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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38957

FusionGeneSummary for TNRC18_HDAC9

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC18_HDAC9
Fusion gene ID: 38957
HgeneTgene
Gene symbol

TNRC18

HDAC9

Gene ID

84629

9734

Gene nametrinucleotide repeat containing 18histone deacetylase 9
SynonymsCAGL79|TNRC18AHD7|HD7b|HD9|HDAC|HDAC7|HDAC7B|HDAC9B|HDAC9FL|HDRP|MITR
Cytomap

7p22.1

7p21.1

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 proteinhistone deacetylase 9MEF-2 interacting transcription repressor (MITR) proteinhistone deacetylase 4/5-related proteinhistone deacetylase 7B
Modification date2018052220180519
UniProtAcc

O15417

Q9UKV0

Ensembl transtripts involved in fusion geneENST00000399537, ENST00000430969, 
ENST00000399434, 		ENST00000406451, 
ENST00000401921, ENST00000432645, 
ENST00000441542, ENST00000417496, 
ENST00000476135, ENST00000405010, 
ENST00000428307, ENST00000406072, 
ENST00000456174, ENST00000524023, 
Fusion gene scores* DoF score16 X 15 X 8=19206 X 4 X 4=96
# samples 255
** MAII scorelog2(25/1920*10)=-2.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC18 [Title/Abstract] AND HDAC9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDAC9

GO:0000122

negative regulation of transcription by RNA polymerase II

10655483|11535832

TgeneHDAC9

GO:0016575

histone deacetylation

11535832

TgeneHDAC9

GO:0032869

cellular response to insulin stimulus

19303849

TgeneHDAC9

GO:0034983

peptidyl-lysine deacetylation

11535832

TgeneHDAC9

GO:0045892

negative regulation of transcription, DNA-templated

11535832

TgeneHDAC9

GO:0070932

histone H3 deacetylation

12590135

TgeneHDAC9

GO:0070933

histone H4 deacetylation

12590135


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-DA-A1HW-06ATNRC18chr7

5401528

-HDAC9chr7

18535885

+
TCGALDSKCMTCGA-DA-A1HW-06ATNRC18chr7

5401528

-HDAC9chr7

18365135

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000399537ENST00000406451TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000399537ENST00000401921TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000399537ENST00000432645TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000399537ENST00000441542TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000399537ENST00000417496TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-3UTRENST00000399537ENST00000476135TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000399537ENST00000405010TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000399537ENST00000428307TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000399537ENST00000406072TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000399537ENST00000456174TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000399537ENST00000524023TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000430969ENST00000406451TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000430969ENST00000401921TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000430969ENST00000432645TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000430969ENST00000441542TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000430969ENST00000417496TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-3UTRENST00000430969ENST00000476135TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000430969ENST00000405010TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000430969ENST00000428307TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-5UTRENST00000430969ENST00000406072TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000430969ENST00000456174TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000430969ENST00000524023TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-5UTRENST00000399434ENST00000406451TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-5UTRENST00000399434ENST00000401921TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-intronENST00000399434ENST00000432645TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-intronENST00000399434ENST00000441542TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-intronENST00000399434ENST00000417496TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-3UTRENST00000399434ENST00000476135TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-5UTRENST00000399434ENST00000405010TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-5UTRENST00000399434ENST00000428307TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-5UTRENST00000399434ENST00000406072TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-intronENST00000399434ENST00000456174TNRC18chr7

5401528

-HDAC9chr7

18535885

+
intron-intronENST00000399434ENST00000524023TNRC18chr7

5401528

-HDAC9chr7

18535885

+
5CDS-intronENST00000399537ENST00000406451TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000401921TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000432645TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000441542TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000417496TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000476135TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000405010TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000428307TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000406072TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000456174TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000399537ENST00000524023TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000406451TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000401921TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000432645TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000441542TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000417496TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000476135TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000405010TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000428307TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000406072TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000456174TNRC18chr7

5401528

-HDAC9chr7

18365135

+
5CDS-intronENST00000430969ENST00000524023TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000406451TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000401921TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000432645TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000441542TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000417496TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000476135TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000405010TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000428307TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000406072TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000456174TNRC18chr7

5401528

-HDAC9chr7

18365135

+
intron-intronENST00000399434ENST00000524023TNRC18chr7

5401528

-HDAC9chr7

18365135

+

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FusionProtFeatures for TNRC18_HDAC9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC18

O15417

HDAC9

Q9UKV0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNRC18_HDAC9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNRC18_HDAC9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNRC18SOX2, HDAC1, EDA, KRAS, XRCC6, NIPSNAP1, SAP30, SIN3B, COPS7A, GATAD1, FAM60A, MDK, PRDM5, PES1, CAMKV, TRIM25HDAC9CTBP1, SIN3A, MORF4L2, HIST4H4, HIST2H3A, HDAC3, SIN3B, NCOR1, ETV6, HDAC4, MEF2A, HDAC1, HEY2, FOXP3, YWHAE, YWHAZ, MEF2C, ESR1, MAPK8, MAPK9, MAPK10, JUN, NUP214, SYK, RFXANK, ANKRA2, PKD1, MEF2B, HDAC9, SFN, CAMK1, H3F3A, CEBPB, PARP1, SMARCA4, MAML1, TRIM29, TP53, BCL6, HINT1, MKI67, TOP1, ADAR, EIF6, H1FX, TMPO, NUP93, TPR, FIP1L1, CCAR2, NOP2, RCC1, RBM14, SMC3, TPX2, ZC3H11A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TNRC18_HDAC9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHDAC9Q9UKV0DB00313Valproic AcidHistone deacetylase 9small moleculeapproved|investigational

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RelatedDiseases for TNRC18_HDAC9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHDAC9C0011570Mental Depression2PSYGENET
TgeneHDAC9C0036341Schizophrenia2PSYGENET
TgeneHDAC9C0011581Depressive disorder1PSYGENET
TgeneHDAC9C0038454Cerebrovascular accident1CTD_human
TgeneHDAC9C0041696Unipolar Depression1PSYGENET