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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 39077

FusionGeneSummary for TOP1_CDH4

check button Fusion gene summary
Fusion gene informationFusion gene name: TOP1_CDH4
Fusion gene ID: 39077
HgeneTgene
Gene symbol

TOP1

CDH4

Gene ID

7150

1002

Gene nameDNA topoisomerase Icadherin 4
SynonymsTOPICAD4|R-CAD|RCAD
Cytomap

20q12

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionDNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerasecadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin
Modification date2018052320180523
UniProtAcc

P11387

P55283

Ensembl transtripts involved in fusion geneENST00000361337, ENST00000360469, 
ENST00000543233, 
Fusion gene scores* DoF score9 X 4 X 7=25210 X 6 X 6=360
# samples 910
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOP1 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOP1

GO:0006265

DNA topological change

14594810


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-05-4244-01ATOP1chr20

39658095

+CDH4chr20

60318619

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361337ENST00000360469TOP1chr20

39658095

+CDH4chr20

60318619

+
5CDS-5UTRENST00000361337ENST00000543233TOP1chr20

39658095

+CDH4chr20

60318619

+

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FusionProtFeatures for TOP1_CDH4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOP1

P11387

CDH4

P55283

Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May play an important role inretinal development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116873_88856917Compositional biasNote=Ser-rich
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015873_888-18843Compositional biasNote=Ser-rich
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116170_27756917DomainCadherin 1
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116278_39256917DomainCadherin 2
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116393_50756917DomainCadherin 3
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116508_61356917DomainCadherin 4
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116614_72456917DomainCadherin 5
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015170_277-18843DomainCadherin 1
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015278_392-18843DomainCadherin 2
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015393_507-18843DomainCadherin 3
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015508_613-18843DomainCadherin 4
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015614_724-18843DomainCadherin 5
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116170_73456917Topological domainExtracellular
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116757_91656917Topological domainCytoplasmic
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015170_734-18843Topological domainExtracellular
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015757_916-18843Topological domainCytoplasmic
TgeneCDH4chr20:39658095chr20:60318619ENST00000360469+116735_75656917TransmembraneHelical
TgeneCDH4chr20:39658095chr20:60318619ENST00000543233+015735_756-18843TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOP1chr20:39658095chr20:60318619ENST00000361337+22123_20419766Compositional biasNote=Lys-rich


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FusionGeneSequence for TOP1_CDH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TOP1_ENST00000361337_chr20_39658095_+_CDH4_ENST00000360469_chr20_60318619_+_880aa
MSGDHLHNDSQIEADFRLNVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSP
HSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPM
EVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDS
TTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTF
AGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMS
FQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTK
NNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRL
NGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMK
RREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFIN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TOP1_ENST00000361337_chr20_39658095_+_CDH4_ENST00000360469_chr20_60318619_+_2640nt
ATGAGTGGGGACCACCTCCACAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGG
ACACAATATGAGACCAACAGCATGGACTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAG
GTGGCGTTCACGGTGACTGCATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCG
CACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAG
CACCAGAACGCCAACGGGCTGAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCG
CAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATG
GAGGTCTTCAGCATTGACTCCATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCC
CACGCTGTGGACATGAATGGCAACAAGGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTC
ATCAACCAGGTCTACAACGGCTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGC
ACCACGGCCAACGGGATGGTGCGGTACCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACT
GGAGATATCGTCACAGTGGCGGCTGGCCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAAT
CTCAACTATGGCCTCTCAAACACAGCCACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTT
GCAGGGGAGGTCCCCGAAAACCGCGTGGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAAT
GCCGTTTACCGCATCATCAGTGGGGATCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTG
AAGGCAGTCGACTACGAGCTCAACAGAGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCC
TTCCAGTCCACGGCAGGGGTGACCATCTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAG
GAGGGCGTGCCCCCCGGCACCGTGCTGACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTG
TCAGACCCAGCGAGCTGGCTGCACATCAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAA
AACAACGTCTACGAGGCCACCTTCCTGGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGAC
ATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGAC
GCTGACGTCGACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTG
AACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAAC
CCTCCCCTGTCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCG
GCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAG
CGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGC
GGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGT
CGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAAT
GAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCA
GGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TOP1_ENST00000361337_chr20_39658095_+_CDH4_ENST00000360469_chr20_60318619_+_6562nt
AGCCCAAATGCGAACTTAGGCTGTTACACAACTGCTGGGGTCTGTTCTCGCCGCCCGCCCGGCAGTCAGGCAGCGTCGCCGCCGTGGTAG
CAGCCTCAGCCGTTTCTGGAGTCTCGGGCCCACAGTCACCGCCGCTTACCTGCGCCTCCTCGAGCCTCCGGAGTCCCCGTCCGCCCGCAC
AGGCCGGTTCGCCGTCTGCGTCTCCCCCACGCCGCCTCGCCTGCCGCCGCGCTCGTCCCTCCGGGCCGACATGAGTGGGGACCACCTCCA
CAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAG
CATGGACTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGC
ATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCA
GAAAGGAAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCT
GAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCG
GTCCGACAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTC
CATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGG
CAACAAGGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGG
CTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGT
GCGGTACCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGC
GGCTGGCCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAA
CACAGCCACAGCCATCATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAA
CCGCGTGGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAG
TGGGGATCCATCCGGGCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCT
CAACAGAGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGT
GACCATCTCCATCATGGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCAC
CGTGCTGACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCT
GCACATCAATGCCACCAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCAC
CTTCCTGGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGA
GCTGCTGCCCAAGGAGGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACAT
CGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACT
CAGCTTGCGCATCCTGTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTC
CATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGC
CATCGTGGCCATCCTCATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCA
CACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGA
CTACGACCTCAGCCAGCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGT
GGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGA
CAACGACCCCACGGCACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAA
CTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGA
AGAGGATTGACTGACCTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTT
CCCGACTCCCTGCGGCTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAG
CGCCCTGCACCCGGCCGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAAC
AGAAGCACTGTTTTTAAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATT
CCCTCAAACTCAGGAGTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAA
GGCATCATTCAGAAATGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTT
GAAAACAGAGTGGGGTTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAG
GCTTAGCCCTTCAGCCCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATG
CTGTGAGGAGCTCAGGCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGAC
ACCTGTCACCCTGAGTGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTC
CAACCCTGGCGACCAGACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAAC
CATCCGGAGGGCTGTGCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACAC
ACCCAGCAGCCTGCGAAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCC
CGTCTTGCCGTGCCTACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCA
GCGGCCGGGTCCAAACTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATT
GGTTCTGCAGGACAGTGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGG
GTGCATTCTCCCTCTGGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAG
CTTTCTGTCTCTCCCAGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAG
GGCGGTGCCAGCACTGGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCT
TTGGGGGCAGCATGAGCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACA
GCTTTGGCCTTGAGTGCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTG
CCCCTGTGCAGCCTTCAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTT
CACTGTGCCACGTGCTGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCA
CCGGGGTCCCCGAGTTCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTA
GTGGAAGGACTGGAAATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATG
GCCCGGGAGCCAGGGCAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACC
CAGCACCAGGAGACCCCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTC
GCCCACAGCCTCTTGTCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCAT
AGGGCTTCCTGTGCCCATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGAT
GGGGTTCCTGCACCTTCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAG
CTTGTAGATACGACTGCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCT
TTAGGGAATTTTTGTTTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCA
GCCTAGGGCCACAGTCCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAA
ATGCTAGGCCTCCTGCCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGC
CGACACACACAGTCCACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAA
AGGAATAACACCAAAAGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCT
CACAACAGGCCCAGCGGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTT
GCATGTTTCTTTTTGAAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCAC
ACCTGCAAATCTGAGCATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCA
TTTTGTACCAAAAAAAAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACT


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FusionGenePPI for TOP1_CDH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOP1CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNACDH4CDH2, CDK5RAP3, FUS, UBE2I, CTNNA3, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTOP1chr20:39658095chr20:60318619ENST00000361337+221425_42619766DNA
HgeneTOP1chr20:39658095chr20:60318619ENST00000361337+221488_49319766DNA
HgeneTOP1chr20:39658095chr20:60318619ENST00000361337+221585_58719766DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TOP1_CDH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTOP1P11387DB00762IrinotecanDNA topoisomerase 1small moleculeapproved|investigational
HgeneTOP1P11387DB01030TopotecanDNA topoisomerase 1small moleculeapproved|investigational
HgeneTOP1P11387DB05630Sodium stibogluconateDNA topoisomerase 1small moleculeapproved|investigational

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RelatedDiseases for TOP1_CDH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTOP1C0041755Adverse reaction to drug1CTD_human