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Fusion gene ID: 39200 |
FusionGeneSummary for TPD52_COPS5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TPD52_COPS5 | Fusion gene ID: 39200 | Hgene | Tgene | Gene symbol | TPD52 | COPS5 | Gene ID | 7163 | 10987 |
| Gene name | tumor protein D52 | COP9 signalosome subunit 5 | |
| Synonyms | D52|N8L|PC-1|PrLZ|hD52 | CSN5|JAB1|MOV-34|SGN5 | |
| Cytomap | 8q21.13 | 8q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor protein D52prostate and colon associated proteinprostate leucine zipperprotein N8 | COP9 signalosome complex subunit 538 kDa Mov34 homologCOP9 constitutive photomorphogenic homolog subunit 5jun activation domain-binding protein 1signalosome subunit 5testis secretory sperm-binding protein Li 231m | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P55327 | Q92905 | |
| Ensembl transtripts involved in fusion gene | ENST00000537855, ENST00000379096, ENST00000518937, ENST00000519303, ENST00000517427, ENST00000520527, ENST00000448733, ENST00000379097, ENST00000523395, | ENST00000357849, ENST00000517736, ENST00000519963, | |
| Fusion gene scores | * DoF score | 9 X 4 X 5=180 | 3 X 3 X 2=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/180*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TPD52 [Title/Abstract] AND COPS5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | COPS5 | GO:0000338 | protein deneddylation | 19141280 |
| Tgene | COPS5 | GO:0016579 | protein deubiquitination | 19246649 |
| Tgene | COPS5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16410250 |
| Tgene | COPS5 | GO:0046328 | regulation of JNK cascade | 16410250 |
| Tgene | COPS5 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 20978819 |
| Tgene | COPS5 | GO:1990182 | exosomal secretion | 19246649 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0XV-01A | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000537855 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000537855 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000537855 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| Frame-shift | ENST00000379096 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| 5CDS-5UTR | ENST00000379096 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| 5CDS-intron | ENST00000379096 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| Frame-shift | ENST00000518937 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| 5CDS-5UTR | ENST00000518937 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| 5CDS-intron | ENST00000518937 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-3CDS | ENST00000519303 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000519303 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000519303 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-3CDS | ENST00000517427 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000517427 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000517427 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-3CDS | ENST00000520527 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000520527 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000520527 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-3CDS | ENST00000448733 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000448733 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000448733 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-3CDS | ENST00000379097 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000379097 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000379097 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-3CDS | ENST00000523395 | ENST00000357849 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-5UTR | ENST00000523395 | ENST00000517736 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
| intron-intron | ENST00000523395 | ENST00000519963 | TPD52 | chr8 | 81083660 | - | COPS5 | chr8 | 67971680 | - |
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FusionProtFeatures for TPD52_COPS5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TPD52 | COPS5 |
| Probable protease subunit of the COP9 signalosomecomplex (CSN), a complex involved in various cellular anddevelopmental processes. The CSN complex is an essential regulatorof the ubiquitin (Ubl) conjugation pathway by mediating thedeneddylation of the cullin subunits of the SCF-type E3 ligasecomplexes, leading to decrease the Ubl ligase activity of SCF-typecomplexes such as SCF, CSA or DDB2. The complex is also involvedin phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA,ITPK1 and IRF8, possibly via its association with CK2 and PKDkinases. CSN-dependent phosphorylation of TP53 and JUN promotesand protects degradation by the Ubl system, respectively. In thecomplex, it probably acts as the catalytic center that mediatesthe cleavage of Nedd8 from cullins. It however has nometalloprotease activity by itself and requires the other subunitsof the CSN complex. Interacts directly with a large number ofproteins that are regulated by the CSN complex, confirming a keyrole in the complex. Promotes the proteasomal degradation ofBRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588,ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143,ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819,ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TPD52_COPS5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TPD52_COPS5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TPD52 | MAL2, TPD52, TPD52L1, TPD52L2, SAR1A, SEPHS1, YWHAQ, BAG3, SOCS2, SENP2, SRPK2, ARPC1B, PDIA6, PRKACA, AARS, CACYBP, PDCD4, PDLIM5, NXF1, MRPS2, CALU, CLIC4, DUT, ENO2, EZR, NACA2, PAIP1, PHB, PTGES3, UCHL3, HIST1H2BG, DYNC1H1, HNRNPU, TSNAX, MTX2, THOC2, CDH1, PPM1H, MRPS11, MEAF6, ZBTB48, ZNF169, CTNNA3, ZNF133, SOD1 | COPS5 | HAND2, S100A7, BCL3, UCHL1, CDKN1B, COPS8, JUN, JUND, MIF, SMAD4, GFER, SAP130, CPSF1, TP53, MDM2, MAPRE1, ERCC8, DDB2, GPS1, NEDD8, SKP2, UCHL3, CUL4B, CUL4A, CUL3, CUL2, CUL1, COPS3, COPS2, LRRC14, VPRBP, COPS6, KLHL18, DCAF4, FBXO22, COPS7A, COPS4, KLHL24, BTBD2, KLHL9, COPS7B, FBXO11, KLHL15, DCAF11, KLHL22, KLHL13, FBXO17, LRR1, PTGS2, DDB1, TRAF2, TOR1AIP2, MAP3K3, MAP3K11, MAP2K2, MAP3K7, MAP4K3, MAP4K5, MEF2D, SREBF2, YWHAZ, MAX, MEF2C, YWHAG, WNK1, BRE, BRCC3, VCP, EDNRA, EDNRB, CSN1S1, IKBKB, CHUK, ABCA1, PPARG, RORA, HNF4A, HNF4G, NR4A2, NR4A3, MALT1, CARD11, GNB2L1, ATRN, LOC284014, C12orf10, PLAC8, PPOX, SHISA5, USP14, VTN, MAPK14, IRF8, CTNNB1, GSK3B, APC, CSNK1A1, ERN1, AMH, BRSK2, PSMA6, SPP1, CAND1, TOP2A, CDT1, PRKD1, HIF1A, VHL, CUL5, ABCA10, ABCF1, ABTB2, ACAT1, ACP1, ACSBG2, ACTA2, ACTB, ACTBL2, ACTR1A, AGL, AHCY, AIFM1, AIMP1, AKAP8, ALDOC, AMBRA1, AMPD1, ANAPC2, ANAPC7, ANKRD12, AP1B1, TINAGL1, ASB6, ASNS, GDNF, ATP1A4, BAG4, BLM, BLMH, BRWD1, BTBD1, BTBD9, BUB3, BYSL, C10orf55, C11orf70, C14orf166, C1QBP, TRMT1L, RTCB, UNC80, DCAF16, YAE1D1, C7orf50, DFFB, CALML5, CAMKV, CAPRIN1, CARM1, CBR1, CCBL2, CFAP58, CCDC47, CCNA1, CCNA2, CCPG1, CCT2, CCT8, POLD1, CDC20, CDK2, CDK3, CDK4, CDKN2A, CHEK1, CIRBP, CKAP4, CKS1B, CLTA, CLTC, CLTCL1, CNTN4, COPS5, CPNE2, CPNE7, CRBN, LUC7L3, YBX3, CSDE1, CTNNA1, CTPS1, CXCL2, DLGAP3, DAZAP1, DCD, DCHS2, DDA1, DDX1, DDX17, DDX18, DDX19B, DDX20, DDX56, DDX3X, DDX5, DDX52, DDX6, DEFB127, DEK, DHX15, DHX29, DHX30, DHX36, DHX57, DHX9, DLAT, DNAH2, DNAJA1, DNAJA2, DNAJC10, DNAJC9, DNM1L, DPF2, DSG1, DSP, DTL, PTPMT1, DYNC1H1, EBNA1BP2, ECSCR, EEF1A1, EEF1A2, EEF1G, EEF2, MICU2, EFTUD2, EHBP1, AGO1, AGO2, EIF2S1, EIF4A1, SNORA67, EIF5A, ELAC2, ELAVL1, ENO1, EPRS, EWSR1, EXOSC9, FAM103A1, FAM114A2, FAM83H, FAM98A, FAM98B, FAU, FBL, FBLL1, FBXL14, FBXL18, FBXL5, FBXO10, FBXO21, FBXO22-AS1, FBXO3, FBXO31, FBXO44, FBXO46, FBXO7, FBXO9, FBXW11, FBXW9, FECH, FEM1B, FEM1C, FIGN, FIP1L1, FLG2, FTSJ3, FUBP1, FUBP3, FUS, FXR1, G3BP1, G3BP2, GADD45GIP1, GALNT13, GAPDH, GGH, GNL3, GRWD1, GSTP1, GTPBP1, GTPBP4, GVINP1, GYS1, HAT1, HDLBP, HIST1H1C, HIST2H2BE, HMGB3P1, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPL, HNRNPM, HNRNPR, HNRNPU, HNRNPUL1, HNRNPUL2, HNRNPDL, HOXA10, HRNR, HSD11B1L, HSD17B10, HSP90AA1, HSP90AA2P, HSP90AB2P, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA4, HSPA5, HSPA6, HSPA7, HSPA8, HSPA9, HSPB1, HSPD1, IARS, IGF2BP1, IGF2BP3, ILF2, ILF3, ILK, CCT4, IMPDH2, IRS4, ISL1, ISL2, JUP, KARS, KBTBD4, KBTBD6, KCTD10, KCTD18, KCTD3, KCTD6, KHK, KHSRP, CIPC, CCAR2, KLHL42, KLHL12, KLHL21, KLHL23, KLHL26, KLHL36, KLHL8, KPNA1, KPNA2, KPNB1, KRT1, KRT10, KRT13, KRT14, KRT16, KRT17, KRT2, KRT24, KRT3, KRT5, KRT6A, KRT6B, KRT6C, KRT71, KRT75, KRT76, KRT78, KRT80, KRT9, LARP1, LARP4B, LDHB, LGALS3BP, LGALS7, LGALS7B, LIN28B, LRCH2, LRRC47, LSM12, LUC7L2, LYAR, MAGED2, MAP4K1, MAPKAPK2, MAT2A, MATR3, MCM3, MCM7, MDH2, MNX1, MOV10, MRPL11, MRPL15, MRPL43, MRPL49, MRPS11, MRPS15, MRPS22, MRPS23, MRPS25, MRPS27, MTHFD1L, MYBBP1A, MYEOV2, MYLK4, MYNN, MYOZ1, NAP1L1, NCBP1, NCL, NDUFV1, NFKB1, NKRF, NONO, NOP16, NOP2, NOP56, NPM1, NQO2, NSUN2, NUDT1, NUDT16L1, NUFIP2, NUP155, NUPL2, NXF1, PABPC1, PABPC4, PABPN1, PARP1, PCBD1, PCBP1, PCBP2, PCMT1, PDE12, PDE6D, PDHA2, PDIA6, PDXK, PFKP, PGAM5, PGK1, PGRMC1, PHRF1, PKM, PLK1, PLOD1, POF1B, POLR2C, POLR2E, POP1, PPIA, PPP1CC, PPP1R15A, PRDX1, PRDX3, PRKDC, PRPF19, PRPF31, PRPF39, PRPF40A, PRPS1L1, PRPSAP1, PRPSAP2, PSMA7, PSME4, PTBP1, PUF60, PWP1, QDPR, QPCT, RBM14, RBM3, RBM39, RBM4, RBM42, RBM5, RBMXL2, RCBTB1, RELN, RFC2, RHOBTB1, RNF138, RNASEH1P1, RNMT, RNPS1, RPL10, RPL10A, RPL10L, RPL10P16, RPL11, RPL12, RPL13, RPL13P12, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21P19, RPL21, RPL21P16, RPL22, RPL23, RPL23A, RPL24, RPL26L1, RPL27, RPL27A, RPL28, RPL29P30, RPL3, RPL30, RPL31, RPL35, RPL36AP37, HNRNPH2, RPL37A, RPL38, RPL4, RPL5, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPN1, RPS10, RPS11, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26P54, RPS27, RPS3, RPS3A, RPS4X, RPS6, RPS7, RPS8, RPS9, RPSAP12, RPSAP15, RPSA, RPSAP55, RRM1, RRP12, RRP15, RSL1D1, RUVBL1, S100A8, S100A9, SAFB2, SDHA, SDHB, SEH1L, SENP6, SERPINB3, SERPINB4, SF3A3, SF3B1, SF3B3, SF3B4, SFPQ, SRSF1, SRSF2, SRSF3, SRSF5, SRSF6, SRSF7, SHKBP1, SKIV2L2, SKP1, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLFN12L, SMARCA4, SMARCB1, SMC3, SNORA7A, RPL32, SNRNP200, SNRNP70, SNRPA, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNX9, SORL1, SPTAN1, SPTBN1, U2SURP, SRP14, SRPK1, SRRM2, SSB, SSBP1, SSR4, SSRP1, STAU2, TTC5, STRBP, SYNCRIP, TAF15, TBL2, TCEB1, TCEB1P3, TCEB2, TCP1, TFAM, TFG, ALYREF, TIA1, TIAL1, TMC1, TNRC6B, TOP1, TRA2A, TRA2B, TRIM28, TRMT61A, TRPC4AP, TTBK2, TTN, TUBA1C, TUBA4A, TUBB, TUBB1, TUBB4B, TUFM, TXN, TYRO3, U2AF2, UBA1, UBAP2L, UBC, UPF1, UPF3B, UROS, USP15, USP7, VIM, DCAF4L1, DCAF12, DCAF8, WDR5, WDR61, WIPI2, XRCC6, XRN2, YBX1, YTHDC2, ZC3HAV1, ZCCHC11, ZFR, ZNF185, ZNF302, ZNF554, ZYG11B, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, DCUN1D1, SMAD7, NRBP1, ITGB2, BCL2L14, FAM188A, EIF2AK3, SMAD5, PGR, NCOA1, CACNA1C, ESR1, RAD1, RAD9A, HUS1, CCNDBP1, FANK1, F2RL1, TP53BP1, NUPR1, HTR6, GFI1B, RFWD2, RBX1, APP, MDC1, IRF5, SMAD2, FBXW4, CENPT, CENPW, ARFGAP1, C6orf203, DDO, APCS, PRDX2, CD93, SHANK3, TYK2, FBXO6, PDLIM7, CAST, EPB41L1, KIF5B, SART3, CREB3, STAT3, RANBP9, LRP1, BACE1, SIAH1, TXNIP, OPRM1, FNIP1, SLC30A9, TPD52L2, GNB5, GUCY1A3, CSNK2A1, EIF3H, POLR2I, EIF3F, LPP, TRIP6, NTRK1, KRAS, RAF1, PRPF4, CDC5L, ERRFI1, CDKN1C, AHR, DENR, APBB3, KLHL10, DET1, UBE2M, DCAF4L2, SIRT7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TPD52_COPS5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPD52_COPS5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TPD52 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | COPS5 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | COPS5 | C2239176 | Liver carcinoma | 1 | CTD_human |
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