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Fusion gene ID: 38971 |
FusionGeneSummary for TNRC6A_METTL9 |
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Fusion gene information | Fusion gene name: TNRC6A_METTL9 | Fusion gene ID: 38971 | Hgene | Tgene | Gene symbol | TNRC6A | METTL9 | Gene ID | 27327 | 51108 |
Gene name | trinucleotide repeat containing 6A | methyltransferase like 9 | |
Synonyms | CAGH26|GW1|GW182|TNRC6 | CGI-81|DREV|DREV1|PAP1 | |
Cytomap | 16p12.1 | 16p12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | methyltransferase-like protein 9CTB-31N19.3DORA reverse strand protein 1p53 activated protein 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8NDV7 | Q9H1A3 | |
Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000358154, ENST00000396014, ENST00000563026, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 3 X 3 X 3=27 |
# samples | 7 | 3 | |
** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TNRC6A [Title/Abstract] AND METTL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-O2-A52S-01A | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000315183 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
Frame-shift | ENST00000315183 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
5CDS-intron | ENST00000315183 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
3UTR-3CDS | ENST00000562829 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
3UTR-3CDS | ENST00000562829 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
3UTR-intron | ENST00000562829 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
In-frame | ENST00000395799 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
Frame-shift | ENST00000395799 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
5CDS-intron | ENST00000395799 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
intron-3CDS | ENST00000432286 | ENST00000358154 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
intron-3CDS | ENST00000432286 | ENST00000396014 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
intron-intron | ENST00000432286 | ENST00000563026 | TNRC6A | chr16 | 24741167 | + | METTL9 | chr16 | 21666548 | + |
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FusionProtFeatures for TNRC6A_METTL9 |
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Hgene | Tgene |
TNRC6A | METTL9 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 7_54 | 1 | 1914 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 7_54 | 1 | 1963 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 192_365 | 1 | 1914 | Compositional bias | Note=Ser-rich |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 93_127 | 1 | 1914 | Compositional bias | Note=Gln-rich |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 192_365 | 1 | 1963 | Compositional bias | Note=Ser-rich |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 93_127 | 1 | 1963 | Compositional bias | Note=Gln-rich |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 1781_1853 | 1 | 1914 | Domain | Note=RRM |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 1781_1853 | 1 | 1963 | Domain | Note=RRM |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 1604_1622 | 1 | 1914 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
Hgene | >TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 1604_1622 | 1 | 1963 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
Tgene | METTL9 | chr16:24741167 | chr16:21666548 | ENST00000358154 | + | 3 | 5 | 44_47 | 250 | 319 | Compositional bias | Note=Poly-Ala |
Tgene | METTL9 | chr16:24741167 | chr16:21666548 | ENST00000396014 | + | 3 | 5 | 44_47 | 250 | 318 | Compositional bias | Note=Poly-Ala |
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FusionGeneSequence for TNRC6A_METTL9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_70aa >In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_70aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_211nt ATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGT TTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGA >In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_211nt ATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGT TTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TNRC6A_ENST00000315183_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_2399nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGTAGGTGGCAAGTGGGAGAAACCATCAGA AATTTTGGAAATCAAAGGACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTT CACCAGACTACCATACCTGTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAAC ACGTGGAGGTCGAAGTCTTCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCC TTGGGGACCGCCATTCTAAATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAA AGACAAAAACCCAACTCTTTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGA TATTTTTTATACTTAATTGCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGA AGACTGGCAATAAAGCTGTCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGT TATTATTCAAGAAAATGTTTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTA GCATTTTTTATTGGTTTGGCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTT CAGACTTGGGGGAAGGGGAGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTC AGATACAGAACTTCAGGGACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATC ACTCATGTCCCATACACTGAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATG CAACTAAAAATGTTTTAATTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGT TTATTATTTGCCAAGAATATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAA ATGCTGCCATAGAGGAACCCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCA GTAATAACAGAAATGTCAATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATT AAGTATTCTCATTTATATGCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAA TTACTTTATTATTCATTAAGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTA TGTGATTTATGCAAAATTGTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGA TTGTAAAAATAGAAAGAGGAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAG GGGTTGCTGTTAGACTGTCAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTT TATGCTCTAATAAGAAAAATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAG TAGTTTCTCAAAAAAATCTGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACAT TTCCTATCGGGTCTTGAAATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCG >In-frame_TNRC6A_ENST00000395799_chr16_24741167_+_METTL9_ENST00000358154_chr16_21666548_+_2381nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGTAGGTGGCAAGTGGGAGAAACCATCAGAAATTTTGGAAATCAAAGG ACAGAACTGGGAAGAACAAGTGAATAGTCTGCCTGAAGTTTTCAGAAAAGCTGGTTTTGTTATCGAAGCTTTCACCAGACTACCATACCT GTGTGAAGGCGACATGTATAATGACTACTACGTTCTGGATGACGCTGTCTTTGTTCTCAAACCAGTATAAACACGTGGAGGTCGAAGTCT TCAGAGTCCGCACCCTCCGGGATGTGCCCTTGGAAGAGGGTCTGTGTTCACAATTACGTGAAGGGAGGACCCTTGGGGACCGCCATTCTA AATATCATGTAGGAATTTAAAAAGCCAAAATACTAATTATTTCTTTGTAGTGTGTAAAGGAATGTTTTTAAAAGACAAAAACCCAACTCT TTGTGGATTTTTATCAACTCTTTACTCAGAGCCACTCTCCAATGCAGGTCACACTCCAATTATGATGGAAGATATTTTTTATACTTAATT GCAGTAGGGACTCATTCCCAGACAAAGCAATAGTCACGACTTCATGGAACCAATCAATGGATTGTTTTTTGAAGACTGGCAATAAAGCTG TCCATTCAATTCCAAATACTGGTTTTAAGGTATAGCCACTGATATTCTTTCATGTTTAGAAATTCTTTCTGTTATTATTCAAGAAAATGT TTTTAATCATGCTAATAAACTTTTTTGGAGATGACTTTGGCATCATGTTTGAATTCATATAAAGCTCCCCTAGCATTTTTTATTGGTTTG GCTTCAGGAGTACCCAAATAGTAGCATTATGAGAATGACGCAGACAATTTGAATAGGGGGGAAGGAAGGCTTCAGACTTGGGGGAAGGGG AGATTATTGCAAATTGCAGTGAACACTGAGTCAGTAAAAAAAAAAAACAGAAACAAAAACCCAGCCTCATTCAGATACAGAACTTCAGGG ACCCCTCCCCCCACCCCCCCAGTTAATGCTGCTGTGAAAAATGCAAAATAACCTGGTTCTGACTTTGTGATCACTCATGTCCCATACACT GAACTTTGTTTTTTTCTGGACAATCTCAGGTTCTCAGAATTGAAACATTCAGTTTTGTCTACTGACAAAATGCAACTAAAAATGTTTTAA TTCAACTTCTTACTCTACACTTATATACCTCTCTCCCAGAGCTTGGCTCTTCCCTGAAATCCTTAAAGGAGTTTATTATTTGCCAAGAAT ATGGTTTGATGAAGACCGTGTCAGACTCATGCATTCTGGAATCCGTGAGTGCCTCCAACCATAAACCCAGAAATGCTGCCATAGAGGAAC CCATTAGCAAGATCAATAACCATCGTGGATATTCCAAAGAGCAGAGCATTTAACCCAGAATCTGAAATCTCAGTAATAACAGAAATGTCA ATATGAGATTGTGGTTATTAACAATATGTTATCCTCACTACTTTATTTCTTTTTTCATCCAGGTGTTTCATTAAGTATTCTCATTTATAT GCTCATAGAAGTCATCAGATCAACACATTCACTCCAACACCTGGGTATAAAGGCGAATTAAAACCTGAAGAATTACTTTATTATTCATTA AGAACTGCATTCCCACATCCTCACACCAATATCTTCCACTGTTACTGTGCAGTCATAATAAGAGTTGGGTTATGTGATTTATGCAAAATT GTTATTGGTGTGTTCTAATGATTTTTTTCCAGGAATTCAAGTAAGTGAAGTACAAATACTTAGCACCATAGATTGTAAAAATAGAAAGAG GAAATGAGAAAACTTAATGTCGTTCTTGTACAGTTGAGTTTTGCTTCTTTATAAACTGTCTGTTAAAATCAGGGGTTGCTGTTAGACTGT CAAGCAGAAGTGATGGATGTTCAAGGAGGCAGGTTGCCCCAAAGTGTTTTCTAACTTTCAAGTAGAGAACTTTATGCTCTAATAAGAAAA ATACAACTCATTCTTAACCACCCCCCCAAAACAGAGAAAACACATACATTTATGCATTTTAAAGATAAAAAGTAGTTTCTCAAAAAAATC TGAAGTTCTCTGAAAACCAGCTTATTAAAAGTGCTGTTTTGTGGTGAAAATTGAAACCAAATCCACTCACATTTCCTATCGGGTCTTGAA ATTCTTGGTGGTGTGTCACCATTCCACTAGATGGCAGTGTTGCTTACTGAGTGTCAATGGCTTTTTTCCCCGTAAATGGAATCATGTTTT |
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FusionGenePPI for TNRC6A_METTL9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNRC6A | AGO2, WNK1, UBC, AGO4, PABPC1, UBR5, CUL3, AGO1, AGO3, SAV1, TRIM65, CEP250, TRIP13, CNOT1, CNOT3, CNOT6L, CNOT7, CNOT10, PAN2, CNOT2, CNOT6, CNOT8, PAN3, BTRC, SSX2IP, CEP152, CNTROB, CEP135, CNTRL, NINL, ODF2, RPGRIP1L, CENPJ, ITGB4, CLTB, CLTC, PICALM, GTSE1, FANCM, KIAA2013, RQCD1, EYA2, SMARCB1, BRCA1 | METTL9 | CHMP6, ZFP36, SLC39A4, P2RY8, TMEFF1, GCNT2, WBP1, DPEP2, CHRNA9, LYPD6, SLC39A5, ARMC6, CLEC2D, C12orf49, ST3GAL1, ADAM32, NOMO1, ARL15, AGPAT3, SERINC1, TMEM120B, NCLN, TMEM120A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000315183 | + | 1 | 24 | 1_932 | 1 | 1914 | argonaute family proteins |
Hgene | TNRC6A | chr16:24741167 | chr16:21666548 | ENST00000395799 | + | 1 | 25 | 1_932 | 1 | 1963 | argonaute family proteins |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC6A_METTL9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC6A_METTL9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |