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Fusion gene ID: 39233 |
FusionGeneSummary for TPM3_FAM193A |
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Fusion gene information | Fusion gene name: TPM3_FAM193A | Fusion gene ID: 39233 | Hgene | Tgene | Gene symbol | TPM3 | FAM193A | Gene ID | 7170 | 8603 |
Gene name | tropomyosin 3 | family with sequence similarity 193 member A | |
Synonyms | CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30 | C4orf8|RES4-22 | |
Cytomap | 1q21.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi | protein FAM193A | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P06753 | P78312 | |
Ensembl transtripts involved in fusion gene | ENST00000368533, ENST00000469717, ENST00000330188, ENST00000341485, ENST00000341372, ENST00000328159, ENST00000271850, ENST00000302206, ENST00000368531, ENST00000323144, ENST00000368530, | ENST00000545951, ENST00000382839, ENST00000324666, ENST00000502458, ENST00000505311, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 5 X 4 X 5=100 |
# samples | 14 | 6 | |
** MAII score | log2(14/252*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TPM3 [Title/Abstract] AND FAM193A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-13-1506-01A | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000368533 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368533 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368533 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368533 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-3UTR | ENST00000368533 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5UTR-intron | ENST00000469717 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5UTR-intron | ENST00000469717 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5UTR-intron | ENST00000469717 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5UTR-intron | ENST00000469717 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5UTR-3UTR | ENST00000469717 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000330188 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000330188 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000330188 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000330188 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-3UTR | ENST00000330188 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000341485 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000341485 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000341485 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000341485 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-3UTR | ENST00000341485 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000341372 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000341372 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000341372 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000341372 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-3UTR | ENST00000341372 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000328159 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000328159 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000328159 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000328159 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-3UTR | ENST00000328159 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000271850 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000271850 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000271850 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000271850 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-3UTR | ENST00000271850 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000302206 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000302206 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000302206 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000302206 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-3UTR | ENST00000302206 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368531 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368531 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368531 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000368531 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-3UTR | ENST00000368531 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000323144 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000323144 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000323144 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-intron | ENST00000323144 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
5CDS-3UTR | ENST00000323144 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000368530 | ENST00000545951 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000368530 | ENST00000382839 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000368530 | ENST00000324666 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-intron | ENST00000368530 | ENST00000502458 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
intron-3UTR | ENST00000368530 | ENST00000505311 | TPM3 | chr1 | 154155464 | - | FAM193A | chr4 | 2733502 | + |
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FusionProtFeatures for TPM3_FAM193A |
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Hgene | Tgene |
TPM3 | FAM193A |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TPM3_FAM193A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TPM3_FAM193A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TPM3 | KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1 | FAM193A | ANKRD28, MDM4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TPM3_FAM193A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPM3_FAM193A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TPM3 | C1836448 | Nemaline myopathy 1 | 9 | CTD_human;ORPHANET;UNIPROT |
Hgene | TPM3 | C0546264 | Congenital Fiber Type Disproportion | 5 | ORPHANET;UNIPROT |
Hgene | TPM3 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Hgene | TPM3 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
Hgene | TPM3 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | TPM3 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | TPM3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | TPM3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | TPM3 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |