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Fusion gene ID: 39140 |
FusionGeneSummary for TP53BP2_RPL30 |
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Fusion gene information | Fusion gene name: TP53BP2_RPL30 | Fusion gene ID: 39140 | Hgene | Tgene | Gene symbol | TP53BP2 | RPL30 | Gene ID | 7159 | 6156 |
Gene name | tumor protein p53 binding protein 2 | ribosomal protein L30 | |
Synonyms | 53BP2|ASPP2|BBP|P53BP2|PPP1R13A | L30 | |
Cytomap | 1q41 | 8q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | apoptosis-stimulating of p53 protein 2BCL2-binding proteinapoptosis-stimulating protein of p53, 2renal carcinoma antigen NY-REN-51tumor suppressor p53-binding protein 2 | 60S ribosomal protein L30large ribosomal subunit protein eL30 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q13625 | P62888 | |
Ensembl transtripts involved in fusion gene | ENST00000391878, ENST00000343537, ENST00000391879, ENST00000498843, | ENST00000518164, ENST00000521291, ENST00000396070, ENST00000287038, ENST00000523172, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 10 X 7 X 5=350 |
# samples | 3 | 15 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/350*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TP53BP2 [Title/Abstract] AND RPL30 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TP53BP2 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11684014 |
Tgene | RPL30 | GO:0002181 | cytoplasmic translation | 25957688 |
Tgene | RPL30 | GO:0031640 | killing of cells of other organism | 15019208 |
Tgene | RPL30 | GO:0050829 | defense response to Gram-negative bacterium | 15019208 |
Tgene | RPL30 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 15019208 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW662691 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000391878 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-intron | ENST00000391878 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391878 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391878 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391878 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000343537 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-intron | ENST00000343537 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000343537 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000343537 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000343537 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391879 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-intron | ENST00000391879 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391879 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391879 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000391879 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000498843 | ENST00000518164 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-intron | ENST00000498843 | ENST00000521291 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000498843 | ENST00000396070 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000498843 | ENST00000287038 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
intron-5UTR | ENST00000498843 | ENST00000523172 | TP53BP2 | chr1 | 223968077 | + | RPL30 | chr8 | 99057760 | - |
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FusionProtFeatures for TP53BP2_RPL30 |
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Hgene | Tgene |
TP53BP2 | RPL30 |
Regulator that plays a central role in regulation ofapoptosis and cell growth via its interactions. Regulates TP53 byenhancing the DNA binding and transactivation function of TP53 onthe promoters of proapoptotic genes in vivo. Inhibits the abilityof APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1ability to induce apoptosis. Impedes cell cycle progression atG2/M. Its apoptosis-stimulating activity is inhibited by itsinteraction with DDX42. {ECO:0000269|PubMed:11684014,ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TP53BP2_RPL30 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TP53BP2_RPL30 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TP53BP2_RPL30 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TP53BP2_RPL30 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |