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Fusion gene ID: 38959 |
FusionGeneSummary for TNRC18_MKLN1 |
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Fusion gene information | Fusion gene name: TNRC18_MKLN1 | Fusion gene ID: 38959 | Hgene | Tgene | Gene symbol | TNRC18 | MKLN1 | Gene ID | 84629 | 4289 |
Gene name | trinucleotide repeat containing 18 | muskelin 1 | |
Synonyms | CAGL79|TNRC18A | TWA2 | |
Cytomap | 7p22.1 | 7q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | trinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 protein | muskelinmuskelin 1, intracellular mediator containing kelch motifs | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | O15417 | Q9UL63 | |
Ensembl transtripts involved in fusion gene | ENST00000399537, ENST00000430969, ENST00000399434, | ENST00000421797, ENST00000429546, ENST00000352689, ENST00000498778, | |
Fusion gene scores | * DoF score | 16 X 15 X 8=1920 | 10 X 9 X 6=540 |
# samples | 25 | 11 | |
** MAII score | log2(25/1920*10)=-2.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNRC18 [Title/Abstract] AND MKLN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-HT-A617-01A | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000399537 | ENST00000421797 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-5UTR | ENST00000399537 | ENST00000429546 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-5UTR | ENST00000399537 | ENST00000352689 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-intron | ENST00000399537 | ENST00000498778 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-5UTR | ENST00000430969 | ENST00000421797 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-5UTR | ENST00000430969 | ENST00000429546 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-5UTR | ENST00000430969 | ENST00000352689 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
5CDS-intron | ENST00000430969 | ENST00000498778 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
intron-5UTR | ENST00000399434 | ENST00000421797 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
intron-5UTR | ENST00000399434 | ENST00000429546 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
intron-5UTR | ENST00000399434 | ENST00000352689 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
intron-intron | ENST00000399434 | ENST00000498778 | TNRC18 | chr7 | 5460691 | - | MKLN1 | chr7 | 131060183 | + |
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FusionProtFeatures for TNRC18_MKLN1 |
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Hgene | Tgene |
TNRC18 | MKLN1 |
Acts as a mediator of cell spreading and cytoskeletalresponses to the extracellular matrix component THBS1.{ECO:0000250|UniProtKB:O89050}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNRC18_MKLN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNRC18_MKLN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNRC18 | SOX2, HDAC1, EDA, KRAS, XRCC6, NIPSNAP1, SAP30, SIN3B, COPS7A, GATAD1, FAM60A, MDK, PRDM5, PES1, CAMKV, TRIM25 | MKLN1 | RNPS1, MYC, RANBP9, ELAVL1, MKLN1, MAEA, GID8, RMND5A, SOX2, PTGER3, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, GGH, MRPL4, GPS2, NR1H3, HLA-DPB1, ADCYAP1, PRG2, IFI30, UNK, DYNC1H1, BMP1, PRG3, INSL6, PIGT, CCDC120, TIGD5, SUCLA2, NFATC1, LILRB4, CARKD, IKZF1, C4orf27, TLE4, ARMC8, ZMYND19, GID4, HTRA2, WDR26, PMFBP1, AAMP, MMADHC, HSPBP1, LONP1, RSPH10B, NDUFS2, SOAT1, RMND5B, YPEL5, RANBP10, RAB8A, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC18_MKLN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC18_MKLN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |