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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 39051

FusionGeneSummary for TOM1L2_NXN

check button Fusion gene summary
Fusion gene informationFusion gene name: TOM1L2_NXN
Fusion gene ID: 39051
HgeneTgene
Gene symbol

TOM1L2

NXN

Gene ID

146691

64359

Gene nametarget of myb1 like 2 membrane trafficking proteinnucleoredoxin
Synonyms-NRX|TRG-4
Cytomap

17p11.2

17p13.3

Type of geneprotein-codingprotein-coding
DescriptionTOM1-like protein 2target of Myb-like protein 2target of myb1-like 2nucleoredoxinnucleoredoxin 1
Modification date2018051920180519
UniProtAcc

Q6ZVM7

Q6DKJ4

Ensembl transtripts involved in fusion geneENST00000581396, ENST00000379504, 
ENST00000318094, ENST00000395739, 
ENST00000535933, ENST00000540946, 
ENST00000542206, ENST00000478943, 
ENST00000577517, 		ENST00000336868, 
ENST00000577098, ENST00000575801, 
ENST00000538650, ENST00000537628, 
Fusion gene scores* DoF score8 X 7 X 6=3368 X 7 X 3=168
# samples 98
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOM1L2 [Title/Abstract] AND NXN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOM1L2

GO:0007165

signal transduction

16479011

HgeneTOM1L2

GO:0045839

negative regulation of mitotic nuclear division

16479011


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-CG-4477-01ATOM1L2chr17

17787948

-NXNchr17

729318

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000581396ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000581396ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000581396ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-intronENST00000581396ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000581396ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
In-frameENST00000379504ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000379504ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000379504ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-intronENST00000379504ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000379504ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-3CDSENST00000318094ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000318094ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000318094ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-intronENST00000318094ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000318094ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-3CDSENST00000395739ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000395739ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000395739ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-intronENST00000395739ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000395739ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
In-frameENST00000535933ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000535933ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000535933ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-intronENST00000535933ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
5CDS-5UTRENST00000535933ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-3CDSENST00000540946ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000540946ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000540946ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-intronENST00000540946ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000540946ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-3CDSENST00000542206ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000542206ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000542206ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-intronENST00000542206ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000542206ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-3CDSENST00000478943ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000478943ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000478943ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-intronENST00000478943ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000478943ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-3CDSENST00000577517ENST00000336868TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000577517ENST00000577098TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000577517ENST00000575801TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-intronENST00000577517ENST00000538650TOM1L2chr17

17787948

-NXNchr17

729318

-
intron-5UTRENST00000577517ENST00000537628TOM1L2chr17

17787948

-NXNchr17

729318

-

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FusionProtFeatures for TOM1L2_NXN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOM1L2

Q6ZVM7

NXN

Q6DKJ4

Probable role in protein transport. May regulate growthfactor-induced mitogenic signaling. {ECO:0000269|PubMed:16412388,ECO:0000269|PubMed:16479011}. Functions as a redox-dependent negative regulator of theWnt signaling pathway, possibly by preventing ubiquitination ofDVL3 by the BCR(KLHL12) complex. May also function as atranscriptional regulator act as a regulator of proteinphosphatase 2A (PP2A) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOM1L2chr17:17787948chr17:729318ENST00000379504-51520_152167508DomainVHS
TgeneNXNchr17:17787948chr17:729318ENST00000336868-08167_321120436DomainThioredoxin
TgeneNXNchr17:17787948chr17:729318ENST00000537628-08167_321-129187DomainThioredoxin
TgeneNXNchr17:17787948chr17:729318ENST00000575801-08167_32112328DomainThioredoxin

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOM1L2chr17:17787948chr17:729318ENST00000318094-11420_152-28463DomainVHS
HgeneTOM1L2chr17:17787948chr17:729318ENST00000318094-114219_307-28463DomainGAT
HgeneTOM1L2chr17:17787948chr17:729318ENST00000379504-515219_307167508DomainGAT
HgeneTOM1L2chr17:17787948chr17:729318ENST00000395739-11420_152-31463DomainVHS
HgeneTOM1L2chr17:17787948chr17:729318ENST00000395739-114219_307-31463DomainGAT
HgeneTOM1L2chr17:17787948chr17:729318ENST00000478943-1920_152-189241DomainVHS
HgeneTOM1L2chr17:17787948chr17:729318ENST00000478943-19219_307-189241DomainGAT
HgeneTOM1L2chr17:17787948chr17:729318ENST00000581396-41420_152117458DomainVHS
HgeneTOM1L2chr17:17787948chr17:729318ENST00000581396-414219_307117458DomainGAT
HgeneTOM1L2chr17:17787948chr17:729318ENST00000318094-114329_334-28463MotifNote=Clathrin-binding
HgeneTOM1L2chr17:17787948chr17:729318ENST00000379504-515329_334167508MotifNote=Clathrin-binding
HgeneTOM1L2chr17:17787948chr17:729318ENST00000395739-114329_334-31463MotifNote=Clathrin-binding
HgeneTOM1L2chr17:17787948chr17:729318ENST00000478943-19329_334-189241MotifNote=Clathrin-binding
HgeneTOM1L2chr17:17787948chr17:729318ENST00000581396-414329_334117458MotifNote=Clathrin-binding


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FusionGeneSequence for TOM1L2_NXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TOM1L2_ENST00000581396_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_433aa
MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNRNYREVMLALTAWADAFRSSPDLTGVVHI
YEELKRKGVEFPMADLDALSPIHTPQRLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNG
QSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQ
GIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKE

>In-frame_TOM1L2_ENST00000379504_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_483aa
MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNRNYREVMLALTVLETCVKNCGHRFHILVA
NRDFIDSVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGVEFPMADLDALSPIHTPQRLKLWNKYRISNIP
SLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIK
EAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVL
ELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSAR

>In-frame_TOM1L2_ENST00000535933_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_483aa
MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNRNYREVMLALTVLETCVKNCGHRFHILVA
NRDFIDSVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGVEFPMADLDALSPIHTPQRLKLWNKYRISNIP
SLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIK
EAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVL
ELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSAR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TOM1L2_ENST00000581396_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_1299nt
ATGGAGTTCCTCCTGGGGAACCCGTTCAGCACACCAGTGGGGCAGTGCCTCGAAAAGGCAACAGATGGCTCCCTGCAAAGTGAGGATTGG
ACGTTGAATATGGAGATCTGTGACATCATCAATGAGACGGAGGAAGGGCCAAAGGATGCCATTCGAGCCCTGAAGAAGCGGCTCAACGGG
AACCGGAACTACAGAGAGGTGATGCTGGCATTAACAGCATGGGCTGATGCCTTTCGAAGCAGTCCTGATCTCACCGGCGTTGTGCACATA
TATGAGGAGCTGAAGAGGAAAGGGGTTGAATTTCCCATGGCAGACTTGGACGCTCTGTCTCCCATACACACACCACAGCGGCTCAAACTT
TGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTG
ATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGG
CAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGG
GTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTC
AAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAA
GGCATCCCCACGCTCATCATGCTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGG
GAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTA
GATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAG
GAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCT
TTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAAT

>In-frame_TOM1L2_ENST00000379504_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_1449nt
ATGGAGTTCCTCCTGGGGAACCCGTTCAGCACACCAGTGGGGCAGTGCCTCGAAAAGGCAACAGATGGCTCCCTGCAAAGTGAGGATTGG
ACGTTGAATATGGAGATCTGTGACATCATCAATGAGACGGAGGAAGGGCCAAAGGATGCCATTCGAGCCCTGAAGAAGCGGCTCAACGGG
AACCGGAACTACAGAGAGGTGATGCTGGCATTAACAGTGCTGGAGACATGTGTGAAGAACTGTGGCCACCGCTTCCACATCCTTGTGGCC
AACCGAGATTTCATCGACAGTGTTCTGGTCAAAATTATATCTCCCAAGAACAACCCTCCCACCATTGTACAGGACAAAGTGCTTGCTCTG
ATCCAGGCATGGGCTGATGCCTTTCGAAGCAGTCCTGATCTCACCGGCGTTGTGCACATATATGAGGAGCTGAAGAGGAAAGGGGTTGAA
TTTCCCATGGCAGACTTGGACGCTCTGTCTCCCATACACACACCACAGCGGCTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCA
TCACTAATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTC
CCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGG
TCTCACGTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAG
GAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTC
GCCGTCCCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCG
CAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTG
GAGCTCTCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCG
GCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCC
GGGGAGGATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGG
GCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAG

>In-frame_TOM1L2_ENST00000535933_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_1449nt
ATGGAGTTCCTCCTGGGGAACCCGTTCAGCACACCAGTGGGGCAGTGCCTCGAAAAGGCAACAGATGGCTCCCTGCAAAGTGAGGATTGG
ACGTTGAATATGGAGATCTGTGACATCATCAATGAGACGGAGGAAGGGCCAAAGGATGCCATTCGAGCCCTGAAGAAGCGGCTCAACGGG
AACCGGAACTACAGAGAGGTGATGCTGGCATTAACAGTGCTGGAGACATGTGTGAAGAACTGTGGCCACCGCTTCCACATCCTTGTGGCC
AACCGAGATTTCATCGACAGTGTTCTGGTCAAAATTATATCTCCCAAGAACAACCCTCCCACCATTGTACAGGACAAAGTGCTTGCTCTG
ATCCAGGCATGGGCTGATGCCTTTCGAAGCAGTCCTGATCTCACCGGCGTTGTGCACATATATGAGGAGCTGAAGAGGAAAGGGGTTGAA
TTTCCCATGGCAGACTTGGACGCTCTGTCTCCCATACACACACCACAGCGGCTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCA
TCACTAATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTC
CCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGG
TCTCACGTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAG
GAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTC
GCCGTCCCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCG
CAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTG
GAGCTCTCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCG
GCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCC
GGGGAGGATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGG
GCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TOM1L2_ENST00000581396_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_3032nt
GGGGGCAAGTGTCAGTCAGGACGGGAGTCCGGCGGGTTACAGCGGAGGCCTAGGTGGCAGACAGGGGGCCCGGGCCGCTGCGTGTTGTCC
ACCCAAGATGGAGTTCCTCCTGGGGAACCCGTTCAGCACACCAGTGGGGCAGTGCCTCGAAAAGGCAACAGATGGCTCCCTGCAAAGTGA
GGATTGGACGTTGAATATGGAGATCTGTGACATCATCAATGAGACGGAGGAAGGGCCAAAGGATGCCATTCGAGCCCTGAAGAAGCGGCT
CAACGGGAACCGGAACTACAGAGAGGTGATGCTGGCATTAACAGCATGGGCTGATGCCTTTCGAAGCAGTCCTGATCTCACCGGCGTTGT
GCACATATATGAGGAGCTGAAGAGGAAAGGGGTTGAATTTCCCATGGCAGACTTGGACGCTCTGTCTCCCATACACACACCACAGCGGCT
CAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCT
GCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAA
CAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCT
CACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGA
GTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGG
AATCCAAGGCATCCCCACGCTCATCATGCTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGA
CTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCT
TTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGC
CAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGC
TGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTT
TGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAGCGTGGCTCCGGCCTCCTGAGACGTTATTTAAAACTCAGCCTTCT
CCTCCTCCCCCTCCTTCCTTCCGCCCTTGGACTTACCCAGCGTGCCCCGAATCCCACCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTG
TTTCTGCAGTAAACTCCTCAGCCAGCACCCTGGGGTGTGGAATCAGCAGCGGCAGAGTCCACCGTGTTTGGAGACTCTGTTTGGGAGCAC
GGGATGGCCGGGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTCGCAAAGTCACTAGCTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGC
AGAGTGAGCGTGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGACTCTGACGTCGGCACACACGGCCCCGGACGGCCAGAGGGGAACCGCCG
GGTGACACCTGCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCTTAGAGCTGCGGGTGAGGACGTCCTTTTCTAAGCAACACAGTCTTCCT
CGGTCTGAGAGAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGGGGATCTCCAAATGCAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGA
AGAAAAATGTAGCTAAGGTAATGGTTCATATCATACAAACAGCTCCCACGATCCTGAAATTCTGTTAACGAATCCTTCTCTTTGGACATC
TTCCCAAGAAACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTGCACCAGCACGGACCTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCC
TGATCTCTGCTGAGGTGCCCACACCCACGTTCGATCACCCCTGCCATTCCCTTTTATTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTC
GCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACTTCAACCTCCGCCCCCAAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGT
AGCTGGGATTACAGGCACCCGCCACCGTACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCT
CGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCT
TTTCAAAGCAGAACTACAAAGATGAGAAATTACCAGAAGCCTCGCCTTTTCCTAAGCACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGT
GAGGGTGGAGGGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCCTTGTATCGGCCCAGGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTG
ACCCCCGAAAGAGAAACAGACAACTCTGTTCTCAGGATTGGGGATGGACGGCTTCGGCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCA
CTCAGCACTCTGCCAGCCAAGACCATTGATTTGGAAAATCCGGTCCCCACCCGCTAATGAGCTGTTGACACTGTTGTTCCTTGCTGAATT
GGATTGTTGACTTGTAGTTCAGAGGCGTACAACTAGTTGGCGATTAGACTTGTTATGTGATGTTACCAGCCTGAAATGCGATCACCCCGT

>In-frame_TOM1L2_ENST00000379504_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_3169nt
AGTCAGGACGGGAGTCCGGCGGGTTACAGCGGAGGCCTAGGTGGCAGACAGGGGGCCCGGGCCGCTGCGTGTTGTCCACCCAAGATGGAG
TTCCTCCTGGGGAACCCGTTCAGCACACCAGTGGGGCAGTGCCTCGAAAAGGCAACAGATGGCTCCCTGCAAAGTGAGGATTGGACGTTG
AATATGGAGATCTGTGACATCATCAATGAGACGGAGGAAGGGCCAAAGGATGCCATTCGAGCCCTGAAGAAGCGGCTCAACGGGAACCGG
AACTACAGAGAGGTGATGCTGGCATTAACAGTGCTGGAGACATGTGTGAAGAACTGTGGCCACCGCTTCCACATCCTTGTGGCCAACCGA
GATTTCATCGACAGTGTTCTGGTCAAAATTATATCTCCCAAGAACAACCCTCCCACCATTGTACAGGACAAAGTGCTTGCTCTGATCCAG
GCATGGGCTGATGCCTTTCGAAGCAGTCCTGATCTCACCGGCGTTGTGCACATATATGAGGAGCTGAAGAGGAAAGGGGTTGAATTTCCC
ATGGCAGACTTGGACGCTCTGTCTCCCATACACACACCACAGCGGCTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTA
ATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGTCTGGAGTTCCCCTGG
GGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCAC
GTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGGAAGATCAAGGAGGCA
GGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTC
CCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATGCTGGACCCGCAGGGC
GAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTC
TCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAGTCCGAGGCGGCCAAG
CAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAG
GATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATGTCAGCCCGGGCCAAG
TACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATC
TAGCGTGGCTCCGGCCTCCTGAGACGTTATTTAAAACTCAGCCTTCTCCTCCTCCCCCTCCTTCCTTCCGCCCTTGGACTTACCCAGCGT
GCCCCGAATCCCACCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTGTTTCTGCAGTAAACTCCTCAGCCAGCACCCTGGGGTGTGGAAT
CAGCAGCGGCAGAGTCCACCGTGTTTGGAGACTCTGTTTGGGAGCACGGGATGGCCGGGGGCCCGGCCAGAGCGGGGCTGCATGGCTTTC
GCAAAGTCACTAGCTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGCAGAGTGAGCGTGGAGGGCCGGTGGGTCCCGCTCGGGCTCTGAC
TCTGACGTCGGCACACACGGCCCCGGACGGCCAGAGGGGAACCGCCGGGTGACACCTGCGTGGAGGCTGAGCTGAGAAAGGGCCTCCGCT
TAGAGCTGCGGGTGAGGACGTCCTTTTCTAAGCAACACAGTCTTCCTCGGTCTGAGAGAAAAGCAGCCCACTCTTGTGTTCTCAGGCAGG
GGATCTCCAAATGCAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGAAGAAAAATGTAGCTAAGGTAATGGTTCATATCATACAAACAGC
TCCCACGATCCTGAAATTCTGTTAACGAATCCTTCTCTTTGGACATCTTCCCAAGAAACTTAGCCCTGAGTCCTAGGAGGAGCACCTCTG
CACCAGCACGGACCTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCCTGATCTCTGCTGAGGTGCCCACACCCACGTTCGATCACCCCTG
CCATTCCCTTTTATTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACTTCAAC
CTCCGCCCCCAAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCGCCACCGTACCTGGCTAATTTTT
GTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAA
AGTGCTGGGATTACAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCTTTTCAAAGCAGAACTACAAAGATGAGAAATTACCAGAAGCCTC
GCCTTTTCCTAAGCACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGTGAGGGTGGAGGGCGCGTCAGCCACGGGTGGGCCTTGTGTCGCC
TTGTATCGGCCCAGGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTGACCCCCGAAAGAGAAACAGACAACTCTGTTCTCAGGATTGGGG
ATGGACGGCTTCGGCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCACTCAGCACTCTGCCAGCCAAGACCATTGATTTGGAAAATCCGG
TCCCCACCCGCTAATGAGCTGTTGACACTGTTGTTCCTTGCTGAATTGGATTGTTGACTTGTAGTTCAGAGGCGTACAACTAGTTGGCGA
TTAGACTTGTTATGTGATGTTACCAGCCTGAAATGCGATCACCCCGTAGGAAATAAAGCAGGCATCTCTGGACCTCATCCACCCTGGGCC

>In-frame_TOM1L2_ENST00000535933_chr17_17787948_-_NXN_ENST00000336868_chr17_729318_-_3192nt
AGAGTGGGGAGGGGGCAAGTGTCAGTCAGGACGGGAGTCCGGCGGGTTACAGCGGAGGCCTAGGTGGCAGACAGGGGGCCCGGGCCGCTG
CGTGTTGTCCACCCAAGATGGAGTTCCTCCTGGGGAACCCGTTCAGCACACCAGTGGGGCAGTGCCTCGAAAAGGCAACAGATGGCTCCC
TGCAAAGTGAGGATTGGACGTTGAATATGGAGATCTGTGACATCATCAATGAGACGGAGGAAGGGCCAAAGGATGCCATTCGAGCCCTGA
AGAAGCGGCTCAACGGGAACCGGAACTACAGAGAGGTGATGCTGGCATTAACAGTGCTGGAGACATGTGTGAAGAACTGTGGCCACCGCT
TCCACATCCTTGTGGCCAACCGAGATTTCATCGACAGTGTTCTGGTCAAAATTATATCTCCCAAGAACAACCCTCCCACCATTGTACAGG
ACAAAGTGCTTGCTCTGATCCAGGCATGGGCTGATGCCTTTCGAAGCAGTCCTGATCTCACCGGCGTTGTGCACATATATGAGGAGCTGA
AGAGGAAAGGGGTTGAATTTCCCATGGCAGACTTGGACGCTCTGTCTCCCATACACACACCACAGCGGCTCAAACTTTGGAACAAATACC
GAATTTCCAACATTCCATCACTAATATTCCTCGACGCCACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACC
CAGAAGGTCTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGAAACAATGGGCAGTCTCTGGAGA
GCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTCTCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAAT
CCTACCGGAAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAGGAGTCCTTCAAACAGTACTTCA
GTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAGGCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGC
TCATCATGCTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAGGACTGCCGGGAGTTCCCCTGGC
ACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCCGCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATG
ACGGAGAGTCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAAGCCAAAGAGGAGGAGGCACCCC
TTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGACTCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCC
TGGACATGTCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCCTTTGTGAATGACTTCCTAGCAG
AGAAGCTCAAACCGGAGCCCATCTAGCGTGGCTCCGGCCTCCTGAGACGTTATTTAAAACTCAGCCTTCTCCTCCTCCCCCTCCTTCCTT
CCGCCCTTGGACTTACCCAGCGTGCCCCGAATCCCACCACCCAAGTGTCCAGCCTCTCTGTGGTGCCTTGTTTCTGCAGTAAACTCCTCA
GCCAGCACCCTGGGGTGTGGAATCAGCAGCGGCAGAGTCCACCGTGTTTGGAGACTCTGTTTGGGAGCACGGGATGGCCGGGGGCCCGGC
CAGAGCGGGGCTGCATGGCTTTCGCAAAGTCACTAGCTTTTGGTGAAGGATCTGCCAGGGTGTCCTGGGCAGAGTGAGCGTGGAGGGCCG
GTGGGTCCCGCTCGGGCTCTGACTCTGACGTCGGCACACACGGCCCCGGACGGCCAGAGGGGAACCGCCGGGTGACACCTGCGTGGAGGC
TGAGCTGAGAAAGGGCCTCCGCTTAGAGCTGCGGGTGAGGACGTCCTTTTCTAAGCAACACAGTCTTCCTCGGTCTGAGAGAAAAGCAGC
CCACTCTTGTGTTCTCAGGCAGGGGATCTCCAAATGCAAAAGGAAGCTTGTAGAGGTTTTTTGGGTGAGAAGAAAAATGTAGCTAAGGTA
ATGGTTCATATCATACAAACAGCTCCCACGATCCTGAAATTCTGTTAACGAATCCTTCTCTTTGGACATCTTCCCAAGAAACTTAGCCCT
GAGTCCTAGGAGGAGCACCTCTGCACCAGCACGGACCTCTCGCTCCACCCAGCTCTGTGCCCAAGGCCCCTGATCTCTGCTGAGGTGCCC
ACACCCACGTTCGATCACCCCTGCCATTCCCTTTTATTTTCTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTG
GCACCATCTTGGCTCACTTCAACCTCCGCCCCCAAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCC
GCCACCGTACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTG
ATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCGCCGTGCCCGGCCCCCTTTTCTTTTCAAAGCAGAACTACAAA
GATGAGAAATTACCAGAAGCCTCGCCTTTTCCTAAGCACCAGCGGAAGGAGCTGTGCCCCGGGATGGAGTGAGGGTGGAGGGCGCGTCAG
CCACGGGTGGGCCTTGTGTCGCCTTGTATCGGCCCAGGTAGGTTGTTGGCCTCTTACTTGGGCTGACCTGACCCCCGAAAGAGAAACAGA
CAACTCTGTTCTCAGGATTGGGGATGGACGGCTTCGGCCAAGCGTTTTAGCCTCATTCACTCAGGCCCCACTCAGCACTCTGCCAGCCAA
GACCATTGATTTGGAAAATCCGGTCCCCACCCGCTAATGAGCTGTTGACACTGTTGTTCCTTGCTGAATTGGATTGTTGACTTGTAGTTC
AGAGGCGTACAACTAGTTGGCGATTAGACTTGTTATGTGATGTTACCAGCCTGAAATGCGATCACCCCGTAGGAAATAAAGCAGGCATCT


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FusionGenePPI for TOM1L2_NXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOM1L2TOLLIP, NEDD4, CLTC, APP, AHCYL1, LAGE3, IGBP1, SULT1A1, RCN1, SIN3A, S100A4, DSTN, DFFA, UBA2, S100A6, SRXN1, SERPINH1, UBC, LAPTM5, RNF11, MYO6, BAG3, MAP3K1, AGL, XPO1, SMURF1, CUEDC1, SZRD1, NDUFA6, WBP2NXNCHMP6, USP3, ELAVL1, C9orf9, GAS2L1, ARRDC1, CRY2, DUSP4, DVL3, CGB2, GORASP1, CDH23, NCKAP1, ABI1, WASF1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TOM1L2_NXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TOM1L2_NXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNXNC0009404Colorectal Neoplasms1CTD_human