|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39017 |
FusionGeneSummary for TNS3_HSPA1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNS3_HSPA1L | Fusion gene ID: 39017 | Hgene | Tgene | Gene symbol | TNS3 | HSPA1L | Gene ID | 64759 | 3305 |
| Gene name | tensin 3 | heat shock protein family A (Hsp70) member 1 like | |
| Synonyms | TEM6|TENS1 | HSP70-1L|HSP70-HOM|HSP70T|hum70t | |
| Cytomap | 7p12.3 | 6p21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6 | heat shock 70 kDa protein 1-likeheat shock 10kDa protein 1-likeheat shock 70 kDa protein 1-Homheat shock 70 kDa protein 1Lheat shock 70kD protein-like 1heat shock 70kDa protein 1-like | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q68CZ2 | P34931 | |
| Ensembl transtripts involved in fusion gene | ENST00000311160, ENST00000355730, ENST00000398879, ENST00000442536, ENST00000458317, ENST00000474346, | ENST00000375654, ENST00000417199, ENST00000426095, ENST00000456772, ENST00000417601, ENST00000383390, | |
| Fusion gene scores | * DoF score | 15 X 13 X 9=1755 | 3 X 1 X 3=9 |
| # samples | 17 | 3 | |
| ** MAII score | log2(17/1755*10)=-3.36786437905422 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TNS3 [Title/Abstract] AND HSPA1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HSPA1L | GO:0042026 | protein refolding | 21231916 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A18L-01A | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000311160 | ENST00000375654 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-5UTR | ENST00000311160 | ENST00000417199 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000311160 | ENST00000426095 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000311160 | ENST00000456772 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000311160 | ENST00000417601 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000311160 | ENST00000383390 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-5UTR | ENST00000355730 | ENST00000375654 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-5UTR | ENST00000355730 | ENST00000417199 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000355730 | ENST00000426095 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000355730 | ENST00000456772 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000355730 | ENST00000417601 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000355730 | ENST00000383390 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-5UTR | ENST00000398879 | ENST00000375654 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-5UTR | ENST00000398879 | ENST00000417199 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000398879 | ENST00000426095 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000398879 | ENST00000456772 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000398879 | ENST00000417601 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| 5CDS-intron | ENST00000398879 | ENST00000383390 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-5UTR | ENST00000442536 | ENST00000375654 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-5UTR | ENST00000442536 | ENST00000417199 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000442536 | ENST00000426095 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000442536 | ENST00000456772 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000442536 | ENST00000417601 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000442536 | ENST00000383390 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-5UTR | ENST00000458317 | ENST00000375654 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-5UTR | ENST00000458317 | ENST00000417199 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000458317 | ENST00000426095 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000458317 | ENST00000456772 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000458317 | ENST00000417601 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000458317 | ENST00000383390 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-5UTR | ENST00000474346 | ENST00000375654 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-5UTR | ENST00000474346 | ENST00000417199 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000474346 | ENST00000426095 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000474346 | ENST00000456772 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000474346 | ENST00000417601 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
| intron-intron | ENST00000474346 | ENST00000383390 | TNS3 | chr7 | 47319762 | - | HSPA1L | chr6 | 31779762 | - |
Top |
FusionProtFeatures for TNS3_HSPA1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNS3 | HSPA1L |
| May play a role in actin remodeling. Involved in thedissociation of the integrin-tensin-actin complex. EGF activatesTNS4 and down-regulates TNS3 which results in capping the tail ofITGB1. Seems to be involved in mammary cell migration. May beinvolved in cell migration and bone development (By similarity).{ECO:0000250, ECO:0000269|PubMed:17643115}. | Molecular chaperone implicated in a wide variety ofcellular processes, including protection of the proteome fromstress, folding and transport of newly synthesized polypeptides,activation of proteolysis of misfolded proteins and the formationand dissociation of protein complexes. Plays a pivotal role in theprotein quality control system, ensuring the correct folding ofproteins, the re-folding of misfolded proteins and controlling thetargeting of proteins for subsequent degradation. This is achievedthrough cycles of ATP binding, ATP hydrolysis and ADP release,mediated by co-chaperones. The affinity for polypeptides isregulated by its nucleotide bound state. In the ATP-bound form, ithas a low affinity for substrate proteins. However, uponhydrolysis of the ATP to ADP, it undergoes a conformational changethat increases its affinity for substrate proteins. It goesthrough repeated cycles of ATP hydrolysis and nucleotide exchange,which permits cycles of substrate binding and release(PubMed:26865365). Positive regulator of PRKN translocation todamaged mitochondria (PubMed:24270810).{ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TNS3_HSPA1L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TNS3_HSPA1L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNS3 | MAT2B, APOA1, ERBB2, ERBB3, PTPN12, DNPEP, GANAB, TRIM47, ENO1, MOV10, NXF1, EGFR, SRPK2, XPO1, CTNNAL1, DMD, DTNB, PYCR2, SNTB1, SNTB2, UTRN, EPHA4, TRIM25 | HSPA1L | RUVBL1, RUVBL2, H2AFX, SIRT1, SIRT3, PSMA3, PCK1, ARRB2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, INPPL1, CBL, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, HSPA5, HSPA6, UQCRC1, MRPL1, NDUFB7, PTPLAD1, MCAM, KIAA2013, FIGNL1, SLC25A3, RPL3, TOMM22, TXN2, NUP214, CDC5L, CYB5R3, ATP5A1, MRPS36, DNAJC19, NDUFB9, DLAT, SHMT1, STOML2, NDUFS2, RAB11A, RRBP1, PIGS, DNAJC12, NDUFV1, RANBP2, HSPA1A, ESR1, TRAF3IP1, HSP90AA1, DCP1A, DCP1B, METTL21A, METTL21B, METTL21C, METTL22, UBL4A, CFTR, HDAC6, BAG3, PARK2, CAMK1D, CLU, GAPDH, NUCB2, RAP1GDS1, UBQLN1, IPO7, XPO1, TRIM25, ZBTB1, BAG4, DNAJC7, STUB1, STAU1, AIRE, CDC20, CEP250, CEP57, NEDD1, TP53, TUBG1, SIRT6, CCNI2, CCAR2, LPGAT1, LRRC28, POC1A, VASH1, TNFAIP1, KCTD13, DND1, EPN3, CYP2W1, ALDH3B1, SMAP1, TBC1D22A, TTLL3, CCDC117, DENND2D, CDK3, PTEN, NINL, NPHP4, NEK8, SNCA, MAP3K1, RELA, TAB1, MAP3K7, NFKB1, TRAF2, ID2, GAN, SKI, MCM5, MCM2, UHRF2, DPF3, MAPRE2, HSF1, PPP1CA, CCDC28B, EDEM3, CCND2, UBE2S, BRCA1, HIF1A, AMFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TNS3_HSPA1L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TNS3_HSPA1L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HSPA1L | C0036341 | Schizophrenia | 4 | PSYGENET |
| Tgene | HSPA1L | C0013182 | Drug Allergy | 1 | CTD_human |
| Tgene | HSPA1L | C0024517 | Single major depressive episode | 1 | PSYGENET |
| Tgene | HSPA1L | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET |
| Tgene | HSPA1L | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | HSPA1L | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|