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Fusion gene ID: 39259 |
FusionGeneSummary for TPRG1_DGKG |
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Fusion gene information | Fusion gene name: TPRG1_DGKG | Fusion gene ID: 39259 | Hgene | Tgene | Gene symbol | TPRG1 | DGKG | Gene ID | 285386 | 1608 |
Gene name | tumor protein p63 regulated 1 | diacylglycerol kinase gamma | |
Synonyms | FAM79B | DAGK3|DGK-GAMMA | |
Cytomap | 3q28 | 3q27.2-q27.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | diacylglycerol kinase gammaDAG kinase gammadiacylglycerol kinase, gamma 90kDadiacylglyerol kinase gammadiglyceride kinase gamma | |
Modification date | 20180403 | 20180519 | |
UniProtAcc | Q6ZUI0 | P49619 | |
Ensembl transtripts involved in fusion gene | ENST00000433971, ENST00000345063, ENST00000488841, | ENST00000447054, ENST00000265022, ENST00000344484, ENST00000382164, ENST00000544847, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 7 X 6=378 |
# samples | 1 | 9 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TPRG1 [Title/Abstract] AND DGKG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DGKG | GO:0046486 | glycerolipid metabolic process | 22627129 |
Tgene | DGKG | GO:0046834 | lipid phosphorylation | 22627129 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A03L-01A | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000433971 | ENST00000447054 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000433971 | ENST00000265022 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000433971 | ENST00000344484 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000433971 | ENST00000382164 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000433971 | ENST00000544847 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000345063 | ENST00000447054 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000345063 | ENST00000265022 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000345063 | ENST00000344484 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000345063 | ENST00000382164 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
5CDS-intron | ENST00000345063 | ENST00000544847 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
intron-intron | ENST00000488841 | ENST00000447054 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
intron-intron | ENST00000488841 | ENST00000265022 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
intron-intron | ENST00000488841 | ENST00000344484 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
intron-intron | ENST00000488841 | ENST00000382164 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
intron-intron | ENST00000488841 | ENST00000544847 | TPRG1 | chr3 | 188933172 | + | DGKG | chr3 | 185983095 | - |
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FusionProtFeatures for TPRG1_DGKG |
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Hgene | Tgene |
TPRG1 | DGKG |
Reverses the normal flow of glycerolipid biosynthesis byphosphorylating diacylglycerol back to phosphatidic acid. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TPRG1_DGKG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TPRG1_DGKG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TPRG1 | DGKG | ARRB1, ALB, SDHA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TPRG1_DGKG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPRG1_DGKG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |