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Fusion gene ID: 39011 |
FusionGeneSummary for TNS3_ALG13 |
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Fusion gene information | Fusion gene name: TNS3_ALG13 | Fusion gene ID: 39011 | Hgene | Tgene | Gene symbol | TNS3 | ALG13 | Gene ID | 64759 | 79868 |
Gene name | tensin 3 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | |
Synonyms | TEM6|TENS1 | CDG1S|CXorf45|EIEE36|GLT28D1|MDS031|TDRD13|YGL047W | |
Cytomap | 7p12.3 | Xq23 | |
Type of gene | protein-coding | protein-coding | |
Description | tensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6 | putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferaseUDP-N-acetylglucosamine transferase subunit ALG13 homologasparagine-linked glycosylation 13 homologg | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q68CZ2 | Q9NP73 | |
Ensembl transtripts involved in fusion gene | ENST00000311160, ENST00000355730, ENST00000398879, ENST00000442536, ENST00000458317, ENST00000474346, | ENST00000371979, ENST00000251943, ENST00000394780, ENST00000470971, | |
Fusion gene scores | * DoF score | 15 X 13 X 9=1755 | 2 X 2 X 2=8 |
# samples | 17 | 2 | |
** MAII score | log2(17/1755*10)=-3.36786437905422 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TNS3 [Title/Abstract] AND ALG13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-FX-A2QS-01A | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000311160 | ENST00000371979 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-5UTR | ENST00000311160 | ENST00000251943 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-5UTR | ENST00000311160 | ENST00000394780 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-intron | ENST00000311160 | ENST00000470971 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-3CDS | ENST00000355730 | ENST00000371979 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000355730 | ENST00000251943 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000355730 | ENST00000394780 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-intron | ENST00000355730 | ENST00000470971 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-3CDS | ENST00000398879 | ENST00000371979 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000398879 | ENST00000251943 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000398879 | ENST00000394780 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-intron | ENST00000398879 | ENST00000470971 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-3CDS | ENST00000442536 | ENST00000371979 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000442536 | ENST00000251943 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000442536 | ENST00000394780 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-intron | ENST00000442536 | ENST00000470971 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-3CDS | ENST00000458317 | ENST00000371979 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000458317 | ENST00000251943 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-5UTR | ENST00000458317 | ENST00000394780 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
intron-intron | ENST00000458317 | ENST00000470971 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-3CDS | ENST00000474346 | ENST00000371979 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-5UTR | ENST00000474346 | ENST00000251943 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-5UTR | ENST00000474346 | ENST00000394780 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
5UTR-intron | ENST00000474346 | ENST00000470971 | TNS3 | chr7 | 47621649 | - | ALG13 | chrX | 110925360 | + |
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FusionProtFeatures for TNS3_ALG13 |
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Hgene | Tgene |
TNS3 | ALG13 |
May play a role in actin remodeling. Involved in thedissociation of the integrin-tensin-actin complex. EGF activatesTNS4 and down-regulates TNS3 which results in capping the tail ofITGB1. Seems to be involved in mammary cell migration. May beinvolved in cell migration and bone development (By similarity).{ECO:0000250, ECO:0000269|PubMed:17643115}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNS3_ALG13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNS3_ALG13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNS3 | MAT2B, APOA1, ERBB2, ERBB3, PTPN12, DNPEP, GANAB, TRIM47, ENO1, MOV10, NXF1, EGFR, SRPK2, XPO1, CTNNAL1, DMD, DTNB, PYCR2, SNTB1, SNTB2, UTRN, EPHA4, TRIM25 | ALG13 | ATN1, ATXN1L, RERE, SAV1, RBFOX1, PITX1, HOXA1, MAPKBP1, CGRRF1, RHOU, EGFL6, PLOD1, ELAVL2, PRG2, WDFY3, CDC16, PLSCR4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNS3_ALG13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNS3_ALG13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ALG13 | C3550904 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 36 | 2 | UNIPROT |