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Fusion gene ID: 38972 |
FusionGeneSummary for TNRC6A_PRKCB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC6A_PRKCB | Fusion gene ID: 38972 | Hgene | Tgene | Gene symbol | TNRC6A | PRKCB | Gene ID | 27327 | 5579 |
| Gene name | trinucleotide repeat containing 6A | protein kinase C beta | |
| Synonyms | CAGH26|GW1|GW182|TNRC6 | PKC-beta|PKCB|PRKCB1|PRKCB2 | |
| Cytomap | 16p12.1 | 16p12.2-p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8NDV7 | P05771 | |
| Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000321728, ENST00000303531, ENST00000482000, ENST00000498058, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 13 X 9 X 10=1170 |
| # samples | 7 | 14 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1170*10)=-3.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNRC6A [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
| Tgene | PRKCB | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0882-01A | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315183 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| In-frame | ENST00000315183 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000315183 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000315183 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-intron | ENST00000562829 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 3UTR-intron | ENST00000562829 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| In-frame | ENST00000395799 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| In-frame | ENST00000395799 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000395799 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| 5CDS-intron | ENST00000395799 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-3CDS | ENST00000432286 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-3CDS | ENST00000432286 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-intron | ENST00000432286 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
| intron-intron | ENST00000432286 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
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FusionProtFeatures for TNRC6A_PRKCB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC6A | PRKCB |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | + | 11 | 17 | 601_671 | 464 | 674 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | + | 11 | 17 | 601_671 | 464 | 672 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | + | 0 | 2 | 173_260 | -32 | 58 | Domain | C2 |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | + | 0 | 2 | 342_600 | -32 | 58 | Domain | Protein kinase |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | + | 0 | 2 | 601_671 | -32 | 58 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | + | 0 | 2 | 348_356 | -32 | 58 | Nucleotide binding | ATP |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | + | 0 | 2 | 101_151 | -32 | 58 | Zinc finger | Phorbol-ester/DAG-type 2 |
| Tgene | >PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | + | 0 | 2 | 36_86 | -32 | 58 | Zinc finger | Phorbol-ester/DAG-type 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 7_54 | 17 | 1914 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 7_54 | 17 | 1963 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 192_365 | 17 | 1914 | Compositional bias | Note=Ser-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 93_127 | 17 | 1914 | Compositional bias | Note=Gln-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 192_365 | 17 | 1963 | Compositional bias | Note=Ser-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 93_127 | 17 | 1963 | Compositional bias | Note=Gln-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 1781_1853 | 17 | 1914 | Domain | Note=RRM |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 1781_1853 | 17 | 1963 | Domain | Note=RRM |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 1604_1622 | 17 | 1914 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Hgene | >TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 1604_1622 | 17 | 1963 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | + | 11 | 17 | 173_260 | 464 | 674 | Domain | C2 |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | + | 11 | 17 | 342_600 | 464 | 674 | Domain | Protein kinase |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | + | 11 | 17 | 173_260 | 464 | 672 | Domain | C2 |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | + | 11 | 17 | 342_600 | 464 | 672 | Domain | Protein kinase |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | + | 11 | 17 | 348_356 | 464 | 674 | Nucleotide binding | ATP |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | + | 11 | 17 | 348_356 | 464 | 672 | Nucleotide binding | ATP |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | + | 11 | 17 | 101_151 | 464 | 674 | Zinc finger | Phorbol-ester/DAG-type 2 |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | + | 11 | 17 | 36_86 | 464 | 674 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | + | 11 | 17 | 101_151 | 464 | 672 | Zinc finger | Phorbol-ester/DAG-type 2 |
| Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | + | 11 | 17 | 36_86 | 464 | 672 | Zinc finger | Phorbol-ester/DAG-type 1 |
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FusionGeneSequence for TNRC6A_PRKCB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_PRKCB_ENST00000321728_chr16_24192111_+_225aa MRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDT >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_PRKCB_ENST00000303531_chr16_24192111_+_227aa MRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAE >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_PRKCB_ENST00000321728_chr16_24192111_+_225aa MRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDT >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_PRKCB_ENST00000303531_chr16_24192111_+_227aa MRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_PRKCB_ENST00000321728_chr16_24192111_+_675nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAG GGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTAC ATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGG CAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAA GCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCAT GCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACC TCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTT >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_PRKCB_ENST00000303531_chr16_24192111_+_681nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAG GGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTAC ATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGG CAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAA GCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCAT GCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAA AACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAA >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_PRKCB_ENST00000321728_chr16_24192111_+_675nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAG GGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTAC ATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGG CAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAA GCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCAT GCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACC TCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTT >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_PRKCB_ENST00000303531_chr16_24192111_+_681nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAG GGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTAC ATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGG CAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAA GCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCAT GCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAA AACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_PRKCB_ENST00000321728_chr16_24192111_+_1320nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC GTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGT AAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTAT GGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAA CTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAA CACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTT GAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCT GTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTC ATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGA TTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTAC ATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGAC AATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTAC AGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGT >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_PRKCB_ENST00000303531_chr16_24192111_+_6623nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC GTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGT AAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTAT GGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAA CTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAA CACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTT GAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCA GTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAA CCCGAAGTCAAGAGCTAAGTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGT TTTTCATTGCCAAGTTGCATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGA GCATCTCTATGAGATGGGATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTT TCCGCAGCATGTCAGCTAAGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAA CCATCCAATCTGTGGATAATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTG CCTAAGAGGAATCCCTCTATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTG TAAACTCAAAGTTAAGATGATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAG GGCAACCAGCTTGGGTGCTACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCA TTTGGCACCACTCTCTGAAACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTT TGGGGTTTTGTTTCTGTTGTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAA TATGTATTCAAATGTTATTAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGG GAATGGGATTTGTTACAAATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGA TGGTTGTATTCCTCACTTTGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTT CTAGCATCGAGATACAATAAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACC TAAACTACAAAGTGGGAACTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGG AGGGGCGGGGGCTGTGGCCCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCC CAAAGTCAAGTTTAGAGACCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATA TTCTTTCTAGCAAGCAGCTTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGG CAGCAGGTGACTCCCCCTCCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCA GAAGTTCCAGGGCTTCTGAGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAA TGGGGTTTGGATTTCTGCTTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTG TCCCCACTGTGGTGGCAATCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCG GAGCAAAGCTCCCTCACTTTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCT GGGTGTCCTGTCCAGAAAGTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATC TGGTGGTTGGATCATGATCCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCT GAGACAACTTTAGAAAACAATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAA AGGAAGGAAGGAAAGAAGGAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGC CATTATTTTTCAAAAGTTTAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTT CTACCACTTCCTTTTCTATCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGG ACCTTCTTGGGGGATTAATGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCA ACCTCAAAGAAATGATCTCAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCAC AGGACAAAGTCCATAAAAGCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTT TCCAAGGTGGGGCTGGTCAGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCT AAAAAAAAGGCAGCTTTGTGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCC CTAACACAGTTCAGTTCATACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTT TGCCTCAGAGTAAAGTTTCTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATA ATTACAAACAACCTACTGTGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTC TCTCCAAGAAATTCTCCAAGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGAT AATTAAAGGATGCTAAAGTGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAA CACCGGAAGTAACATGCCGAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCA GGTGGGACATGGTAGAGATGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTG CTCCTGAGTTCAGTGTGCCCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTA TCTCAGGGGAGCAGCCACAAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTA GTGCCCATTAGGGGGCTAAACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTA TAATCTGAGGCAACTTTGGCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACA GCCATGGGGTTGTCCCTCCAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAAT CTTGGGCAAGCCACCCTGCCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTG GGTGTGGTGATGATGAGGAAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCT GATGTTCCCTGGTGAGACTTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATG CCAGACTTACTAGGAGAATCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCT TTAAGCTTTGGGTTTTCTCTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTA GACTGTGGGTGGATTTTCGAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGG GGGCAGAGTAGATGGGCAGCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGC TCTACCTAATGATTATTTCTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACA CACACACACACACACACACACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTT TCTTAGAAAATTTCCACCACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTT TCAGCACAGGGCTCTTTCTGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACG CTGTGTTAATGTGTTTACTTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAAC TGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATG TGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGG TGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAA AATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCA AAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATT CTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGG >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_PRKCB_ENST00000321728_chr16_24192111_+_1302nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC AGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGAT GGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGG TGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATG GAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTG GGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAG CCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACT GATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAAT GCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTG GCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTT TAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTG TCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCT TCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTT >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_PRKCB_ENST00000303531_chr16_24192111_+_6605nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC AGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGAT GGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGG TGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATG GAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTG GGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAG CCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGAC CAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAA GTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGTTTTTCATTGCCAAGTTGC ATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGG ATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTTTCCGCAGCATGTCAGCTA AGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAACCATCCAATCTGTGGATA ATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCT ATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTGTAAACTCAAAGTTAAGAT GATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGC TACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCATTTGGCACCACTCTCTGA AACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTT GTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAATATGTATTCAAATGTTAT TAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGGGAATGGGATTTGTTACAA ATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGATGGTTGTATTCCTCACTT TGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTTCTAGCATCGAGATACAAT AAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACCTAAACTACAAAGTGGGAA CTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGC CCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGA CCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGC TTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCT CCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTG AGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGC TTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAA TCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACT TTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAA GTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATCTGGTGGTTGGATCATGAT CCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCTGAGACAACTTTAGAAAAC AATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAG GAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTT TAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTA TCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGGACCTTCTTGGGGGATTAA TGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCAACCTCAAAGAAATGATCT CAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCACAGGACAAAGTCCATAAAA GCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTC AGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTG TGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCA TACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTT CTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATAATTACAAACAACCTACTG TGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCA AGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGATAATTAAAGGATGCTAAAG TGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAACACCGGAAGTAACATGCC GAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGA TGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTGCTCCTGAGTTCAGTGTGC CCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTATCTCAGGGGAGCAGCCAC AAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTA AACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTATAATCTGAGGCAACTTTG GCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTC CAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAATCTTGGGCAAGCCACCCTG CCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGG AAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCTGATGTTCCCTGGTGAGAC TTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATGCCAGACTTACTAGGAGAA TCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCT CTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTAGACTGTGGGTGGATTTTC GAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCA GCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGCTCTACCTAATGATTATTT CTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACACACACACACACACACACA CACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTTTCTTAGAAAATTTCCACC ACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTC TGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTAC TTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAAC TCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACT CCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCA ACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATA AGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATA CCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGA ATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAA |
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FusionGenePPI for TNRC6A_PRKCB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNRC6A | AGO2, WNK1, UBC, AGO4, PABPC1, UBR5, CUL3, AGO1, AGO3, SAV1, TRIM65, CEP250, TRIP13, CNOT1, CNOT3, CNOT6L, CNOT7, CNOT10, PAN2, CNOT2, CNOT6, CNOT8, PAN3, BTRC, SSX2IP, CEP152, CNTROB, CEP135, CNTRL, NINL, ODF2, RPGRIP1L, CENPJ, ITGB4, CLTB, CLTC, PICALM, GTSE1, FANCM, KIAA2013, RQCD1, EYA2, SMARCB1, BRCA1 | PRKCB | RASGRP3, NCAM1, ADRBK1, BTK, GNB2L1, CSF2RB, YWHAG, GNA12, GNA13, RIPK4, RGS2, TIAM1, PDLIM5, NCF1, PDPK1, AFAP1, LMNB1, CDK1, RBCK1, HSPA4, IKBKG, HIST1H3A, PRKCB, DDX58, TRIM41, EGFR, TERF1, TINF2, RNF31, IBTK, KCNA5, TOP2A, HIST1H1A, LSP1, H1F0, CARD11, SDC2, ITGB2, PPP2R4, PPP1CA, TNFRSF1A, FN1, HSP90AA1, GSK3A, CASR, RB1, SYT6, HIST1H1B, MARCKS, NUMB, LYN, MBP, PRKCD, EP300, SHCBP1, DAB2, AKT1, IKBKB, CHUK, GSK3B, ARRB2, ITGB3, PRKCA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 1_932 | 17 | 1914 | argonaute family proteins |
| Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 1_932 | 17 | 1963 | argonaute family proteins |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC6A_PRKCB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PRKCB | P05771 | DB08862 | Cholecystokinin | Protein kinase C beta type | small molecule | approved|investigational |
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RelatedDiseases for TNRC6A_PRKCB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRKCB | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | PRKCB | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | PRKCB | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | PRKCB | C0018800 | Cardiomegaly | 1 | CTD_human |
| Tgene | PRKCB | C0020456 | Hyperglycemia | 1 | CTD_human |
| Tgene | PRKCB | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Tgene | PRKCB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | PRKCB | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | PRKCB | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | PRKCB | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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