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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38989

FusionGeneSummary for TNRC6B_TMEM184B

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC6B_TMEM184B
Fusion gene ID: 38989
HgeneTgene
Gene symbol

TNRC6B

TMEM184B

Gene ID

23112

25829

Gene nametrinucleotide repeat containing 6Btransmembrane protein 184B
Synonyms-C22orf5|FM08|HS5O6A|HSPC256
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 6B proteintransmembrane protein 184Bputative MAPK-activating protein FM08
Modification date2018051920180523
UniProtAcc

Q9UPQ9

Q9Y519

Ensembl transtripts involved in fusion geneENST00000301923, ENST00000402203, 
ENST00000454349, ENST00000335727, 
ENST00000497559, 		ENST00000361906, 
ENST00000361684, ENST00000504337, 
Fusion gene scores* DoF score19 X 13 X 12=29646 X 5 X 7=210
# samples 238
** MAII scorelog2(23/2964*10)=-3.68783968136146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC6B [Title/Abstract] AND TMEM184B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-WY-A859-01ATNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
ChiTaRS3.1DA995057TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000301923ENST00000361906TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000301923ENST00000361684TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
5CDS-intronENST00000301923ENST00000504337TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000402203ENST00000361906TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000402203ENST00000361684TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
5CDS-intronENST00000402203ENST00000504337TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000454349ENST00000361906TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000454349ENST00000361684TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-intronENST00000454349ENST00000504337TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000335727ENST00000361906TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000335727ENST00000361684TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-intronENST00000335727ENST00000504337TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000497559ENST00000361906TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000497559ENST00000361684TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-intronENST00000497559ENST00000504337TNRC6Bchr22

40552186

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000301923ENST00000361906TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-5UTRENST00000301923ENST00000361684TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-intronENST00000301923ENST00000504337TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-5UTRENST00000402203ENST00000361906TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-5UTRENST00000402203ENST00000361684TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-intronENST00000402203ENST00000504337TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
5CDS-5UTRENST00000454349ENST00000361906TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
5CDS-5UTRENST00000454349ENST00000361684TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
5CDS-intronENST00000454349ENST00000504337TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
5CDS-5UTRENST00000335727ENST00000361906TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
5CDS-5UTRENST00000335727ENST00000361684TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
5CDS-intronENST00000335727ENST00000504337TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-5UTRENST00000497559ENST00000361906TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-5UTRENST00000497559ENST00000361684TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-
intron-intronENST00000497559ENST00000504337TNRC6Bchr22

40574145

+TMEM184Bchr22

38644027

-

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FusionProtFeatures for TNRC6B_TMEM184B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC6B

Q9UPQ9

TMEM184B

Q9Y519

Plays a role in RNA-mediated gene silencing by bothmicro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Requiredfor miRNA-dependent translational repression and siRNA-dependentendonucleolytic cleavage of complementary mRNAs by argonautefamily proteins. As scaffoldng protein associates with argonauteproteins bound to partially complementary mRNAs and simultaneouslycan recruit CCR4-NOT and PAN deadenylase complexes.{ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051,ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}. May activate the MAP kinase signaling pathway.{ECO:0000269|PubMed:12761501}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNRC6B_TMEM184B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNRC6B_TMEM184B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNRC6BAGO1, AGO2, GIGYF2, UBC, AGO3, AGO4, PABPC1, CUL3, CUL2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, UBQLN4, LATS2, SAV1, CARM1, APBA3, CSK, FBRS, GMPS, NUP155, FLAD1, CHEK1, GARS, TRIM65, PFAS, NXF1, BMI1, CNOT1, CNOT2, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT3, PAN3, BTRC, MED4, MED23, SSX2IP, OFD1, B9D2, MKS1, CEP97, CEP104, CEP120, CEP152, CNTROB, CEP128, CEP135, CEP44, CEP63, CNTRL, FBF1, NINL, NIN, NPHP1, ODF2, RPGRIP1L, SCLT1, SASS6, RPGRIP1, STIL, CENPJ, CLTC, KAT6A, GTSE1, RNASEH2B, G3BP1, BRCA1TMEM184BLPAR6, ERGIC3, SNIP1, REN, CLASRP, CCDC9, ACIN1, INPPL1, TIMM23, FPR2, GPR21, C17orf85, SLC22A9, CLEC2D, YTHDF1, ZFYVE27, PDCD1, ABCG8, BBS4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNRC6B_TMEM184B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNRC6B_TMEM184B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNRC6BC0032460Polycystic Ovary Syndrome1CTD_human
TgeneTMEM184BC0023893Liver Cirrhosis, Experimental1CTD_human