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Fusion gene ID: 39086 |
FusionGeneSummary for TOP2A_TNS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP2A_TNS4 | Fusion gene ID: 39086 | Hgene | Tgene | Gene symbol | TOP2A | TNS4 | Gene ID | 7153 | 84951 |
| Gene name | DNA topoisomerase II alpha | tensin 4 | |
| Synonyms | TOP2|TP2A | CTEN|PP14434 | |
| Cytomap | 17q21.2 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDa | tensin-4C terminal tensin likeC-terminal tensin-like protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P11388 | Q8IZW8 | |
| Ensembl transtripts involved in fusion gene | ENST00000423485, | ENST00000254051, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 3=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP2A [Title/Abstract] AND TNS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP2A | GO:0006265 | DNA topological change | 22323612 |
| Hgene | TOP2A | GO:0006266 | DNA ligation | 15491148 |
| Hgene | TOP2A | GO:0006974 | cellular response to DNA damage stimulus | 16611985 |
| Hgene | TOP2A | GO:0030263 | apoptotic chromosome condensation | 10959840 |
| Hgene | TOP2A | GO:0043065 | positive regulation of apoptotic process | 16611985 |
| Tgene | TNS4 | GO:0008104 | protein localization | 17190795 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-PC-A5DO-01A | TOP2A | chr17 | 38545768 | - | TNS4 | chr17 | 38640861 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000423485 | ENST00000254051 | TOP2A | chr17 | 38545768 | - | TNS4 | chr17 | 38640861 | - |
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FusionProtFeatures for TOP2A_TNS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP2A | TNS4 |
| May be involved in cell migration, cartilage developmentand in linking signal transduction pathways to the cytoskeleton(By similarity). May promote apoptosis, via its cleavage bycaspase-3. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TOP2A_TNS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TOP2A_TNS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TOP2A | DHX9, HDAC1, HDAC2, PIN1, TOP2B, XRCC5, TP53, DFFB, YWHAE, JUN, CDC5L, CDT1, AIRE, NR4A1, BRCA1, SETMAR, MAPK1, HIST1H3E, H3F3A, MYC, BMI1, RING1, CTCF, SMARCAD1, ISG15, CUL2, TCEB1, VHL, FBXW7, COPS5, CSNK2A1, GSK3B, CUL5, BLM, TERF2, PRKCA, PRKCB, PRKCG, UPF3B, CSNK2A2, ESR1, RB1, FN1, VCAM1, SRPK1, ITGA4, CTNNB1, LMNA, RPA3, RPA2, RPA1, EIF6, CUL7, OBSL1, CCDC8, UBE2I, PIAS4, SUMO2, RAC1, RBM4B, THBS3, UHRF1, UNK, CSNK2B, GLYR1, PATL1, RANBP2, SSRP1, TOP1, NOP2, IFI16, SPICE1, DAXX, HNRNPU, RNF2, RPL10, CKAP5, TFG, NOP56, L3MBTL3, FOXD3, FOXP1, MCM5, KMT2E, PLK1, AHSA1, ASB3, HSD3B2, FAM131B, INTU, CDH19, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, VDAC1, FOXA1, RNF168, SMURF2 | TNS4 | SFN, EGFR, ERBB3, CBL, GSTCD, NME4, P4HA2, PIK3R1, RPAIN, KCTD4, MCM2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP2A_TNS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TOP2A | P11388 | DB00385 | Valrubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00444 | Teniposide | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00445 | Epirubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00487 | Pefloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00694 | Daunorubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00773 | Etoposide | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01059 | Norfloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01165 | Ofloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01177 | Idarubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01179 | Podofilox | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB04576 | Fleroxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00218 | Moxifloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00276 | Amsacrine | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00467 | Enoxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00537 | Ciprofloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00970 | Dactinomycin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00978 | Lomefloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00997 | Doxorubicin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB01137 | Levofloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB01204 | Mitoxantrone | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB01208 | Sparfloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB06263 | Amrubicin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00685 | Trovafloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational|withdrawn |
| Hgene | TOP2A | P11388 | DB00380 | Dexrazoxane | DNA topoisomerase 2-alpha | small molecule | approved|withdrawn |
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RelatedDiseases for TOP2A_TNS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TOP2A | C1458155 | Mammary Neoplasms | 4 | CTD_human |
| Hgene | TOP2A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | TOP2A | C0017638 | Glioma | 1 | CTD_human |
| Hgene | TOP2A | C0023418 | leukemia | 1 | CTD_human |
| Hgene | TOP2A | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Hgene | TOP2A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | TOP2A | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Hgene | TOP2A | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
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