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Fusion gene ID: 39088 |
FusionGeneSummary for TOP2B_GADL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP2B_GADL1 | Fusion gene ID: 39088 | Hgene | Tgene | Gene symbol | TOP2B | GADL1 | Gene ID | 7155 | 339896 |
| Gene name | DNA topoisomerase II beta | glutamate decarboxylase like 1 | |
| Synonyms | TOPIIB|top2beta | ADC|CSADC|HuADC|HuCSADC | |
| Cytomap | 3p24.2 | 3p24.1-p23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIb | acidic amino acid decarboxylase GADL1aspartate 1-decarboxylasecysteine sulfinic acid decarboxylaseglutamate decarboxylase-like protein 1 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q02880 | Q6ZQY3 | |
| Ensembl transtripts involved in fusion gene | ENST00000435706, ENST00000264331, ENST00000542520, ENST00000540199, ENST00000475717, | ENST00000282538, ENST00000498387, ENST00000454381, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 5 X 5 X 5=125 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP2B [Title/Abstract] AND GADL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP2B | GO:0006265 | DNA topological change | 10684600 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-67-3774-01A | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000435706 | ENST00000282538 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000435706 | ENST00000498387 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000435706 | ENST00000454381 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| Frame-shift | ENST00000264331 | ENST00000282538 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000264331 | ENST00000498387 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000264331 | ENST00000454381 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| Frame-shift | ENST00000542520 | ENST00000282538 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000542520 | ENST00000498387 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000542520 | ENST00000454381 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| Frame-shift | ENST00000540199 | ENST00000282538 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000540199 | ENST00000498387 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| 5CDS-intron | ENST00000540199 | ENST00000454381 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| intron-3CDS | ENST00000475717 | ENST00000282538 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| intron-intron | ENST00000475717 | ENST00000498387 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
| intron-intron | ENST00000475717 | ENST00000454381 | TOP2B | chr3 | 25646251 | - | GADL1 | chr3 | 30885958 | - |
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FusionProtFeatures for TOP2B_GADL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP2B | GADL1 |
| Control of topological states of DNA by transientbreakage and subsequent rejoining of DNA strands. Topoisomerase IImakes double-strand breaks. {ECO:0000269|PubMed:10684600}. | May catalyze the decarboxylation of aspartate, cysteinesulfinic acid, and cysteic acid to beta-alanine, hypotaurine andtaurine, respectively. Does not exhibit any decarboxylationactivity toward glutamate. {ECO:0000269|PubMed:23038267}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TOP2B_GADL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TOP2B_GADL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TOP2B | TOPBP1, HDAC1, HDAC2, MTA2, TOP2A, TP53, SUMO1, CD3E, CSNK2B, ESR1, PARP1, SRRM1, PML, RARA, USF1, RANBP2, CUL5, BAZ1B, SMARCA2, SMARCB1, SMARCC1, SMARCA4, SMARCC2, SMARCE1, SMARCD2, SEPT7, SFPQ, HNRNPR, NCSTN, SNRPE, RBM14, HDAC3, IK, MSH2, S100A9, SNRNP200, XPC, NOTCH1, RPA1, RPA2, RPA3, ERG, EIF6, CUL7, OBSL1, UBE2I, SUMO2, CTCF, LAMTOR5, UNK, GLYR1, POLE3, SUPT16H, TOP1, NTRK1, SCARNA22, IFI16, SPICE1, CEP164, DAXX, RPL10, FOXD3, ASB3, HSD3B2, PLAUR, GPATCH4, COX15, DLST | GADL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP2B_GADL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TOP2B | Q02880 | DB00694 | Daunorubicin | DNA topoisomerase 2-beta | small molecule | approved |
| Hgene | TOP2B | Q02880 | DB00773 | Etoposide | DNA topoisomerase 2-beta | small molecule | approved |
| Hgene | TOP2B | Q02880 | DB00380 | Dexrazoxane | DNA topoisomerase 2-beta | small molecule | approved|withdrawn |
| Tgene | GADL1 | Q6ZQY3 | DB00114 | Pyridoxal Phosphate | Acidic amino acid decarboxylase GADL1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for TOP2B_GADL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TOP2B | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Hgene | TOP2B | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
| Tgene | GADL1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | GADL1 | C0853193 | Bipolar I disorder | 1 | PSYGENET |
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