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Fusion gene ID: 39082 |
FusionGeneSummary for TOP1_PZP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP1_PZP | Fusion gene ID: 39082 | Hgene | Tgene | Gene symbol | TOP1 | PZP | Gene ID | 7150 | 5858 |
| Gene name | DNA topoisomerase I | PZP, alpha-2-macroglobulin like | |
| Synonyms | TOPI | CPAMD6 | |
| Cytomap | 20q12 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase | pregnancy zone proteinC3 and PZP-like alpha-2-macroglobulin domain-containing protein 6Pregnancy zone proteinpregnancy-zone protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P11387 | P20742 | |
| Ensembl transtripts involved in fusion gene | ENST00000361337, | ENST00000261336, ENST00000381997, ENST00000539983, | |
| Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TOP1 [Title/Abstract] AND PZP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP1 | GO:0006265 | DNA topological change | 14594810 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A14R-01A | TOP1 | chr20 | 39690130 | + | PZP | chr12 | 9356547 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361337 | ENST00000261336 | TOP1 | chr20 | 39690130 | + | PZP | chr12 | 9356547 | - |
| 5CDS-intron | ENST00000361337 | ENST00000381997 | TOP1 | chr20 | 39690130 | + | PZP | chr12 | 9356547 | - |
| 5CDS-intron | ENST00000361337 | ENST00000539983 | TOP1 | chr20 | 39690130 | + | PZP | chr12 | 9356547 | - |
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FusionProtFeatures for TOP1_PZP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP1 | PZP |
| Is able to inhibit all four classes of proteinases by aunique 'trapping' mechanism. This protein has a peptide stretch,called the 'bait region' which contains specific cleavage sitesfor different proteinases. When a proteinase cleaves the baitregion, a conformational change is induced in the protein whichtraps the proteinase. The entrapped enzyme remains active againstlow molecular weight substrates (activity against high molecularweight substrates is greatly reduced). Following cleavage in thebait region a thioester bond is hydrolyzed and mediates thecovalent binding of the protein to the proteinase. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PZP | chr20:39690130 | chr12:9356547 | ENST00000261336 | - | 0 | 36 | 685_735 | 27 | 1483 | Region | Note=Bait region |
| Tgene | >PZP | chr20:39690130 | chr12:9356547 | ENST00000381997 | - | 0 | 31 | 685_735 | 0 | 1269 | Region | Note=Bait region |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TOP1 | chr20:39690130 | chr12:9356547 | ENST00000361337 | + | 3 | 21 | 23_204 | 51 | 766 | Compositional bias | Note=Lys-rich |
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FusionGeneSequence for TOP1_PZP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TOP1_ENST00000361337_chr20_39690130_+_PZP_ENST00000261336_chr12_9356547_-_1507aa MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNRQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLESG RENRSLFTDLVAEKDLFHCVSFTLPRISASSEVAFLSIQIKGPTQDFRKRNTVLVLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFRP RNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVN ITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQITNTGFEMKLRVEARIREEGTDLEVTANRI SEITNIVSKLKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSISVNKLFVRVFTVHPNL CFHYSWVAEDHQGAQHTANRVFSLSGSYIHLEPVAGTLPCGHTETITAHYTLNRQAMGELSELSFHYLIMAKGVIVRSGTHTLPVESGDM KGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPE AELSVSSVYNLLTVKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKVFTNSKIRKPKSCSVIPSVSAGAV GQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGI SSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGEESYCICGNERQTLSWTVTPKTLGNVNF SVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGIEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQ NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFA QARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVTNPIVRNALFCLESAWNVAKEGTH GSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLTAQPAPTSGDLTS ATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTNFQVDNNNLLLLQQISLPELPGEYVITVTGER CVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLTISYTGNRPASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTEV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TOP1_ENST00000361337_chr20_39690130_+_PZP_ENST00000261336_chr12_9356547_-_4521nt ATGAGTGGGGACCACCTCCACAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGATTCTCATAAACACAAAGATAAACACAAAGAT CGAGAACACCGGCACAAAGAACACAAGAAGGAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGGCAGTATATGGTGCTGGTCCCCTCC CTGCTCCACACTGAGGCCCCTAAGAAGGGCTGTGTCCTTCTGAGCCACCTGAATGAGACAGTGACTGTAAGTGCTTCCTTGGAGTCTGGC AGGGAAAACAGGAGCCTCTTCACTGACCTGGTGGCGGAGAAGGACTTATTCCACTGTGTCTCCTTCACTCTCCCAAGGATCTCAGCCTCT TCAGAGGTGGCATTCCTTAGCATCCAGATAAAGGGGCCTACGCAAGATTTCAGGAAGAGGAACACAGTTCTGGTACTGAACACCCAAAGT CTGGTCTTTGTCCAGACAGACAAACCCATGTATAAACCAGGACAGACAGTAAGATTCCGTGTTGTCTCCGTGGATGAAAATTTTCGCCCT CGAAATGAACTGATTCCACTGATATACCTTGAGAACCCAAGAAGAAATCGAATTGCACAATGGCAGAGTCTCAAGCTAGAAGCTGGCATC AATCAGTTGTCCTTTCCCCTCTCATCAGAGCCCATTCAGGGCTCCTACAGGGTGGTGGTACAGACAGAATCAGGTGGAAGGATACAGCAC CCCTTCACCGTGGAGGAATTTGTGCTTCCCAAGTTTGAGGTCAAAGTTCAGGTGCCAAAGATAATCAGTATCATGGATGAAAAAGTGAAC ATAACAGTCTGTGGAGAATACACTTATGGGAAGCCTGTCCCAGGACTTGCAACTGTGAGCCTGTGTAGAAAATTATCTCGTGTTCTTAAT TGTGACAAGCAGGAGGTCTGTGAGGAATTCAGTCAACAGCTTAACAGCAATGGCTGCATCACCCAACAAGTACACACCAAAATGCTCCAG ATTACAAATACGGGCTTTGAAATGAAGCTTAGAGTGGAAGCCAGGATCAGAGAAGAGGGGACAGACCTGGAAGTCACTGCAAACAGGATC AGTGAAATCACAAACATTGTATCCAAACTCAAATTCGTGAAAGTGGATTCACACTTTAGACAAGGAATCCCCTTTTTTGCACAGGTGCTT CTGGTGGATGGAAAAGGTGTGCCCATCCCCAATAAACTCTTCTTCATCTCTGTGAATGACGCCAATTATTACTCCAATGCAACCACCAAT GAGCAGGGTCTTGCACAGTTTTCAATCAATACTACCAGTATCTCGGTTAATAAACTTTTTGTCCGGGTTTTCACTGTGCATCCCAACTTG TGTTTTCACTATTCATGGGTAGCAGAAGACCACCAGGGTGCTCAGCACACTGCAAATCGTGTTTTCTCCTTAAGTGGAAGTTACATTCAC CTGGAGCCTGTGGCTGGTACCCTGCCCTGTGGCCACACGGAGACTATCACGGCACACTATACACTGAATAGACAGGCCATGGGAGAGTTA TCGGAGCTCAGTTTCCATTACCTGATCATGGCTAAGGGAGTCATCGTCAGATCTGGAACCCACACTCTGCCTGTGGAGTCAGGAGACATG AAAGGCAGTTTTGCCTTATCCTTCCCTGTGGAGTCAGACGTTGCCCCCATTGCACGAATGTTCATCTTTGCCATTTTACCAGATGGAGAA GTTGTTGGAGACTCTGAAAAATTTGAGATTGAAAACTGTCTAGCCAACAAGGTGGATTTGAGCTTCAGCCCAGCACAAAGTCCCCCAGCC TCACATGCCCACCTGCAAGTAGCAGCTGCTCCGCAGTCCCTCTGTGCCCTTCGTGCTGTGGACCAAAGTGTGCTGCTCATGAAGCCTGAG GCTGAGCTCTCTGTGTCCTCAGTATATAATCTGCTAACTGTGAAGGATCTCACCAATTTTCCTGACAATGTGGACCAGCAGGAGGAAGAA CAAGGACACTGTCCCCGTCCTTTCTTCATTCATAATGGAGCCATCTATGTTCCCTTATCAAGTAATGAAGCAGATATTTATAGCTTCCTC AAGGGGATGGGATTGAAGGTGTTCACTAACTCAAAAATCCGAAAACCAAAGTCGTGTTCAGTCATCCCTTCCGTGTCTGCAGGAGCAGTA GGTCAAGGATACTATGGAGCAGGTCTAGGAGTAGTAGAGAGACCATATGTTCCTCAATTAGGCACATATAATGTGATACCCTTAAATAAT GAACAAAGTTCAGGGCCAGTCCCTGAAACGGTGCGAAGCTATTTTCCTGAGACTTGGATCTGGGAGTTGGTGGCAGTGAACTCATCAGGT GTGGCTGAGGTAGGAGTAACAGTCCCTGACACCATCACCGAGTGGAAGGCAGGGGCCTTCTGCCTGTCCGAAGATGCTGGACTTGGTATC TCTTCCACTGCCTCTCTCCGAGCCTTCCAGCCCTTCTTTGTGGAGCTCACAATGCCTTACTCTGTGATTCGTGGAGAGGTCTTCACACTC AAGGCCACGGTCCTAAACTACCTTCCCAAATGCATCCGGGTCAGTGTGCAGCTGAAAGCCTCTCCAGCCTTCCTAGCTTCCCAAAATACA AAGGGAGAAGAATCCTATTGTATCTGTGGAAATGAGAGACAAACCTTGTCTTGGACAGTGACTCCTAAAACTCTGGGGAATGTGAACTTC TCAGTGAGTGCAGAGGCAATGCAGTCCTTAGAACTCTGTGGAAATGAGGTTGTTGAGGTCCCTGAGATTAAAAGAAAAGACACAGTCATC AAAACCCTGTTGGTGGAGGCTGAAGGTATTGAGCAAGAAAAGACTTTCAGTTCTATGACCTGTGCCTCAGGTGCTAATGTGTCTGAGCAG TTGTCCTTGAAGCTCCCATCAAATGTGGTCAAAGAATCTGCCAGAGCTTCTTTCTCAGTTCTGGGTGACATATTAGGTTCTGCTATGCAA AATATACAAAATCTCCTCCAGATGCCATATGGCTGTGGAGAACAGAACATGGTCCTATTTGCTCCTAACATCTATGTCTTGAACTATCTG AATGAAACCCAGCAGCTGACGCAGGAGATCAAGGCCAAGGCCGTTGGCTATCTCATCACTGGTTACCAGAGACAGCTGAACTACAAACAC CAAGATGGCTCCTACAGCACCTTTGGGGAACGATATGGCAGGAACCAGGGCAACACTTGGCTCACAGCTTTTGTACTGAAGACTTTCGCC CAGGCTCGATCCTACATCTTCATTGATGAAGCACACATTACCCAATCTCTCACGTGGCTCTCCCAGATGCAGAAGGACAATGGCTGTTTC AGGAGCTCTGGGTCACTGCTCAACAATGCCATAAAGGGAGGTGTAGAAGATGAAGCGACCCTCTCCGCCTATGTTACTATTGCCCTTCTG GAAATTCCTCTCCCAGTCACTAACCCTATTGTTCGCAATGCCCTGTTCTGCCTGGAGTCAGCCTGGAATGTAGCAAAGGAGGGGACCCAT GGGAGCCATGTCTACACCAAGGCATTGCTGGCCTATGCTTTTTCCCTACTGGGAAAGCAAAATCAGAATAGAGAAATACTGAACTCACTT GATAAGGAAGCTGTGAAAGAAGACAACCTCGTCCATTGGGAGCGCCCTCAGAGACCCAAGGCACCAGTGGGGCATCTTTACCAAACCCAG GCTCCCTCTGCTGAGGTGGAGATGACATCCTATGTGCTCCTCGCTTATCTCACGGCCCAGCCAGCCCCCACCTCAGGGGACCTGACCTCT GCAACTAACATTGTGAAGTGGATCATGAAGCAGCAGAACGCCCAAGGTGGTTTCTCCTCCACCCAGGACACAGTGGTGGCTCTCCATGCC CTGTCCAGGTATGGAGCAGCCACTTTCACCAGAACTGAGAAAACTGCACAGGTCACCGTTCAGGATTCACAGACCTTTTCTACAAATTTC CAAGTAGACAACAACAACCTCCTATTACTGCAGCAGATCTCATTGCCAGAGCTCCCTGGAGAATATGTCATAACAGTAACTGGGGAAAGA TGTGTGTATCTTCAGACATCCATGAAATACAATATTCTTCCAGAGAAAGAGGACTCCCCATTTGCTTTAAAAGTGCAGACTGTGCCCCAA ACTTGCGATGGACACAAAGCCCACACCAGCTTTCAGATCTCACTGACCATCAGTTACACAGGAAACCGTCCTGCTTCCAATATGGTGATT GTTGATGTAAAGATGGTATCTGGTTTTATTCCCCTGAAACCAACAGTAAAAATGCTTGAAAGATCTAGCTCTGTGAGCCGGACAGAAGTG AGCAACAACCATGTCCTCATTTATGTGGAACAGGTGACAAATCAGACGCTAAGTTTTTCCTTCATGGTTCTGCAAGACATCCCAGTAGGA GACTTGAAGCCAGCAATTGTTAAAGTCTATGATTACTATGAGACAGATGAGTCTGTGGTTGCTGAGTATATCGCCCCCTGCAGCACAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TOP1_ENST00000361337_chr20_39690130_+_PZP_ENST00000261336_chr12_9356547_-_4903nt AGCCCAAATGCGAACTTAGGCTGTTACACAACTGCTGGGGTCTGTTCTCGCCGCCCGCCCGGCAGTCAGGCAGCGTCGCCGCCGTGGTAG CAGCCTCAGCCGTTTCTGGAGTCTCGGGCCCACAGTCACCGCCGCTTACCTGCGCCTCCTCGAGCCTCCGGAGTCCCCGTCCGCCCGCAC AGGCCGGTTCGCCGTCTGCGTCTCCCCCACGCCGCCTCGCCTGCCGCCGCGCTCGTCCCTCCGGGCCGACATGAGTGGGGACCACCTCCA CAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGATTCTCATAAACACAAAGATAAACACAAAGATCGAGAACACCGGCACAAAGA ACACAAGAAGGAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGGCAGTATATGGTGCTGGTCCCCTCCCTGCTCCACACTGAGGCCCC TAAGAAGGGCTGTGTCCTTCTGAGCCACCTGAATGAGACAGTGACTGTAAGTGCTTCCTTGGAGTCTGGCAGGGAAAACAGGAGCCTCTT CACTGACCTGGTGGCGGAGAAGGACTTATTCCACTGTGTCTCCTTCACTCTCCCAAGGATCTCAGCCTCTTCAGAGGTGGCATTCCTTAG CATCCAGATAAAGGGGCCTACGCAAGATTTCAGGAAGAGGAACACAGTTCTGGTACTGAACACCCAAAGTCTGGTCTTTGTCCAGACAGA CAAACCCATGTATAAACCAGGACAGACAGTAAGATTCCGTGTTGTCTCCGTGGATGAAAATTTTCGCCCTCGAAATGAACTGATTCCACT GATATACCTTGAGAACCCAAGAAGAAATCGAATTGCACAATGGCAGAGTCTCAAGCTAGAAGCTGGCATCAATCAGTTGTCCTTTCCCCT CTCATCAGAGCCCATTCAGGGCTCCTACAGGGTGGTGGTACAGACAGAATCAGGTGGAAGGATACAGCACCCCTTCACCGTGGAGGAATT TGTGCTTCCCAAGTTTGAGGTCAAAGTTCAGGTGCCAAAGATAATCAGTATCATGGATGAAAAAGTGAACATAACAGTCTGTGGAGAATA CACTTATGGGAAGCCTGTCCCAGGACTTGCAACTGTGAGCCTGTGTAGAAAATTATCTCGTGTTCTTAATTGTGACAAGCAGGAGGTCTG TGAGGAATTCAGTCAACAGCTTAACAGCAATGGCTGCATCACCCAACAAGTACACACCAAAATGCTCCAGATTACAAATACGGGCTTTGA AATGAAGCTTAGAGTGGAAGCCAGGATCAGAGAAGAGGGGACAGACCTGGAAGTCACTGCAAACAGGATCAGTGAAATCACAAACATTGT ATCCAAACTCAAATTCGTGAAAGTGGATTCACACTTTAGACAAGGAATCCCCTTTTTTGCACAGGTGCTTCTGGTGGATGGAAAAGGTGT GCCCATCCCCAATAAACTCTTCTTCATCTCTGTGAATGACGCCAATTATTACTCCAATGCAACCACCAATGAGCAGGGTCTTGCACAGTT TTCAATCAATACTACCAGTATCTCGGTTAATAAACTTTTTGTCCGGGTTTTCACTGTGCATCCCAACTTGTGTTTTCACTATTCATGGGT AGCAGAAGACCACCAGGGTGCTCAGCACACTGCAAATCGTGTTTTCTCCTTAAGTGGAAGTTACATTCACCTGGAGCCTGTGGCTGGTAC CCTGCCCTGTGGCCACACGGAGACTATCACGGCACACTATACACTGAATAGACAGGCCATGGGAGAGTTATCGGAGCTCAGTTTCCATTA CCTGATCATGGCTAAGGGAGTCATCGTCAGATCTGGAACCCACACTCTGCCTGTGGAGTCAGGAGACATGAAAGGCAGTTTTGCCTTATC CTTCCCTGTGGAGTCAGACGTTGCCCCCATTGCACGAATGTTCATCTTTGCCATTTTACCAGATGGAGAAGTTGTTGGAGACTCTGAAAA ATTTGAGATTGAAAACTGTCTAGCCAACAAGGTGGATTTGAGCTTCAGCCCAGCACAAAGTCCCCCAGCCTCACATGCCCACCTGCAAGT AGCAGCTGCTCCGCAGTCCCTCTGTGCCCTTCGTGCTGTGGACCAAAGTGTGCTGCTCATGAAGCCTGAGGCTGAGCTCTCTGTGTCCTC AGTATATAATCTGCTAACTGTGAAGGATCTCACCAATTTTCCTGACAATGTGGACCAGCAGGAGGAAGAACAAGGACACTGTCCCCGTCC TTTCTTCATTCATAATGGAGCCATCTATGTTCCCTTATCAAGTAATGAAGCAGATATTTATAGCTTCCTCAAGGGGATGGGATTGAAGGT GTTCACTAACTCAAAAATCCGAAAACCAAAGTCGTGTTCAGTCATCCCTTCCGTGTCTGCAGGAGCAGTAGGTCAAGGATACTATGGAGC AGGTCTAGGAGTAGTAGAGAGACCATATGTTCCTCAATTAGGCACATATAATGTGATACCCTTAAATAATGAACAAAGTTCAGGGCCAGT CCCTGAAACGGTGCGAAGCTATTTTCCTGAGACTTGGATCTGGGAGTTGGTGGCAGTGAACTCATCAGGTGTGGCTGAGGTAGGAGTAAC AGTCCCTGACACCATCACCGAGTGGAAGGCAGGGGCCTTCTGCCTGTCCGAAGATGCTGGACTTGGTATCTCTTCCACTGCCTCTCTCCG AGCCTTCCAGCCCTTCTTTGTGGAGCTCACAATGCCTTACTCTGTGATTCGTGGAGAGGTCTTCACACTCAAGGCCACGGTCCTAAACTA CCTTCCCAAATGCATCCGGGTCAGTGTGCAGCTGAAAGCCTCTCCAGCCTTCCTAGCTTCCCAAAATACAAAGGGAGAAGAATCCTATTG TATCTGTGGAAATGAGAGACAAACCTTGTCTTGGACAGTGACTCCTAAAACTCTGGGGAATGTGAACTTCTCAGTGAGTGCAGAGGCAAT GCAGTCCTTAGAACTCTGTGGAAATGAGGTTGTTGAGGTCCCTGAGATTAAAAGAAAAGACACAGTCATCAAAACCCTGTTGGTGGAGGC TGAAGGTATTGAGCAAGAAAAGACTTTCAGTTCTATGACCTGTGCCTCAGGTGCTAATGTGTCTGAGCAGTTGTCCTTGAAGCTCCCATC AAATGTGGTCAAAGAATCTGCCAGAGCTTCTTTCTCAGTTCTGGGTGACATATTAGGTTCTGCTATGCAAAATATACAAAATCTCCTCCA GATGCCATATGGCTGTGGAGAACAGAACATGGTCCTATTTGCTCCTAACATCTATGTCTTGAACTATCTGAATGAAACCCAGCAGCTGAC GCAGGAGATCAAGGCCAAGGCCGTTGGCTATCTCATCACTGGTTACCAGAGACAGCTGAACTACAAACACCAAGATGGCTCCTACAGCAC CTTTGGGGAACGATATGGCAGGAACCAGGGCAACACTTGGCTCACAGCTTTTGTACTGAAGACTTTCGCCCAGGCTCGATCCTACATCTT CATTGATGAAGCACACATTACCCAATCTCTCACGTGGCTCTCCCAGATGCAGAAGGACAATGGCTGTTTCAGGAGCTCTGGGTCACTGCT CAACAATGCCATAAAGGGAGGTGTAGAAGATGAAGCGACCCTCTCCGCCTATGTTACTATTGCCCTTCTGGAAATTCCTCTCCCAGTCAC TAACCCTATTGTTCGCAATGCCCTGTTCTGCCTGGAGTCAGCCTGGAATGTAGCAAAGGAGGGGACCCATGGGAGCCATGTCTACACCAA GGCATTGCTGGCCTATGCTTTTTCCCTACTGGGAAAGCAAAATCAGAATAGAGAAATACTGAACTCACTTGATAAGGAAGCTGTGAAAGA AGACAACCTCGTCCATTGGGAGCGCCCTCAGAGACCCAAGGCACCAGTGGGGCATCTTTACCAAACCCAGGCTCCCTCTGCTGAGGTGGA GATGACATCCTATGTGCTCCTCGCTTATCTCACGGCCCAGCCAGCCCCCACCTCAGGGGACCTGACCTCTGCAACTAACATTGTGAAGTG GATCATGAAGCAGCAGAACGCCCAAGGTGGTTTCTCCTCCACCCAGGACACAGTGGTGGCTCTCCATGCCCTGTCCAGGTATGGAGCAGC CACTTTCACCAGAACTGAGAAAACTGCACAGGTCACCGTTCAGGATTCACAGACCTTTTCTACAAATTTCCAAGTAGACAACAACAACCT CCTATTACTGCAGCAGATCTCATTGCCAGAGCTCCCTGGAGAATATGTCATAACAGTAACTGGGGAAAGATGTGTGTATCTTCAGACATC CATGAAATACAATATTCTTCCAGAGAAAGAGGACTCCCCATTTGCTTTAAAAGTGCAGACTGTGCCCCAAACTTGCGATGGACACAAAGC CCACACCAGCTTTCAGATCTCACTGACCATCAGTTACACAGGAAACCGTCCTGCTTCCAATATGGTGATTGTTGATGTAAAGATGGTATC TGGTTTTATTCCCCTGAAACCAACAGTAAAAATGCTTGAAAGATCTAGCTCTGTGAGCCGGACAGAAGTGAGCAACAACCATGTCCTCAT TTATGTGGAACAGGTGACAAATCAGACGCTAAGTTTTTCCTTCATGGTTCTGCAAGACATCCCAGTAGGAGACTTGAAGCCAGCAATTGT TAAAGTCTATGATTACTATGAGACAGATGAGTCTGTGGTTGCTGAGTATATCGCCCCCTGCAGCACAGATACAGAGCATGGAAATGTTTG AGGACCATACAGGCTGTATATTTTGGTGGATTCTCTGTCCTATACATTTACTTAGAAGGAATGGAGTTATTTGTCTCTATAAAATAGACA |
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FusionGenePPI for TOP1_PZP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TOP1 | CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNA | PZP | MMP2, TGFB1, TGFB2, TUBGCP4, TMEM248, A2M, DEFA6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TOP1 | chr20:39690130 | chr12:9356547 | ENST00000361337 | + | 3 | 21 | 425_426 | 51 | 766 | DNA |
| Hgene | TOP1 | chr20:39690130 | chr12:9356547 | ENST00000361337 | + | 3 | 21 | 488_493 | 51 | 766 | DNA |
| Hgene | TOP1 | chr20:39690130 | chr12:9356547 | ENST00000361337 | + | 3 | 21 | 585_587 | 51 | 766 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP1_PZP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TOP1 | P11387 | DB00762 | Irinotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Hgene | TOP1 | P11387 | DB01030 | Topotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Hgene | TOP1 | P11387 | DB05630 | Sodium stibogluconate | DNA topoisomerase 1 | small molecule | approved|investigational |
| Tgene | PZP | P20742 | DB01593 | Zinc | Pregnancy zone protein | small molecule | approved|investigational |
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RelatedDiseases for TOP1_PZP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TOP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | PZP | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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