FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39200

FusionGeneSummary for TPD52_COPS5

check button Fusion gene summary
Fusion gene informationFusion gene name: TPD52_COPS5
Fusion gene ID: 39200
HgeneTgene
Gene symbol

TPD52

COPS5

Gene ID

7163

10987

Gene nametumor protein D52COP9 signalosome subunit 5
SynonymsD52|N8L|PC-1|PrLZ|hD52CSN5|JAB1|MOV-34|SGN5
Cytomap

8q21.13

8q13.1

Type of geneprotein-codingprotein-coding
Descriptiontumor protein D52prostate and colon associated proteinprostate leucine zipperprotein N8COP9 signalosome complex subunit 538 kDa Mov34 homologCOP9 constitutive photomorphogenic homolog subunit 5jun activation domain-binding protein 1signalosome subunit 5testis secretory sperm-binding protein Li 231m
Modification date2018052720180527
UniProtAcc

P55327

Q92905

Ensembl transtripts involved in fusion geneENST00000537855, ENST00000379096, 
ENST00000518937, ENST00000519303, 
ENST00000517427, ENST00000520527, 
ENST00000448733, ENST00000379097, 
ENST00000523395, 
ENST00000357849, 
ENST00000517736, ENST00000519963, 
Fusion gene scores* DoF score9 X 4 X 5=1803 X 3 X 2=18
# samples 93
** MAII scorelog2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPD52 [Title/Abstract] AND COPS5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOPS5

GO:0000338

protein deneddylation

19141280

TgeneCOPS5

GO:0016579

protein deubiquitination

19246649

TgeneCOPS5

GO:0045944

positive regulation of transcription by RNA polymerase II

16410250

TgeneCOPS5

GO:0046328

regulation of JNK cascade

16410250

TgeneCOPS5

GO:0051091

positive regulation of DNA binding transcription factor activity

20978819

TgeneCOPS5

GO:1990182

exosomal secretion

19246649


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0XV-01ATPD52chr8

81083660

-COPS5chr8

67971680

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000537855ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000537855ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000537855ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
Frame-shitENST00000379096ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
5CDS-5UTRENST00000379096ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
5CDS-intronENST00000379096ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
Frame-shitENST00000518937ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
5CDS-5UTRENST00000518937ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
5CDS-intronENST00000518937ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-3CDSENST00000519303ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000519303ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000519303ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-3CDSENST00000517427ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000517427ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000517427ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-3CDSENST00000520527ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000520527ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000520527ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-3CDSENST00000448733ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000448733ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000448733ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-3CDSENST00000379097ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000379097ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000379097ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-3CDSENST00000523395ENST00000357849TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-5UTRENST00000523395ENST00000517736TPD52chr8

81083660

-COPS5chr8

67971680

-
intron-intronENST00000523395ENST00000519963TPD52chr8

81083660

-COPS5chr8

67971680

-

Top

FusionProtFeatures for TPD52_COPS5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPD52

P55327

COPS5

Q92905

Probable protease subunit of the COP9 signalosomecomplex (CSN), a complex involved in various cellular anddevelopmental processes. The CSN complex is an essential regulatorof the ubiquitin (Ubl) conjugation pathway by mediating thedeneddylation of the cullin subunits of the SCF-type E3 ligasecomplexes, leading to decrease the Ubl ligase activity of SCF-typecomplexes such as SCF, CSA or DDB2. The complex is also involvedin phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA,ITPK1 and IRF8, possibly via its association with CK2 and PKDkinases. CSN-dependent phosphorylation of TP53 and JUN promotesand protects degradation by the Ubl system, respectively. In thecomplex, it probably acts as the catalytic center that mediatesthe cleavage of Nedd8 from cullins. It however has nometalloprotease activity by itself and requires the other subunitsof the CSN complex. Interacts directly with a large number ofproteins that are regulated by the CSN complex, confirming a keyrole in the complex. Promotes the proteasomal degradation ofBRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588,ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143,ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819,ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TPD52_COPS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TPD52_COPS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TPD52MAL2, TPD52, TPD52L1, TPD52L2, SAR1A, SEPHS1, YWHAQ, BAG3, SOCS2, SENP2, SRPK2, ARPC1B, PDIA6, PRKACA, AARS, CACYBP, PDCD4, PDLIM5, NXF1, MRPS2, CALU, CLIC4, DUT, ENO2, EZR, NACA2, PAIP1, PHB, PTGES3, UCHL3, HIST1H2BG, DYNC1H1, HNRNPU, TSNAX, MTX2, THOC2, CDH1, PPM1H, MRPS11, MEAF6, ZBTB48, ZNF169, CTNNA3, ZNF133, SOD1COPS5HAND2, S100A7, BCL3, UCHL1, CDKN1B, COPS8, JUN, JUND, MIF, SMAD4, GFER, SAP130, CPSF1, TP53, MDM2, MAPRE1, ERCC8, DDB2, GPS1, NEDD8, SKP2, UCHL3, CUL4B, CUL4A, CUL3, CUL2, CUL1, COPS3, COPS2, LRRC14, VPRBP, COPS6, KLHL18, DCAF4, FBXO22, COPS7A, COPS4, KLHL24, BTBD2, KLHL9, COPS7B, FBXO11, KLHL15, DCAF11, KLHL22, KLHL13, FBXO17, LRR1, PTGS2, DDB1, TRAF2, TOR1AIP2, MAP3K3, MAP3K11, MAP2K2, MAP3K7, MAP4K3, MAP4K5, MEF2D, SREBF2, YWHAZ, MAX, MEF2C, YWHAG, WNK1, BRE, BRCC3, VCP, EDNRA, EDNRB, CSN1S1, IKBKB, CHUK, ABCA1, PPARG, RORA, HNF4A, HNF4G, NR4A2, NR4A3, MALT1, CARD11, GNB2L1, ATRN, LOC284014, C12orf10, PLAC8, PPOX, SHISA5, USP14, VTN, MAPK14, IRF8, CTNNB1, GSK3B, APC, CSNK1A1, ERN1, AMH, BRSK2, PSMA6, SPP1, CAND1, TOP2A, CDT1, PRKD1, HIF1A, VHL, CUL5, ABCA10, ABCF1, ABTB2, ACAT1, ACP1, ACSBG2, ACTA2, ACTB, ACTBL2, ACTR1A, AGL, AHCY, AIFM1, AIMP1, AKAP8, ALDOC, AMBRA1, AMPD1, ANAPC2, ANAPC7, ANKRD12, AP1B1, TINAGL1, ASB6, ASNS, GDNF, ATP1A4, BAG4, BLM, BLMH, BRWD1, BTBD1, BTBD9, BUB3, BYSL, C10orf55, C11orf70, C14orf166, C1QBP, TRMT1L, RTCB, UNC80, DCAF16, YAE1D1, C7orf50, DFFB, CALML5, CAMKV, CAPRIN1, CARM1, CBR1, CCBL2, CFAP58, CCDC47, CCNA1, CCNA2, CCPG1, CCT2, CCT8, POLD1, CDC20, CDK2, CDK3, CDK4, CDKN2A, CHEK1, CIRBP, CKAP4, CKS1B, CLTA, CLTC, CLTCL1, CNTN4, COPS5, CPNE2, CPNE7, CRBN, LUC7L3, YBX3, CSDE1, CTNNA1, CTPS1, CXCL2, DLGAP3, DAZAP1, DCD, DCHS2, DDA1, DDX1, DDX17, DDX18, DDX19B, DDX20, DDX56, DDX3X, DDX5, DDX52, DDX6, DEFB127, DEK, DHX15, DHX29, DHX30, DHX36, DHX57, DHX9, DLAT, DNAH2, DNAJA1, DNAJA2, DNAJC10, DNAJC9, DNM1L, DPF2, DSG1, DSP, DTL, PTPMT1, DYNC1H1, EBNA1BP2, ECSCR, EEF1A1, EEF1A2, EEF1G, EEF2, MICU2, EFTUD2, EHBP1, AGO1, AGO2, EIF2S1, EIF4A1, SNORA67, EIF5A, ELAC2, ELAVL1, ENO1, EPRS, EWSR1, EXOSC9, FAM103A1, FAM114A2, FAM83H, FAM98A, FAM98B, FAU, FBL, FBLL1, FBXL14, FBXL18, FBXL5, FBXO10, FBXO21, FBXO22-AS1, FBXO3, FBXO31, FBXO44, FBXO46, FBXO7, FBXO9, FBXW11, FBXW9, FECH, FEM1B, FEM1C, FIGN, FIP1L1, FLG2, FTSJ3, FUBP1, FUBP3, FUS, FXR1, G3BP1, G3BP2, GADD45GIP1, GALNT13, GAPDH, GGH, GNL3, GRWD1, GSTP1, GTPBP1, GTPBP4, GVINP1, GYS1, HAT1, HDLBP, HIST1H1C, HIST2H2BE, HMGB3P1, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPL, HNRNPM, HNRNPR, HNRNPU, HNRNPUL1, HNRNPUL2, HNRNPDL, HOXA10, HRNR, HSD11B1L, HSD17B10, HSP90AA1, HSP90AA2P, HSP90AB2P, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA4, HSPA5, HSPA6, HSPA7, HSPA8, HSPA9, HSPB1, HSPD1, IARS, IGF2BP1, IGF2BP3, ILF2, ILF3, ILK, CCT4, IMPDH2, IRS4, ISL1, ISL2, JUP, KARS, KBTBD4, KBTBD6, KCTD10, KCTD18, KCTD3, KCTD6, KHK, KHSRP, CIPC, CCAR2, KLHL42, KLHL12, KLHL21, KLHL23, KLHL26, KLHL36, KLHL8, KPNA1, KPNA2, KPNB1, KRT1, KRT10, KRT13, KRT14, KRT16, KRT17, KRT2, KRT24, KRT3, KRT5, KRT6A, KRT6B, KRT6C, KRT71, KRT75, KRT76, KRT78, KRT80, KRT9, LARP1, LARP4B, LDHB, LGALS3BP, LGALS7, LGALS7B, LIN28B, LRCH2, LRRC47, LSM12, LUC7L2, LYAR, MAGED2, MAP4K1, MAPKAPK2, MAT2A, MATR3, MCM3, MCM7, MDH2, MNX1, MOV10, MRPL11, MRPL15, MRPL43, MRPL49, MRPS11, MRPS15, MRPS22, MRPS23, MRPS25, MRPS27, MTHFD1L, MYBBP1A, MYEOV2, MYLK4, MYNN, MYOZ1, NAP1L1, NCBP1, NCL, NDUFV1, NFKB1, NKRF, NONO, NOP16, NOP2, NOP56, NPM1, NQO2, NSUN2, NUDT1, NUDT16L1, NUFIP2, NUP155, NUPL2, NXF1, PABPC1, PABPC4, PABPN1, PARP1, PCBD1, PCBP1, PCBP2, PCMT1, PDE12, PDE6D, PDHA2, PDIA6, PDXK, PFKP, PGAM5, PGK1, PGRMC1, PHRF1, PKM, PLK1, PLOD1, POF1B, POLR2C, POLR2E, POP1, PPIA, PPP1CC, PPP1R15A, PRDX1, PRDX3, PRKDC, PRPF19, PRPF31, PRPF39, PRPF40A, PRPS1L1, PRPSAP1, PRPSAP2, PSMA7, PSME4, PTBP1, PUF60, PWP1, QDPR, QPCT, RBM14, RBM3, RBM39, RBM4, RBM42, RBM5, RBMXL2, RCBTB1, RELN, RFC2, RHOBTB1, RNF138, RNASEH1P1, RNMT, RNPS1, RPL10, RPL10A, RPL10L, RPL10P16, RPL11, RPL12, RPL13, RPL13P12, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21P19, RPL21, RPL21P16, RPL22, RPL23, RPL23A, RPL24, RPL26L1, RPL27, RPL27A, RPL28, RPL29P30, RPL3, RPL30, RPL31, RPL35, RPL36AP37, HNRNPH2, RPL37A, RPL38, RPL4, RPL5, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPN1, RPS10, RPS11, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26P54, RPS27, RPS3, RPS3A, RPS4X, RPS6, RPS7, RPS8, RPS9, RPSAP12, RPSAP15, RPSA, RPSAP55, RRM1, RRP12, RRP15, RSL1D1, RUVBL1, S100A8, S100A9, SAFB2, SDHA, SDHB, SEH1L, SENP6, SERPINB3, SERPINB4, SF3A3, SF3B1, SF3B3, SF3B4, SFPQ, SRSF1, SRSF2, SRSF3, SRSF5, SRSF6, SRSF7, SHKBP1, SKIV2L2, SKP1, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLFN12L, SMARCA4, SMARCB1, SMC3, SNORA7A, RPL32, SNRNP200, SNRNP70, SNRPA, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNX9, SORL1, SPTAN1, SPTBN1, U2SURP, SRP14, SRPK1, SRRM2, SSB, SSBP1, SSR4, SSRP1, STAU2, TTC5, STRBP, SYNCRIP, TAF15, TBL2, TCEB1, TCEB1P3, TCEB2, TCP1, TFAM, TFG, ALYREF, TIA1, TIAL1, TMC1, TNRC6B, TOP1, TRA2A, TRA2B, TRIM28, TRMT61A, TRPC4AP, TTBK2, TTN, TUBA1C, TUBA4A, TUBB, TUBB1, TUBB4B, TUFM, TXN, TYRO3, U2AF2, UBA1, UBAP2L, UBC, UPF1, UPF3B, UROS, USP15, USP7, VIM, DCAF4L1, DCAF12, DCAF8, WDR5, WDR61, WIPI2, XRCC6, XRN2, YBX1, YTHDC2, ZC3HAV1, ZCCHC11, ZFR, ZNF185, ZNF302, ZNF554, ZYG11B, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, DCUN1D1, SMAD7, NRBP1, ITGB2, BCL2L14, FAM188A, EIF2AK3, SMAD5, PGR, NCOA1, CACNA1C, ESR1, RAD1, RAD9A, HUS1, CCNDBP1, FANK1, F2RL1, TP53BP1, NUPR1, HTR6, GFI1B, RFWD2, RBX1, APP, MDC1, IRF5, SMAD2, FBXW4, CENPT, CENPW, ARFGAP1, C6orf203, DDO, APCS, PRDX2, CD93, SHANK3, TYK2, FBXO6, PDLIM7, CAST, EPB41L1, KIF5B, SART3, CREB3, STAT3, RANBP9, LRP1, BACE1, SIAH1, TXNIP, OPRM1, FNIP1, SLC30A9, TPD52L2, GNB5, GUCY1A3, CSNK2A1, EIF3H, POLR2I, EIF3F, LPP, TRIP6, NTRK1, KRAS, RAF1, PRPF4, CDC5L, ERRFI1, CDKN1C, AHR, DENR, APBB3, KLHL10, DET1, UBE2M, DCAF4L2, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TPD52_COPS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TPD52_COPS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPD52C0033578Prostatic Neoplasms1CTD_human
TgeneCOPS5C0038325Stevens-Johnson Syndrome1CTD_human
TgeneCOPS5C2239176Liver carcinoma1CTD_human