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Fusion gene ID: 38969 |
FusionGeneSummary for TNRC6A_LCMT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC6A_LCMT1 | Fusion gene ID: 38969 | Hgene | Tgene | Gene symbol | TNRC6A | LCMT1 | Gene ID | 27327 | 51451 |
| Gene name | trinucleotide repeat containing 6A | leucine carboxyl methyltransferase 1 | |
| Synonyms | CAGH26|GW1|GW182|TNRC6 | CGI-68|LCMT|PPMT1 | |
| Cytomap | 16p12.1 | 16p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | leucine carboxyl methyltransferase 1[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1protein phosphatase methyltransferase 1protein-leucine O-methyltransferase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8NDV7 | Q9UIC8 | |
| Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000399069, ENST00000380966, ENST00000572869, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TNRC6A [Title/Abstract] AND LCMT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
| Tgene | LCMT1 | GO:0006481 | C-terminal protein methylation | 10600115 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0765-01A | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315183 | ENST00000399069 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| In-frame | ENST00000315183 | ENST00000380966 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| 5CDS-intron | ENST00000315183 | ENST00000572869 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000399069 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| 3UTR-3CDS | ENST00000562829 | ENST00000380966 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| 3UTR-intron | ENST00000562829 | ENST00000572869 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| In-frame | ENST00000395799 | ENST00000399069 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| In-frame | ENST00000395799 | ENST00000380966 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| 5CDS-intron | ENST00000395799 | ENST00000572869 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| intron-3CDS | ENST00000432286 | ENST00000399069 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| intron-3CDS | ENST00000432286 | ENST00000380966 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
| intron-intron | ENST00000432286 | ENST00000572869 | TNRC6A | chr16 | 24741621 | + | LCMT1 | chr16 | 25139796 | + |
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FusionProtFeatures for TNRC6A_LCMT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC6A | LCMT1 |
| Methylates the carboxyl group of the C-terminal leucineresidue of protein phosphatase 2A catalytic subunits to formalpha-leucine ester residues. {ECO:0000269|PubMed:10600115}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LCMT1 | chr16:24741621 | chr16:25139796 | ENST00000380966 | + | 0 | 9 | 171_172 | 37 | 280 | Region | S-adenosyl-L-methionine binding |
| Tgene | >LCMT1 | chr16:24741621 | chr16:25139796 | ENST00000399069 | + | 0 | 11 | 171_172 | 37 | 335 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000315183 | + | 2 | 24 | 7_54 | 17 | 1914 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000395799 | + | 2 | 25 | 7_54 | 17 | 1963 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000315183 | + | 2 | 24 | 192_365 | 17 | 1914 | Compositional bias | Note=Ser-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000315183 | + | 2 | 24 | 93_127 | 17 | 1914 | Compositional bias | Note=Gln-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000395799 | + | 2 | 25 | 192_365 | 17 | 1963 | Compositional bias | Note=Ser-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000395799 | + | 2 | 25 | 93_127 | 17 | 1963 | Compositional bias | Note=Gln-rich |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000315183 | + | 2 | 24 | 1781_1853 | 17 | 1914 | Domain | Note=RRM |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000395799 | + | 2 | 25 | 1781_1853 | 17 | 1963 | Domain | Note=RRM |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000315183 | + | 2 | 24 | 1604_1622 | 17 | 1914 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
| Hgene | >TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000395799 | + | 2 | 25 | 1604_1622 | 17 | 1963 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
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FusionGeneSequence for TNRC6A_LCMT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_315aa MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD EDLLPSKYFEVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECV LVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPR >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_260aa MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD EDLLPSKYFEVDFPMIVTRKLHSIKLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGV >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_315aa MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD EDLLPSKYFEVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECV LVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPR >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_260aa MRELEAKATKDVERNLSRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKD EDLLPSKYFEVDFPMIVTRKLHSIKLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_945nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTA TCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCA GATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTG CTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAG GTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCA TTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGA GCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCA >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_780nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTG ATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTC ATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTG GAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTAC AACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTAC >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_945nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTA TCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCA GATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTG CTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAG GTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCA TTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGA GCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCA >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_780nt ATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTAC ATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGAT GAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTG ATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTC ATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTG GAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTAC AACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_1300nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC GTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGG AAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCAT TGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTT GACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTATCCAGCCCCATTCTAGAACTGCATTCAGAGGAC ACACTTCAGATGGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAG CTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAAC CTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATG ATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAAT GGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTC CTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAG ATAACTTATTAATCTGTCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGT GGGCGGGCCTCGTCCGCAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTT >In-frame_TNRC6A_ENST00000315183_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_927nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC GTAGAAAGAAATCTTAGCAGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGG AAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCAT TGTCAAATTGTCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTT GACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCA GAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGG TTTGGGCAGATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAA CGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATA GAATCACTTGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAG >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000399069_chr16_25139796_+_1282nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC AGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAAC AGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTT GGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTC ACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTATCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGA CACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATG AATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCC AACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGA CGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCG GCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTG CTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAATCTGTC GAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGGGCGGGCCTCGTCCGCA GGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGACATGTCGTTGTTTAAA >In-frame_TNRC6A_ENST00000395799_chr16_24741621_+_LCMT1_ENST00000380966_chr16_25139796_+_909nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC AGGTTTGCAGTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCTGAAATCAAC AGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTT GGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATTGTC ACGAGAAAGCTGCACAGTATCAAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTC CTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATT GAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGG TGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTG GATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATA |
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FusionGenePPI for TNRC6A_LCMT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNRC6A | AGO2, WNK1, UBC, AGO4, PABPC1, UBR5, CUL3, AGO1, AGO3, SAV1, TRIM65, CEP250, TRIP13, CNOT1, CNOT3, CNOT6L, CNOT7, CNOT10, PAN2, CNOT2, CNOT6, CNOT8, PAN3, BTRC, SSX2IP, CEP152, CNTROB, CEP135, CNTRL, NINL, ODF2, RPGRIP1L, CENPJ, ITGB4, CLTB, CLTC, PICALM, GTSE1, FANCM, KIAA2013, RQCD1, EYA2, SMARCB1, BRCA1 | LCMT1 | FXR2, TAB1, BRCA1, PPP2CA, PPP4C, EIF1AX, PPP4R2, CASP3, NECAP1, TANGO2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000315183 | + | 2 | 24 | 1_932 | 17 | 1914 | argonaute family proteins |
| Hgene | TNRC6A | chr16:24741621 | chr16:25139796 | ENST00000395799 | + | 2 | 25 | 1_932 | 17 | 1963 | argonaute family proteins |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC6A_LCMT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC6A_LCMT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LCMT1 | C0752351 | Embryo Loss | 1 | CTD_human |
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