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Fusion gene ID: 39077 |
FusionGeneSummary for TOP1_CDH4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP1_CDH4 | Fusion gene ID: 39077 | Hgene | Tgene | Gene symbol | TOP1 | CDH4 | Gene ID | 7150 | 1002 |
| Gene name | DNA topoisomerase I | cadherin 4 | |
| Synonyms | TOPI | CAD4|R-CAD|RCAD | |
| Cytomap | 20q12 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase | cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P11387 | P55283 | |
| Ensembl transtripts involved in fusion gene | ENST00000361337, | ENST00000360469, ENST00000543233, | |
| Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 10 X 6 X 6=360 |
| # samples | 9 | 10 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP1 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP1 | GO:0006265 | DNA topological change | 14594810 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-05-4244-01A | TOP1 | chr20 | 39658095 | + | CDH4 | chr20 | 60318619 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361337 | ENST00000360469 | TOP1 | chr20 | 39658095 | + | CDH4 | chr20 | 60318619 | + |
| 5CDS-5UTR | ENST00000361337 | ENST00000543233 | TOP1 | chr20 | 39658095 | + | CDH4 | chr20 | 60318619 | + |
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FusionProtFeatures for TOP1_CDH4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP1 | CDH4 |
| Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May play an important role inretinal development. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 873_888 | 56 | 917 | Compositional bias | Note=Ser-rich |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 873_888 | -18 | 843 | Compositional bias | Note=Ser-rich |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 170_277 | 56 | 917 | Domain | Cadherin 1 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 278_392 | 56 | 917 | Domain | Cadherin 2 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 393_507 | 56 | 917 | Domain | Cadherin 3 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 508_613 | 56 | 917 | Domain | Cadherin 4 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 614_724 | 56 | 917 | Domain | Cadherin 5 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 170_277 | -18 | 843 | Domain | Cadherin 1 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 278_392 | -18 | 843 | Domain | Cadherin 2 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 393_507 | -18 | 843 | Domain | Cadherin 3 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 508_613 | -18 | 843 | Domain | Cadherin 4 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 614_724 | -18 | 843 | Domain | Cadherin 5 |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 170_734 | 56 | 917 | Topological domain | Extracellular |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 757_916 | 56 | 917 | Topological domain | Cytoplasmic |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 170_734 | -18 | 843 | Topological domain | Extracellular |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 757_916 | -18 | 843 | Topological domain | Cytoplasmic |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000360469 | + | 1 | 16 | 735_756 | 56 | 917 | Transmembrane | Helical |
| Tgene | >CDH4 | chr20:39658095 | chr20:60318619 | ENST00000543233 | + | 0 | 15 | 735_756 | -18 | 843 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TOP1 | chr20:39658095 | chr20:60318619 | ENST00000361337 | + | 2 | 21 | 23_204 | 19 | 766 | Compositional bias | Note=Lys-rich |
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FusionGeneSequence for TOP1_CDH4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TOP1_ENST00000361337_chr20_39658095_+_CDH4_ENST00000360469_chr20_60318619_+_880aa MSGDHLHNDSQIEADFRLNVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSP HSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPM EVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDS TTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTF AGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMS FQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTK NNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRL NGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMK RREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFIN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TOP1_ENST00000361337_chr20_39658095_+_CDH4_ENST00000360469_chr20_60318619_+_2640nt ATGAGTGGGGACCACCTCCACAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGG ACACAATATGAGACCAACAGCATGGACTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAG GTGGCGTTCACGGTGACTGCATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCG CACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAG CACCAGAACGCCAACGGGCTGAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCG CAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATG GAGGTCTTCAGCATTGACTCCATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCC CACGCTGTGGACATGAATGGCAACAAGGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTC ATCAACCAGGTCTACAACGGCTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGC ACCACGGCCAACGGGATGGTGCGGTACCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACT GGAGATATCGTCACAGTGGCGGCTGGCCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAAT CTCAACTATGGCCTCTCAAACACAGCCACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTT GCAGGGGAGGTCCCCGAAAACCGCGTGGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAAT GCCGTTTACCGCATCATCAGTGGGGATCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTG AAGGCAGTCGACTACGAGCTCAACAGAGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCC TTCCAGTCCACGGCAGGGGTGACCATCTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAG GAGGGCGTGCCCCCCGGCACCGTGCTGACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTG TCAGACCCAGCGAGCTGGCTGCACATCAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAA AACAACGTCTACGAGGCCACCTTCCTGGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGAC ATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGAC GCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTG AACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAAC CCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCG GCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAG CGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGC GGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGT CGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAAT GAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCA GGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TOP1_ENST00000361337_chr20_39658095_+_CDH4_ENST00000360469_chr20_60318619_+_6562nt AGCCCAAATGCGAACTTAGGCTGTTACACAACTGCTGGGGTCTGTTCTCGCCGCCCGCCCGGCAGTCAGGCAGCGTCGCCGCCGTGGTAG CAGCCTCAGCCGTTTCTGGAGTCTCGGGCCCACAGTCACCGCCGCTTACCTGCGCCTCCTCGAGCCTCCGGAGTCCCCGTCCGCCCGCAC AGGCCGGTTCGCCGTCTGCGTCTCCCCCACGCCGCCTCGCCTGCCGCCGCGCTCGTCCCTCCGGGCCGACATGAGTGGGGACCACCTCCA CAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAG CATGGACTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGC ATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCA GAAAGGAAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCT GAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCG GTCCGACAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTC CATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGG CAACAAGGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGG CTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGT GCGGTACCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGC GGCTGGCCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAA CACAGCCACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAA CCGCGTGGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAG TGGGGATCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCT CAACAGAGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGT GACCATCTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCAC CGTGCTGACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCT GCACATCAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCAC CTTCCTGGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGA GCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACAT CGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACT CAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTC CATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGC CATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCA CACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGA CTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGT GGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGA CAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAA CTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGA AGAGGATTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTT CCCGACTCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAG CGCCCTGCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAAC AGAAGCACTGTTTTTAAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATT CCCTCAAACTCAGGAGTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAA GGCATCATTCAGAAATGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTT GAAAACAGAGTGGGGTTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAG GCTTAGCCCTTCAGCCCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATG CTGTGAGGAGCTCAGGCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGAC ACCTGTCACCCTGAGTGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTC CAACCCTGGCGACCAGACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAAC CATCCGGAGGGCTGTGCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACAC ACCCAGCAGCCTGCGAAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCC CGTCTTGCCGTGCCTACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCA GCGGCCGGGTCCAAACTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATT GGTTCTGCAGGACAGTGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGG GTGCATTCTCCCTCTGGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAG CTTTCTGTCTCTCCCAGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAG GGCGGTGCCAGCACTGGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCT TTGGGGGCAGCATGAGCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACA GCTTTGGCCTTGAGTGCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTG CCCCTGTGCAGCCTTCAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTT CACTGTGCCACGTGCTGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCA CCGGGGTCCCCGAGTTCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTA GTGGAAGGACTGGAAATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATG GCCCGGGAGCCAGGGCAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACC CAGCACCAGGAGACCCCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTC GCCCACAGCCTCTTGTCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCAT AGGGCTTCCTGTGCCCATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGAT GGGGTTCCTGCACCTTCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAG CTTGTAGATACGACTGCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCT TTAGGGAATTTTTGTTTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCA GCCTAGGGCCACAGTCCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAA ATGCTAGGCCTCCTGCCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGC CGACACACACAGTCCACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAA AGGAATAACACCAAAAGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCT CACAACAGGCCCAGCGGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTT GCATGTTTCTTTTTGAAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCAC ACCTGCAAATCTGAGCATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCA TTTTGTACCAAAAAAAAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACT |
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FusionGenePPI for TOP1_CDH4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TOP1 | CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNA | CDH4 | CDH2, CDK5RAP3, FUS, UBE2I, CTNNA3, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TOP1 | chr20:39658095 | chr20:60318619 | ENST00000361337 | + | 2 | 21 | 425_426 | 19 | 766 | DNA |
| Hgene | TOP1 | chr20:39658095 | chr20:60318619 | ENST00000361337 | + | 2 | 21 | 488_493 | 19 | 766 | DNA |
| Hgene | TOP1 | chr20:39658095 | chr20:60318619 | ENST00000361337 | + | 2 | 21 | 585_587 | 19 | 766 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP1_CDH4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TOP1 | P11387 | DB00762 | Irinotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Hgene | TOP1 | P11387 | DB01030 | Topotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Hgene | TOP1 | P11387 | DB05630 | Sodium stibogluconate | DNA topoisomerase 1 | small molecule | approved|investigational |
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RelatedDiseases for TOP1_CDH4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TOP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
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