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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39259

FusionGeneSummary for TPRG1_DGKG

check button Fusion gene summary
Fusion gene informationFusion gene name: TPRG1_DGKG
Fusion gene ID: 39259
HgeneTgene
Gene symbol

TPRG1

DGKG

Gene ID

285386

1608

Gene nametumor protein p63 regulated 1diacylglycerol kinase gamma
SynonymsFAM79BDAGK3|DGK-GAMMA
Cytomap

3q28

3q27.2-q27.3

Type of geneprotein-codingprotein-coding
Descriptiontumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member Bdiacylglycerol kinase gammaDAG kinase gammadiacylglycerol kinase, gamma 90kDadiacylglyerol kinase gammadiglyceride kinase gamma
Modification date2018040320180519
UniProtAcc

Q6ZUI0

P49619

Ensembl transtripts involved in fusion geneENST00000433971, ENST00000345063, 
ENST00000488841, 
ENST00000447054, 
ENST00000265022, ENST00000344484, 
ENST00000382164, ENST00000544847, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 7 X 6=378
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPRG1 [Title/Abstract] AND DGKG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDGKG

GO:0046486

glycerolipid metabolic process

22627129

TgeneDGKG

GO:0046834

lipid phosphorylation

22627129


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03L-01ATPRG1chr3

188933172

+DGKGchr3

185983095

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000433971ENST00000447054TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000433971ENST00000265022TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000433971ENST00000344484TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000433971ENST00000382164TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000433971ENST00000544847TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000345063ENST00000447054TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000345063ENST00000265022TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000345063ENST00000344484TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000345063ENST00000382164TPRG1chr3

188933172

+DGKGchr3

185983095

-
5CDS-intronENST00000345063ENST00000544847TPRG1chr3

188933172

+DGKGchr3

185983095

-
intron-intronENST00000488841ENST00000447054TPRG1chr3

188933172

+DGKGchr3

185983095

-
intron-intronENST00000488841ENST00000265022TPRG1chr3

188933172

+DGKGchr3

185983095

-
intron-intronENST00000488841ENST00000344484TPRG1chr3

188933172

+DGKGchr3

185983095

-
intron-intronENST00000488841ENST00000382164TPRG1chr3

188933172

+DGKGchr3

185983095

-
intron-intronENST00000488841ENST00000544847TPRG1chr3

188933172

+DGKGchr3

185983095

-

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FusionProtFeatures for TPRG1_DGKG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPRG1

Q6ZUI0

DGKG

P49619

Reverses the normal flow of glycerolipid biosynthesis byphosphorylating diacylglycerol back to phosphatidic acid.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPRG1_DGKG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPRG1_DGKG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TPRG1DGKGARRB1, ALB, SDHA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPRG1_DGKG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TPRG1_DGKG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource