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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39298

FusionGeneSummary for TRA2A_HECW1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRA2A_HECW1
Fusion gene ID: 39298
HgeneTgene
Gene symbol

TRA2A

HECW1

Gene ID

29896

23072

Gene nametransformer 2 alpha homologHECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
SynonymsAWMS1|HSU53209NEDL1
Cytomap

7p15.3

7p14.1-p13

Type of geneprotein-codingprotein-coding
Descriptiontransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog AE3 ubiquitin-protein ligase HECW1HECT type E3 ubiquitin ligaseHECT-type E3 ubiquitin transferase HECW1NEDD4-like ubiquitin-protein ligase 1
Modification date2018052320180523
UniProtAcc

Q13595

Q76N89

Ensembl transtripts involved in fusion geneENST00000297071, ENST00000392502, 
ENST00000538367, ENST00000474586, 
ENST00000395891, ENST00000453890, 
ENST00000471043, 
Fusion gene scores* DoF score8 X 7 X 5=2805 X 5 X 4=100
# samples 105
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRA2A [Title/Abstract] AND HECW1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A3U0-01ATRA2Achr7

23561326

-HECW1chr7

43351362

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000297071ENST00000395891TRA2Achr7

23561326

-HECW1chr7

43351362

+
Frame-shitENST00000297071ENST00000453890TRA2Achr7

23561326

-HECW1chr7

43351362

+
5CDS-intronENST00000297071ENST00000471043TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-3CDSENST00000392502ENST00000395891TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-3CDSENST00000392502ENST00000453890TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-intronENST00000392502ENST00000471043TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-3CDSENST00000538367ENST00000395891TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-3CDSENST00000538367ENST00000453890TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-intronENST00000538367ENST00000471043TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-3CDSENST00000474586ENST00000395891TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-3CDSENST00000474586ENST00000453890TRA2Achr7

23561326

-HECW1chr7

43351362

+
5UTR-intronENST00000474586ENST00000471043TRA2Achr7

23561326

-HECW1chr7

43351362

+

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FusionProtFeatures for TRA2A_HECW1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRA2A

Q13595

HECW1

Q76N89

Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent degradation of DVL1. Also targets the mutant SOD1protein involved in familial amyotrophic lateral sclerosis (FALS).Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 thatlead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRA2A_HECW1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRA2A_HECW1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRA2ATADA2A, YWHAG, NUDT21, SELENBP1, CRABP1, TNNT1, CDK2AP2, C11orf58, ELAVL1, CUL3, CUL5, COPS5, SRSF10, RBM25, SRSF5, CDC5L, SEPT2, NFIA, NHP2L1, NCSTN, SF3A1, BUD31, SF3B3, PHGDH, S100A9, HNRNPC, HNRNPU, PRPF40A, SF3B6, HNRNPM, SAP18, PRPF6, IK, HP1BP3, SEPT7, SMARCB1, PLEC, BARD1, PAXIP1, MAGOH, EIF4A3, PPP1CC, DHX15, U2SURP, CDK6, LBP, NXF1, YTHDC1, CLK3, SRPK2, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, ZNF22, LARP7, SRRM1, MRPS9, MRPS26, THRAP3, LUC7L2, LUC7L, ZNF768, PTCD1, PTCD3, SRRM2, C17orf85, ZFR, PABPC4L, PABPC4, RBBP6, ELAVL2, RPL6, MRPS23, MRPS27, TRUB2, MRPS6, RPL26L1, MTERF3, PAIP1, MRPS18B, MRPL32, C10orf2, MRPS10, DAP3, MEPCE, UPF1, PPIG, LARP1, LARP1B, PHAX, MRPS31, MKRN1, MRPS18C, MRPS5, MRPS7, MRPS22, MRPS15, MRPS35, MRPS25, RRP9, NGRN, MRPS2, MOV10, MRPS33, SRRT, PRPF3, MRPS11, PNN, SRP14, GAR1, MRPS24, CASC3, WDR33, CSNK1E, CSNK1D, MRPS14, GAPDHS, ZCCHC3, MKRN2, ZC3H11A, NOA1, TRA2B, ISY1, SRSF8, CLK1, SRSF7, APOBEC3F, HIST1H2AG, SRSF12, CLK2, MRPL34, MRPS21, SNIP1, NTRK1, SRSF3, SRSF6, EWSR1, CNTRL, CDK2, FEN1, U2AF2, SNRNP70, ZC3H18, C11orf57, SNRPN, NCOA5, PABPC1, SYF2, APOBEC3D, NR3C1, FOXA1HECW1DVL1, SSR4, SOD1, SCNN1A, SCNN1B, TNK2, CACNA1A, TP53, RNF43, GFI1B, USP7, FBXL15, HECW2, LDLRAD4, MPHOSPH8, UBC, UBE2D1, UBE2D2, UBE2D3, UBE2L3, HECW1, UBE2J2, FAM189B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRA2A_HECW1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRA2A_HECW1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRA2AC0037274Dermatologic disorders1CTD_human
HgeneTRA2AC0311375Arsenic Poisoning1CTD_human