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Fusion gene ID: 39071 |
FusionGeneSummary for TOMM7_KLK2 |
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Fusion gene information | Fusion gene name: TOMM7_KLK2 | Fusion gene ID: 39071 | Hgene | Tgene | Gene symbol | TOMM7 | KLK2 | Gene ID | 54543 | 3817 |
Gene name | translocase of outer mitochondrial membrane 7 | kallikrein related peptidase 2 | |
Synonyms | TOM7 | KLK2A2|hGK-1|hK2 | |
Cytomap | 7p15.3 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | mitochondrial import receptor subunit TOM7 homolog6.2 kd proteintranslocase of outer membrane 7 kDa subunit homologtranslocase of outer mitochondrial membrane 7 homolog | kallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9P0U1 | P20151 | |
Ensembl transtripts involved in fusion gene | ENST00000463284, ENST00000358435, ENST00000405021, ENST00000372879, | ENST00000325321, ENST00000391810, ENST00000358049, ENST00000597509, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 3 X 2=24 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TOMM7 [Title/Abstract] AND KLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-KK-A6E4-01A | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000463284 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-5UTR | ENST00000463284 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-intron | ENST00000463284 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-intron | ENST00000463284 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-5UTR | ENST00000358435 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-5UTR | ENST00000358435 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-intron | ENST00000358435 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
intron-intron | ENST00000358435 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-5UTR | ENST00000405021 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-5UTR | ENST00000405021 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-intron | ENST00000405021 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-intron | ENST00000405021 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-5UTR | ENST00000372879 | ENST00000325321 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-5UTR | ENST00000372879 | ENST00000391810 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-intron | ENST00000372879 | ENST00000358049 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
5CDS-intron | ENST00000372879 | ENST00000597509 | TOMM7 | chr7 | 22852592 | - | KLK2 | chr19 | 51376695 | + |
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FusionProtFeatures for TOMM7_KLK2 |
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Hgene | Tgene |
TOMM7 | KLK2 |
Required for assembly and stability of the TOM complex.Positive regulator of PRKN translocation to damaged mitochondria.Acts probably by stabilizing PINK1 on the outer membrane ofdepolarized mitochondria. {ECO:0000269|PubMed:18331822,ECO:0000269|PubMed:24270810}. | Glandular kallikreins cleave Met-Lys and Arg-Ser bondsin kininogen to release Lys-bradykinin. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TOMM7_KLK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TOMM7_KLK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TOMM7 | TOMM40, TOMM22, TOMM70A, TOMM20, SDHB, NDUFB7, FAM3C, CISD1, UQCRFS1, SRSF3, ERGIC1, COX15, SFXN1, BAK1, TIMM50, SFXN2, ACAT1, PEX5 | KLK2 | SERPINF2, SERPINA3, SERPINA5, SERPINB6, APP, SUZ12, RNF2, ADAMTS1, SERPINE2, APLP2, GLG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TOMM7_KLK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TOMM7_KLK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KLK2 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |