FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39071

FusionGeneSummary for TOMM7_KLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: TOMM7_KLK2
Fusion gene ID: 39071
HgeneTgene
Gene symbol

TOMM7

KLK2

Gene ID

54543

3817

Gene nametranslocase of outer mitochondrial membrane 7kallikrein related peptidase 2
SynonymsTOM7KLK2A2|hGK-1|hK2
Cytomap

7p15.3

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import receptor subunit TOM7 homolog6.2 kd proteintranslocase of outer membrane 7 kDa subunit homologtranslocase of outer mitochondrial membrane 7 homologkallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2
Modification date2018052220180523
UniProtAcc

Q9P0U1

P20151

Ensembl transtripts involved in fusion geneENST00000463284, ENST00000358435, 
ENST00000405021, ENST00000372879, 
ENST00000325321, ENST00000391810, 
ENST00000358049, ENST00000597509, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 3 X 2=24
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TOMM7 [Title/Abstract] AND KLK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A6E4-01ATOMM7chr7

22852592

-KLK2chr19

51376695

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000463284ENST00000325321TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-5UTRENST00000463284ENST00000391810TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-intronENST00000463284ENST00000358049TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-intronENST00000463284ENST00000597509TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-5UTRENST00000358435ENST00000325321TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-5UTRENST00000358435ENST00000391810TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-intronENST00000358435ENST00000358049TOMM7chr7

22852592

-KLK2chr19

51376695

+
intron-intronENST00000358435ENST00000597509TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-5UTRENST00000405021ENST00000325321TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-5UTRENST00000405021ENST00000391810TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-intronENST00000405021ENST00000358049TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-intronENST00000405021ENST00000597509TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-5UTRENST00000372879ENST00000325321TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-5UTRENST00000372879ENST00000391810TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-intronENST00000372879ENST00000358049TOMM7chr7

22852592

-KLK2chr19

51376695

+
5CDS-intronENST00000372879ENST00000597509TOMM7chr7

22852592

-KLK2chr19

51376695

+

Top

FusionProtFeatures for TOMM7_KLK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOMM7

Q9P0U1

KLK2

P20151

Required for assembly and stability of the TOM complex.Positive regulator of PRKN translocation to damaged mitochondria.Acts probably by stabilizing PINK1 on the outer membrane ofdepolarized mitochondria. {ECO:0000269|PubMed:18331822,ECO:0000269|PubMed:24270810}. Glandular kallikreins cleave Met-Lys and Arg-Ser bondsin kininogen to release Lys-bradykinin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TOMM7_KLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TOMM7_KLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOMM7TOMM40, TOMM22, TOMM70A, TOMM20, SDHB, NDUFB7, FAM3C, CISD1, UQCRFS1, SRSF3, ERGIC1, COX15, SFXN1, BAK1, TIMM50, SFXN2, ACAT1, PEX5KLK2SERPINF2, SERPINA3, SERPINA5, SERPINB6, APP, SUZ12, RNF2, ADAMTS1, SERPINE2, APLP2, GLG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TOMM7_KLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TOMM7_KLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKLK2C0033578Prostatic Neoplasms2CTD_human