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Fusion gene ID: 39148 |
FusionGeneSummary for TP53INP2_RPL34 |
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Fusion gene information | Fusion gene name: TP53INP2_RPL34 | Fusion gene ID: 39148 | Hgene | Tgene | Gene symbol | TP53INP2 | RPL34 | Gene ID | 58476 | 6164 |
Gene name | tumor protein p53 inducible nuclear protein 2 | ribosomal protein L34 | |
Synonyms | C20orf110|DOR|PIG-U|PIGU|PINH|dJ1181N3.1 | L34 | |
Cytomap | 20q11.22 | 4q25 | |
Type of gene | protein-coding | protein-coding | |
Description | tumor protein p53-inducible nuclear protein 2diabetes and obesity-regulatedp53-inducible protein U | 60S ribosomal protein L34large ribosomal subunit protein eL34leukemia-associated protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q8IXH6 | P49207 | |
Ensembl transtripts involved in fusion gene | ENST00000374810, ENST00000374809, | ENST00000394667, ENST00000502534, ENST00000394665, ENST00000506397, ENST00000394668, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TP53INP2 [Title/Abstract] AND RPL34 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TP53INP2 | GO:0000045 | autophagosome assembly | 19056683 |
Hgene | TP53INP2 | GO:0045893 | positive regulation of transcription, DNA-templated | 22470510 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM810873 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000374810 | ENST00000394667 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374810 | ENST00000502534 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374810 | ENST00000394665 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374810 | ENST00000506397 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374810 | ENST00000394668 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374809 | ENST00000394667 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374809 | ENST00000502534 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374809 | ENST00000394665 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374809 | ENST00000506397 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
3UTR-3CDS | ENST00000374809 | ENST00000394668 | TP53INP2 | chr20 | 33298208 | + | RPL34 | chr4 | 109543688 | + |
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FusionProtFeatures for TP53INP2_RPL34 |
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Hgene | Tgene |
TP53INP2 | RPL34 |
Dual regulator of transcription and autophagy.Positively regulates autophagy and is required for autophagosomeformation and processing. May act as a scaffold protein thatrecruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to theautophagosome membrane by interacting with VMP1 where, incooperation with the BECN1-PI3-kinase class III complex, theytrigger autophagosome development. Acts as a transcriptionalactivator of THRA. {ECO:0000269|PubMed:18030323,ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22470510}. | Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TP53INP2_RPL34 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TP53INP2_RPL34 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TP53INP2_RPL34 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TP53INP2_RPL34 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |