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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38969

FusionGeneSummary for TNRC6A_LCMT1

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC6A_LCMT1
Fusion gene ID: 38969
HgeneTgene
Gene symbol

TNRC6A

LCMT1

Gene ID

27327

51451

Gene nametrinucleotide repeat containing 6Aleucine carboxyl methyltransferase 1
SynonymsCAGH26|GW1|GW182|TNRC6CGI-68|LCMT|PPMT1
Cytomap

16p12.1

16p12.1

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDaleucine carboxyl methyltransferase 1[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1protein phosphatase methyltransferase 1protein-leucine O-methyltransferase
Modification date2018051920180523
UniProtAcc

Q8NDV7

Q9UIC8

Ensembl transtripts involved in fusion geneENST00000315183, ENST00000562829, 
ENST00000395799, ENST00000432286, 
ENST00000399069, ENST00000380966, 
ENST00000572869, 
Fusion gene scores* DoF score7 X 6 X 6=2521 X 1 X 1=1
# samples 71
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: TNRC6A [Title/Abstract] AND LCMT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNRC6A

GO:0035278

miRNA mediated inhibition of translation

17671087

TgeneLCMT1

GO:0006481

C-terminal protein methylation

10600115


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0765-01ATNRC6Achr16

24741621

+LCMT1chr16

25139796

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000315183ENST00000399069TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
In-frameENST00000315183ENST00000380966TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
5CDS-intronENST00000315183ENST00000572869TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
3UTR-3CDSENST00000562829ENST00000399069TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
3UTR-3CDSENST00000562829ENST00000380966TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
3UTR-intronENST00000562829ENST00000572869TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
In-frameENST00000395799ENST00000399069TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
In-frameENST00000395799ENST00000380966TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
5CDS-intronENST00000395799ENST00000572869TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
intron-3CDSENST00000432286ENST00000399069TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
intron-3CDSENST00000432286ENST00000380966TNRC6Achr16

24741621

+LCMT1chr16

25139796

+
intron-intronENST00000432286ENST00000572869TNRC6Achr16

24741621

+LCMT1chr16

25139796

+

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FusionProtFeatures for TNRC6A_LCMT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC6A

Q8NDV7

LCMT1

Q9UIC8

Methylates the carboxyl group of the C-terminal leucineresidue of protein phosphatase 2A catalytic subunits to formalpha-leucine ester residues. {ECO:0000269|PubMed:10600115}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLCMT1chr16:24741621chr16:25139796ENST00000380966+09171_17237280RegionS-adenosyl-L-methionine binding
TgeneLCMT1chr16:24741621chr16:25139796ENST00000399069+011171_17237335RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000315183+2247_54171914Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000395799+2257_54171963Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000315183+224192_365171914Compositional biasNote=Ser-rich
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000315183+22493_127171914Compositional biasNote=Gln-rich
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000395799+225192_365171963Compositional biasNote=Ser-rich
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000395799+22593_127171963Compositional biasNote=Gln-rich
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000315183+2241781_1853171914DomainNote=RRM
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000395799+2251781_1853171963DomainNote=RRM
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000315183+2241604_1622171914RegionNote=PABPC1-interacting motif-2 (PAM2)
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000395799+2251604_1622171963RegionNote=PABPC1-interacting motif-2 (PAM2)


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FusionGeneSequence for TNRC6A_LCMT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_315aa
MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD
EDLLPSKYFEVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECV
LVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPR

>In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_260aa
MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD
EDLLPSKYFEVDFPMIVTRKLHSIKLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGV

>In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_315aa
MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD
EDLLPSKYFEVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECV
LVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPR

>In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_260aa
MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD
EDLLPSKYFEVDFPMIVTRKLHSIKLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_945nt
ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC
ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT
ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT
GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTA
TCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCA
GATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTG
CTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAG
GTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCA
TTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGA
GCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCA

>In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_780nt
ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC
ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT
ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT
GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTG
ATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTC
ATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTG
GAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTAC
AACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTAC

>In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_945nt
ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC
ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT
ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT
GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTA
TCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCA
GATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTG
CTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAG
GTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCA
TTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGA
GCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCA

>In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_780nt
ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC
ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT
ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT
GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTG
ATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTC
ATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTG
GAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTAC
AACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_1300nt
GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG
GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC
GTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGG
AAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCAT
TGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTT
GACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTATCCAGCCCCATTCTAGAACTGCATTCAGAGGAC
ACACTTCAGATGGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAG
CTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAAC
CTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATG
ATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAAT
GGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTC
CTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAG
ATAACTTATTAATCTGTCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGT
GGGCGGGCCTCGTCCGCAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTT

>In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_927nt
GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG
GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC
GTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGG
AAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCAT
TGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTT
GACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCA
GAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGG
TTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAA
CGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATA
GAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAG

>In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_1282nt
GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC
TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC
AGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAAC
AGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTT
GGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTC
ACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTATCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGA
CACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATG
AATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCC
AACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGA
CGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCG
GCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTG
CTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAATCTGTC
GAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGGGCGGGCCTCGTCCGCA
GGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGACATGTCGTTGTTTAAA

>In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_909nt
GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC
TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC
AGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAAC
AGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTT
GGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTC
ACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTC
CTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATT
GAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGG
TGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTG
GATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATA


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FusionGenePPI for TNRC6A_LCMT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNRC6AAGO2, WNK1, UBC, AGO4, PABPC1, UBR5, CUL3, AGO1, AGO3, SAV1, TRIM65, CEP250, TRIP13, CNOT1, CNOT3, CNOT6L, CNOT7, CNOT10, PAN2, CNOT2, CNOT6, CNOT8, PAN3, BTRC, SSX2IP, CEP152, CNTROB, CEP135, CNTRL, NINL, ODF2, RPGRIP1L, CENPJ, ITGB4, CLTB, CLTC, PICALM, GTSE1, FANCM, KIAA2013, RQCD1, EYA2, SMARCB1, BRCA1LCMT1FXR2, TAB1, BRCA1, PPP2CA, PPP4C, EIF1AX, PPP4R2, CASP3, NECAP1, TANGO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000315183+2241_932171914argonaute family proteins
HgeneTNRC6Achr16:24741621chr16:25139796ENST00000395799+2251_932171963argonaute family proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNRC6A_LCMT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNRC6A_LCMT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLCMT1C0752351Embryo Loss1CTD_human