FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3906

FusionGeneSummary for BBX_SPARCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: BBX_SPARCL1
Fusion gene ID: 3906
HgeneTgene
Gene symbol

BBX

SPARCL1

Gene ID

56987

8404

Gene nameBBX, HMG-box containingSPARC like 1
SynonymsARTC1|HBP2|HSPC339|MDS001MAST 9|MAST9|PIG33|SC1
Cytomap

3q13.12

4q22.1

Type of geneprotein-codingprotein-coding
DescriptionHMG box transcription factor BBXAg recognized by Treg cells 1HMG box-containing protein 2bobby sox homologx 001 proteinSPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33
Modification date2018051920180523
UniProtAcc

Q8WY36

Q14515

Ensembl transtripts involved in fusion geneENST00000415149, ENST00000402543, 
ENST00000325805, ENST00000416476, 
ENST00000406780, ENST00000473542, 
ENST00000282470, ENST00000418378, 
ENST00000503414, 
Fusion gene scores* DoF score11 X 10 X 7=77010 X 8 X 5=400
# samples 1511
** MAII scorelog2(15/770*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BBX [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE176379BBXchr3

107492189

-SPARCL1chr4

88412796

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000415149ENST00000282470BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000415149ENST00000418378BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000415149ENST00000503414BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000402543ENST00000282470BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000402543ENST00000418378BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000402543ENST00000503414BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000325805ENST00000282470BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000325805ENST00000418378BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000325805ENST00000503414BBXchr3

107492189

-SPARCL1chr4

88412796

+
intron-3CDSENST00000416476ENST00000282470BBXchr3

107492189

-SPARCL1chr4

88412796

+
intron-3CDSENST00000416476ENST00000418378BBXchr3

107492189

-SPARCL1chr4

88412796

+
intron-3CDSENST00000416476ENST00000503414BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000406780ENST00000282470BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000406780ENST00000418378BBXchr3

107492189

-SPARCL1chr4

88412796

+
Frame-shiftENST00000406780ENST00000503414BBXchr3

107492189

-SPARCL1chr4

88412796

+
intron-3CDSENST00000473542ENST00000282470BBXchr3

107492189

-SPARCL1chr4

88412796

+
intron-3CDSENST00000473542ENST00000418378BBXchr3

107492189

-SPARCL1chr4

88412796

+
intron-3CDSENST00000473542ENST00000503414BBXchr3

107492189

-SPARCL1chr4

88412796

+

Top

FusionProtFeatures for BBX_SPARCL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BBX

Q8WY36

SPARCL1

Q14515

Transcription factor that is necessary for cell cycleprogression from G1 to S phase. {ECO:0000269|PubMed:11680820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BBX_SPARCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BBX_SPARCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BBX_SPARCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BBX_SPARCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPARCL1C0014175Endometriosis1CTD_human
TgeneSPARCL1C0014544Epilepsy1CTD_human