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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39214

FusionGeneSummary for TPK1_CYCS

check button Fusion gene summary
Fusion gene informationFusion gene name: TPK1_CYCS
Fusion gene ID: 39214
HgeneTgene
Gene symbol

TPK1

CYCS

Gene ID

27010

54205

Gene namethiamin pyrophosphokinase 1cytochrome c, somatic
SynonymsHTPK1|PP20|THMD5CYC|HCS|THC4
Cytomap

7q35

7p15.3

Type of geneprotein-codingprotein-coding
Descriptionthiamin pyrophosphokinase 1placental protein 20thiamine diphosphokinasethiamine kinasecytochrome c
Modification date2018052320180523
UniProtAcc

Q9H3S4

P99999

Ensembl transtripts involved in fusion geneENST00000360057, ENST00000538212, 
ENST00000549981, ENST00000378099, 
ENST00000547966, 
ENST00000305786, 
ENST00000409409, ENST00000409764, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: TPK1 [Title/Abstract] AND CYCS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM459600TPK1chr7

144344086

+CYCSchr7

25162542

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000360057ENST00000305786TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000360057ENST00000409409TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000360057ENST00000409764TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-3UTRENST00000538212ENST00000305786TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000538212ENST00000409409TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000538212ENST00000409764TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-3UTRENST00000549981ENST00000305786TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000549981ENST00000409409TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000549981ENST00000409764TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-3UTRENST00000378099ENST00000305786TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000378099ENST00000409409TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000378099ENST00000409764TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-3UTRENST00000547966ENST00000305786TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000547966ENST00000409409TPK1chr7

144344086

+CYCSchr7

25162542

-
intron-intronENST00000547966ENST00000409764TPK1chr7

144344086

+CYCSchr7

25162542

-

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FusionProtFeatures for TPK1_CYCS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPK1

Q9H3S4

CYCS

P99999

Catalyzes the phosphorylation of thiamine to thiaminepyrophosphate. Can also catalyze the phosphorylation ofpyrithiamine to pyrithiamine pyrophosphate.{ECO:0000269|PubMed:11342111}. Electron carrier protein. The oxidized form of thecytochrome c heme group can accept an electron from the heme groupof the cytochrome c1 subunit of cytochrome reductase. Cytochrome cthen transfers this electron to the cytochrome oxidase complex,the final protein carrier in the mitochondrial electron-transportchain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members ofthe Bcl-2 family leads to altered mitochondrial membranepermeability resulting in release of cytochrome c into thecytosol. Binding of cytochrome c to Apaf-1 triggers the activationof caspase-9, which then accelerates apoptosis by activating othercaspases.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPK1_CYCS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPK1_CYCS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPK1_CYCS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTPK1Q9H3S4DB00152ThiamineThiamin pyrophosphokinase 1small moleculeapproved|investigational|nutraceutical|vet_approved
TgeneCYCSP99999DB01017MinocyclineCytochrome csmall moleculeapproved|investigational
TgeneCYCSP99999DB11638ArtenimolCytochrome csmall moleculeapproved|investigational

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RelatedDiseases for TPK1_CYCS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPK1C3280866THIAMINE METABOLISM DYSFUNCTION SYNDROME 5 (EPISODIC ENCEPHALOPATHY TYPE)1ORPHANET;UNIPROT
TgeneCYCSC0007786Brain Ischemia1CTD_human
TgeneCYCSC0007787Transient Ischemic Attack1CTD_human
TgeneCYCSC0015695Fatty Liver1CTD_human
TgeneCYCSC0022116Ischemia1CTD_human
TgeneCYCSC0028754Obesity1CTD_human
TgeneCYCSC0040034Thrombocytopenia1CTD_human;HPO
TgeneCYCSC0263454Chloracne1CTD_human
TgeneCYCSC0268583Methylmalonic acidemia1CTD_human
TgeneCYCSC2677608Thrombocytopenia 41CTD_human;UNIPROT