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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39308

FusionGeneSummary for TRABD2A_CHMP3

check button Fusion gene summary
Fusion gene informationFusion gene name: TRABD2A_CHMP3
Fusion gene ID: 39308
HgeneTgene
Gene symbol

TRABD2A

CHMP3

Gene ID

129293

51652

Gene nameTraB domain containing 2Acharged multivesicular body protein 3
SynonymsC2orf89|TIKI1CGI-149|NEDF|VPS24
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionmetalloprotease TIKI1TRAB domain-containing protein 2AUPF0632 protein C2orf89charged multivesicular body protein 325.1 proteinCHMP family, member 3chromatin-modifying protein 3neuroendocrine differentiation factorvacuolar protein sorting 24 homologvacuolar protein sorting-associated protein 24
Modification date2018032920180523
UniProtAcc

Q86V40

Q9Y3E7

Ensembl transtripts involved in fusion geneENST00000335459, ENST00000409520, 
ENST00000409133, ENST00000479944, 
ENST00000263856, ENST00000409727, 
ENST00000409225, ENST00000439940, 
ENST00000494623, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 2=18
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRABD2A [Title/Abstract] AND CHMP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRABD2A

GO:0006508

proteolysis

22726442

HgeneTRABD2A

GO:0030178

negative regulation of Wnt signaling pathway

22726442

TgeneCHMP3

GO:0039702

viral budding via host ESCRT complex

24878737

TgeneCHMP3

GO:0051258

protein polymerization

23051622


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-77-A5GH-01ATRABD2Achr2

85059179

-CHMP3chr2

86734716

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000335459ENST00000263856TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000335459ENST00000409727TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000335459ENST00000409225TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000335459ENST00000439940TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5CDS-5UTRENST00000335459ENST00000494623TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000409520ENST00000263856TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000409520ENST00000409727TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000409520ENST00000409225TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
Frame-shitENST00000409520ENST00000439940TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5CDS-5UTRENST00000409520ENST00000494623TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
intron-3CDSENST00000409133ENST00000263856TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
intron-3CDSENST00000409133ENST00000409727TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
intron-3CDSENST00000409133ENST00000409225TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
intron-3CDSENST00000409133ENST00000439940TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
intron-5UTRENST00000409133ENST00000494623TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5UTR-3CDSENST00000479944ENST00000263856TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5UTR-3CDSENST00000479944ENST00000409727TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5UTR-3CDSENST00000479944ENST00000409225TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5UTR-3CDSENST00000479944ENST00000439940TRABD2Achr2

85059179

-CHMP3chr2

86734716

-
5UTR-5UTRENST00000479944ENST00000494623TRABD2Achr2

85059179

-CHMP3chr2

86734716

-

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FusionProtFeatures for TRABD2A_CHMP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRABD2A

Q86V40

CHMP3

Q9Y3E7

Metalloprotease that acts as a negative regulator of theWnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage,Wnt proteins become oxidized and form large disulfide-bondoligomers, leading to their inactivation. Able to cleave WNT3A,WNT5, but not WNT11. Required for head formation.{ECO:0000269|PubMed:22726442}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRABD2A_CHMP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRABD2A_CHMP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRABD2ACHMP3IGFBP7, STAMBP, CHMP2A, VTA1, VPS4A, VAV2, CHMP4A, CHMP3, CHMP4B, CHMP2B, TNPO3, RAB11A, ATP6V1B1, APP, SMAD1, SMAD5, MEPCE, CXorf56, VAX2, CHMP1B, DAXX, TFG, SIX2, CHMP5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRABD2A_CHMP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRABD2A_CHMP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource