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Fusion gene ID: 39075 |
FusionGeneSummary for TOP1_C17orf64 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP1_C17orf64 | Fusion gene ID: 39075 | Hgene | Tgene | Gene symbol | TOP1 | C17orf64 | Gene ID | 7150 | 124773 |
| Gene name | DNA topoisomerase I | chromosome 17 open reading frame 64 | |
| Synonyms | TOPI | - | |
| Cytomap | 20q12 | 17q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase | uncharacterized protein C17orf64 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P11387 | Q86WR6 | |
| Ensembl transtripts involved in fusion gene | ENST00000361337, | ENST00000269127, | |
| Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 6 X 3 X 3=54 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TOP1 [Title/Abstract] AND C17orf64 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP1 | GO:0006265 | DNA topological change | 14594810 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A273-01A | TOP1 | chr20 | 39729993 | + | C17orf64 | chr17 | 58503144 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361337 | ENST00000269127 | TOP1 | chr20 | 39729993 | + | C17orf64 | chr17 | 58503144 | + |
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FusionProtFeatures for TOP1_C17orf64 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TOP1 | C17orf64 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TOP1 | chr20:39729993 | chr17:58503144 | ENST00000361337 | + | 13 | 21 | 23_204 | 436 | 766 | Compositional bias | Note=Lys-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TOP1_C17orf64 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TOP1_ENST00000361337_chr20_39729993_+_C17orf64_ENST00000269127_chr17_58503144_+_656aa MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRK EEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTT KEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKVTNVSCLETSSSAS PARDSLMRHAKGLDQDTFKTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQAWEIKHWRKMLWRFISLFSE LEAKQLRRLYKYTKSSQPAKFLVTFCASDAPERSLLADREDSLPKLCHAWGLHSNISGMKERLSNMQTPGQGSPLPGQPRSQDHVKKDSL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TOP1_ENST00000361337_chr20_39729993_+_C17orf64_ENST00000269127_chr17_58503144_+_1968nt ATGAGTGGGGACCACCTCCACAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGATTCTCATAAACACAAAGATAAACACAAAGAT CGAGAACACCGGCACAAAGAACACAAGAAGGAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTCTGAAAAGAAA CACAAAGAGAAGGAGAAGACCAAACACAAAGATGGAAGCTCAGAAAAGCATAAAGACAAACATAAAGACAGAGACAAGGAAAAACGAAAA GAGGAAAAGGTTCGAGCCTCTGGGGATGCAAAAATAAAGAAGGAGAAGGAAAATGGCTTCTCTAGTCCACCACAAATTAAAGATGAACCT GAAGATGATGGCTATTTTGTTCCTCCTAAAGAGGATATAAAGCCATTAAAGAGACCTCGAGATGAGGATGATGCTGATTATAAACCTAAG AAAATTAAAACAGAAGATACCAAGAAGGAGAAGAAAAGAAAACTAGAAGAAGAAGAGGATGGTAAATTGAAAAAACCCAAGAATAAAGAT AAAGATAAAAAAGTTCCTGAGCCAGATAACAAGAAAAAGAAGCCGAAGAAAGAAGAGGAACAGAAGTGGAAATGGTGGGAAGAAGAGCGC TATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTT TATTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACC AAGGAAATATTTAGGAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGT GATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAG AATGAAAAATTACTGAAAGAATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTT TTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCC AAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATC CAAGGTTCCATTAAATACATCATGCTTAACCCTAGTTCACGAATCAAGGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGC CCTGCTAGAGACTCGCTCATGCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAG TTCCTGCGAAAGTTGCACCTGCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCAC ATCAACACCTTTCTGCAGCATTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAG CTGGAAGCAAAGCAGCTTCGCCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCG CCGGAGAGGTCCTTGCTGGCCGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAG GAGCGGCTGTCCAACATGCAGACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TOP1_ENST00000361337_chr20_39729993_+_C17orf64_ENST00000269127_chr17_58503144_+_2373nt AGCCCAAATGCGAACTTAGGCTGTTACACAACTGCTGGGGTCTGTTCTCGCCGCCCGCCCGGCAGTCAGGCAGCGTCGCCGCCGTGGTAG CAGCCTCAGCCGTTTCTGGAGTCTCGGGCCCACAGTCACCGCCGCTTACCTGCGCCTCCTCGAGCCTCCGGAGTCCCCGTCCGCCCGCAC AGGCCGGTTCGCCGTCTGCGTCTCCCCCACGCCGCCTCGCCTGCCGCCGCGCTCGTCCCTCCGGGCCGACATGAGTGGGGACCACCTCCA CAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGATTCTCATAAACACAAAGATAAACACAAAGATCGAGAACACCGGCACAAAGA ACACAAGAAGGAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTCTGAAAAGAAACACAAAGAGAAGGAGAAGAC CAAACACAAAGATGGAAGCTCAGAAAAGCATAAAGACAAACATAAAGACAGAGACAAGGAAAAACGAAAAGAGGAAAAGGTTCGAGCCTC TGGGGATGCAAAAATAAAGAAGGAGAAGGAAAATGGCTTCTCTAGTCCACCACAAATTAAAGATGAACCTGAAGATGATGGCTATTTTGT TCCTCCTAAAGAGGATATAAAGCCATTAAAGAGACCTCGAGATGAGGATGATGCTGATTATAAACCTAAGAAAATTAAAACAGAAGATAC CAAGAAGGAGAAGAAAAGAAAACTAGAAGAAGAAGAGGATGGTAAATTGAAAAAACCCAAGAATAAAGATAAAGATAAAAAAGTTCCTGA GCCAGATAACAAGAAAAAGAAGCCGAAGAAAGAAGAGGAACAGAAGTGGAAATGGTGGGAAGAAGAGCGCTATCCTGAAGGCATCAAGTG GAAATTCCTAGAACATAAAGGTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTATTATGATGGTAAAGTCAT GAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAGGAAAAA TTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGAATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCA GTATTTCAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGAAAATCAAAGAGGAGAATGAAAAATTACTGAAAGA ATATGGATTCTGTATTATGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGACTTTTCCGTGGCCGCGGCAACCA CCCCAAGATGGGCATGCTGAAGAGACGAATCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCC AGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTACTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACAT CATGCTTAACCCTAGTTCACGAATCAAGGTGACAAATGTGTCATGCCTGGAGACAAGCTCCAGCGCCAGCCCTGCTAGAGACTCGCTCAT GCGCCATGCCAAGGGCCTGGATCAGGACACCTTCAAAACTTGTAAAGAATACCTAAGACCGCTGAAGAAGTTCCTGCGAAAGTTGCACCT GCCCAGGGACCTTCCCCAGAAGAAGAAGCTGAAGTACATGAAGCAGAGCCTTGTGGTCCTAGGGGACCACATCAACACCTTTCTGCAGCA TTACTGCCAAGCCTGGGAAATCAAACACTGGAGAAAGATGCTCTGGCGGTTCATCTCCCTCTTCTCGGAGCTGGAAGCAAAGCAGCTTCG CCGACTTTACAAGTACACCAAGAGCAGCCAGCCGGCCAAGTTCCTGGTGACATTCTGCGCCTCGGATGCGCCGGAGAGGTCCTTGCTGGC CGACCGGGAAGACAGTCTGCCCAAGCTCTGCCATGCATGGGGGCTGCACAGCAACATCAGCGGCATGAAGGAGCGGCTGTCCAACATGCA GACCCCAGGTCAAGGGAGCCCCCTGCCTGGGCAGCCAAGATCCCAGGACCATGTCAAGAAAGATTCTTTAAGGGAGCTTTCTCAAAAACC AAAACTCAAGAGGAAGAGGATAAAGGAAGCCCCAGAAACTCCAGAGACTGAACCGTAAGAAGACCAACTGGGACAAAGGGCCCGCTTGTC CTGGCTCTCAGAGCACGGGGAATGGAGACCAAAAAGGGAAAAGAATTGTCCTTATCAAAAAGATTCTCAGGTCTTAATTAGGAATAAATG |
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FusionGenePPI for TOP1_C17orf64 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TOP1 | CSNK2A1, CSNK2A2, TP53, TAL1, NCL, SRSF1, BTBD1, BTBD2, TOPORS, SRSF11, SFPQ, UBE2I, CDT1, CDKN2A, RRP1B, H2AFY, PMS1, MGMT, HIST1H3E, H3F3A, MYC, ICT1, HDAC5, NOP56, NPM1, FBL, HIST1H1C, H1FX, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPK, HNRNPL, HNRNPR, ELAVL1, MKI67, NAT10, DHX9, NOP2, NONO, PARP1, DDX21, DDX17, SF3B3, SF3B1, TCOF1, SNRPA1, DDX23, EFTUD2, SNRNP200, PRPF8, OAS3, EIF2AK2, PCNA, HDGF, SIRT7, GTF3C1, XRCC5, CUL3, CDK2, CUL1, COPS5, CAND1, DDB2, ERCC8, ATM, IRF4, BARD1, ELK3, TARBP2, KMT2A, IRF8, IRF9, SNW1, PRB1, SNRNP70, U2AF2, LSM4, GEMIN4, CDK8, BUB3, RBL1, RBL2, GRWD1, SYMPK, JAK1, LIG4, PPP2R2B, TRIM32, RCVRN, PYGM, APAF1, CKAP5, TUBD1, PDE10A, APP, HNRNPM, RPS14, SNRPD1, IK, RBM39, SF3B6, SUPT16H, UTP20, S100A9, NCSTN, RBM14, TPR, ESR1, NKX3-1, VCP, PA2G4, VCAM1, IL7R, ITGA4, HDAC9, CDK14, TARDBP, SHFM1, ERG, MDM2, CUL7, OBSL1, EED, RNF2, EAF1, ZRANB2, APLF, NTRK1, RBM25, PWP1, RBM28, TOP2A, TOP2B, SCARNA22, FSHR, SRPK2, LAMB3, TRIM26, NLRP3, MCM5, NF2, CDC5L, PES1, POU5F1, EGFR, FNTA, ARID1A, PDGFRA, ROR1, PBRM1, TSC1, ERBB2, MTOR, BRCA1, CDK4, ESAM, CIDEC, SNRPG, PRICKLE3, DUS4L, GTF2E2, NR3C1, CHEK1, BRCA2, WEE1, PALB2, RAD17, LLGL1, MSH2, NF1, RPS11, CDC73, CDC6, MAP3K4, TTN, FH, COX15, DLST, PDHA1, VDAC1, TRIM25, LMNA | C17orf64 | DUSP12 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | TOP1 | chr20:39729993 | chr17:58503144 | ENST00000361337 | + | 13 | 21 | 425_426 | 436 | 766 | DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TOP1 | chr20:39729993 | chr17:58503144 | ENST00000361337 | + | 13 | 21 | 488_493 | 436 | 766 | DNA |
| Hgene | TOP1 | chr20:39729993 | chr17:58503144 | ENST00000361337 | + | 13 | 21 | 585_587 | 436 | 766 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOP1_C17orf64 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | TOP1 | P11387 | DB00762 | Irinotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Hgene | TOP1 | P11387 | DB01030 | Topotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
| Hgene | TOP1 | P11387 | DB05630 | Sodium stibogluconate | DNA topoisomerase 1 | small molecule | approved|investigational |
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RelatedDiseases for TOP1_C17orf64 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TOP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
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