	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 39216

FusionGeneSummary for TPM1_GK

Fusion gene summary

Fusion gene information	Fusion gene name: TPM1_GK
	Fusion gene ID: 39216
		Hgene	Tgene
	Gene symbol	TPM1	GK
	Gene ID	7168	2710
	Gene name	tropomyosin 1	glycerol kinase
	Synonyms	C15orf13\|CMD1Y\|CMH3\|HEL-S-265\|HTM-alpha\|LVNC9\|TMSA	GK1\|GKD
	Cytomap	15q22.2	Xp21.2
	Type of gene	protein-coding	protein-coding
	Description	tropomyosin alpha-1 chainalpha-tropomyosincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappatropomyosin 1 (alpha)	glycerol kinaseATP:glycerol 3-phosphotransferaseglycerokinase
	Modification date	20180523	20180523
	UniProtAcc	P09493	P32189
	Ensembl transtripts involved in fusion gene	ENST00000288398, ENST00000358278, ENST00000560445, ENST00000403994, ENST00000357980, ENST00000559556, ENST00000559397, ENST00000267996, ENST00000334895, ENST00000404484, ENST00000560959, ENST00000559281, ENST00000317516,	ENST00000378946, ENST00000378943, ENST00000378945, ENST00000427190, ENST00000378941,
Fusion gene scores	* DoF score	6 X 7 X 2=84	1 X 1 X 1=1
	# samples	8	1
	** MAII score	log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: TPM1 [Title/Abstract] AND GK [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA089671	TPM1	chr15	63353135	+	GK	chrX	30686569	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000288398	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000288398	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000288398	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000288398	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000288398	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000358278	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000358278	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000358278	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000358278	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000358278	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
intron-intron	ENST00000560445	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
intron-intron	ENST00000560445	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
intron-intron	ENST00000560445	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
intron-intron	ENST00000560445	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
intron-intron	ENST00000560445	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000403994	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000403994	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000403994	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000403994	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000403994	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000357980	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000357980	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000357980	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000357980	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000357980	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559556	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559556	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559556	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559556	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559556	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559397	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559397	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559397	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559397	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559397	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000267996	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000267996	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000267996	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000267996	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000267996	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000334895	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000334895	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000334895	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000334895	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000334895	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000404484	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000404484	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000404484	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000404484	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000404484	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000560959	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000560959	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000560959	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000560959	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000560959	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559281	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559281	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559281	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559281	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000559281	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000317516	ENST00000378946	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000317516	ENST00000378943	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000317516	ENST00000378945	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000317516	ENST00000427190	TPM1	chr15	63353135	+	GK	chrX	30686569	+
5CDS-intron	ENST00000317516	ENST00000378941	TPM1	chr15	63353135	+	GK	chrX	30686569	+

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FusionProtFeatures for TPM1_GK

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TPM1 P09493	GK P32189
	Key enzyme in the regulation of glycerol uptake andmetabolism.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TPM1_GK

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPM1_GK

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TPM1_GK

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	TPM1	P09493	DB11638	Artenimol	Tropomyosin alpha-1 chain	small molecule	approved\|investigational

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RelatedDiseases for TPM1_GK

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TPM1	C1861863	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)	5	CTD_human;UNIPROT
Hgene	TPM1	C2678476	Cardiomyopathy, Dilated, 1y	2	CTD_human;UNIPROT
Hgene	TPM1	C0014859	Esophageal Neoplasms	1	CTD_human
Hgene	TPM1	C0020538	Hypertensive disease	1	CTD_human
Hgene	TPM1	C0022548	Keloid	1	CTD_human
Hgene	TPM1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	TPM1	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
Hgene	TPM1	C0949658	Cardiomyopathy, Hypertrophic, Familial	1	CTD_human
Tgene	GK	C0268418	Deficiency of glycerol kinase	3	CTD_human;UNIPROT
Tgene	GK	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	GK	C0151744	Myocardial Ischemia	1	CTD_human

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Fusion gene ID: 39216

FusionGeneSummary for TPM1_GK

FusionProtFeatures for TPM1_GK

FusionGeneSequence for TPM1_GK

FusionGenePPI for TPM1_GK

RelatedDrugs for TPM1_GK

RelatedDiseases for TPM1_GK