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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39306

FusionGeneSummary for TRA2B_KIFC1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRA2B_KIFC1
Fusion gene ID: 39306
HgeneTgene
Gene symbol

TRA2B

KIFC1

Gene ID

6434

3833

Gene nametransformer 2 beta homologkinesin family member C1
SynonymsHtra2-beta|PPP1R156|SFRS10|SRFS10|TRA2-BETA|TRAN2BHSET|KNSL2
Cytomap

3q27.2

6p21.32

Type of geneprotein-codingprotein-coding
Descriptiontransformer-2 protein homolog betaTRA-2 betaprotein phosphatase 1, regulatory subunit 156splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)transformer-2 protein homolog Bkinesin-like protein KIFC1kinesin-like 2kinesin-like protein 2kinesin-related protein HSET
Modification date2018052320180523
UniProtAcc

P62995

Q9BW19

Ensembl transtripts involved in fusion geneENST00000453386, ENST00000382191, 
ENST00000471134, ENST00000342294, 
ENST00000428849, ENST00000486695, 
ENST00000417146, ENST00000374523, 
ENST00000492999, ENST00000448818, 
ENST00000467671, 
Fusion gene scores* DoF score5 X 3 X 3=453 X 3 X 2=18
# samples 53
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRA2B [Title/Abstract] AND KIFC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRA2B

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

12165565|12761049

HgeneTRA2B

GO:0000398

mRNA splicing, via spliceosome

9546399

HgeneTRA2B

GO:0048026

positive regulation of mRNA splicing, via spliceosome

15009664

HgeneTRA2B

GO:0051259

protein complex oligomerization

10749975


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN257709TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000453386ENST00000428849TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000453386ENST00000486695TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000453386ENST00000417146TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000453386ENST00000374523TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000453386ENST00000492999TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000453386ENST00000448818TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000453386ENST00000467671TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000428849TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000486695TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000417146TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000374523TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000492999TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000448818TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5UTR-intronENST00000382191ENST00000467671TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000428849TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000486695TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000417146TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000374523TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000492999TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000448818TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
intron-intronENST00000471134ENST00000467671TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000428849TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000486695TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000417146TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000374523TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000492999TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000448818TRA2Bchr3

185655612

-KIFC1chr6

4854399

+
5CDS-intronENST00000342294ENST00000467671TRA2Bchr3

185655612

-KIFC1chr6

4854399

+

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FusionProtFeatures for TRA2B_KIFC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRA2B

P62995

KIFC1

Q9BW19

Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. Can either activate orsuppress exon inclusion. Acts additively with RBMX to promote exon7 inclusion of the survival motor neuron SMN2. Activates thesplicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns byantagonizing the effects of splicing regulators, like RBMX. Bindsto the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049,ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. Minus end-directed microtubule-dependent motor requiredfor bipolar spindle formation (PubMed:15843429). May contribute tomovement of early endocytic vesicles (By similarity). Regulatescilium formation and structure (By similarity).{ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRA2B_KIFC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRA2B_KIFC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRA2B_KIFC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRA2B_KIFC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource