | -147 | 828 | Domain | REM-1 3 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 330_463 | -147 | 828 | Domain | Note=C2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 33_109 | -147 | 828 | Domain | REM-1 1 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 657_916 | -147 | 828 | Domain | Protein kinase |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 917_984 | -147 | 828 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 121_203 | 16 | 937 | Domain | REM-1 2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 204_284 | 16 | 937 | Domain | REM-1 3 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 330_463 | 16 | 937 | Domain | Note=C2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 33_109 | 16 | 937 | Domain | REM-1 1 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 657_916 | 16 | 937 | Domain | Protein kinase |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 917_984 | 16 | 937 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 121_203 | 16 | 985 | Domain | REM-1 2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 204_284 | 16 | 985 | Domain | REM-1 3 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 330_463 | 16 | 985 | Domain | Note=C2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 33_109 | 16 | 985 | Domain | REM-1 1 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 657_916 | 16 | 985 | Domain | Protein kinase |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 917_984 | 16 | 985 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 121_203 | -37 | 659 | Domain | REM-1 2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 204_284 | -37 | 659 | Domain | REM-1 3 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 330_463 | -37 | 659 | Domain | Note=C2 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 33_109 | -37 | 659 | Domain | REM-1 1 |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 657_916 | -37 | 659 | Domain | Protein kinase |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 917_984 | -37 | 659 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 663_671 | -147 | 828 | Nucleotide binding | ATP |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 663_671 | 16 | 937 | Nucleotide binding | ATP |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 663_671 | 16 | 985 | Nucleotide binding | ATP |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 663_671 | -37 | 659 | Nucleotide binding | ATP |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 382_463 | -147 | 828 | Region | Necessary to rescue apical junction formation |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 917_977 | -147 | 828 | Region | Note=Necessary for the catalytic activity |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370505 | + | 0 | 21 | 978_984 | -147 | 828 | Region | Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 382_463 | 16 | 937 | Region | Necessary to rescue apical junction formation |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 917_977 | 16 | 937 | Region | Note=Necessary for the catalytic activity |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370513 | + | 0 | 21 | 978_984 | 16 | 937 | Region | Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 382_463 | 16 | 985 | Region | Necessary to rescue apical junction formation |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 917_977 | 16 | 985 | Region | Note=Necessary for the catalytic activity |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000370521 | + | 0 | 22 | 978_984 | 16 | 985 | Region | Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 382_463 | -37 | 659 | Region | Necessary to rescue apical junction formation |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 917_977 | -37 | 659 | Region | Note=Necessary for the catalytic activity |
| Tgene | >PKN2 | chr1:48459706 | chr1:89206671 | ENST00000544045 | + | 0 | 17 | 978_984 | -37 | 659 | Region | Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TRABD2B | chr1:48459706 | chr1:89206671 | ENST00000606738 | - | 2 | 7 | 20_494 | 222 | 518 | Topological domain | Extracellular |
| Hgene | >TRABD2B | chr1:48459706 | chr1:89206671 | ENST00000606738 | - | 2 | 7 | 516_517 | 222 | 518 | Topological domain | Cytoplasmic |
| Hgene | >TRABD2B | chr1:48459706 | chr1:89206671 | ENST00000606738 | - | 2 | 7 | 495_515 | 222 | 518 | Transmembrane | Helical |
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FusionGeneSequence for TRABD2B_PKN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PKN2_ENST00000316005_chr1_89206671_+_811aa MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTD PYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRF RGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKE GAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQG AENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLG SGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVR LMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLE LDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINI ATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPARYVSEILSISYTKLLGHSYVLIIAGVLSLAFFPSSILKVVFCLLKK >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PKN2_ENST00000370521_chr1_89206671_+_1191aa MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTD PYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRF RGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKE GAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQG AENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLG SGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVR LMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLE LDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINI ATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSE TVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIV ARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLK LDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEV RYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PKN2_ENST00000316005_chr1_89206671_+_2433nt ATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGACGGAGGACAGTGCCGG CCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGGCACTATTCACGTCCCC TACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGAGCTGGACCTTACAGAC CCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCACGAGCTTTACTGGCGC TTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCTCTATGCTGACTACCTA TTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGAGAGGGACGTGCGCTTC CGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGAGCAGGTGGAGGAGCAG TGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAGTGCTGTTCAAAAATTA GACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGAACTGAAAATCAAAGAA GGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATCAAATAAAAAATTAGAA GAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCCAAGGACTCCAGATACT CCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACTTAAAGTAAAACAAGGT GCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACTGCTCCAGGACAGCAAG ACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAAACCTGTGATAAGTCCT CTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGTAATGAAATTACTTGGC TCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGACCTTTTAAAGTATTCA TTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGTTGCTGCATCACCAACA CTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGGTACTTTGGAAGTTCGT CTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTGGAGTCCAAGTGAAACC AGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTTGTCCAATGATGTCTGT GCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCAGAAGTTTACACTGGAA CTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCTGAGGTTAGAAGATTTT TTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTTTAATCCAGTTATTGAA AGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCAAATGAATATTAATATT GCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCCTGTGCCTACTACAGTG CCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGGTATGTGTCTGAGATTTTAAGCATCTCTTATACAAAGTTATTGGGA CATTCTTACGTACTGATTATAGCAGGTGTACTGAGTCTTGCTTTTTTCCCAAGTAGTATTTTGAAAGTAGTGTTCTGTTTACTTAAAAAG >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PKN2_ENST00000370521_chr1_89206671_+_3573nt ATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGACGGAGGACAGTGCCGG CCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGGCACTATTCACGTCCCC TACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGAGCTGGACCTTACAGAC CCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCACGAGCTTTACTGGCGC TTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCTCTATGCTGACTACCTA TTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGAGAGGGACGTGCGCTTC CGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGAGCAGGTGGAGGAGCAG TGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAGTGCTGTTCAAAAATTA GACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGAACTGAAAATCAAAGAA GGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATCAAATAAAAAATTAGAA GAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCCAAGGACTCCAGATACT CCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACTTAAAGTAAAACAAGGT GCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACTGCTCCAGGACAGCAAG ACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAAACCTGTGATAAGTCCT CTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGTAATGAAATTACTTGGC TCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGACCTTTTAAAGTATTCA TTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGTTGCTGCATCACCAACA CTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGGTACTTTGGAAGTTCGT CTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTGGAGTCCAAGTGAAACC AGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTTGTCCAATGATGTCTGT GCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCAGAAGTTTACACTGGAA CTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCTGAGGTTAGAAGATTTT TTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTTTAATCCAGTTATTGAA AGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCAAATGAATATTAATATT GCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCCTGTGCCTACTACAGTG CCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGTGATTCTACAGTAACCAAATTGGACTTTGATCTTGAGCCTGAACCT CCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGAAATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACCAGGACAGGATTCAGAG ACTGTTTTTGATATTCAGAATGACAGAAATAGTATACTTCCAAAATCTCAATCTGAATACAAGCCTGATACTCCTCAGTCAGGCCTAGAA TATAGTGGTATTCAAGAACTTGAGGACAGAAGATCTCAGCAAAGGTTTCAGTTTAATCTACAAGATTTCAGGTGTTGTGCTGTCTTGGGA AGAGGACATTTTGGAAAGGTGCTTTTAGCTGAATATAAAAACACAAATGAGATGTTTGCTATAAAAGCCTTAAAGAAAGGAGATATTGTG GCTCGAGATGAAGTAGACAGCCTGATGTGTGAAAAAAGAATTTTTGAAACTGTGAATAGTGTAAGGCATCCCTTTTTGGTGAACCTTTTT GCATGTTTCCAAACCAAAGAGCATGTTTGCTTTGTAATGGAATATGCTGCCGGTGGGGACCTAATGATGCACATTCATACTGATGTCTTT TCTGAACCAAGAGCTGTATTTTATGCTGCTTGTGTAGTTCTTGGGTTGCAGTATTTACATGAACACAAAATTGTTTATAGAGATTTGAAA TTGGATAACTTATTGCTAGATACAGAGGGCTTTGTGAAAATTGCTGATTTTGGTCTTTGCAAAGAAGGAATGGGATATGGAGATAGAACA AGCACATTTTGTGGCACTCCTGAATTTCTTGCCCCAGAAGTATTAACAGAAACTTCTTATACAAGGGCTGTAGATTGGTGGGGCCTTGGC GTGCTTATATATGAAATGCTTGTTGGTGAGTCTCCCTTTCCTGGTGATGATGAAGAGGAAGTTTTTGACAGTATTGTAAATGATGAAGTA AGGTATCCAAGGTTCTTATCTACAGAAGCCATTTCTATAATGAGAAGGCTGTTAAGAAGAAATCCTGAACGGCGCCTTGGGGCTAGCGAG AAAGATGCAGAGGATGTAAAAAAGCACCCATTTTTCCGGCTAATTGATTGGAGCGCTCTGATGGACAAAAAAGTAAAGCCACCATTTATA CCTACCATAAGAGGACGAGAAGATGTTAGTAATTTTGATGATGAATTTACCTCAGAAGCACCTATTCTGACTCCACCTCGAGAACCAAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PKN2_ENST00000316005_chr1_89206671_+_2997nt TGGAGCCCCGTGCTCCAGAGGAAACTCCGTGCCCAACTGGGGGCTCCCCGCCCCGCTGAGGGGCGCCGCCCAGGAGGGTCCCCCGCGCCC CGCGGGCCCTGGCAGGATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGA CGGAGGACAGTGCCGGCCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGG CACTATTCACGTCCCCTACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGA GCTGGACCTTACAGACCCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCA CGAGCTTTACTGGCGCTTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCT CTATGCTGACTACCTATTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGA GAGGGACGTGCGCTTCCGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGA GCAGGTGGAGGAGCAGTGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAG TGCTGTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGA ACTGAAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATC AAATAAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCC AAGGACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACT TAAAGTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACT GCTCCAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAA ACCTGTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGT AATGAAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGA CCTTTTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGT TGCTGCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGG TACTTTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTG GAGTCCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTT GTCCAATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCA GAAGTTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCT GAGGTTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTT TAATCCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCA AATGAATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCC TGTGCCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGGTATGTGTCTGAGATTTTAAGCATCTCTTA TACAAAGTTATTGGGACATTCTTACGTACTGATTATAGCAGGTGTACTGAGTCTTGCTTTTTTCCCAAGTAGTATTTTGAAAGTAGTGTT CTGTTTACTTAAAAAGTAAATTGTTTGCTTTAATTTTAAAGCTGTTTAAAATACAGACTTTCTATTACTGTTTTGGTGAGTTACTTTATC TTCTATAAGTGATTCTACAGTAACCAAATTGGACTTTGATCTTGAGCCTGAACCTCCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGA AATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACCAGGACAGGCAAGCCATTTTAAACCTTGCATAATTCCTCTTCACTGAATGAA TTAGCAATAAAAGCATCATAGTGAATAAGGCGTGTCTTTCCATTTAAAATTGCCACTGAACTGTGAATTTATGGTTTTTTGTTTGTTTTT TGTTTTTGTTTTTGTTTTTTGAGACAGAGTTTCACTCTTGTTACCCAGGCTGGAGTGCAATGGCATGATCTCGGCTCACTGCAACCTCCG >In-frame_TRABD2B_ENST00000606738_chr1_48459706_-_PKN2_ENST00000370521_chr1_89206671_+_6486nt TGGAGCCCCGTGCTCCAGAGGAAACTCCGTGCCCAACTGGGGGCTCCCCGCCCCGCTGAGGGGCGCCGCCCAGGAGGGTCCCCCGCGCCC CGCGGGCCCTGGCAGGATGCACGCCGCCCTGGCGGGGCCGCTGCTCGCCGCCCTCCTCGCCACCGCTCGCGCCCGCCCGCAGCCCCCGGA CGGAGGACAGTGCCGGCCGCCCGGATCGCAGAGGGACTTGAACTCCTTCCTGTGGACGATTCGGCGTGATCCTCCGGCCTACCTGTTTGG CACTATTCACGTCCCCTACACCCGCGTCTGGGACTTCATCCCGGACAACTCCAAGGCAGCCTTCCAGGCTAGCACCCGTGTCTACTTTGA GCTGGACCTTACAGACCCCTACACCATCTCGGCCCTGGCCAGCTGCCAGCTGCTGCCGCACGGGGAAAACCTGCAGGACGTGCTGCCCCA CGAGCTTTACTGGCGCTTGAAGCGCCACCTGGACTACGTGAAGTTGATGATGCCCTCCTGGATGACGCCCGCTCAGCGGGGCAAGGGGCT CTATGCTGACTACCTATTCAATGCCATCGCGGGCAACTGGGAGCGCAAGAGGCCCGTCTGGGTGATGCTCATGGTAAACTCGCTCACAGA GAGGGACGTGCGCTTCCGTGGTGTGCCCGTGCTCGACCTCTACCTGGCCCAGCAGGCTGAGAAGATGAAGAAGACCACAGGGGCTGTGGA GCAGGTGGAGGAGCAGTGCCATCCCCTCAACAACGGGCTCAACTTCTCCCAGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAG TGCTGTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGA ACTGAAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATC AAATAAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCC AAGGACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACT TAAAGTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACT GCTCCAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAA ACCTGTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGT AATGAAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGA CCTTTTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGT TGCTGCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGG TACTTTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTG GAGTCCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTT GTCCAATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCA GAAGTTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCT GAGGTTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTT TAATCCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCA AATGAATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCC TGTGCCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGTGATTCTACAGTAACCAAATTGGACTTTGA TCTTGAGCCTGAACCTCCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGAAATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACC AGGACAGGATTCAGAGACTGTTTTTGATATTCAGAATGACAGAAATAGTATACTTCCAAAATCTCAATCTGAATACAAGCCTGATACTCC TCAGTCAGGCCTAGAATATAGTGGTATTCAAGAACTTGAGGACAGAAGATCTCAGCAAAGGTTTCAGTTTAATCTACAAGATTTCAGGTG TTGTGCTGTCTTGGGAAGAGGACATTTTGGAAAGGTGCTTTTAGCTGAATATAAAAACACAAATGAGATGTTTGCTATAAAAGCCTTAAA GAAAGGAGATATTGTGGCTCGAGATGAAGTAGACAGCCTGATGTGTGAAAAAAGAATTTTTGAAACTGTGAATAGTGTAAGGCATCCCTT TTTGGTGAACCTTTTTGCATGTTTCCAAACCAAAGAGCATGTTTGCTTTGTAATGGAATATGCTGCCGGTGGGGACCTAATGATGCACAT TCATACTGATGTCTTTTCTGAACCAAGAGCTGTATTTTATGCTGCTTGTGTAGTTCTTGGGTTGCAGTATTTACATGAACACAAAATTGT TTATAGAGATTTGAAATTGGATAACTTATTGCTAGATACAGAGGGCTTTGTGAAAATTGCTGATTTTGGTCTTTGCAAAGAAGGAATGGG ATATGGAGATAGAACAAGCACATTTTGTGGCACTCCTGAATTTCTTGCCCCAGAAGTATTAACAGAAACTTCTTATACAAGGGCTGTAGA TTGGTGGGGCCTTGGCGTGCTTATATATGAAATGCTTGTTGGTGAGTCTCCCTTTCCTGGTGATGATGAAGAGGAAGTTTTTGACAGTAT TGTAAATGATGAAGTAAGGTATCCAAGGTTCTTATCTACAGAAGCCATTTCTATAATGAGAAGGCTGTTAAGAAGAAATCCTGAACGGCG CCTTGGGGCTAGCGAGAAAGATGCAGAGGATGTAAAAAAGCACCCATTTTTCCGGCTAATTGATTGGAGCGCTCTGATGGACAAAAAAGT AAAGCCACCATTTATACCTACCATAAGAGGACGAGAAGATGTTAGTAATTTTGATGATGAATTTACCTCAGAAGCACCTATTCTGACTCC ACCTCGAGAACCAAGGATACTTTCGGAAGAGGAGCAGGAAATGTTCAGAGATTTTGACTACATTGCTGATTGGTGTTAAGTTGCTAGACA CTGCGAAACCAAGCTGACTCACAAGAAGACCTCTTAAAAATAGCAACCCTTCATTTGCTCTCTGTGCCACCAATAGCTTCTGAGTTTTTT GTTGTTGTTGTTTTTATTGAAACACGTGAAGATTTGTTTAAAAGTACCATTCTAATACTTCTTCAAAAGTGGCTCCTCATTGTACTTCAG CGTAAATATGAGCACTGGAAACAGTTTCATGGAGTTTAAGTTGAGTGAACATCGGCCATGAAAATCCATCACGAATACTTTTGGATCAAT AGTCTATTTTTAAAAAGAAAGAAAAAAACCACTTTTTTATAGTCCCTAGCTTTGCCATATGCCCGCCTTAAGTGGAAGGAAAGTTAATCA CTTAACTATGTTTTATAAAAAGAAAAAAGGGCTTGGAATGCTATTACTGTTCACACAAAGTATGATTCTGTTTGAATAAGGCAAATGCTC CTTTTTTTAAAAAAAAAGACATTACTGTAATATCAAAAACCGTGGCAGTTTGTATACAACTCGGGGCTTGATTTTTTTTAAAAAAACAGA ATGAATTGATGTCTTATTTTATAAATGTTCTATATTTATTAGGAGAAAACTTTATATTGCCTTTTTTATCAATCATGTAACAGGCTTATA GCTTTCCAACAGAGCTGCTTGCCAAACAATTTTTTTTGTTTATTAAACAGTGCTGAAACAAACAGGATCAGCATTTACTTAAGATGTTAA GAATGAGGACTTTTAATCAGCCGAACCAAGATATTGTTACCTGTATGCATTCCCAAAGTCTAGATGCTCAGTATGTTCAGTCATATCTTT CAGAATCAGTGAACCGATTACCCTTTTTTTGGTATTCACTCTACATCTGCCAACCTAGTTCACCTTGGTTTTGTGTCTGCTGTAGAAGGG AACCATAACTTGGTTAAACCGTAGGGATTATCATTGTATACATGCTGTGAACATGTATATGTGCAAGTTTTAATGTATTCTATGTTGTAG GCTTATTATTTAATTTTACCACTTCATCACTTTTGTACAGTGGCCAAGCAGACACCTCAAACTCCAGCATTTACATTAAGTGCATTTGTA CATTTTAGGCCACTGGATCCAGATTTTATATTGGCAGTTATTGAGGGCAAAAGCAATATATTGTAACAGAATGTATAAATATTTTTGATA AAACAGTCTATATTTTATTAAAAAATGAATTATAACACTAAAGCTGTACCTCAAAAGTCTCAAAAATAATTTGATGAAATATTTTATACA ACTCTTCAAAGGATCCGTCTGTGGCTTTTTATACTCTTTTAGGGTTGTCTTTTTACAAACCATGACTTTCCACTTGCCTGTAGTTTTTTG TTTGTTTTGGTTTGGTTTGATTTTATATTTTTTTCTCCTAATCTATGACTTTATTGTTTTTTCTTAGTTTAGTAATAGCATCTTTGATCC TGTGCTTAGCATGTTAGGGTCATTATACCTCAGGAATAGCAAGCTGTTAAGTAACCATACTGAATTAACTATTTAATTACAGTGAGCTCA TCTCTTAAAAATTGTTCAGGTGTAAATCTTATGAGAAACATGAAAAAGCACACTGATTTATGGAGAGTTGAGCTAAAAACATTTATAAAT ATTTGCTGGGATGTTTTAGCATCTTTTCATTGTACTCTGAGAACAATTAAAATTGTCCAGAGATCATTTATATTACCTTCCAAATTGTTT ATTACCCAAGATCCTTTGGGAGAAAATCTTATAGAATGGGGGAACAATATGTGGTTTAAAGTTATTTTAAAATGCCAGTTAATTTCCTCG GCAAAGGACAATAGAGGAACTTAGCTTAATTGTCTGGCTTTAATTTAAACTGTGTTAATACAACATTAAAATAAAACACTAAATACTTTT GAGGTACAGTCTGCTCACTTTTTTGGTTCTCAAATAGCAAAGAAAGTAATGTCTAAAATAGGCTCTTAGCATTAAAAACTGACAGCATTT CGTAACTACACAGTGTACAGAATTTTTTTTTAATTGAAGTCAATCACTAAAAAAATTAGAAGGCAGGGTCTATTTACACAATTAAGCTGA AGAAAGCACTAATTTTTTGTAGTTTAAAATATATATATATTTTAGTCAGATTTAAAATTTTAAGCTTTATAGAGTGTAAATATATTTTGC TATTACTGTATGTGTATGTGACTGCTCAAGCACTTTGTAAAGAAATTAGGATATTTTAGAATGGTACACTATGCATTCAAATGAAATGTG CCTTTCACTATGTCATTCTAAGAAAACAAGTGTTTTTTGCAGTCATAAATTATCACAAATGCACAAATTAAAGTCTATATAGATTGAAAT TTGTAACTTTGGTTTTAAGTATTCTTTCCTTTTAGAAACTTCCTAATGATTAAAATATACTTTAACTTTTCTGTGTTCAAAATCTCAAAG ACTAATTAACTTTAATAAACATTCTTGCAAGTACTTTTTGTCCTAGTGAAGGCTTAAAACCATGAACATTCAGAGCAAACTGTCCACTTC ATTGGGAATAATGGGAAAAGTTTGTATTCTGCTCCTGTAAGGTCAGTAGCATCTTTTATTTGAAGCATATTTATGGACTGCTTACTGTGT ATAGATACTGAGAATAGGAAGTTTTTTTTTTTAAAGCAACAAAATGTTGATGAATGAAGAACAGCCTGTTTTAATTAAGATGCAAGCACC AGTATTGTATGTACTTTTCTCTTGTTTGAGGTTAGCTTATTTTAATTTAGGACCTGGCTTCTCAAAAAGGCAAATGAATAAAACAGAATA |
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FusionGenePPI for TRABD2B_PKN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRABD2B | PKN2 | PTPN13, NCK1, PLCG1, RHOA, PDPK1, PDK1, AKT1, NCK2, PKN2, USP11, WDR20, HDAC5, PTEN, CCDC136, CHGB, MYO9B, FAM193B, EIF3G, EEF1A1, NEDD4, CEBPA, ELAVL1, VCP, HSP90AA1, HECW2, FRMPD2, TGFBR2, SKAP1, THBS3, CYP1A1, UNK, ACBD3, LSM2, LSM3, LSM4, LSM6, LSM7, CCT6A, PPM1B, RPE, PCM1, CEP162, CEP128, CEP44, CEP19, CETN2, CENPJ, ATP2A2, BTF3, DARS, EEF1D, EEF1G, EPRS, IARS, KARS, KTN1, MARS, RUFY1, RARS, SOAT1, VARS, SGPL1, VAPB, EEF1E1, ERLIN1, CKAP4, TRAM1, LARS, WDR74, MBOAT7, TRMT1L, TMUB1, RABL3, SNW1, CDC5L, AHSA1, CDH1, CETN1, CAMKV, GOPC, ZNF785, DFFB, DEF8, HAVCR2, PPIAL4G, LGALS7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRABD2B_PKN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRABD2B_PKN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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