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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39302

FusionGeneSummary for TRA2A_TRA2A

check button Fusion gene summary
Fusion gene informationFusion gene name: TRA2A_TRA2A
Fusion gene ID: 39302
HgeneTgene
Gene symbol

TRA2A

TRA2A

Gene ID

29896

29896

Gene nametransformer 2 alpha homologtransformer 2 alpha homolog
SynonymsAWMS1|HSU53209AWMS1|HSU53209
Cytomap

7p15.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptiontransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog Atransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A
Modification date2018052320180523
UniProtAcc

Q13595

Q13595

Ensembl transtripts involved in fusion geneENST00000297071, ENST00000392502, 
ENST00000538367, ENST00000474586, 
ENST00000297071, ENST00000392502, 
ENST00000538367, ENST00000474586, 
Fusion gene scores* DoF score8 X 7 X 5=2805 X 6 X 5=150
# samples 107
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRA2A [Title/Abstract] AND TRA2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399

TgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW936418TRA2Achr7

23554430

-TRA2Achr7

23567534

-
ChiTaRS3.1BF356549TRA2Achr7

23563520

+TRA2Achr7

23563645

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000297071ENST00000297071TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000297071ENST00000392502TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000297071ENST00000538367TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000297071ENST00000474586TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000392502ENST00000297071TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000392502ENST00000392502TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000392502ENST00000538367TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000392502ENST00000474586TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000538367ENST00000297071TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000538367ENST00000392502TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000538367ENST00000538367TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000538367ENST00000474586TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000474586ENST00000297071TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000474586ENST00000392502TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000474586ENST00000538367TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000474586ENST00000474586TRA2Achr7

23554430

-TRA2Achr7

23567534

-
intron-intronENST00000297071ENST00000297071TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000297071ENST00000392502TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000297071ENST00000538367TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000297071ENST00000474586TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000392502ENST00000297071TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000392502ENST00000392502TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000392502ENST00000538367TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000392502ENST00000474586TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000538367ENST00000297071TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000538367ENST00000392502TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000538367ENST00000538367TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000538367ENST00000474586TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000474586ENST00000297071TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000474586ENST00000392502TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000474586ENST00000538367TRA2Achr7

23563520

+TRA2Achr7

23563645

-
intron-intronENST00000474586ENST00000474586TRA2Achr7

23563520

+TRA2Achr7

23563645

-

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FusionProtFeatures for TRA2A_TRA2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRA2A

Q13595

TRA2A

Q13595

Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRA2A_TRA2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRA2A_TRA2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRA2A_TRA2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRA2A_TRA2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRA2AC0037274Dermatologic disorders1CTD_human
HgeneTRA2AC0311375Arsenic Poisoning1CTD_human
TgeneTRA2AC0037274Dermatologic disorders1CTD_human
TgeneTRA2AC0311375Arsenic Poisoning1CTD_human