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Fusion gene ID: 39205 |
FusionGeneSummary for TPGS1_CHRNA3 |
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Fusion gene information | Fusion gene name: TPGS1_CHRNA3 | Fusion gene ID: 39205 | Hgene | Tgene | Gene symbol | TPGS1 | CHRNA3 | Gene ID | 91978 | 1136 |
Gene name | tubulin polyglutamylase complex subunit 1 | cholinergic receptor nicotinic alpha 3 subunit | |
Synonyms | C19orf20|GTRGEO22|PGs1 | LNCR2|NACHRA3|PAOD2 | |
Cytomap | 19p13.3 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tubulin polyglutamylase complex subunit 1gene trap ROSA b-geo 22 | neuronal acetylcholine receptor subunit alpha-3cholinergic receptor, nicotinic alpha 3cholinergic receptor, nicotinic, alpha 3 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 3neuronal nicotinic acetylcholine receptor, alpha3 subunit | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6ZTW0 | P32297 | |
Ensembl transtripts involved in fusion gene | ENST00000359315, | ENST00000348639, ENST00000326828, ENST00000559941, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 3=36 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TPGS1 [Title/Abstract] AND CHRNA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CHRNA3 | GO:0007165 | signal transduction | 8906617 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF507699 | TPGS1 | chr19 | 507516 | - | CHRNA3 | chr15 | 78894021 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000359315 | ENST00000348639 | TPGS1 | chr19 | 507516 | - | CHRNA3 | chr15 | 78894021 | - |
In-frame | ENST00000359315 | ENST00000326828 | TPGS1 | chr19 | 507516 | - | CHRNA3 | chr15 | 78894021 | - |
5CDS-intron | ENST00000359315 | ENST00000559941 | TPGS1 | chr19 | 507516 | - | CHRNA3 | chr15 | 78894021 | - |
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FusionProtFeatures for TPGS1_CHRNA3 |
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Hgene | Tgene |
TPGS1 | CHRNA3 |
May act in the targeting of the tubulin polyglutamylasecomplex. Required for the development of the spermatid flagellum(By similarity). {ECO:0000250}. | After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TPGS1_CHRNA3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TPGS1_ENST00000359315_chr19_507516_-_CHRNA3_ENST00000348639_chr15_78894021_-_0aa >In-frame_TPGS1_ENST00000359315_chr19_507516_-_CHRNA3_ENST00000326828_chr15_78894021_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TPGS1_ENST00000359315_chr19_507516_-_CHRNA3_ENST00000348639_chr15_78894021_-_0nt >In-frame_TPGS1_ENST00000359315_chr19_507516_-_CHRNA3_ENST00000326828_chr15_78894021_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TPGS1_ENST00000359315_chr19_507516_-_CHRNA3_ENST00000348639_chr15_78894021_-_0nt >In-frame_TPGS1_ENST00000359315_chr19_507516_-_CHRNA3_ENST00000326828_chr15_78894021_-_0nt |
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FusionGenePPI for TPGS1_CHRNA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TPGS1_CHRNA3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CHRNA3 | P32297 | DB00184 | Nicotine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB00514 | Dextromethorphan | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB00674 | Galantamine | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB00898 | Ethanol | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB01156 | Bupropion | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved |
Tgene | CHRNA3 | P32297 | DB01227 | Levomethadyl Acetate | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
Tgene | CHRNA3 | P32297 | DB01273 | Varenicline | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational |
Tgene | CHRNA3 | P32297 | DB00848 | Levamisole | Neuronal acetylcholine receptor subunit alpha-3 | small molecule | approved|investigational|vet_approved|withdrawn |
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RelatedDiseases for TPGS1_CHRNA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CHRNA3 | C0001973 | Alcoholic Intoxication, Chronic | 4 | CTD_human;PSYGENET |
Tgene | CHRNA3 | C0600427 | Cocaine Dependence | 2 | PSYGENET |
Tgene | CHRNA3 | C1861063 | TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 2 | CTD_human |
Tgene | CHRNA3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | CHRNA3 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CHRNA3 | C0036572 | Seizures | 1 | CTD_human |
Tgene | CHRNA3 | C0040336 | Tobacco Use Disorder | 1 | CTD_human |