FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39289

FusionGeneSummary for TPX2_ID1

check button Fusion gene summary
Fusion gene informationFusion gene name: TPX2_ID1
Fusion gene ID: 39289
HgeneTgene
Gene symbol

TPX2

ID1

Gene ID

22974

3397

Gene nameTPX2, microtubule nucleation factorinhibitor of DNA binding 1, HLH protein
SynonymsC20orf1|C20orf2|DIL-2|DIL2|FLS353|GD:C20orf1|HCA519|HCTP4|REPP86|p100ID|bHLHb24
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptiontargeting protein for Xklp2TPX2, microtubule-associated protein homologTPX2, microtubule-associated, homologdifferentially expressed in cancerous and non-cancerous lung cells 2differentially expressed in lung cellshepatocellular carcinoma-associated DNA-binding protein inhibitor ID-1class B basic helix-loop-helix protein 24dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)inhibitor of DNA binding 1, dominant negative helix-loop-helix proteininhibitor of differen
Modification date2018051920180523
UniProtAcc

Q9ULW0

P41134

Ensembl transtripts involved in fusion geneENST00000340513, ENST00000300403, 
ENST00000376112, ENST00000376105, 
Fusion gene scores* DoF score14 X 8 X 12=13441 X 1 X 2=2
# samples 232
** MAII scorelog2(23/1344*10)=-2.54682737183439
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: TPX2 [Title/Abstract] AND ID1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPX2

GO:0032147

activation of protein kinase activity

14580337|19801554

HgeneTPX2

GO:0090307

mitotic spindle assembly

26165940

TgeneID1

GO:0043433

negative regulation of DNA binding transcription factor activity

15138269

TgeneID1

GO:0045892

negative regulation of transcription, DNA-templated

15138269


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A400-01ATPX2chr20

30327424

+ID1chr20

30193175

+
TCGALDCESCTCGA-IR-A3LH-01ATPX2chr20

30327424

+ID1chr20

30193175

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000340513ENST00000376112TPX2chr20

30327424

+ID1chr20

30193175

+
5UTR-5UTRENST00000340513ENST00000376105TPX2chr20

30327424

+ID1chr20

30193175

+
5UTR-5UTRENST00000300403ENST00000376112TPX2chr20

30327424

+ID1chr20

30193175

+
5UTR-5UTRENST00000300403ENST00000376105TPX2chr20

30327424

+ID1chr20

30193175

+

Top

FusionProtFeatures for TPX2_ID1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPX2

Q9ULW0

ID1

P41134

Spindle assembly factor required for normal assembly ofmitotic spindles. Required for normal assembly of microtubulesduring apoptosis. Required for chromatin and/or kinetochoredependent microtubule nucleation. Mediates AURKA localization tospindle microtubules (PubMed:18663142, PubMed:19208764). ActivatesAURKA by promoting its autophosphorylation at 'Thr-288' andprotects this residue against dephosphorylation (PubMed:18663142,PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interactswith importin-alpha, liberating TPX2 from importin-alpha, allowingTPX2 to activates AURKA kinase and stimulates local microtubulenucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142,ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TPX2_ID1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TPX2_ID1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TPX2AURKA, FZR1, KPNA1, KPNB1, HMMR, BRCA1, SIAH2, ZNF598, NDUFA7, THUMPD2, DNAJC8, MRPL53, SERPINH1, UBE2S, PPIF, SARNP, TWF1, SCAMP3, CDK6, IKBKB, CHUK, IKBKG, AURKB, LMNA, HDAC9, THAP11, NAP1L1, RPA3, RPA2, RPA1, GOLGA2, MAPK14, GSTM3, HIST1H2BG, AFAP1, SAP130, RBPJ, CDC5L, RNF111ID1CASK, MYOD1, TCF4, TCF12, MYF5, TCF3, GATA4, NKX2-5, IKBKG, SMURF2, PSMD4, CDC20, FZR1, RASSF1, CAV1, PPP2CA, COPB1, SUV39H1, APPL1, COL12A1, MPP1, PSMD5, DPF2, STXBP1, PIAS1, MKNK1, BUD31, CHD1L, USP15, TXNL4A, B4GALT7, ERP44, ZC3H13, POT1, CCDC9, THOC6, TCEB1, VHL, DNMT3L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TPX2_ID1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TPX2_ID1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneID1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneID1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneID1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneID1C0151744Myocardial Ischemia1CTD_human