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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38981

FusionGeneSummary for TNRC6B_FAM19A5

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC6B_FAM19A5
Fusion gene ID: 38981
HgeneTgene
Gene symbol

TNRC6B

FAM19A5

Gene ID

23112

25817

Gene nametrinucleotide repeat containing 6Bfamily with sequence similarity 19 member A5, C-C motif chemokine like
Synonyms-QLLK5208|TAFA-5|TAFA5|UNQ5208
Cytomap

22q13.1

22q13.32

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 6B proteinprotein FAM19A5TAFA protein 5chemokine-like protein TAFA-5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
Modification date2018051920180329
UniProtAcc

Q9UPQ9

Q7Z5A7

Ensembl transtripts involved in fusion geneENST00000301923, ENST00000402203, 
ENST00000454349, ENST00000335727, 
ENST00000497559, 		ENST00000402357, 
ENST00000358295, ENST00000473898, 
ENST00000406880, 
Fusion gene scores* DoF score19 X 13 X 12=29646 X 3 X 5=90
# samples 236
** MAII scorelog2(23/2964*10)=-3.68783968136146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC6B [Title/Abstract] AND FAM19A5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7659-01ATNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000301923ENST00000402357TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
Frame-shiftENST00000301923ENST00000358295TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
5CDS-3UTRENST00000301923ENST00000473898TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
5CDS-3UTRENST00000301923ENST00000406880TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
In-frameENST00000402203ENST00000402357TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
Frame-shiftENST00000402203ENST00000358295TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
5CDS-3UTRENST00000402203ENST00000473898TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
5CDS-3UTRENST00000402203ENST00000406880TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3CDSENST00000454349ENST00000402357TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3CDSENST00000454349ENST00000358295TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3UTRENST00000454349ENST00000473898TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3UTRENST00000454349ENST00000406880TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3CDSENST00000335727ENST00000402357TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3CDSENST00000335727ENST00000358295TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3UTRENST00000335727ENST00000473898TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3UTRENST00000335727ENST00000406880TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3CDSENST00000497559ENST00000402357TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3CDSENST00000497559ENST00000358295TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3UTRENST00000497559ENST00000473898TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+
intron-3UTRENST00000497559ENST00000406880TNRC6Bchr22

40552186

+FAM19A5chr22

49145651

+

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FusionProtFeatures for TNRC6B_FAM19A5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC6B

Q9UPQ9

FAM19A5

Q7Z5A7

Plays a role in RNA-mediated gene silencing by bothmicro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Requiredfor miRNA-dependent translational repression and siRNA-dependentendonucleolytic cleavage of complementary mRNAs by argonautefamily proteins. As scaffoldng protein associates with argonauteproteins bound to partially complementary mRNAs and simultaneouslycan recruit CCR4-NOT and PAN deadenylase complexes.{ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051,ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000301923+4241_39371030Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000402203+4241_39371030Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000335727+1211_39-651724Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000454349+1231_39-711834Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000301923+4241150_1220371030Compositional biasNote=Gln-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000301923+424825_880371030Compositional biasNote=Pro-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000335727+1211150_1220-651724Compositional biasNote=Gln-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000335727+121825_880-651724Compositional biasNote=Pro-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000402203+4241150_1220371030Compositional biasNote=Gln-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000402203+424825_880371030Compositional biasNote=Pro-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000454349+1231150_1220-711834Compositional biasNote=Gln-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000454349+123825_880-711834Compositional biasNote=Pro-rich
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000301923+4241648_1720371030DomainNote=RRM
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000335727+1211648_1720-651724DomainNote=RRM
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000402203+4241648_1720371030DomainNote=RRM
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000454349+1231648_1720-711834DomainNote=RRM
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000301923+4241472_1490371030RegionNote=PABPC1-interacting motif-2 (PAM2)
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000335727+1211472_1490-651724RegionNote=PABPC1-interacting motif-2 (PAM2)
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000402203+4241472_1490371030RegionNote=PABPC1-interacting motif-2 (PAM2)
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000454349+1231472_1490-711834RegionNote=PABPC1-interacting motif-2 (PAM2)
TgeneFAM19A5chr22:40552186chr22:49145651ENST00000358295+2415_37123126TransmembraneHelical
TgeneFAM19A5chr22:40552186chr22:49145651ENST00000402357+2415_37130133TransmembraneHelical
TgeneFAM19A5chr22:40552186chr22:49145651ENST00000406880+1315_375154TransmembraneHelical


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FusionGeneSequence for TNRC6B_FAM19A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TNRC6B_ENST00000301923_chr22_40552186_+_FAM19A5_ENST00000402357_chr22_49145651_+_40aa

>In-frame_TNRC6B_ENST00000402203_chr22_40552186_+_FAM19A5_ENST00000402357_chr22_49145651_+_40aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TNRC6B_ENST00000301923_chr22_40552186_+_FAM19A5_ENST00000402357_chr22_49145651_+_122nt
ATGCAAACCAATGAGGGAGAAGTATCGGAAGAAAGCAGTTCCAAGGTGGAACAGGAGGATTTTGTAATGGAAGGGCATGGCAAGACTCCA

>In-frame_TNRC6B_ENST00000402203_chr22_40552186_+_FAM19A5_ENST00000402357_chr22_49145651_+_122nt
ATGCAAACCAATGAGGGAGAAGTATCGGAAGAAAGCAGTTCCAAGGTGGAACAGGAGGATTTTGTAATGGAAGGGCATGGCAAGACTCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TNRC6B_ENST00000301923_chr22_40552186_+_FAM19A5_ENST00000402357_chr22_49145651_+_1400nt
TTGTTTATTTTGTTTTTAGTTTTTGGGGTCCCCGTGCTGCTGCAAGGCGAAACGGGAGGGAGTGACCCCTGCGCCCCTCAGTCCCCCCTA
CGACGTCGCCTCCATAGTCTGCGGAGAAGCGGAGACTGCGCGCCTCGCCTCACAGCGAAACGCCGCGCACTCGGAGCCGGCACGGCTCGG
CGGGTTGTGGTTTTTTGCACTGAATGTAACCTAGACTCATCTTCACGGGCTTGTGTTGCCCCAGGTACTGTCAAAGGCAGTATTTTTGTG
TTTCTGCAGAGTTTTGCACAAAATCTGTTCCCATGCAAACCAATGAGGGAGAAGTATCGGAAGAAAGCAGTTCCAAGGTGGAACAGGAGG
ATTTTGTAATGGAAGGGCATGGCAAGACTCCACCTCCTGGTGAAGAAAGCAAACAGTCTCCTGACAAACACAGCCCCTGAGGGGCCCCGG
GAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACTTCACCCGTTCTCTGCCGCCCGCCCACTC
CGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCCAGCCGACCCGAGGAGGCCGGACTCAGAC
ACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCCCAGCCCCCGCCGACCGTGGCGTTGGCCC
TGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCAGCCCGCCTGAGACACGACGCCTGCCCCA
GGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTATTTTCTTATACTTTCAGTATACTCCATAG
ACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGCTTGTGCGGGCGGGAGGGCAATGGTGGCA
GAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAGGAGCACCCCGCGCACCCTCGGAGGACGG
GCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACGCCGGGAACGCAGGCCGCTTTATTCCTCT
GTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTCTTCTACAGCTCCATTTTTGATAGTTGGA
TAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCATTTAGCTCCAGAAAGCAAAGAAAACTCG

>In-frame_TNRC6B_ENST00000402203_chr22_40552186_+_FAM19A5_ENST00000402357_chr22_49145651_+_1333nt
CGGCCCGCGGAGGCGCGTCCGCCCCTGGCTGGCGGTGGCAGAGGGAGGCGTCAGGCCTCGGATCCTCGGGTCCCTGCGCAGCGTCCCGGC
CTGTGTGCAGGACCTGCGTGACAAGGGTTGTGGTTTTTTGCACTGAATGTAACCTAGACTCATCTTCACGGGCTTGTGTTGCCCCAGGTA
CTGTCAAAGGCAGTATTTTTGTGTTTCTGCAGAGTTTTGCACAAAATCTGTTCCCATGCAAACCAATGAGGGAGAAGTATCGGAAGAAAG
CAGTTCCAAGGTGGAACAGGAGGATTTTGTAATGGAAGGGCATGGCAAGACTCCACCTCCTGGTGAAGAAAGCAAACAGTCTCCTGACAA
ACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACTTCACC
CGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCCAGCCG
ACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCCCAGCC
CCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCAGCCCG
CCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTATTTTCT
TATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGCTTGTG
CGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAGGAGCA
CCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACGCCGGG
AACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTCTTCTA
CAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCATTTAG


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FusionGenePPI for TNRC6B_FAM19A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNRC6BAGO1, AGO2, GIGYF2, UBC, AGO3, AGO4, PABPC1, CUL3, CUL2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, UBQLN4, LATS2, SAV1, CARM1, APBA3, CSK, FBRS, GMPS, NUP155, FLAD1, CHEK1, GARS, TRIM65, PFAS, NXF1, BMI1, CNOT1, CNOT2, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT3, PAN3, BTRC, MED4, MED23, SSX2IP, OFD1, B9D2, MKS1, CEP97, CEP104, CEP120, CEP152, CNTROB, CEP128, CEP135, CEP44, CEP63, CNTRL, FBF1, NINL, NIN, NPHP1, ODF2, RPGRIP1L, SCLT1, SASS6, RPGRIP1, STIL, CENPJ, CLTC, KAT6A, GTSE1, RNASEH2B, G3BP1, BRCA1FAM19A5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000301923+4241_994371030argonaute proteins
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000335727+1211_994-651724argonaute proteins
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000402203+4241_994371030argonaute proteins
HgeneTNRC6Bchr22:40552186chr22:49145651ENST00000454349+1231_994-711834argonaute proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNRC6B_FAM19A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNRC6B_FAM19A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNRC6BC0032460Polycystic Ovary Syndrome1CTD_human