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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39085

FusionGeneSummary for TOP2A_TLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: TOP2A_TLK2
Fusion gene ID: 39085
HgeneTgene
Gene symbol

TOP2A

TLK2

Gene ID

7153

11011

Gene nameDNA topoisomerase II alphatousled like kinase 2
SynonymsTOP2|TP2AHsHPK|PKU-ALPHA
Cytomap

17q21.2

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionDNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDaserine/threonine-protein kinase tousled-like 2
Modification date2018052320180519
UniProtAcc

P11388

Q86UE8

Ensembl transtripts involved in fusion geneENST00000423485, ENST00000582809, 
ENST00000577616, ENST00000326270, 
ENST00000346027, ENST00000343388, 
ENST00000542523, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 3 X 2=24
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TOP2A [Title/Abstract] AND TLK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOP2A

GO:0006265

DNA topological change

22323612

HgeneTOP2A

GO:0006266

DNA ligation

15491148

HgeneTOP2A

GO:0006974

cellular response to DNA damage stimulus

16611985

HgeneTOP2A

GO:0030263

apoptotic chromosome condensation

10959840

HgeneTOP2A

GO:0043065

positive regulation of apoptotic process

16611985

TgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

TgeneTLK2

GO:0006468

protein phosphorylation

12660173

TgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

TgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

TgeneTLK2

GO:0035556

intracellular signal transduction

12660173

TgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-BA-A4II-01ATOP2Achr17

38572992

-TLK2chr17

60637377

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000423485ENST00000582809TOP2Achr17

38572992

-TLK2chr17

60637377

+
5CDS-intronENST00000423485ENST00000577616TOP2Achr17

38572992

-TLK2chr17

60637377

+
5CDS-intronENST00000423485ENST00000326270TOP2Achr17

38572992

-TLK2chr17

60637377

+
5CDS-intronENST00000423485ENST00000346027TOP2Achr17

38572992

-TLK2chr17

60637377

+
5CDS-intronENST00000423485ENST00000343388TOP2Achr17

38572992

-TLK2chr17

60637377

+
5CDS-intronENST00000423485ENST00000542523TOP2Achr17

38572992

-TLK2chr17

60637377

+

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FusionProtFeatures for TOP2A_TLK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOP2A

P11388

TLK2

Q86UE8

Serine/threonine-protein kinase involved in the processof chromatin assembly and probably also DNA replication,transcription, repair, and chromosome segregation. Phosphorylatesthe chromatin assembly factors ASF1A AND ASF1B. Phosphorylation ofASF1A prevents its proteasome-mediated degradation, therebyenhancing chromatin assembly. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000269|PubMed:10523312,ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173,ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786,ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTLK2chr17:38572992chr17:60637377ENST00000326270+823317_347240773Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000326270+823403_451240773Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000343388+721225_276208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000343388+721317_347208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000343388+721403_451208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000346027+822317_347240751Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000346027+822403_451240751Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000542523+721225_276208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000542523+721317_347208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000542523+721403_451208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000326270+823462_741240773DomainProtein kinase
TgeneTLK2chr17:38572992chr17:60637377ENST00000343388+721462_741208719DomainProtein kinase
TgeneTLK2chr17:38572992chr17:60637377ENST00000346027+822462_741240751DomainProtein kinase
TgeneTLK2chr17:38572992chr17:60637377ENST00000542523+721462_741208719DomainProtein kinase
TgeneTLK2chr17:38572992chr17:60637377ENST00000326270+823468_476240773Nucleotide bindingATP
TgeneTLK2chr17:38572992chr17:60637377ENST00000343388+721468_476208719Nucleotide bindingATP
TgeneTLK2chr17:38572992chr17:60637377ENST00000346027+822468_476240751Nucleotide bindingATP
TgeneTLK2chr17:38572992chr17:60637377ENST00000542523+721468_476208719Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOP2Achr17:38572992chr17:60637377ENST00000423485-235455_572591532DomainToprim
HgeneTOP2Achr17:38572992chr17:60637377ENST00000423485-2351018_1028591532MotifNote=Nuclear export signal
HgeneTOP2Achr17:38572992chr17:60637377ENST00000423485-235148_150591532Nucleotide bindingATP
HgeneTOP2Achr17:38572992chr17:60637377ENST00000423485-235161_168591532Nucleotide bindingATP
HgeneTOP2Achr17:38572992chr17:60637377ENST00000423485-235376_378591532Nucleotide bindingATP
TgeneTLK2chr17:38572992chr17:60637377ENST00000326270+823225_276240773Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:38572992chr17:60637377ENST00000346027+822225_276240751Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for TOP2A_TLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TOP2A_ENST00000423485_chr17_38572992_-_TLK2_ENST00000582809_chr17_60637377_+_570aa
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQANCDLRRQIDEQQKMLEKYKERLNRCVTMSK
KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQK
QRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGF
SEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMS
EKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGK
EPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TOP2A_ENST00000423485_chr17_38572992_-_TLK2_ENST00000582809_chr17_60637377_+_1710nt
ATGGAAGTGTCACCATTGCAGCCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTT
GAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGGCC
AACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGATGTGTGACAATGAGCAAG
AAACTCCTTATAGAAAAGTCAAAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACTACT
GTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGGAAAGGATAAATTCACAG
AGGGAAGAGATAGAAAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAAA
CAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATTA
GGTCATCTTAAAAAGGAGGAAGCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAAAGG
ATACATAATGAAGATAATTCACAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTTTGGGTAGAGGAGGTTTC
AGTGAAGTTTACAAGGCATTTGATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAAA
AAGGAGAATTACCACAAGCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTAAGCTGTATGATTACTTT
TCACTGGATACTGACTCGTTTTGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATGTCG
GAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCATCATACACTATGACCTC
AAACCAGGTAATATTCTTTTAGTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGATGAT
AGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGTGTTTTGTGGTTGGGAAA
GAACCACCAAAGATCTCAAATAAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGCCAT
AACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGAA
GCAAAGGCGTTTATTCGACGATGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTGCCT
CACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATAACAGTTCTTCTAATTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TOP2A_ENST00000423485_chr17_38572992_-_TLK2_ENST00000582809_chr17_60637377_+_2968nt
GATTGGCTGGTCTGCTTCGGGCGGGCTAAAGGAAGGTTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGG
GGGTGGTCTCGTGGGGTCCTGCCTGTTTAGTCGCTTTCAGGGTTCTTGAGCCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAG
CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTTGAAAGAATCTATCAAAAGAAA
ACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGGCCAACTGTGATTTGAGACGGCAG
ATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGATGTGTGACAATGAGCAAGAAACTCCTTATAGAAAAGTCA
AAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACTACTGTCCGACACGGAGCCTCATTT
ACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGGAAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAA
CGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAAACAGCGGAAAAGCAAGACCAAT
GGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATTAGGTCATCTTAAAAAGGAGGAA
GCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAAAGGATACATAATGAAGATAATTCA
CAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTTTGGGTAGAGGAGGTTTCAGTGAAGTTTACAAGGCATTT
GATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAAAAAGGAGAATTACCACAAGCAT
GCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTAAGCTGTATGATTACTTTTCACTGGATACTGACTCGTTT
TGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATGTCGGAGAAAGAGGCCCGGTCCATT
ATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCATCATACACTATGACCTCAAACCAGGTAATATTCTTTTA
GTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGATGATAGCTACAATTCAGTGGATGGC
ATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGTGTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAAT
AAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGCCATAACCAGTCTCAGCAAGACATC
CTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGAAGCAAAGGCGTTTATTCGACGA
TGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTGCCTCACATCCGAAAGTCAGTCTCT
ACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATAACAGTTCTTCTAATTGAGACTGACTCCAAGGCCACAAA
CTGTTCAACACACACAAAGTGGACAAATGGCGTTCAGCAGCGGGTTTGGAACATAGCGAATCCGAATGGATCTGATGAAACCTGTACCAG
GTGCTTTTATTTTCTTGCTTTTTTCCCATCCATAGAGCATGACAGCATCGATTCTCATTGAGGAGAAACCTTGGGCAGCTCCGGCCAGGC
CTTGTAGGAAAAGGCCCCGCCCGAGGTTCCAGCGTCAACGGCCACTGTGTGTGGCTGCTCTGAGTGAGGAAAAAATTAAAAAGAAAAACT
GGTTCCATGTACTGTGAACTTGAAAACTTGCAGACTCAGGGGGGTCCCTGATGCAGTGCTTCAGATGAAGAATGTGGACTTGAAAATACA
GACTGGGCTAGTCCAGTGTCTATATTTAAACTTGTTCTTTTCTTTTAATAAAGTTTAGGTAACATCTCCTGAAAAGCTTGTAGCACAAAG
GCTCAGCTGGGGATGGTGTTTGACTTCGGAGGAAAAAAGTTGCTATTGCCCGTTAAAGGCACTAGAGTTAGTGTTTTATCCCTAAATAAT
TTCAATTTTTAAAAACATGCAGCTTCCCTCTCCCCTTTTTTATTTTTGAAAGAATACATTTGGTCATAAAGTGAAACCCGTATTAGCAAG
TACGTGGCAATGTTCATTCCAATCAGATGCAGCTTTCTCCTCCGTCTGGTCTCCTGTTTGCAATTGCTTCCCTCATCTCAGTAGGGAAAA
AATTGAGTGGGAGTACTGAGATGTGTGGGTTTTTGCCATTGGACAAAGAATGAGGTTAGAAGACTGCAGCTTGGAGTCTCTCTAGGTTTT
CAACTATTTCTTCACAATTTGAACACTTGACGGTTGTCCCTTTTAATTTATTTGAAGTGCTATTTTTTTAAATAAAGGTTCATCTGTCCA
TGCAGTCCTCTTGGATTCTCTGAATGTAGTAACTATGAAGCTATGCCAAAGGTAGGCAGAAAATGGGCTTGGGAGCCAGACACTCCAGGG


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FusionGenePPI for TOP2A_TLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOP2ADHX9, HDAC1, HDAC2, PIN1, TOP2B, XRCC5, TP53, DFFB, YWHAE, JUN, CDC5L, CDT1, AIRE, NR4A1, BRCA1, SETMAR, MAPK1, HIST1H3E, H3F3A, MYC, BMI1, RING1, CTCF, SMARCAD1, ISG15, CUL2, TCEB1, VHL, FBXW7, COPS5, CSNK2A1, GSK3B, CUL5, BLM, TERF2, PRKCA, PRKCB, PRKCG, UPF3B, CSNK2A2, ESR1, RB1, FN1, VCAM1, SRPK1, ITGA4, CTNNB1, LMNA, RPA3, RPA2, RPA1, EIF6, CUL7, OBSL1, CCDC8, UBE2I, PIAS4, SUMO2, RAC1, RBM4B, THBS3, UHRF1, UNK, CSNK2B, GLYR1, PATL1, RANBP2, SSRP1, TOP1, NOP2, IFI16, SPICE1, DAXX, HNRNPU, RNF2, RPL10, CKAP5, TFG, NOP56, L3MBTL3, FOXD3, FOXP1, MCM5, KMT2E, PLK1, AHSA1, ASB3, HSD3B2, FAM131B, INTU, CDH19, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, VDAC1, FOXA1, RNF168, SMURF2TLK2ASF1B, ASF1A, TLK1, FEZ1, FEZ2, AURKA, IRF4, IRF7, ELAVL1, XPO7, XPO1, RPS6KA1, RFPL3, EID3, LHX6, STK24, NTRK1, DYNLL1, NFATC2, SPATA1, RPS27A, CABIN1, IL36A, DYNLL2, AMOTL1, IFFO1, CDADC1, SCML1, COBLL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTOP2Achr17:38572992chr17:60637377ENST00000423485-235990_999591532DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TOP2A_TLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTOP2AP11388DB00385ValrubicinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB00444TeniposideDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB00445EpirubicinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB00487PefloxacinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB00694DaunorubicinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB00773EtoposideDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB01059NorfloxacinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB01165OfloxacinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB01177IdarubicinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB01179PodofiloxDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB04576FleroxacinDNA topoisomerase 2-alphasmall moleculeapproved
HgeneTOP2AP11388DB00218MoxifloxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00276AmsacrineDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00467EnoxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00537CiprofloxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00970DactinomycinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00978LomefloxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00997DoxorubicinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB01137LevofloxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB01204MitoxantroneDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB01208SparfloxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB06263AmrubicinDNA topoisomerase 2-alphasmall moleculeapproved|investigational
HgeneTOP2AP11388DB00685TrovafloxacinDNA topoisomerase 2-alphasmall moleculeapproved|investigational|withdrawn
HgeneTOP2AP11388DB00380DexrazoxaneDNA topoisomerase 2-alphasmall moleculeapproved|withdrawn

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RelatedDiseases for TOP2A_TLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTOP2AC1458155Mammary Neoplasms4CTD_human
HgeneTOP2AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneTOP2AC0017638Glioma1CTD_human
HgeneTOP2AC0023418leukemia1CTD_human
HgeneTOP2AC0032460Polycystic Ovary Syndrome1CTD_human
HgeneTOP2AC0033578Prostatic Neoplasms1CTD_human
HgeneTOP2AC0036095Salivary Gland Neoplasms1CTD_human
HgeneTOP2AC0206686Adrenocortical carcinoma1CTD_human