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Fusion gene ID: 38971 |
FusionGeneSummary for TNRC6A_METTL9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC6A_METTL9 | Fusion gene ID: 38971 | Hgene | Tgene | Gene symbol | TNRC6A | METTL9 | Gene ID | 27327 | 51108 |
| Gene name | trinucleotide repeat containing 6A | methyltransferase like 9 | |
| Synonyms | CAGH26|GW1|GW182|TNRC6 | CGI-81|DREV|DREV1|PAP1 | |
| Cytomap | 16p12.1 | 16p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | methyltransferase-like protein 9CTB-31N19.3DORA reverse strand protein 1p53 activated protein 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8NDV7 | Q9H1A3 | |
| Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000358154, ENST00000396014, ENST00000563026, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TNRC6A [Title/Abstract] AND METTL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-O2-A52S-01A | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315183 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| Frame-shift | ENST00000315183 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 5CDS-intron | ENST00000315183 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 3UTR-intron | ENST00000562829 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| In-frame | ENST00000395799 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| Frame-shift | ENST00000395799 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| 5CDS-intron | ENST00000395799 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| intron-3CDS | ENST00000432286 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| intron-3CDS | ENST00000432286 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
| intron-intron | ENST00000432286 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
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FusionProtFeatures for TNRC6A_METTL9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC6A | METTL9 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 7_54 | 1 | 1914 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 7_54 | 1 | 1963 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 192_365 | 1 | 1914 | Compositional bias | Note=Ser-rich |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 93_127 | 1 | 1914 | Compositional bias | Note=Gln-rich |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 192_365 | 1 | 1963 | Compositional bias | Note=Ser-rich |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 93_127 | 1 | 1963 | Compositional bias | Note=Gln-rich |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 1781_1853 | 1 | 1914 | Domain | Note=RRM |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 1781_1853 | 1 | 1963 | Domain | Note=RRM |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 1604_1622 | 1 | 1914 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 1604_1622 | 1 | 1963 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Tgene | METTL9 | chr16:24741167 | chr16:21666548 | ENST00000358154 | + | 3 | 5 | 44_47 | 250 | 319 | Compositional bias | Note=Poly-Ala |
| Tgene | METTL9 | chr16:24741167 | chr16:21666548 | ENST00000396014 | + | 3 | 5 | 44_47 | 250 | 318 | Compositional bias | Note=Poly-Ala |
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FusionGeneSequence for TNRC6A_METTL9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_70aa >In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_70aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_211nt ATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGT TTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGA >In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_211nt ATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGT TTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_2399nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGTAGGTGGCAAGTGGGAGAAACCATCAGA AATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTT CACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAAC ACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCC TTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAA AGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGA TATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGA AGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGT TATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTA GCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTT CAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTC AGATACAGAACTTCAGGGACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATC ACTCATGTCCCATACACTGAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATG CAACTAAAAATGTTTTAATTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGT TTATTATTTGCCAAGAATATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAA ATGCTGCCATAGAGGAACCCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCA GTAATAACAGAAATGTCAATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATT AAGTATTCTCATTTATATGCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAA TTACTTTATTATTCATTAAGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTA TGTGATTTATGCAAAATTGTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGA TTGTAAAAATAGAAAGAGGAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAG GGGTTGCTGTTAGACTGTCAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTT TATGCTCTAATAAGAAAAATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAG TAGTTTCTCAAAAAAATCTGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACAT TTCCTATCGGGTCTTGAAATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCG >In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_2381nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGG ACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCT GTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCT TCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTA AATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCT TTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATT GCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTG TCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGT TTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTG GCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGG AGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTCAGATACAGAACTTCAGGG ACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATCACTCATGTCCCATACACT GAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATGCAACTAAAAATGTTTTAA TTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGTTTATTATTTGCCAAGAAT ATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAAATGCTGCCATAGAGGAAC CCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCAGTAATAACAGAAATGTCA ATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATTAAGTATTCTCATTTATAT GCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAATTACTTTATTATTCATTA AGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTATGTGATTTATGCAAAATT GTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGATTGTAAAAATAGAAAGAG GAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAGGGGTTGCTGTTAGACTGT CAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTTTATGCTCTAATAAGAAAA ATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAGTAGTTTCTCAAAAAAATC TGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACATTTCCTATCGGGTCTTGAA ATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCGTAAATGGAATCATGTTTT |
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FusionGenePPI for TNRC6A_METTL9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNRC6A | AGO2, WNK1, UBC, AGO4, PABPC1, UBR5, CUL3, AGO1, AGO3, SAV1, TRIM65, CEP250, TRIP13, CNOT1, CNOT3, CNOT6L, CNOT7, CNOT10, PAN2, CNOT2, CNOT6, CNOT8, PAN3, BTRC, SSX2IP, CEP152, CNTROB, CEP135, CNTRL, NINL, ODF2, RPGRIP1L, CENPJ, ITGB4, CLTB, CLTC, PICALM, GTSE1, FANCM, KIAA2013, RQCD1, EYA2, SMARCB1, BRCA1 | METTL9 | CHMP6, ZFP36, SLC39A4, P2RY8, TMEFF1, GCNT2, WBP1, DPEP2, CHRNA9, LYPD6, SLC39A5, ARMC6, CLEC2D, C12orf49, ST3GAL1, ADAM32, NOMO1, ARL15, AGPAT3, SERINC1, TMEM120B, NCLN, TMEM120A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 1_932 | 1 | 1914 | argonaute family proteins |
| Hgene | TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 1_932 | 1 | 1963 | argonaute family proteins |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC6A_METTL9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC6A_METTL9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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