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Fusion gene ID: 38949 |
FusionGeneSummary for TNPO3_FN1 |
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Fusion gene information | Fusion gene name: TNPO3_FN1 | Fusion gene ID: 38949 | Hgene | Tgene | Gene symbol | TNPO3 | FN1 | Gene ID | 23534 | 2335 |
Gene name | transportin 3 | fibronectin 1 | |
Synonyms | IPO12|LGMD1F|MTR10A|TRN-SR|TRN-SR2|TRNSR | CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF | |
Cytomap | 7q32.1 | 2q35 | |
Type of gene | protein-coding | protein-coding | |
Description | transportin-3imp12importin 12limb girdle muscular dystrophy 1F (autosomal dominant)transportin-SR | fibronectincold-insoluble globulinmigration-stimulating factor | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9Y5L0 | P02751 | |
Ensembl transtripts involved in fusion gene | ENST00000393245, ENST00000265388, ENST00000482320, ENST00000471234, ENST00000471166, | ENST00000421182, ENST00000357867, ENST00000323926, ENST00000336916, ENST00000354785, ENST00000357009, ENST00000346544, ENST00000345488, ENST00000359671, ENST00000446046, ENST00000443816, ENST00000432072, ENST00000356005, ENST00000490833, ENST00000426059, | |
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 20 X 22 X 3=1320 |
# samples | 5 | 26 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/1320*10)=-2.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNPO3 [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FN1 | GO:0001932 | regulation of protein phosphorylation | 11792823 |
Tgene | FN1 | GO:0008284 | positive regulation of cell proliferation | 25834989 |
Tgene | FN1 | GO:0010628 | positive regulation of gene expression | 25834989 |
Tgene | FN1 | GO:0018149 | peptide cross-linking | 3997886 |
Tgene | FN1 | GO:0034446 | substrate adhesion-dependent cell spreading | 16236823 |
Tgene | FN1 | GO:0035987 | endodermal cell differentiation | 23154389 |
Tgene | FN1 | GO:0048146 | positive regulation of fibroblast proliferation | 25834989 |
Tgene | FN1 | GO:0051702 | interaction with symbiont | 12167537|12421310|19429745 |
Tgene | FN1 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction | 17849409 |
Tgene | FN1 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 11792823 |
Tgene | FN1 | GO:1904237 | positive regulation of substrate-dependent cell migration, cell attachment to substrate | 25834989 |
Tgene | FN1 | GO:2001202 | negative regulation of transforming growth factor-beta secretion | 25834989 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF773006 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000393245 | ENST00000421182 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000357867 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000323926 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000336916 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000354785 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000357009 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000346544 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000345488 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000359671 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000446046 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000443816 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000432072 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000356005 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000490833 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000393245 | ENST00000426059 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000421182 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000357867 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000323926 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000336916 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000354785 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000357009 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000346544 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000345488 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000359671 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000446046 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000443816 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000432072 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000356005 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000490833 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000265388 | ENST00000426059 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000421182 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000357867 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000323926 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000336916 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000354785 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000357009 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000346544 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000345488 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000359671 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000446046 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000443816 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000432072 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000356005 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000490833 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000482320 | ENST00000426059 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000421182 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000357867 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000323926 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000336916 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000354785 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000357009 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000346544 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000345488 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000359671 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000446046 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000443816 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000432072 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000356005 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000490833 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471234 | ENST00000426059 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000421182 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000357867 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000323926 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000336916 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000354785 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000357009 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000346544 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000345488 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000359671 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000446046 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000443816 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000432072 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000356005 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000490833 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
intron-intron | ENST00000471166 | ENST00000426059 | TNPO3 | chr7 | 128658520 | + | FN1 | chr2 | 216241456 | - |
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FusionProtFeatures for TNPO3_FN1 |
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Hgene | Tgene |
TNPO3 | FN1 |
Seems to function in nuclear protein import as nucleartransport receptor. In vitro, mediates the nuclear import ofsplicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizingphosphorylated RS domains. {ECO:0000269|PubMed:10366588,ECO:0000269|PubMed:10713112, ECO:0000269|PubMed:11517331,ECO:0000269|PubMed:12628928}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNPO3_FN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNPO3_FN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNPO3_FN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FN1 | P02751 | DB08888 | Ocriplasmin | Fibronectin | biotech | approved |
Tgene | FN1 | P02751 | DB01593 | Zinc | Fibronectin | small molecule | approved|investigational |
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RelatedDiseases for TNPO3_FN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TNPO3 | C1842062 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1F | 1 | ORPHANET;UNIPROT |
Tgene | FN1 | C0020538 | Hypertensive disease | 2 | CTD_human;HPO |
Tgene | FN1 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | FN1 | C0003504 | Aortic Valve Insufficiency | 1 | CTD_human |
Tgene | FN1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Tgene | FN1 | C0010346 | Crohn Disease | 1 | CTD_human |
Tgene | FN1 | C0011849 | Diabetes Mellitus | 1 | CTD_human |
Tgene | FN1 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Tgene | FN1 | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | FN1 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Tgene | FN1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | FN1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | FN1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | FN1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Tgene | FN1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | FN1 | C0085762 | Alcohol abuse | 1 | PSYGENET |
Tgene | FN1 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
Tgene | FN1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | FN1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | FN1 | C1866075 | GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder) | 1 | UNIPROT |