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Fusion gene ID: 39308 |
FusionGeneSummary for TRABD2A_CHMP3 |
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Fusion gene information | Fusion gene name: TRABD2A_CHMP3 | Fusion gene ID: 39308 | Hgene | Tgene | Gene symbol | TRABD2A | CHMP3 | Gene ID | 129293 | 51652 |
Gene name | TraB domain containing 2A | charged multivesicular body protein 3 | |
Synonyms | C2orf89|TIKI1 | CGI-149|NEDF|VPS24 | |
Cytomap | 2p11.2 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | metalloprotease TIKI1TRAB domain-containing protein 2AUPF0632 protein C2orf89 | charged multivesicular body protein 325.1 proteinCHMP family, member 3chromatin-modifying protein 3neuroendocrine differentiation factorvacuolar protein sorting 24 homologvacuolar protein sorting-associated protein 24 | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q86V40 | Q9Y3E7 | |
Ensembl transtripts involved in fusion gene | ENST00000335459, ENST00000409520, ENST00000409133, ENST00000479944, | ENST00000263856, ENST00000409727, ENST00000409225, ENST00000439940, ENST00000494623, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TRABD2A [Title/Abstract] AND CHMP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TRABD2A | GO:0006508 | proteolysis | 22726442 |
Hgene | TRABD2A | GO:0030178 | negative regulation of Wnt signaling pathway | 22726442 |
Tgene | CHMP3 | GO:0039702 | viral budding via host ESCRT complex | 24878737 |
Tgene | CHMP3 | GO:0051258 | protein polymerization | 23051622 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-77-A5GH-01A | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000335459 | ENST00000263856 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000335459 | ENST00000409727 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000335459 | ENST00000409225 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000335459 | ENST00000439940 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5CDS-5UTR | ENST00000335459 | ENST00000494623 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000409520 | ENST00000263856 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000409520 | ENST00000409727 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000409520 | ENST00000409225 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
Frame-shift | ENST00000409520 | ENST00000439940 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5CDS-5UTR | ENST00000409520 | ENST00000494623 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
intron-3CDS | ENST00000409133 | ENST00000263856 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
intron-3CDS | ENST00000409133 | ENST00000409727 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
intron-3CDS | ENST00000409133 | ENST00000409225 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
intron-3CDS | ENST00000409133 | ENST00000439940 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
intron-5UTR | ENST00000409133 | ENST00000494623 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5UTR-3CDS | ENST00000479944 | ENST00000263856 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5UTR-3CDS | ENST00000479944 | ENST00000409727 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5UTR-3CDS | ENST00000479944 | ENST00000409225 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5UTR-3CDS | ENST00000479944 | ENST00000439940 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
5UTR-5UTR | ENST00000479944 | ENST00000494623 | TRABD2A | chr2 | 85059179 | - | CHMP3 | chr2 | 86734716 | - |
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FusionProtFeatures for TRABD2A_CHMP3 |
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Hgene | Tgene |
TRABD2A | CHMP3 |
Metalloprotease that acts as a negative regulator of theWnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage,Wnt proteins become oxidized and form large disulfide-bondoligomers, leading to their inactivation. Able to cleave WNT3A,WNT5, but not WNT11. Required for head formation.{ECO:0000269|PubMed:22726442}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRABD2A_CHMP3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRABD2A_CHMP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRABD2A | CHMP3 | IGFBP7, STAMBP, CHMP2A, VTA1, VPS4A, VAV2, CHMP4A, CHMP3, CHMP4B, CHMP2B, TNPO3, RAB11A, ATP6V1B1, APP, SMAD1, SMAD5, MEPCE, CXorf56, VAX2, CHMP1B, DAXX, TFG, SIX2, CHMP5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRABD2A_CHMP3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRABD2A_CHMP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |