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Fusion gene ID: 39084 |
FusionGeneSummary for TOP2A_IKZF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP2A_IKZF3 | Fusion gene ID: 39084 | Hgene | Tgene | Gene symbol | TOP2A | IKZF3 | Gene ID | 7153 | 22806 |
| Gene name | DNA topoisomerase II alpha | IKAROS family zinc finger 3 | |
| Synonyms | TOP2|TP2A | AIO|AIOLOS|ZNFN1A3 | |
| Cytomap | 17q21.2 | 17q12-q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDa | zinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P11388 | Q9UKT9 | |
| Ensembl transtripts involved in fusion gene | ENST00000423485, | ENST00000346872, ENST00000394189, ENST00000439167, ENST00000535189, ENST00000377944, ENST00000377945, ENST00000377952, ENST00000377958, ENST00000346243, ENST00000350532, ENST00000351680, ENST00000467757, ENST00000439016, ENST00000583368, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 27 X 9 X 12=2916 |
| # samples | 3 | 34 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(34/2916*10)=-3.10038406818924 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP2A [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP2A | GO:0006265 | DNA topological change | 22323612 |
| Hgene | TOP2A | GO:0006266 | DNA ligation | 15491148 |
| Hgene | TOP2A | GO:0006974 | cellular response to DNA damage stimulus | 16611985 |
| Hgene | TOP2A | GO:0030263 | apoptotic chromosome condensation | 10959840 |
| Hgene | TOP2A | GO:0043065 | positive regulation of apoptotic process | 16611985 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-AF-A56L-01A | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000423485 | ENST00000346872 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000394189 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000439167 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000535189 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000377944 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000377945 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000377952 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000377958 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| In-frame | ENST00000423485 | ENST00000346243 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| In-frame | ENST00000423485 | ENST00000350532 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| In-frame | ENST00000423485 | ENST00000351680 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| In-frame | ENST00000423485 | ENST00000467757 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000439016 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
| Frame-shift | ENST00000423485 | ENST00000583368 | TOP2A | chr17 | 38567361 | - | IKZF3 | chr17 | 37922746 | - |
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FusionProtFeatures for TOP2A_IKZF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP2A | IKZF3 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TOP2A_IKZF3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000346243_chr17_37922746_-_635aa MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILV NAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSY VDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAVRSATALMSTIIQVTCMRKRVSSYRPAXWTKPSITPSAILAPKPCAPWS RHRLLPPRRWFQLSAACIPXPSPGLRCQTVPLKSWKRKASTFQRRACLLREASLPTIVATTPRTLTATMKNARITSISKITWSCLGPAMG CHFXRRFPALTNSSSPRPSAQETPSKXSTRKGRXWMCIGVTTAASSSWTMXCSRFTWAATASVTLSSVTCVDIEAMIGMSSRLTXPEENT >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000350532_chr17_37922746_-_635aa MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILV NAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSY VDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAVRSATALMSTIIQVTCMRKRVSSYRPAXWTKPSITPSAILAPKPCAPWS RHRLLPPRRWFQLSAACIPXPSPGLRCQTVPLKSWKRKASTFQRRACLLREASLPTIVATTPRTLTATMKNARITSISKITWSCLGPAMG CHFXRRFPALTNSSSPRPSAQETPSKXSTRKGRXWMCIGVTTAASSSWTMXCSRFTWAATASVTLSSVTCVDIEAMIGMSSRLTXPEENT >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000351680_chr17_37922746_-_635aa MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILV NAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSY VDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAVRSATALMSTIIQVTCMRKRVSSYRPAXWTKPSITPSAILAPKPCAPWS RHRLLPPRRWFQLSAACIPXPSPGLRCQTVPLKSWKRKASTFQRRACLLREASLPTIVATTPRTLTATMKNARITSISKITWSCLGPAMG CHFXRRFPALTNSSSPRPSAQETPSKXSTRKGRXWMCIGVTTAASSSWTMXCSRFTWAATASVTLSSVTCVDIEAMIGMSSRLTXPEENT >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000467757_chr17_37922746_-_635aa MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILV NAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSY VDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAVRSATALMSTIIQVTCMRKRVSSYRPAXWTKPSITPSAILAPKPCAPWS RHRLLPPRRWFQLSAACIPXPSPGLRCQTVPLKSWKRKASTFQRRACLLREASLPTIVATTPRTLTATMKNARITSISKITWSCLGPAMG CHFXRRFPALTNSSSPRPSAQETPSKXSTRKGRXWMCIGVTTAASSSWTMXCSRFTWAATASVTLSSVTCVDIEAMIGMSSRLTXPEENT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000346243_chr17_37922746_-_1907nt ATGGAAGTGTCACCATTGCAGCCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTT GAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAA ATGTGGGTTTACGATGAAGATGTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTT AATGCTGCGGACAACAAACAAAGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAAT AATGGAAAAGGTATTCCTGTTGTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAAC TATGATGATGATGAAAAGAAAGTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAA ACAGCCAGTAGAGAATACAAGAAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAAT GGAGAAGATTATACATGTATCACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTC AGAAGAGCATATGATATTGCTGGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTAT GTGGACATGTATTTGAAGGACAAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGT TTAACTATGAGTGAAAAAGGCTTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCT GATCAGATTGTGACTAAACTTGTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATG TGGATTTTTGTAAATGCCTTAATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCA ACATGCCAATTGAGTGAAAAATTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAG AGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCC AGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTG CCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACG ACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGA TGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGG AAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACG GCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACA >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000350532_chr17_37922746_-_1907nt ATGGAAGTGTCACCATTGCAGCCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTT GAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAA ATGTGGGTTTACGATGAAGATGTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTT AATGCTGCGGACAACAAACAAAGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAAT AATGGAAAAGGTATTCCTGTTGTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAAC TATGATGATGATGAAAAGAAAGTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAA ACAGCCAGTAGAGAATACAAGAAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAAT GGAGAAGATTATACATGTATCACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTC AGAAGAGCATATGATATTGCTGGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTAT GTGGACATGTATTTGAAGGACAAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGT TTAACTATGAGTGAAAAAGGCTTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCT GATCAGATTGTGACTAAACTTGTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATG TGGATTTTTGTAAATGCCTTAATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCA ACATGCCAATTGAGTGAAAAATTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAG AGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCC AGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTG CCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACG ACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGA TGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGG AAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACG GCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACA >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000351680_chr17_37922746_-_1907nt ATGGAAGTGTCACCATTGCAGCCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTT GAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAA ATGTGGGTTTACGATGAAGATGTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTT AATGCTGCGGACAACAAACAAAGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAAT AATGGAAAAGGTATTCCTGTTGTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAAC TATGATGATGATGAAAAGAAAGTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAA ACAGCCAGTAGAGAATACAAGAAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAAT GGAGAAGATTATACATGTATCACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTC AGAAGAGCATATGATATTGCTGGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTAT GTGGACATGTATTTGAAGGACAAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGT TTAACTATGAGTGAAAAAGGCTTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCT GATCAGATTGTGACTAAACTTGTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATG TGGATTTTTGTAAATGCCTTAATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCA ACATGCCAATTGAGTGAAAAATTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAG AGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCC AGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTG CCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACG ACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGA TGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGG AAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACG GCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACA >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000467757_chr17_37922746_-_1907nt ATGGAAGTGTCACCATTGCAGCCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTT GAAAGAATCTATCAAAAGAAAACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAA ATGTGGGTTTACGATGAAGATGTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTT AATGCTGCGGACAACAAACAAAGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAAT AATGGAAAAGGTATTCCTGTTGTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAAC TATGATGATGATGAAAAGAAAGTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAA ACAGCCAGTAGAGAATACAAGAAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAAT GGAGAAGATTATACATGTATCACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTC AGAAGAGCATATGATATTGCTGGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTAT GTGGACATGTATTTGAAGGACAAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGT TTAACTATGAGTGAAAAAGGCTTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCT GATCAGATTGTGACTAAACTTGTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATG TGGATTTTTGTAAATGCCTTAATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCA ACATGCCAATTGAGTGAAAAATTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAG AGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCC AGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTG CCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACG ACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGA TGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGG AAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACG GCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000346243_chr17_37922746_-_2066nt GATTGGCTGGTCTGCTTCGGGCGGGCTAAAGGAAGGTTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGG GGGTGGTCTCGTGGGGTCCTGCCTGTTTAGTCGCTTTCAGGGTTCTTGAGCCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAG CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTTGAAAGAATCTATCAAAAGAAA ACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAAATGTGGGTTTACGATGAAGAT GTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTTAATGCTGCGGACAACAAACAA AGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAATAATGGAAAAGGTATTCCTGTT GTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAACTATGATGATGATGAAAAGAAA GTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAAACAGCCAGTAGAGAATACAAG AAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAATGGAGAAGATTATACATGTATC ACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTCAGAAGAGCATATGATATTGCT GGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTATGTGGACATGTATTTGAAGGAC AAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGTTTAACTATGAGTGAAAAAGGC TTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCTGATCAGATTGTGACTAAACTT GTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATGTGGATTTTTGTAAATGCCTTA ATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCAACATGCCAATTGAGTGAAAAA TTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCC GCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCT CGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGA AAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCA ACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTC CCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGT ATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGT >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000350532_chr17_37922746_-_2066nt GATTGGCTGGTCTGCTTCGGGCGGGCTAAAGGAAGGTTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGG GGGTGGTCTCGTGGGGTCCTGCCTGTTTAGTCGCTTTCAGGGTTCTTGAGCCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAG CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTTGAAAGAATCTATCAAAAGAAA ACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAAATGTGGGTTTACGATGAAGAT GTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTTAATGCTGCGGACAACAAACAA AGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAATAATGGAAAAGGTATTCCTGTT GTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAACTATGATGATGATGAAAAGAAA GTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAAACAGCCAGTAGAGAATACAAG AAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAATGGAGAAGATTATACATGTATC ACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTCAGAAGAGCATATGATATTGCT GGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTATGTGGACATGTATTTGAAGGAC AAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGTTTAACTATGAGTGAAAAAGGC TTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCTGATCAGATTGTGACTAAACTT GTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATGTGGATTTTTGTAAATGCCTTA ATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCAACATGCCAATTGAGTGAAAAA TTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCC GCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCT CGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGA AAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCA ACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTC CCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGT ATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGT >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000351680_chr17_37922746_-_2066nt GATTGGCTGGTCTGCTTCGGGCGGGCTAAAGGAAGGTTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGG GGGTGGTCTCGTGGGGTCCTGCCTGTTTAGTCGCTTTCAGGGTTCTTGAGCCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAG CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTTGAAAGAATCTATCAAAAGAAA ACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAAATGTGGGTTTACGATGAAGAT GTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTTAATGCTGCGGACAACAAACAA AGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAATAATGGAAAAGGTATTCCTGTT GTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAACTATGATGATGATGAAAAGAAA GTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAAACAGCCAGTAGAGAATACAAG AAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAATGGAGAAGATTATACATGTATC ACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTCAGAAGAGCATATGATATTGCT GGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTATGTGGACATGTATTTGAAGGAC AAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGTTTAACTATGAGTGAAAAAGGC TTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCTGATCAGATTGTGACTAAACTT GTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATGTGGATTTTTGTAAATGCCTTA ATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCAACATGCCAATTGAGTGAAAAA TTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCC GCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCT CGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGA AAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCA ACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTC CCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGT ATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGT >In-frame_TOP2A_ENST00000423485_chr17_38567361_-_IKZF3_ENST00000467757_chr17_37922746_-_2066nt GATTGGCTGGTCTGCTTCGGGCGGGCTAAAGGAAGGTTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGG GGGTGGTCTCGTGGGGTCCTGCCTGTTTAGTCGCTTTCAGGGTTCTTGAGCCCCTTCACGACCGTCACCATGGAAGTGTCACCATTGCAG CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAGAAAAATGAAGATGCTAAGAAAAGACTGTCTGTTGAAAGAATCTATCAAAAGAAA ACACAATTGGAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGGAATTAGTGACCCAGCAAATGTGGGTTTACGATGAAGAT GTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACAAAATCTTTGATGAGATTCTAGTTAATGCTGCGGACAACAAACAA AGGGACCCAAAAATGTCTTGTATTAGAGTCACAATTGATCCGGAAAACAATTTAATTAGTATATGGAATAATGGAAAAGGTATTCCTGTT GTTGAACACAAAGTTGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTAACTTCTAGTAACTATGATGATGATGAAAAGAAA GTGACAGGTGGTCGAAATGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTACTGTGGAAACAGCCAGTAGAGAATACAAG AAAATGTTCAAACAGACATGGATGGATAATATGGGAAGAGCTGGTGAGATGGAACTCAAGCCCTTCAATGGAGAAGATTATACATGTATC ACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTCAGAAGAGCATATGATATTGCT GGATCCACCAAAGATGTCAAAGTCTTTCTTAATGGAAATAAACTGCCAGTAAAAGGATTTCGTAGTTATGTGGACATGTATTTGAAGGAC AAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGTTTAACTATGAGTGAAAAAGGC TTTCAGCAAATTAGCTTTGTCAACAGCATTGCTACATCCAAGGGTGGCAGACATGTTGATTATGTAGCTGATCAGATTGTGACTAAACTT GTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAGGTGAAAAATCACATGTGGATTTTTGTAAATGCCTTA ATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAGCTTTGGATCAACATGCCAATTGAGTGAAAAA TTTATCAAAGCTGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCC GCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCT CGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGA AAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCA ACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTC CCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGT ATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGT |
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FusionGenePPI for TOP2A_IKZF3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TOP2A | DHX9, HDAC1, HDAC2, PIN1, TOP2B, XRCC5, TP53, DFFB, YWHAE, JUN, CDC5L, CDT1, AIRE, NR4A1, BRCA1, SETMAR, MAPK1, HIST1H3E, H3F3A, MYC, BMI1, RING1, CTCF, SMARCAD1, ISG15, CUL2, TCEB1, VHL, FBXW7, COPS5, CSNK2A1, GSK3B, CUL5, BLM, TERF2, PRKCA, PRKCB, PRKCG, UPF3B, CSNK2A2, ESR1, RB1, FN1, VCAM1, SRPK1, ITGA4, CTNNB1, LMNA, RPA3, RPA2, RPA1, EIF6, CUL7, OBSL1, CCDC8, UBE2I, PIAS4, SUMO2, RAC1, RBM4B, THBS3, UHRF1, UNK, CSNK2B, GLYR1, PATL1, RANBP2, SSRP1, TOP1, NOP2, IFI16, SPICE1, DAXX, HNRNPU, RNF2, RPL10, CKAP5, TFG, NOP56, L3MBTL3, FOXD3, FOXP1, MCM5, KMT2E, PLK1, AHSA1, ASB3, HSD3B2, FAM131B, INTU, CDH19, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, VDAC1, FOXA1, RNF168, SMURF2 | IKZF3 | UBE2I, SIN3A, SIN3B, HDAC2, HDAC4, HDAC5, HDAC7, CHD4, IKZF4, IKZF5, IKZF2, HRAS, BCL2L1, IKZF1, NOTCH1, FOXP3, CRBN, UBC, ARNT2, DGCR6, PRKAB2, AES, AQP1, RHOA, CDKN1A, CDKN2D, GEM, GRB2, HNRNPF, KRT19, LMO1, LMO2, PFDN5, PIK3R2, PIN1, PRKAA1, PSMA1, RAD51D, STK16, STX11, POLR1C, EMC2, FAM115A, AKAP9, BCAS2, KAT5, MRPL28, FARS2, NEK6, IKZF3, ABLIM3, PPP1R16B, POLM, OSGIN1, CHCHD2, SPG21, OAZ3, C1orf109, MAGOHB, FANCL, TBC1D22B, RCOR3, PCID2, CABP5, LGALS14, EXOSC5, STAMBPL1, TRAPPC6A, ARMC7, TSSK3, ING5, ZGPAT, FBF1, ATPAF2, EFHC1, MRPL53, EXOC8, TEKT4, TSTD2, NATD1, MORN3, TRIM42, ARMC8, SETMAR, DGCR14, GID4, MAD1L1, LDOC1, STK26, SUMO1, PRDM1, CUL4A, GATAD2B, TRIM25, SMARCB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP2A_IKZF3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TOP2A | P11388 | DB00385 | Valrubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00444 | Teniposide | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00445 | Epirubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00487 | Pefloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00694 | Daunorubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00773 | Etoposide | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01059 | Norfloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01165 | Ofloxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01177 | Idarubicin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB01179 | Podofilox | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB04576 | Fleroxacin | DNA topoisomerase 2-alpha | small molecule | approved |
| Hgene | TOP2A | P11388 | DB00218 | Moxifloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00276 | Amsacrine | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00467 | Enoxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00537 | Ciprofloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00970 | Dactinomycin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00978 | Lomefloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00997 | Doxorubicin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB01137 | Levofloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB01204 | Mitoxantrone | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB01208 | Sparfloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB06263 | Amrubicin | DNA topoisomerase 2-alpha | small molecule | approved|investigational |
| Hgene | TOP2A | P11388 | DB00685 | Trovafloxacin | DNA topoisomerase 2-alpha | small molecule | approved|investigational|withdrawn |
| Hgene | TOP2A | P11388 | DB00380 | Dexrazoxane | DNA topoisomerase 2-alpha | small molecule | approved|withdrawn |
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RelatedDiseases for TOP2A_IKZF3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TOP2A | C1458155 | Mammary Neoplasms | 4 | CTD_human |
| Hgene | TOP2A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | TOP2A | C0017638 | Glioma | 1 | CTD_human |
| Hgene | TOP2A | C0023418 | leukemia | 1 | CTD_human |
| Hgene | TOP2A | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Hgene | TOP2A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | TOP2A | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Hgene | TOP2A | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | IKZF3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | IKZF3 | C0004096 | Asthma | 1 | CTD_human |
| Tgene | IKZF3 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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