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Fusion gene ID: 38951 |
FusionGeneSummary for TNPO3_TNPO3 |
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Fusion gene information | Fusion gene name: TNPO3_TNPO3 | Fusion gene ID: 38951 | Hgene | Tgene | Gene symbol | TNPO3 | TNPO3 | Gene ID | 23534 | 23534 |
Gene name | transportin 3 | transportin 3 | |
Synonyms | IPO12|LGMD1F|MTR10A|TRN-SR|TRN-SR2|TRNSR | IPO12|LGMD1F|MTR10A|TRN-SR|TRN-SR2|TRNSR | |
Cytomap | 7q32.1 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transportin-3imp12importin 12limb girdle muscular dystrophy 1F (autosomal dominant)transportin-SR | transportin-3imp12importin 12limb girdle muscular dystrophy 1F (autosomal dominant)transportin-SR | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y5L0 | Q9Y5L0 | |
Ensembl transtripts involved in fusion gene | ENST00000393245, ENST00000265388, ENST00000482320, ENST00000471234, ENST00000471166, | ENST00000393245, ENST00000265388, ENST00000482320, ENST00000471234, ENST00000471166, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TNPO3 [Title/Abstract] AND TNPO3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW236972 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000393245 | ENST00000393245 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000393245 | ENST00000265388 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000393245 | ENST00000482320 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000393245 | ENST00000471234 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000393245 | ENST00000471166 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000265388 | ENST00000393245 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000265388 | ENST00000265388 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000265388 | ENST00000482320 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000265388 | ENST00000471234 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000265388 | ENST00000471166 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000482320 | ENST00000393245 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000482320 | ENST00000265388 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000482320 | ENST00000482320 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000482320 | ENST00000471234 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000482320 | ENST00000471166 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471234 | ENST00000393245 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471234 | ENST00000265388 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471234 | ENST00000482320 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471234 | ENST00000471234 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471234 | ENST00000471166 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471166 | ENST00000393245 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471166 | ENST00000265388 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471166 | ENST00000482320 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471166 | ENST00000471234 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
intron-intron | ENST00000471166 | ENST00000471166 | TNPO3 | chr7 | 128594476 | - | TNPO3 | chr7 | 128595684 | - |
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FusionProtFeatures for TNPO3_TNPO3 |
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Hgene | Tgene |
TNPO3 | TNPO3 |
Seems to function in nuclear protein import as nucleartransport receptor. In vitro, mediates the nuclear import ofsplicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizingphosphorylated RS domains. {ECO:0000269|PubMed:10366588,ECO:0000269|PubMed:10713112, ECO:0000269|PubMed:11517331,ECO:0000269|PubMed:12628928}. | Seems to function in nuclear protein import as nucleartransport receptor. In vitro, mediates the nuclear import ofsplicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizingphosphorylated RS domains. {ECO:0000269|PubMed:10366588,ECO:0000269|PubMed:10713112, ECO:0000269|PubMed:11517331,ECO:0000269|PubMed:12628928}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNPO3_TNPO3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNPO3_TNPO3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNPO3_TNPO3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNPO3_TNPO3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TNPO3 | C1842062 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1F | 1 | ORPHANET;UNIPROT |
Tgene | TNPO3 | C1842062 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1F | 1 | ORPHANET;UNIPROT |