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Fusion gene ID: 39298 |
FusionGeneSummary for TRA2A_HECW1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRA2A_HECW1 | Fusion gene ID: 39298 | Hgene | Tgene | Gene symbol | TRA2A | HECW1 | Gene ID | 29896 | 23072 |
| Gene name | transformer 2 alpha homolog | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | |
| Synonyms | AWMS1|HSU53209 | NEDL1 | |
| Cytomap | 7p15.3 | 7p14.1-p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A | E3 ubiquitin-protein ligase HECW1HECT type E3 ubiquitin ligaseHECT-type E3 ubiquitin transferase HECW1NEDD4-like ubiquitin-protein ligase 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13595 | Q76N89 | |
| Ensembl transtripts involved in fusion gene | ENST00000297071, ENST00000392502, ENST00000538367, ENST00000474586, | ENST00000395891, ENST00000453890, ENST00000471043, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 5 X 5 X 4=100 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRA2A [Title/Abstract] AND HECW1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRA2A | GO:0000398 | mRNA splicing, via spliceosome | 9546399 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A3U0-01A | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000297071 | ENST00000395891 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| Frame-shift | ENST00000297071 | ENST00000453890 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5CDS-intron | ENST00000297071 | ENST00000471043 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-3CDS | ENST00000392502 | ENST00000395891 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-3CDS | ENST00000392502 | ENST00000453890 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-intron | ENST00000392502 | ENST00000471043 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-3CDS | ENST00000538367 | ENST00000395891 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-3CDS | ENST00000538367 | ENST00000453890 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-intron | ENST00000538367 | ENST00000471043 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-3CDS | ENST00000474586 | ENST00000395891 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-3CDS | ENST00000474586 | ENST00000453890 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
| 5UTR-intron | ENST00000474586 | ENST00000471043 | TRA2A | chr7 | 23561326 | - | HECW1 | chr7 | 43351362 | + |
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FusionProtFeatures for TRA2A_HECW1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRA2A | HECW1 |
| Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. | E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent degradation of DVL1. Also targets the mutant SOD1protein involved in familial amyotrophic lateral sclerosis (FALS).Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 thatlead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRA2A_HECW1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRA2A_HECW1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRA2A | TADA2A, YWHAG, NUDT21, SELENBP1, CRABP1, TNNT1, CDK2AP2, C11orf58, ELAVL1, CUL3, CUL5, COPS5, SRSF10, RBM25, SRSF5, CDC5L, SEPT2, NFIA, NHP2L1, NCSTN, SF3A1, BUD31, SF3B3, PHGDH, S100A9, HNRNPC, HNRNPU, PRPF40A, SF3B6, HNRNPM, SAP18, PRPF6, IK, HP1BP3, SEPT7, SMARCB1, PLEC, BARD1, PAXIP1, MAGOH, EIF4A3, PPP1CC, DHX15, U2SURP, CDK6, LBP, NXF1, YTHDC1, CLK3, SRPK2, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, ZNF22, LARP7, SRRM1, MRPS9, MRPS26, THRAP3, LUC7L2, LUC7L, ZNF768, PTCD1, PTCD3, SRRM2, C17orf85, ZFR, PABPC4L, PABPC4, RBBP6, ELAVL2, RPL6, MRPS23, MRPS27, TRUB2, MRPS6, RPL26L1, MTERF3, PAIP1, MRPS18B, MRPL32, C10orf2, MRPS10, DAP3, MEPCE, UPF1, PPIG, LARP1, LARP1B, PHAX, MRPS31, MKRN1, MRPS18C, MRPS5, MRPS7, MRPS22, MRPS15, MRPS35, MRPS25, RRP9, NGRN, MRPS2, MOV10, MRPS33, SRRT, PRPF3, MRPS11, PNN, SRP14, GAR1, MRPS24, CASC3, WDR33, CSNK1E, CSNK1D, MRPS14, GAPDHS, ZCCHC3, MKRN2, ZC3H11A, NOA1, TRA2B, ISY1, SRSF8, CLK1, SRSF7, APOBEC3F, HIST1H2AG, SRSF12, CLK2, MRPL34, MRPS21, SNIP1, NTRK1, SRSF3, SRSF6, EWSR1, CNTRL, CDK2, FEN1, U2AF2, SNRNP70, ZC3H18, C11orf57, SNRPN, NCOA5, PABPC1, SYF2, APOBEC3D, NR3C1, FOXA1 | HECW1 | DVL1, SSR4, SOD1, SCNN1A, SCNN1B, TNK2, CACNA1A, TP53, RNF43, GFI1B, USP7, FBXL15, HECW2, LDLRAD4, MPHOSPH8, UBC, UBE2D1, UBE2D2, UBE2D3, UBE2L3, HECW1, UBE2J2, FAM189B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRA2A_HECW1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRA2A_HECW1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRA2A | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | TRA2A | C0311375 | Arsenic Poisoning | 1 | CTD_human |
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