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Fusion gene ID: 3929 |
FusionGeneSummary for BCAR3_CTSL |
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Fusion gene information | Fusion gene name: BCAR3_CTSL | Fusion gene ID: 3929 | Hgene | Tgene | Gene symbol | BCAR3 | CTSL | Gene ID | 8412 | 1514 |
Gene name | BCAR3, NSP family adaptor protein | cathepsin L | |
Synonyms | AND-34|NSP2|SH2D3B | CATL|CTSL1|MEP | |
Cytomap | 1p22.1 | 9q21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | breast cancer anti-estrogen resistance protein 3SH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistance 3)novel SH2-containing protein | cathepsin L1major excreted protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O75815 | P07711 | |
Ensembl transtripts involved in fusion gene | ENST00000260502, ENST00000370244, ENST00000370243, ENST00000370247, ENST00000539242, ENST00000466632, | ENST00000343150, ENST00000340342, ENST00000495822, ENST00000342020, | |
Fusion gene scores | * DoF score | 7 X 8 X 6=336 | 3 X 5 X 1=15 |
# samples | 8 | 6 | |
** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/15*10)=2 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BCAR3 [Title/Abstract] AND CTSL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CTSL | GO:0006508 | proteolysis | 8811434|21326229 |
Tgene | CTSL | GO:0030574 | collagen catabolic process | 22952693 |
Tgene | CTSL | GO:0051603 | proteolysis involved in cellular protein catabolic process | 22952693 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG015981 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000260502 | ENST00000343150 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000260502 | ENST00000340342 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3UTR | ENST00000260502 | ENST00000495822 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-intron | ENST00000260502 | ENST00000342020 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000370244 | ENST00000343150 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000370244 | ENST00000340342 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3UTR | ENST00000370244 | ENST00000495822 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-intron | ENST00000370244 | ENST00000342020 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000370243 | ENST00000343150 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000370243 | ENST00000340342 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3UTR | ENST00000370243 | ENST00000495822 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-intron | ENST00000370243 | ENST00000342020 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000370247 | ENST00000343150 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000370247 | ENST00000340342 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3UTR | ENST00000370247 | ENST00000495822 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-intron | ENST00000370247 | ENST00000342020 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000539242 | ENST00000343150 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000539242 | ENST00000340342 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3UTR | ENST00000539242 | ENST00000495822 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-intron | ENST00000539242 | ENST00000342020 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000466632 | ENST00000343150 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3CDS | ENST00000466632 | ENST00000340342 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-3UTR | ENST00000466632 | ENST00000495822 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
intron-intron | ENST00000466632 | ENST00000342020 | BCAR3 | chr1 | 94245905 | + | CTSL | chr9 | 90345987 | + |
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FusionProtFeatures for BCAR3_CTSL |
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Hgene | Tgene |
BCAR3 | CTSL |
May act as an adapter protein and couple activatedgrowth factor receptors to a signaling pathway that regulates theproliferation in breast cancer cells. When overexpressed, itconfers anti-estrogen resistance in breast cancer cell lines. Mayalso be regulated by cellular adhesion to extracellular matrixproteins. {ECO:0000269|PubMed:9582273}. | Important for the overall degradation of proteins inlysosomes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCAR3_CTSL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BCAR3_CTSL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCAR3_CTSL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCAR3_CTSL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BCAR3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | BCAR3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | CTSL | C0025286 | Meningioma | 1 | CTD_human |
Tgene | CTSL | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | CTSL | C0038356 | Stomach Neoplasms | 1 | CTD_human |