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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39243

FusionGeneSummary for TPM4_PROM1

check button Fusion gene summary
Fusion gene informationFusion gene name: TPM4_PROM1
Fusion gene ID: 39243
HgeneTgene
Gene symbol

TPM4

PROM1

Gene ID

7171

8842

Gene nametropomyosin 4prominin 1
SynonymsHEL-S-108AC133|CD133|CORD12|MCDR2|MSTP061|PROML1|RP41|STGD4
Cytomap

19p13.12-p13.11

4p15.32

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 108prominin-1antigen AC133hPromininhematopoietic stem cell antigenprominin-like protein 1
Modification date2018052320180523
UniProtAcc

P67936

O43490

Ensembl transtripts involved in fusion geneENST00000344824, ENST00000538887, 
ENST00000300933, ENST00000591645, 
ENST00000540805, ENST00000539194, 
ENST00000447510, ENST00000505450, 
ENST00000508167, ENST00000510224, 
ENST00000543373, ENST00000502943, 
Fusion gene scores* DoF score10 X 9 X 4=3602 X 2 X 1=4
# samples 112
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TPM4 [Title/Abstract] AND PROM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG955881TPM4chr19

16190831

-PROM1chr4

15980665

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000344824ENST00000540805TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000539194TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000447510TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000505450TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000508167TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000510224TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000543373TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000344824ENST00000502943TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000540805TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000539194TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000447510TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000505450TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000508167TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000510224TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000543373TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000538887ENST00000502943TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000540805TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000539194TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000447510TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000505450TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000508167TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000510224TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000543373TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000300933ENST00000502943TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000540805TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000539194TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000447510TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000505450TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000508167TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000510224TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000543373TPM4chr19

16190831

-PROM1chr4

15980665

+
intron-intronENST00000591645ENST00000502943TPM4chr19

16190831

-PROM1chr4

15980665

+

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FusionProtFeatures for TPM4_PROM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPM4

P67936

PROM1

O43490

May play a role in cell differentiation, proliferationand apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in theorganization of the apical plasma membrane in epithelial cells.During early retinal development acts as a key regulator of diskmorphogenesis. Involved in regulation of MAPK and Akt signalingpathways. In neuroblastoma cells suppresses cell differentiationsuch as neurite outgrowth in a RET-dependent manner(PubMed:20818439). {ECO:0000269|PubMed:20818439,ECO:0000269|PubMed:24556617}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPM4_PROM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPM4_PROM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPM4_PROM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TPM4_PROM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPM4C0003949Asbestosis1CTD_human
HgeneTPM4C0014859Esophageal Neoplasms1CTD_human
HgeneTPM4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTPM4C0027627Neoplasm Metastasis1CTD_human
HgeneTPM4C0029456Osteoporosis1CTD_human
HgeneTPM4C0032927Precancerous Conditions1CTD_human
HgeneTPM4C0043094Weight Gain1CTD_human
HgeneTPM4C0948089Acute Coronary Syndrome1CTD_human
TgenePROM1C0017636Glioblastoma3CTD_human
TgenePROM1C0009375Colonic Neoplasms1CTD_human
TgenePROM1C0009404Colorectal Neoplasms1CTD_human
TgenePROM1C0041696Unipolar Depression1PSYGENET
TgenePROM1C0042138Uterine Neoplasms1CTD_human
TgenePROM1C0206627Mixed Tumor, Mullerian1CTD_human
TgenePROM1C1269683Major Depressive Disorder1PSYGENET
TgenePROM1C2675210CONE-ROD DYSTROPHY 12 (disorder)1CTD_human;UNIPROT