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Fusion gene ID: 39085 |
FusionGeneSummary for TOP2A_TLK2 |
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Fusion gene information | Fusion gene name: TOP2A_TLK2 | Fusion gene ID: 39085 | Hgene | Tgene | Gene symbol | TOP2A | TLK2 | Gene ID | 7153 | 11011 |
Gene name | DNA topoisomerase II alpha | tousled like kinase 2 | |
Synonyms | TOP2|TP2A | HsHPK|PKU-ALPHA | |
Cytomap | 17q21.2 | 17q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDa | serine/threonine-protein kinase tousled-like 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P11388 | Q86UE8 | |
Ensembl transtripts involved in fusion gene | ENST00000423485, | ENST00000582809, ENST00000577616, ENST00000326270, ENST00000346027, ENST00000343388, ENST00000542523, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 3 X 2=24 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TOP2A [Title/Abstract] AND TLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TOP2A | GO:0006265 | DNA topological change | 22323612 |
Hgene | TOP2A | GO:0006266 | DNA ligation | 15491148 |
Hgene | TOP2A | GO:0006974 | cellular response to DNA damage stimulus | 16611985 |
Hgene | TOP2A | GO:0030263 | apoptotic chromosome condensation | 10959840 |
Hgene | TOP2A | GO:0043065 | positive regulation of apoptotic process | 16611985 |
Tgene | TLK2 | GO:0001672 | regulation of chromatin assembly or disassembly | 12660173 |
Tgene | TLK2 | GO:0006468 | protein phosphorylation | 12660173 |
Tgene | TLK2 | GO:0006974 | cellular response to DNA damage stimulus | 12660173 |
Tgene | TLK2 | GO:0018105 | peptidyl-serine phosphorylation | 20016786 |
Tgene | TLK2 | GO:0035556 | intracellular signal transduction | 12660173 |
Tgene | TLK2 | GO:0071480 | cellular response to gamma radiation | 12660173 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-BA-A4II-01A | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000423485 | ENST00000582809 | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
5CDS-intron | ENST00000423485 | ENST00000577616 | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
5CDS-intron | ENST00000423485 | ENST00000326270 | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
5CDS-intron | ENST00000423485 | ENST00000346027 | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
5CDS-intron | ENST00000423485 | ENST00000343388 | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
5CDS-intron | ENST00000423485 | ENST00000542523 | TOP2A | chr17 | 38572992 | - | TLK2 | chr17 | 60637377 | + |
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FusionProtFeatures for TOP2A_TLK2 |
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Hgene | Tgene |
TOP2A | TLK2 |
Serine/threonine-protein kinase involved in the processof chromatin assembly and probably also DNA replication,transcription, repair, and chromosome segregation. Phosphorylatesthe chromatin assembly factors ASF1A AND ASF1B. Phosphorylation ofASF1A prevents its proteasome-mediated degradation, therebyenhancing chromatin assembly. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000269|PubMed:10523312,ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173,ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786,ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000326270 | + | 8 | 23 | 317_347 | 240 | 773 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000326270 | + | 8 | 23 | 403_451 | 240 | 773 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000343388 | + | 7 | 21 | 225_276 | 208 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000343388 | + | 7 | 21 | 317_347 | 208 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000343388 | + | 7 | 21 | 403_451 | 208 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000346027 | + | 8 | 22 | 317_347 | 240 | 751 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000346027 | + | 8 | 22 | 403_451 | 240 | 751 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000542523 | + | 7 | 21 | 225_276 | 208 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000542523 | + | 7 | 21 | 317_347 | 208 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000542523 | + | 7 | 21 | 403_451 | 208 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000326270 | + | 8 | 23 | 462_741 | 240 | 773 | Domain | Protein kinase |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000343388 | + | 7 | 21 | 462_741 | 208 | 719 | Domain | Protein kinase |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000346027 | + | 8 | 22 | 462_741 | 240 | 751 | Domain | Protein kinase |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000542523 | + | 7 | 21 | 462_741 | 208 | 719 | Domain | Protein kinase |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000326270 | + | 8 | 23 | 468_476 | 240 | 773 | Nucleotide binding | ATP |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000343388 | + | 7 | 21 | 468_476 | 208 | 719 | Nucleotide binding | ATP |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000346027 | + | 8 | 22 | 468_476 | 240 | 751 | Nucleotide binding | ATP |
Tgene | >TLK2 | chr17:38572992 | chr17:60637377 | ENST00000542523 | + | 7 | 21 | 468_476 | 208 | 719 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TOP2A | chr17:38572992 | chr17:60637377 | ENST00000423485 | - | 2 | 35 | 455_572 | 59 | 1532 | Domain | Toprim |
Hgene | >TOP2A | chr17:38572992 | chr17:60637377 | ENST00000423485 | - | 2 | 35 | 1018_1028 | 59 | 1532 | Motif | Note=Nuclear export signal |
Hgene | >TOP2A | chr17:38572992 | chr17:60637377 | ENST00000423485 | - | 2 | 35 | 148_150 | 59 | 1532 | Nucleotide binding | ATP |
Hgene | >TOP2A | chr17:38572992 | chr17:60637377 | ENST00000423485 | - | 2 | 35 | 161_168 | 59 | 1532 | Nucleotide binding | ATP |
Hgene | >TOP2A | chr17:38572992 | chr17:60637377 | ENST00000423485 | - | 2 | 35 | 376_378 | 59 | 1532 | Nucleotide binding | ATP |
Tgene | TLK2 | chr17:38572992 | chr17:60637377 | ENST00000326270 | + | 8 | 23 | 225_276 | 240 | 773 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | TLK2 | chr17:38572992 | chr17:60637377 | ENST00000346027 | + | 8 | 22 | 225_276 | 240 | 751 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for TOP2A_TLK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TOP2A_ENST00000423485_chr17_38572992_-_TLK2_ENST00000582809_chr17_60637377_+_570aa MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQANCDLRRQIDEQQKMLEKYKERLNRCVTMSK KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQK QRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGF SEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMS EKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGK EPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TOP2A_ENST00000423485_chr17_38572992_-_TLK2_ENST00000582809_chr17_60637377_+_1710nt ATGGAAGTGTCACCATTGCAGCCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTT GAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGGCC AACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGATGTGTGACAATGAGCAAG AAACTCCTTATAGAAAAGTCAAAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACTACT GTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGGAAAGGATAAATTCACAG AGGGAAGAGATAGAAAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAAA CAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATTA GGTCATCTTAAAAAGGAGGAAGCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAAAGG ATACATAATGAAGATAATTCACAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTTTGGGTAGAGGAGGTTTC AGTGAAGTTTACAAGGCATTTGATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAAA AAGGAGAATTACCACAAGCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTAAGCTGTATGATTACTTT TCACTGGATACTGACTCGTTTTGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATGTCG GAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCATCATACACTATGACCTC AAACCAGGTAATATTCTTTTAGTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGATGAT AGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGTGTTTTGTGGTTGGGAAA GAACCACCAAAGATCTCAAATAAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGCCAT AACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGAA GCAAAGGCGTTTATTCGACGATGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTGCCT CACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATAACAGTTCTTCTAATTGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TOP2A_ENST00000423485_chr17_38572992_-_TLK2_ENST00000582809_chr17_60637377_+_2968nt GATTGGCTGGTCTGCTTCGGGCGGGCTAAAGGAAGGTTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGG GGGTGGTCTCGTGGGGTCCTGCCTGTTTAGTCGCTTTCAGGGTTCTTGAGCCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAG CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTTGAAAGAATCTATCAAAAGAAA ACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGGCCAACTGTGATTTGAGACGGCAG ATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGATGTGTGACAATGAGCAAGAAACTCCTTATAGAAAAGTCA AAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACTACTGTCCGACACGGAGCCTCATTT ACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGGAAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAA CGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAAACAGCGGAAAAGCAAGACCAAT GGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATTAGGTCATCTTAAAAAGGAGGAA GCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAAAGGATACATAATGAAGATAATTCA CAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTTTGGGTAGAGGAGGTTTCAGTGAAGTTTACAAGGCATTT GATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAAAAAGGAGAATTACCACAAGCAT GCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTAAGCTGTATGATTACTTTTCACTGGATACTGACTCGTTT TGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATGTCGGAGAAAGAGGCCCGGTCCATT ATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCATCATACACTATGACCTCAAACCAGGTAATATTCTTTTA GTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGATGATAGCTACAATTCAGTGGATGGC ATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGTGTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAAT AAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGCCATAACCAGTCTCAGCAAGACATC CTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGAAGCAAAGGCGTTTATTCGACGA TGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTGCCTCACATCCGAAAGTCAGTCTCT ACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATAACAGTTCTTCTAATTGAGACTGACTCCAAGGCCACAAA CTGTTCAACACACACAAAGTGGACAAATGGCGTTCAGCAGCGGGTTTGGAACATAGCGAATCCGAATGGATCTGATGAAACCTGTACCAG GTGCTTTTATTTTCTTGCTTTTTTCCCATCCATAGAGCATGACAGCATCGATTCTCATTGAGGAGAAACCTTGGGCAGCTCCGGCCAGGC CTTGTAGGAAAAGGCCCCGCCCGAGGTTCCAGCGTCAACGGCCACTGTGTGTGGCTGCTCTGAGTGAGGAAAAAATTAAAAAGAAAAACT GGTTCCATGTACTGTGAACTTGAAAACTTGCAGACTCAGGGGGGTCCCTGATGCAGTGCTTCAGATGAAGAATGTGGACTTGAAAATACA GACTGGGCTAGTCCAGTGTCTATATTTAAACTTGTTCTTTTCTTTTAATAAAGTTTAGGTAACATCTCCTGAAAAGCTTGTAGCACAAAG GCTCAGCTGGGGATGGTGTTTGACTTCGGAGGAAAAAAGTTGCTATTGCCCGTTAAAGGCACTAGAGTTAGTGTTTTATCCCTAAATAAT TTCAATTTTTAAAAACATGCAGCTTCCCTCTCCCCTTTTTTATTTTTGAAAGAATACATTTGGTCATAAAGTGAAACCCGTATTAGCAAG TACGTGGCAATGTTCATTCCAATCAGATGCAGCTTTCTCCTCCGTCTGGTCTCCTGTTTGCAATTGCTTCCCTCATCTCAGTAGGGAAAA AATTGAGTGGGAGTACTGAGATGTGTGGGTTTTTGCCATTGGACAAAGAATGAGGTTAGAAGACTGCAGCTTGGAGTCTCTCTAGGTTTT CAACTATTTCTTCACAATTTGAACACTTGACGGTTGTCCCTTTTAATTTATTTGAAGTGCTATTTTTTTAAATAAAGGTTCATCTGTCCA TGCAGTCCTCTTGGATTCTCTGAATGTAGTAACTATGAAGCTATGCCAAAGGTAGGCAGAAAATGGGCTTGGGAGCCAGACACTCCAGGG |
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FusionGenePPI for TOP2A_TLK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TOP2A | DHX9, HDAC1, HDAC2, PIN1, TOP2B, XRCC5, TP53, DFFB, YWHAE, JUN, CDC5L, CDT1, AIRE, NR4A1, BRCA1, SETMAR, MAPK1, HIST1H3E, H3F3A, MYC, BMI1, RING1, CTCF, SMARCAD1, ISG15, CUL2, TCEB1, VHL, FBXW7, COPS5, CSNK2A1, GSK3B, CUL5, BLM, TERF2, PRKCA, PRKCB, PRKCG, UPF3B, CSNK2A2, ESR1, RB1, FN1, VCAM1, SRPK1, ITGA4, CTNNB1, LMNA, RPA3, RPA2, RPA1, EIF6, CUL7, OBSL1, CCDC8, UBE2I, PIAS4, SUMO2, RAC1, RBM4B, THBS3, UHRF1, UNK, CSNK2B, GLYR1, PATL1, RANBP2, SSRP1, TOP1, NOP2, IFI16, SPICE1, DAXX, HNRNPU, RNF2, RPL10, CKAP5, TFG, NOP56, L3MBTL3, FOXD3, FOXP1, MCM5, KMT2E, PLK1, AHSA1, ASB3, HSD3B2, FAM131B, INTU, CDH19, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, VDAC1, FOXA1, RNF168, SMURF2 | TLK2 | ASF1B, ASF1A, TLK1, FEZ1, FEZ2, AURKA, IRF4, IRF7, ELAVL1, XPO7, XPO1, RPS6KA1, RFPL3, EID3, LHX6, STK24, NTRK1, DYNLL1, NFATC2, SPATA1, RPS27A, CABIN1, IL36A, DYNLL2, AMOTL1, IFFO1, CDADC1, SCML1, COBLL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | TOP2A | chr17:38572992 | chr17:60637377 | ENST00000423485 | - | 2 | 35 | 990_999 | 59 | 1532 | DNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP2A_TLK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | TOP2A | P11388 | DB00385 | Valrubicin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB00444 | Teniposide | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB00445 | Epirubicin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB00487 | Pefloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB00694 | Daunorubicin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB00773 | Etoposide | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB01059 | Norfloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB01165 | Ofloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB01177 | Idarubicin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB01179 | Podofilox | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB04576 | Fleroxacin | DNA topoisomerase 2-alpha | small molecule | approved |
Hgene | TOP2A | P11388 | DB00218 | Moxifloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00276 | Amsacrine | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00467 | Enoxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00537 | Ciprofloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00970 | Dactinomycin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00978 | Lomefloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00997 | Doxorubicin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB01137 | Levofloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB01204 | Mitoxantrone | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB01208 | Sparfloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB06263 | Amrubicin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
Hgene | TOP2A | P11388 | DB00685 | Trovafloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational|withdrawn |
Hgene | TOP2A | P11388 | DB00380 | Dexrazoxane | DNA topoisomerase 2-alpha | small molecule | approved|withdrawn |
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RelatedDiseases for TOP2A_TLK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TOP2A | C1458155 | Mammary Neoplasms | 4 | CTD_human |
Hgene | TOP2A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | TOP2A | C0017638 | Glioma | 1 | CTD_human |
Hgene | TOP2A | C0023418 | leukemia | 1 | CTD_human |
Hgene | TOP2A | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | TOP2A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | TOP2A | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Hgene | TOP2A | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |