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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38971

FusionGeneSummary for TNRC6A_METTL9

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC6A_METTL9
Fusion gene ID: 38971
HgeneTgene
Gene symbol

TNRC6A

METTL9

Gene ID

27327

51108

Gene nametrinucleotide repeat containing 6Amethyltransferase like 9
SynonymsCAGH26|GW1|GW182|TNRC6CGI-81|DREV|DREV1|PAP1
Cytomap

16p12.1

16p12.2

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDamethyltransferase-like protein 9CTB-31N19.3DORA reverse strand protein 1p53 activated protein 1
Modification date2018051920180519
UniProtAcc

Q8NDV7

Q9H1A3

Ensembl transtripts involved in fusion geneENST00000315183, ENST00000562829, 
ENST00000395799, ENST00000432286, 
ENST00000358154, ENST00000396014, 
ENST00000563026, 
Fusion gene scores* DoF score7 X 6 X 6=2523 X 3 X 3=27
# samples 73
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TNRC6A [Title/Abstract] AND METTL9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNRC6A

GO:0035278

miRNA mediated inhibition of translation

17671087


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-O2-A52S-01ATNRC6Achr16

24741167

+METTL9chr16

21666548

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000315183ENST00000358154TNRC6Achr16

24741167

+METTL9chr16

21666548

+
Frame-shiftENST00000315183ENST00000396014TNRC6Achr16

24741167

+METTL9chr16

21666548

+
5CDS-intronENST00000315183ENST00000563026TNRC6Achr16

24741167

+METTL9chr16

21666548

+
3UTR-3CDSENST00000562829ENST00000358154TNRC6Achr16

24741167

+METTL9chr16

21666548

+
3UTR-3CDSENST00000562829ENST00000396014TNRC6Achr16

24741167

+METTL9chr16

21666548

+
3UTR-intronENST00000562829ENST00000563026TNRC6Achr16

24741167

+METTL9chr16

21666548

+
In-frameENST00000395799ENST00000358154TNRC6Achr16

24741167

+METTL9chr16

21666548

+
Frame-shiftENST00000395799ENST00000396014TNRC6Achr16

24741167

+METTL9chr16

21666548

+
5CDS-intronENST00000395799ENST00000563026TNRC6Achr16

24741167

+METTL9chr16

21666548

+
intron-3CDSENST00000432286ENST00000358154TNRC6Achr16

24741167

+METTL9chr16

21666548

+
intron-3CDSENST00000432286ENST00000396014TNRC6Achr16

24741167

+METTL9chr16

21666548

+
intron-intronENST00000432286ENST00000563026TNRC6Achr16

24741167

+METTL9chr16

21666548

+

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FusionProtFeatures for TNRC6A_METTL9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC6A

Q8NDV7

METTL9

Q9H1A3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000315183+1247_5411914Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000395799+1257_5411963Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000315183+124192_36511914Compositional biasNote=Ser-rich
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000315183+12493_12711914Compositional biasNote=Gln-rich
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000395799+125192_36511963Compositional biasNote=Ser-rich
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000395799+12593_12711963Compositional biasNote=Gln-rich
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000315183+1241781_185311914DomainNote=RRM
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000395799+1251781_185311963DomainNote=RRM
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000315183+1241604_162211914RegionNote=PABPC1-interacting motif-2 (PAM2)
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000395799+1251604_162211963RegionNote=PABPC1-interacting motif-2 (PAM2)
TgeneMETTL9chr16:24741167chr16:21666548ENST00000358154+3544_47250319Compositional biasNote=Poly-Ala
TgeneMETTL9chr16:24741167chr16:21666548ENST00000396014+3544_47250318Compositional biasNote=Poly-Ala


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FusionGeneSequence for TNRC6A_METTL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_70aa

>In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_70aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_211nt
ATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGT
TTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGA

>In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_211nt
ATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGT
TTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_2399nt
GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG
GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGTAGGTGGCAAGTGGGAGAAACCATCAGA
AATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTT
CACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAAC
ACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCC
TTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAA
AGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGA
TATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGA
AGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGT
TATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTA
GCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTT
CAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTC
AGATACAGAACTTCAGGGACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATC
ACTCATGTCCCATACACTGAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATG
CAACTAAAAATGTTTTAATTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGT
TTATTATTTGCCAAGAATATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAA
ATGCTGCCATAGAGGAACCCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCA
GTAATAACAGAAATGTCAATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATT
AAGTATTCTCATTTATATGCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAA
TTACTTTATTATTCATTAAGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTA
TGTGATTTATGCAAAATTGTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGA
TTGTAAAAATAGAAAGAGGAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAG
GGGTTGCTGTTAGACTGTCAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTT
TATGCTCTAATAAGAAAAATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAG
TAGTTTCTCAAAAAAATCTGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACAT
TTCCTATCGGGTCTTGAAATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCG

>In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_2381nt
GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC
TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGG
ACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCT
GTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCT
TCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTA
AATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCT
TTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATT
GCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTG
TCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGT
TTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTG
GCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGG
AGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTCAGATACAGAACTTCAGGG
ACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATCACTCATGTCCCATACACT
GAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATGCAACTAAAAATGTTTTAA
TTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGTTTATTATTTGCCAAGAAT
ATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAAATGCTGCCATAGAGGAAC
CCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCAGTAATAACAGAAATGTCA
ATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATTAAGTATTCTCATTTATAT
GCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAATTACTTTATTATTCATTA
AGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTATGTGATTTATGCAAAATT
GTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGATTGTAAAAATAGAAAGAG
GAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAGGGGTTGCTGTTAGACTGT
CAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTTTATGCTCTAATAAGAAAA
ATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAGTAGTTTCTCAAAAAAATC
TGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACATTTCCTATCGGGTCTTGAA
ATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCGTAAATGGAATCATGTTTT


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FusionGenePPI for TNRC6A_METTL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNRC6AAGO2, WNK1, UBC, AGO4, PABPC1, UBR5, CUL3, AGO1, AGO3, SAV1, TRIM65, CEP250, TRIP13, CNOT1, CNOT3, CNOT6L, CNOT7, CNOT10, PAN2, CNOT2, CNOT6, CNOT8, PAN3, BTRC, SSX2IP, CEP152, CNTROB, CEP135, CNTRL, NINL, ODF2, RPGRIP1L, CENPJ, ITGB4, CLTB, CLTC, PICALM, GTSE1, FANCM, KIAA2013, RQCD1, EYA2, SMARCB1, BRCA1METTL9CHMP6, ZFP36, SLC39A4, P2RY8, TMEFF1, GCNT2, WBP1, DPEP2, CHRNA9, LYPD6, SLC39A5, ARMC6, CLEC2D, C12orf49, ST3GAL1, ADAM32, NOMO1, ARL15, AGPAT3, SERINC1, TMEM120B, NCLN, TMEM120A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000315183+1241_93211914argonaute family proteins
HgeneTNRC6Achr16:24741167chr16:21666548ENST00000395799+1251_93211963argonaute family proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNRC6A_METTL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNRC6A_METTL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource