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Fusion gene ID: 38967 |
FusionGeneSummary for TNRC18_ZC3HAV1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNRC18_ZC3HAV1 | Fusion gene ID: 38967 | Hgene | Tgene | Gene symbol | TNRC18 | ZC3HAV1 | Gene ID | 84629 | 56829 |
| Gene name | trinucleotide repeat containing 18 | zinc finger CCCH-type containing, antiviral 1 | |
| Synonyms | CAGL79|TNRC18A | ARTD13|FLB6421|PARP13|ZAP|ZC3H2|ZC3HDC2 | |
| Cytomap | 7p22.1 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 protein | zinc finger CCCH-type antiviral protein 1ADP-ribosyltransferase diphtheria toxin-like 13zinc finger CCCH domain-containing protein 2zinc finger CCCH-type, antiviral 1 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | O15417 | Q7Z2W4 | |
| Ensembl transtripts involved in fusion gene | ENST00000399537, ENST00000430969, ENST00000399434, | ENST00000242351, ENST00000464606, ENST00000471652, | |
| Fusion gene scores | * DoF score | 16 X 15 X 8=1920 | 4 X 4 X 3=48 |
| # samples | 25 | 4 | |
| ** MAII score | log2(25/1920*10)=-2.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNRC18 [Title/Abstract] AND ZC3HAV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZC3HAV1 | GO:0009615 | response to virus | 21876179 |
| Tgene | ZC3HAV1 | GO:0045071 | negative regulation of viral genome replication | 21876179 |
| Tgene | ZC3HAV1 | GO:0061014 | positive regulation of mRNA catabolic process | 21876179 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0B2-01A | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000399537 | ENST00000242351 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| 5UTR-3CDS | ENST00000399537 | ENST00000464606 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| 5UTR-3CDS | ENST00000399537 | ENST00000471652 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| 5UTR-3CDS | ENST00000430969 | ENST00000242351 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| 5UTR-3CDS | ENST00000430969 | ENST00000464606 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| 5UTR-3CDS | ENST00000430969 | ENST00000471652 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| intron-3CDS | ENST00000399434 | ENST00000242351 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| intron-3CDS | ENST00000399434 | ENST00000464606 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
| intron-3CDS | ENST00000399434 | ENST00000471652 | TNRC18 | chr7 | 5463072 | - | ZC3HAV1 | chr7 | 138768778 | - |
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FusionProtFeatures for TNRC18_ZC3HAV1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNRC18 | ZC3HAV1 |
| Antiviral protein which inhibits the replication ofviruses by recruiting the cellular RNA degradation machineries todegrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE)present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body fromthe 3'-end. It also recruits the decapping complex DCP1-DCP2through RNA helicase p72 (DDX17) to remove the cap structure ofthe viral mRNA to initiate its degradation from the 5'-end. Itstarget viruses belong to families which include retroviridae:human immunodeficiency virus type 1 (HIV-1), moloney and murineleukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV),filoviridae: ebola virus (EBOV) and marburg virus (MARV),togaviridae: sindbis virus (SINV) and Ross river virus (RRV).Specifically targets the multiply spliced but not unspliced orsingly spliced HIV-1 mRNAs for degradation. Isoform 1 is a morepotent viral inhibitor than isoform 2. Isoform 2 acts as apositive regulator of DDX58/RIG-I signaling resulting inactivation of the downstream effector IRF3 leading to theexpression of type I IFNs and IFN stimulated genes (ISGs).{ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435,ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNRC18_ZC3HAV1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNRC18_ZC3HAV1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNRC18 | SOX2, HDAC1, EDA, KRAS, XRCC6, NIPSNAP1, SAP30, SIN3B, COPS7A, GATAD1, FAM60A, MDK, PRDM5, PES1, CAMKV, TRIM25 | ZC3HAV1 | SAP25, PPP2R2B, HDGF, ELAVL1, SIRT7, ISG15, CUL3, COPS5, CAND1, APP, RTCA, PVR, SLTM, RAE1, USP48, SFPQ, NTHL1, ESR2, TARDBP, LIN28A, IVNS1ABP, SPRTN, AURKB, CEP250, BRCA1, EZH2, RNF2, BMI1, ILK, MAST3, WDR76, HIST1H1A, NOL12, RPL8, NIFK, NTRK1, IFI16, TMEM17, XPO1, AHSA1, SORT1, CBX8, LDHD, PES1, MIRLET7A1, MEX3C, TRIM25, CDH1, EGFR, HIST1H1D, HIST1H1C, HIST1H1T, ZNF777, RPL37A, RRP8, BAZ1B, H2AFX, PABPC4L, KHNYN, RPL26L1, ZBTB48, ZNF354A, RBM34, KIAA0020, CNBP, GNL2, NOP2, DKC1, RPL30, GLTSCR2, RBM28, LARP1, RBM19, RPS8, RPL18A, MRPS9, RPL17, ZNF574, BRIX1, YBX1, RPL10A, RPL36, ZCRB1, DHX30, RPS3A, RPS15, PRDM15, GLYR1, YBX3, GADD45GIP1, WDR46, STAU1, STAU2, NOP16, RPL18, HP1BP3, EBNA1BP2, DGCR8, NMNAT1, KRR1, ZNF2, GTPBP4, RRS1, RPL12, PPAN-P2RY11, NGRN, NSA2, DDX24, PAPD5, RPL7, RPL32, GPATCH4, RPL7A, MRPS35, DDX27, RPL13, RPS13, LIN28B, RPL26, MAK16, MOV10, UPF1, DDX10, NXF2, NIP7, RPLP0, MRPS31, LLPH, MPHOSPH10, WHSC1, RPS6, COPZ1, DRG1, NCL, COX15, DLD, PDHA1, G3BP1, TES, URI1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC18_ZC3HAV1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC18_ZC3HAV1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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