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Fusion gene ID: 39 |
FusionGeneSummary for AAK1_WFDC13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AAK1_WFDC13 | Fusion gene ID: 39 | Hgene | Tgene | Gene symbol | AAK1 | WFDC13 | Gene ID | 22848 | 164237 |
| Gene name | AP2 associated kinase 1 | WAP four-disulfide core domain 13 | |
| Synonyms | - | C20orf138|WAP13|dJ601O1.3 | |
| Cytomap | 2p13.3 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP2-associated protein kinase 1adaptor-associated kinase 1 | WAP four-disulfide core domain protein 13protease inhibitor WAP13protein WFDC13 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q2M2I8 | Q8IUB5 | |
| Ensembl transtripts involved in fusion gene | ENST00000409068, ENST00000409085, ENST00000406297, ENST00000470281, | ENST00000305479, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 2 X 1 X 2=4 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: AAK1 [Title/Abstract] AND WFDC13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AAK1 | GO:0006468 | protein phosphorylation | 17494869|18657069 |
| Hgene | AAK1 | GO:0032880 | regulation of protein localization | 18657069 |
| Hgene | AAK1 | GO:0045747 | positive regulation of Notch signaling pathway | 21464124 |
| Hgene | AAK1 | GO:0050821 | protein stabilization | 21464124 |
| Hgene | AAK1 | GO:2000369 | regulation of clathrin-dependent endocytosis | 18657069 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-22-A5C4-01A | AAK1 | chr2 | 69732701 | - | WFDC13 | chr20 | 44333083 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000409068 | ENST00000305479 | AAK1 | chr2 | 69732701 | - | WFDC13 | chr20 | 44333083 | + |
| In-frame | ENST00000409085 | ENST00000305479 | AAK1 | chr2 | 69732701 | - | WFDC13 | chr20 | 44333083 | + |
| In-frame | ENST00000406297 | ENST00000305479 | AAK1 | chr2 | 69732701 | - | WFDC13 | chr20 | 44333083 | + |
| intron-3CDS | ENST00000470281 | ENST00000305479 | AAK1 | chr2 | 69732701 | - | WFDC13 | chr20 | 44333083 | + |
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FusionProtFeatures for AAK1_WFDC13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AAK1 | WFDC13 |
| Regulates clathrin-mediated endocytosis byphosphorylating the AP2M1/mu2 subunit of the adaptor proteincomplex 2 (AP-2) which ensures high affinity binding of AP-2 tocargo membrane proteins during the initial stages of endocytosis.Isoform 1 and isoform 2 display similar levels of kinase activitytowards AP2M1. Regulates phosphorylation of other AP-2 subunits aswell as AP-2 localization and AP-2-mediated internalization ofligand complexes. Phosphorylates NUMB and regulates its cellularlocalization, promoting NUMB localization to endosomes. Binds toand stabilizes the activated form of NOTCH1, increases itslocalization in endosomes and regulates its transcriptionalactivity. {ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124}. | Putative acid-stable proteinase inhibitor.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AAK1_WFDC13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AAK1_ENST00000409085_chr2_69732701_-_WFDC13_ENST00000305479_chr20_44333083_+_821aa MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE IQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAIC DGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQA QGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRA GHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTEYILEPPPCISAPENCTHLCTMQEDCEKGFQCCSSFCGIVCSSETFQKRNRIKH >In-frame_AAK1_ENST00000406297_chr2_69732701_-_WFDC13_ENST00000305479_chr20_44333083_+_821aa MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE IQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAIC DGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQA QGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRA GHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTEYILEPPPCISAPENCTHLCTMQEDCEKGFQCCSSFCGIVCSSETFQKRNRIKH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AAK1_ENST00000409085_chr2_69732701_-_WFDC13_ENST00000305479_chr20_44333083_+_2463nt ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA ATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGAGTAGCGGTGATGTATGG GAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAGGCTTTACAGAGAATGAA GTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACCGGGACCTGAAGGTTGAA AACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATCCACAAACTGAGGGAGTC AATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACAGTGGCAAAATCATCACT ACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAAGTCAGGTGGCAATTTGT GATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGGAACCAGACCCTGACAAA AGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTACAGAACTCTCCCATTCCT GCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAGATCCCATTCCCACCACA GAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCCAGCCAGCGCTGACACCC CGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTGTTCCCCAACCAAAACCC CAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGACGCCTTCTACTCAGGCC CAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGCAGCAACAGCCACCGCCA GCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATCCAGCAACCCAGAAACCA GCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGCAGCAGCAGCAGCAACAA CAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGCAAAAGCCCACTATGGCA GCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAGCCCCAGTAAGACAACAG CCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCCCCAAAACCCAACGTGCT GGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGCTGCTCCAGGCAGCTGCA GCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAAACGTTTATAATCCTTCA GAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGGACTTTGCCAAGCTTGGG GAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTGATGCTTTTGCTACGACC TCATTTTCTGCTGGAACTGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACTGTACTCACCTGTGTACAATGCAGGAA GATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACATTTCAAAAGCGCAACAGAATCAAACAC >In-frame_AAK1_ENST00000406297_chr2_69732701_-_WFDC13_ENST00000305479_chr20_44333083_+_2463nt ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA ATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGAGTAGCGGTGATGTATGG GAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAGGCTTTACAGAGAATGAA GTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACCGGGACCTGAAGGTTGAA AACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATCCACAAACTGAGGGAGTC AATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACAGTGGCAAAATCATCACT ACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAAGTCAGGTGGCAATTTGT GATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGGAACCAGACCCTGACAAA AGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTACAGAACTCTCCCATTCCT GCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAGATCCCATTCCCACCACA GAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCCAGCCAGCGCTGACACCC CGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTGTTCCCCAACCAAAACCC CAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGACGCCTTCTACTCAGGCC CAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGCAGCAACAGCCACCGCCA GCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATCCAGCAACCCAGAAACCA GCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGCAGCAGCAGCAGCAACAA CAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGCAAAAGCCCACTATGGCA GCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAGCCCCAGTAAGACAACAG CCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCCCCAAAACCCAACGTGCT GGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGCTGCTCCAGGCAGCTGCA GCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAAACGTTTATAATCCTTCA GAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGGACTTTGCCAAGCTTGGG GAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTGATGCTTTTGCTACGACC TCATTTTCTGCTGGAACTGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACTGTACTCACCTGTGTACAATGCAGGAA GATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACATTTCAAAAGCGCAACAGAATCAAACAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AAK1_ENST00000409085_chr2_69732701_-_WFDC13_ENST00000305479_chr20_44333083_+_3822nt GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACTGTACTCACC TGTGTACAATGCAGGAAGATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACATTTCAAAAGC GCAACAGAATCAAACACAAGGGCTCAGAAGTCATCATGCCTGCCAACTGAGGCATATTTCCTAGATCATTTTGCCTCTACGATGTTTTTT CTTGGTCCACCTTTAGGAAGGTATTGAGAAGCAAGAAACTGGAGGCCCAATATCTAACCTGCAAATCGTTTTTGAGTTTGGCAATAAAGG CTAATCTACCATAAAACTCTTGAAGCTTAAGCTTTAGGTCAACACTTGCAAGAGCCCCTTCCAAAGCTCAGCACAGTTTCCTCCTGGGAT GAGGAGAGGAATCAGAAACCCCACTTTGGCATAGAGACAAGCAGCACTGTTCCAGTCCAGGGATGCTGTGTGTGCCCTGGTGGTGGTCTT AAGGACCTACCACATCAACATCTGGACAACCCTCACTGATTACCTGCCCTTGGTTGCACTCATCAGGCTAATTGATCCCATATTTAACCT CAAGGAGAAATATCAACCAGACACTGCATGGCAACCTCCTTGGGGCCAGCCTTCAAGGCTTCATGGCCATATCATGAACCCAGGACAGGC ACAGTGGGGGTGGTGAGGACCTGATAGAGTTGGATCAGTGACTAAGAGGCTGCAATAAGGTGCCATGAAATCAAAATCAAAGGGCTAGAA CTCTCCAAGGTCTTGCCCCCGGCATGTAGCACCACCTGAGCCAGAAACTGCAGAGGACATGACAGTGTGGCATTACTGATAAGTTATGGA AATGGAAATAATCTTTCCTAAACTACCAATAATAACTTTAAATTTTTGATCAACCATGCTAGAGCAAAGATTGAATTATCCTTCTGTTCT CTCTACAGAAATGATATAAAAACTATAGTCATAAGAAGAGACAATCAAAAATAATCAGCCATAAAATATTAAAAAGGTATTATAAAGGTA TTTAAAATAATAATAATAAAGTGTTATTTTCCTGGGATTCATGATATTTGATATATTCGTAAGCTTTTGTTAAGTTTGTAATTTGTTGCA >In-frame_AAK1_ENST00000406297_chr2_69732701_-_WFDC13_ENST00000305479_chr20_44333083_+_3822nt GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGAGTATATCTTGGAACCTCCACCCTGCATATCAGCACCTGAAAACTGTACTCACC TGTGTACAATGCAGGAAGATTGCGAGAAAGGATTTCAGTGCTGTTCCTCCTTCTGTGGGATAGTCTGTTCATCAGAAACATTTCAAAAGC GCAACAGAATCAAACACAAGGGCTCAGAAGTCATCATGCCTGCCAACTGAGGCATATTTCCTAGATCATTTTGCCTCTACGATGTTTTTT CTTGGTCCACCTTTAGGAAGGTATTGAGAAGCAAGAAACTGGAGGCCCAATATCTAACCTGCAAATCGTTTTTGAGTTTGGCAATAAAGG CTAATCTACCATAAAACTCTTGAAGCTTAAGCTTTAGGTCAACACTTGCAAGAGCCCCTTCCAAAGCTCAGCACAGTTTCCTCCTGGGAT GAGGAGAGGAATCAGAAACCCCACTTTGGCATAGAGACAAGCAGCACTGTTCCAGTCCAGGGATGCTGTGTGTGCCCTGGTGGTGGTCTT AAGGACCTACCACATCAACATCTGGACAACCCTCACTGATTACCTGCCCTTGGTTGCACTCATCAGGCTAATTGATCCCATATTTAACCT CAAGGAGAAATATCAACCAGACACTGCATGGCAACCTCCTTGGGGCCAGCCTTCAAGGCTTCATGGCCATATCATGAACCCAGGACAGGC ACAGTGGGGGTGGTGAGGACCTGATAGAGTTGGATCAGTGACTAAGAGGCTGCAATAAGGTGCCATGAAATCAAAATCAAAGGGCTAGAA CTCTCCAAGGTCTTGCCCCCGGCATGTAGCACCACCTGAGCCAGAAACTGCAGAGGACATGACAGTGTGGCATTACTGATAAGTTATGGA AATGGAAATAATCTTTCCTAAACTACCAATAATAACTTTAAATTTTTGATCAACCATGCTAGAGCAAAGATTGAATTATCCTTCTGTTCT CTCTACAGAAATGATATAAAAACTATAGTCATAAGAAGAGACAATCAAAAATAATCAGCCATAAAATATTAAAAAGGTATTATAAAGGTA TTTAAAATAATAATAATAAAGTGTTATTTTCCTGGGATTCATGATATTTGATATATTCGTAAGCTTTTGTTAAGTTTGTAATTTGTTGCA 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FusionGenePPI for AAK1_WFDC13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AAK1 | AP2M1, ATP13A2, APP, AP2A1, AP2B1, NTRK1, DYNLT1, XPO1, CLTB, CLTC, GAK, HSPA5, GTSE1, ANLN, CDH1, AP2S1, REPS1, RUNDC3A, RALBP1, PLEC, PPIP5K2, SEC24B, CCDC88A, EYA4, UBE2D2, LUZP1, URGCP, NUP88, DVL3, QSER1, WNK1 | WFDC13 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AAK1_WFDC13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AAK1_WFDC13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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