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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 38934

FusionGeneSummary for TNPO1_MEF2C

check button Fusion gene summary
Fusion gene informationFusion gene name: TNPO1_MEF2C
Fusion gene ID: 38934
HgeneTgene
Gene symbol

TNPO1

MEF2C

Gene ID

3842

4208

Gene nametransportin 1myocyte enhancer factor 2C
SynonymsIPO2|KPNB2|MIP|MIP1|TRNC5DELq14.3|DEL5q14.3
Cytomap

5q13.2

5q14.3

Type of geneprotein-codingprotein-coding
Descriptiontransportin-1M9 region interaction proteinimportin 2importin beta 2karyopherin (importin) beta 2karyopherin beta-2myocyte-specific enhancer factor 2CMADS box transcription enhancer factor 2, polypeptide C
Modification date2018052320180524
UniProtAcc

Q92973

Q06413

Ensembl transtripts involved in fusion geneENST00000337273, ENST00000454282, 
ENST00000447967, ENST00000523768, 
ENST00000513944, ENST00000506351, 
ENST00000340208, ENST00000424173, 
ENST00000504921, ENST00000514028, 
ENST00000437473, ENST00000510942, 
ENST00000506554, ENST00000508569, 
ENST00000514015, ENST00000539796, 
ENST00000503554, 
Fusion gene scores* DoF score7 X 6 X 6=2528 X 8 X 2=128
# samples 88
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNPO1 [Title/Abstract] AND MEF2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEF2C

GO:0000165

MAPK cascade

9858528

TgeneMEF2C

GO:0006355

regulation of transcription, DNA-templated

24008018

TgeneMEF2C

GO:0010628

positive regulation of gene expression

9857019|21556048

TgeneMEF2C

GO:0030279

negative regulation of ossification

17696759

TgeneMEF2C

GO:0045893

positive regulation of transcription, DNA-templated

17696759

TgeneMEF2C

GO:0045944

positive regulation of transcription by RNA polymerase II

8455629|15486975|16043483

TgeneMEF2C

GO:0071374

cellular response to parathyroid hormone stimulus

17696759

TgeneMEF2C

GO:0071560

cellular response to transforming growth factor beta stimulus

9770491

TgeneMEF2C

GO:2000727

positive regulation of cardiac muscle cell differentiation

9857019

TgeneMEF2C

GO:2001016

positive regulation of skeletal muscle cell differentiation

21556048


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5J1-01ATNPO1chr5

72112579

+MEF2Cchr5

88057145

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000337273ENST00000340208TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000424173TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000504921TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000514028TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000437473TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000510942TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000506554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000508569TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000514015TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000337273ENST00000539796TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-5UTRENST00000337273ENST00000503554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
In-frameENST00000454282ENST00000340208TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000424173TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000504921TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000514028TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000437473TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000510942TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000506554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000508569TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000514015TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000454282ENST00000539796TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-5UTRENST00000454282ENST00000503554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-3CDSENST00000447967ENST00000340208TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000424173TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000504921TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000514028TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000437473TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000510942TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000506554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000508569TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000514015TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-intronENST00000447967ENST00000539796TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5UTR-5UTRENST00000447967ENST00000503554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
In-frameENST00000523768ENST00000340208TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000424173TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000504921TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000514028TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000437473TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000510942TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000506554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000508569TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000514015TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-intronENST00000523768ENST00000539796TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
5CDS-5UTRENST00000523768ENST00000503554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-3CDSENST00000513944ENST00000340208TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000424173TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000504921TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000514028TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000437473TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000510942TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000506554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000508569TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000514015TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000513944ENST00000539796TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-5UTRENST00000513944ENST00000503554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-3CDSENST00000506351ENST00000340208TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000424173TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000504921TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000514028TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000437473TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000510942TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000506554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000508569TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000514015TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-intronENST00000506351ENST00000539796TNPO1chr5

72112579

+MEF2Cchr5

88057145

-
intron-5UTRENST00000506351ENST00000503554TNPO1chr5

72112579

+MEF2Cchr5

88057145

-

Top

FusionProtFeatures for TNPO1_MEF2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNPO1

Q92973

MEF2C

Q06413

Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates (PubMed:24753571). Is thought to mediatedocking of the importin/substrate complex to the nuclear porecomplex (NPC) through binding to nucleoporin and the complex issubsequently translocated through the pore by an energy requiring,Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region ofthe heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2and mediates their nuclear import. Appears also to be involved inhnRNP A1/A2 nuclear export. Mediates the nuclear import ofribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-likeimport receptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (Bysimilarity). Mediates nuclear import of ADAR/ADAR1 isoform 1 andisoform 5 in a RanGTP-dependent manner (PubMed:19124606,PubMed:24753571). {ECO:0000250|UniProtKB:Q8BFY9,ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606,ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:8986607,ECO:0000269|PubMed:9687515}. (Microbial infection) In case of HIV-1 infection, bindsand mediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:16704975}. Transcription activator which binds specifically to theMEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, andis also involved in vascular development. Plays an essential rolein hippocampal-dependent learning and memory by suppressing thenumber of excitatory synapses and thus regulating basal and evokedsynaptic transmission. Crucial for normal neuronal development,distribution, and electrical activity in the neocortex. Necessaryfor proper development of megakaryocytes and platelets and forbone marrow B-lymphopoiesis. Required for B-cell survival andproliferation in response to BCR stimulation, efficient IgG1antibody responses to T-cell-dependent antigens and for normalinduction of germinal center B-cells. May also be involved inneurogenesis and in the development of cortical architecture (Bysimilarity). Isoform 3 and isoform 4, which lack the repressordomain, are more active than isoform 1 and isoform 2.{ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443,ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463,ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290,ECO:0000269|PubMed:9384584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000340208-312146_18386484Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000424173-011146_183-143464Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000424173-0114_31-143464Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000437473-211146_18386474Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000510942-210146_18386466Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514015-211146_18386442Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514028-211146_18386474Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000539796-08146_1830418Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000539796-084_310418Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000424173-01158_86-143464DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000539796-0858_860418DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000424173-0113_57-143464DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000539796-083_570418DomainMADS-box

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125358_37653427Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124358_37652688Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125358_376-26949Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123358_3765849Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12541_10953427DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12441_10952688DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12541_109-26949DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12341_1095849DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125137_17453427RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125181_21153427RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12519_4653427RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125224_25153427RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125263_29053427RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125306_39753427RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125405_43353427RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125445_47253427RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125486_51953427RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12551_8953427RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125527_56053427RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125568_60653427RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125614_66553427RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125676_70753427RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125715_74853427RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125756_79153427RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125799_83253427RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125841_87253427RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125875_89553427RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12598_13153427RepeatHEAT 3
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124137_17452688RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124181_21152688RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12419_4652688RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124224_25152688RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124263_29052688RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124306_39752688RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124405_43352688RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124445_47252688RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124486_51952688RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12451_8952688RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124527_56052688RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124568_60652688RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124614_66552688RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124676_70752688RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124715_74852688RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124756_79152688RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124799_83252688RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124841_87252688RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124875_89552688RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12498_13152688RepeatHEAT 3
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125137_174-26949RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125181_211-26949RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12519_46-26949RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125224_251-26949RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125263_290-26949RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125306_397-26949RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125405_433-26949RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125445_472-26949RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125486_519-26949RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12551_89-26949RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125527_560-26949RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125568_606-26949RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125614_665-26949RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125676_707-26949RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125715_748-26949RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125756_791-26949RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125799_832-26949RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125841_872-26949RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125875_895-26949RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12598_131-26949RepeatHEAT 3
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123137_1745849RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123181_2115849RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12319_465849RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123224_2515849RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123263_2905849RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123306_3975849RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123405_4335849RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123445_4725849RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123486_5195849RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12351_895849RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123527_5605849RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123568_6065849RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123614_6655849RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123676_7075849RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123715_7485849RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123756_7915849RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123799_8325849RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123841_8725849RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123875_8955849RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12398_1315849RepeatHEAT 3
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000340208-3124_3186484Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000437473-2114_3186474Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000510942-2104_3186466Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514015-2114_3186442Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514028-2114_3186474Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000340208-31258_8686484DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000437473-21158_8686474DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000510942-21058_8686466DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514015-21158_8686442DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514028-21158_8686474DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000340208-3123_5786484DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000437473-2113_5786474DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000510942-2103_5786466DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514015-2113_5786442DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514028-2113_5786474DomainMADS-box


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FusionGeneSequence for TNPO1_MEF2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TNPO1_ENST00000337273_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_403aa
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY

>In-frame_TNPO1_ENST00000454282_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_403aa
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY

>In-frame_TNPO1_ENST00000523768_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_403aa
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TNPO1_ENST00000337273_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_1209nt
ATGGTGTGGGACCGGACGTTGAGAAAGAAGGGCCTTAATGGCTGTGACAGCCCAGACCCCGATGCGGACGATTCCGCATTGAACAAGAAA
GAAAACAAAGGCTGTGAAAGCCCCGATCCCGACTCCTCTTATGCACTCACCCCACGCACTGAAGAAAAATACAAAAAAATTAATGAAGAA
TTTGATAATATGATCAAGAGTCATAAAATTCCTGCTGTTCCACCTCCCAACTTCGAGATGCCAGTCTCCATCCCAGTGTCCAGCCACAAC
AGTTTGGTGTACAGCAACCCTGTCAGCTCACTGGGAAACCCCAACCTATTGCCACTGGCTCACCCTTCTCTGCAGAGGAATAGTATGTCT
CCTGGTGTAACACATCGACCTCCAAGTGCAGGTAACACAGGTGGTCTGATGGGTGGAGACCTCACGTCTGGTGCAGGCACCAGTGCAGGG
AACGGGTATGGCAATCCCCGAAACTCACCAGGTCTGCTGGTCTCACCTGGTAACTTGAACAAGAATATGCAAGCAAAATCTCCTCCCCCA
ATGAATTTAGGAATGAATAACCGTAAACCAGATCTCCGAGTTCTTATTCCACCAGGCAGCAAGAATACGATGCCATCAGTGAATCAAAGG
ATAAATAACTCCCAGTCGGCTCAGTCATTGGCTACCCCAGTGGTTTCCGTAGCAACTCCTACTTTACCAGGACAAGGAATGGGAGGATAT
CCATCAGCCATTTCAACAACATATGGTACCGAGTACTCTCTGAGTAGTGCAGACCTGTCATCTCTGTCTGGGTTTAACACCGCCAGCGCT
CTTCACCTTGGTTCAGTAACTGGCTGGCAACAGCAACACCTACATAACATGCCACCATCTGCCCTCAGTCAGTTGGGAGCTTGCACTAGC
ACTCATTTATCTCAGAGTTCAAATCTCTCCCTGCCTTCTACTCAAAGCCTCAACATCAAGTCAGAACCTGTTTCTCCTCCTAGAGACCGT
ACCACCACCCCTTCGAGATACCCACAACACACGCGCCACGAGGCGGGGAGATCTCCTGTTGACAGCTTGAGCAGCTGTAGCAGTTCGTAC
GACGGGAGCGACCGAGAGGATCACCGGAACGAATTCCACTCCCCCATTGGACTCACCAGACCTTCGCCGGACGAAAGGGAAAGTCCCTCA

>In-frame_TNPO1_ENST00000454282_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_1209nt
ATGGTGTGGGACCGGACGTTGAGAAAGAAGGGCCTTAATGGCTGTGACAGCCCAGACCCCGATGCGGACGATTCCGCATTGAACAAGAAA
GAAAACAAAGGCTGTGAAAGCCCCGATCCCGACTCCTCTTATGCACTCACCCCACGCACTGAAGAAAAATACAAAAAAATTAATGAAGAA
TTTGATAATATGATCAAGAGTCATAAAATTCCTGCTGTTCCACCTCCCAACTTCGAGATGCCAGTCTCCATCCCAGTGTCCAGCCACAAC
AGTTTGGTGTACAGCAACCCTGTCAGCTCACTGGGAAACCCCAACCTATTGCCACTGGCTCACCCTTCTCTGCAGAGGAATAGTATGTCT
CCTGGTGTAACACATCGACCTCCAAGTGCAGGTAACACAGGTGGTCTGATGGGTGGAGACCTCACGTCTGGTGCAGGCACCAGTGCAGGG
AACGGGTATGGCAATCCCCGAAACTCACCAGGTCTGCTGGTCTCACCTGGTAACTTGAACAAGAATATGCAAGCAAAATCTCCTCCCCCA
ATGAATTTAGGAATGAATAACCGTAAACCAGATCTCCGAGTTCTTATTCCACCAGGCAGCAAGAATACGATGCCATCAGTGAATCAAAGG
ATAAATAACTCCCAGTCGGCTCAGTCATTGGCTACCCCAGTGGTTTCCGTAGCAACTCCTACTTTACCAGGACAAGGAATGGGAGGATAT
CCATCAGCCATTTCAACAACATATGGTACCGAGTACTCTCTGAGTAGTGCAGACCTGTCATCTCTGTCTGGGTTTAACACCGCCAGCGCT
CTTCACCTTGGTTCAGTAACTGGCTGGCAACAGCAACACCTACATAACATGCCACCATCTGCCCTCAGTCAGTTGGGAGCTTGCACTAGC
ACTCATTTATCTCAGAGTTCAAATCTCTCCCTGCCTTCTACTCAAAGCCTCAACATCAAGTCAGAACCTGTTTCTCCTCCTAGAGACCGT
ACCACCACCCCTTCGAGATACCCACAACACACGCGCCACGAGGCGGGGAGATCTCCTGTTGACAGCTTGAGCAGCTGTAGCAGTTCGTAC
GACGGGAGCGACCGAGAGGATCACCGGAACGAATTCCACTCCCCCATTGGACTCACCAGACCTTCGCCGGACGAAAGGGAAAGTCCCTCA

>In-frame_TNPO1_ENST00000523768_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_1209nt
ATGGTGTGGGACCGGACGTTGAGAAAGAAGGGCCTTAATGGCTGTGACAGCCCAGACCCCGATGCGGACGATTCCGCATTGAACAAGAAA
GAAAACAAAGGCTGTGAAAGCCCCGATCCCGACTCCTCTTATGCACTCACCCCACGCACTGAAGAAAAATACAAAAAAATTAATGAAGAA
TTTGATAATATGATCAAGAGTCATAAAATTCCTGCTGTTCCACCTCCCAACTTCGAGATGCCAGTCTCCATCCCAGTGTCCAGCCACAAC
AGTTTGGTGTACAGCAACCCTGTCAGCTCACTGGGAAACCCCAACCTATTGCCACTGGCTCACCCTTCTCTGCAGAGGAATAGTATGTCT
CCTGGTGTAACACATCGACCTCCAAGTGCAGGTAACACAGGTGGTCTGATGGGTGGAGACCTCACGTCTGGTGCAGGCACCAGTGCAGGG
AACGGGTATGGCAATCCCCGAAACTCACCAGGTCTGCTGGTCTCACCTGGTAACTTGAACAAGAATATGCAAGCAAAATCTCCTCCCCCA
ATGAATTTAGGAATGAATAACCGTAAACCAGATCTCCGAGTTCTTATTCCACCAGGCAGCAAGAATACGATGCCATCAGTGAATCAAAGG
ATAAATAACTCCCAGTCGGCTCAGTCATTGGCTACCCCAGTGGTTTCCGTAGCAACTCCTACTTTACCAGGACAAGGAATGGGAGGATAT
CCATCAGCCATTTCAACAACATATGGTACCGAGTACTCTCTGAGTAGTGCAGACCTGTCATCTCTGTCTGGGTTTAACACCGCCAGCGCT
CTTCACCTTGGTTCAGTAACTGGCTGGCAACAGCAACACCTACATAACATGCCACCATCTGCCCTCAGTCAGTTGGGAGCTTGCACTAGC
ACTCATTTATCTCAGAGTTCAAATCTCTCCCTGCCTTCTACTCAAAGCCTCAACATCAAGTCAGAACCTGTTTCTCCTCCTAGAGACCGT
ACCACCACCCCTTCGAGATACCCACAACACACGCGCCACGAGGCGGGGAGATCTCCTGTTGACAGCTTGAGCAGCTGTAGCAGTTCGTAC
GACGGGAGCGACCGAGAGGATCACCGGAACGAATTCCACTCCCCCATTGGACTCACCAGACCTTCGCCGGACGAAAGGGAAAGTCCCTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TNPO1_ENST00000337273_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_6081nt
ACAGTCTGGGCAACCACACCGGCGGGCCGTTTTGCTCACAGCCCCACCGCGCCGGGCAGCGTCTGCAGCTGCTGCGTGCGAGACCCAGAG
GCTCCGGTCAGCGCGCCGGCCGCAGGGAGTGCGAGCACTTGTGAGCCCCGCGCCGGGCCGGTGAAGTCTGGTGCTGCCGAGCCCGCTTAG
AAAGCACGGCCGCGCGCTGTCGGACGCAGGCCCACAGGCCCAGCCGACCCAGGCAGCAATTTTCCTAGCCCCGCCGCCGTTGCCAAGGCG
ACCGCCGCCGAATGTTCCCGCCGCGGGCTCCGCCCCCCGGCCAATCGGACCGGCGCTCGGTGAAGCCCAGATTCTCTTTGTTCCGCAGCC
ATTTCAGGCCCCGGACAGGAGGCAGTGCCGCTTCGGCCGAAGGCCCGAGCGCCCGAGGCGTCTGGGATGGTGTGGGACCGGACGTTGAGA
AAGAAGGGCCTTAATGGCTGTGACAGCCCAGACCCCGATGCGGACGATTCCGCATTGAACAAGAAAGAAAACAAAGGCTGTGAAAGCCCC
GATCCCGACTCCTCTTATGCACTCACCCCACGCACTGAAGAAAAATACAAAAAAATTAATGAAGAATTTGATAATATGATCAAGAGTCAT
AAAATTCCTGCTGTTCCACCTCCCAACTTCGAGATGCCAGTCTCCATCCCAGTGTCCAGCCACAACAGTTTGGTGTACAGCAACCCTGTC
AGCTCACTGGGAAACCCCAACCTATTGCCACTGGCTCACCCTTCTCTGCAGAGGAATAGTATGTCTCCTGGTGTAACACATCGACCTCCA
AGTGCAGGTAACACAGGTGGTCTGATGGGTGGAGACCTCACGTCTGGTGCAGGCACCAGTGCAGGGAACGGGTATGGCAATCCCCGAAAC
TCACCAGGTCTGCTGGTCTCACCTGGTAACTTGAACAAGAATATGCAAGCAAAATCTCCTCCCCCAATGAATTTAGGAATGAATAACCGT
AAACCAGATCTCCGAGTTCTTATTCCACCAGGCAGCAAGAATACGATGCCATCAGTGAATCAAAGGATAAATAACTCCCAGTCGGCTCAG
TCATTGGCTACCCCAGTGGTTTCCGTAGCAACTCCTACTTTACCAGGACAAGGAATGGGAGGATATCCATCAGCCATTTCAACAACATAT
GGTACCGAGTACTCTCTGAGTAGTGCAGACCTGTCATCTCTGTCTGGGTTTAACACCGCCAGCGCTCTTCACCTTGGTTCAGTAACTGGC
TGGCAACAGCAACACCTACATAACATGCCACCATCTGCCCTCAGTCAGTTGGGAGCTTGCACTAGCACTCATTTATCTCAGAGTTCAAAT
CTCTCCCTGCCTTCTACTCAAAGCCTCAACATCAAGTCAGAACCTGTTTCTCCTCCTAGAGACCGTACCACCACCCCTTCGAGATACCCA
CAACACACGCGCCACGAGGCGGGGAGATCTCCTGTTGACAGCTTGAGCAGCTGTAGCAGTTCGTACGACGGGAGCGACCGAGAGGATCAC
CGGAACGAATTCCACTCCCCCATTGGACTCACCAGACCTTCGCCGGACGAAAGGGAAAGTCCCTCAGTCAAGCGCATGCGACTTTCTGAA
GGATGGGCAACATGATCAGATTATTACTTACTAGTTTTTTTTTTTTTCTTGCAGTGTGTGTGTGTGCTATACCTTAATGGGGAAGGGGGG
TCGATATGCATTATATGTGCCGTGTGTGGAAAAAAAAAAAGTCAGGTACTCTGTTTTGTAAAAGTACTTTTAAATTGCCTCAGTGATACA
GTATAAAGATAAACAGAAATGCTGAGATAAGCTTAGCACTTGAGTTGTACAACAGAACACTTGTACAAAATAGATTTTAAGGCTAACTTC
TTTTCACTGTTGTGCTCCTTTGCAAAATGTATGTTACAATAGATAGTGTCATGTTGCAGGTTCAACGTTATTTACATGTAAATAGACAAA
AGGAAACATTTGCCAAAAGCGGCAGATCTTTACTGAAAGAGAGAGCAGCTGTTATGCAACATATAGAAAAATGTATAGATGCTTGGACAG
ACCCGGTAATGGGTGGCCATTGGTAAATGTTAGGAACACACCAGGTCACCTGACATCCCAAGAATGCTCACAAACCTGCAGGCATATCAT
TGGCGTATGGCACTCATTAAAAAGGATCAGAGACCATTAAAAGAGGACCATACCTATTAAAAAAAAATGTGGAGTTGGAGGGCTAACATA
TTTAATTAAATAAATAAATAAATCTGGGTCTGCATCTCTTATTAAATAAAAATATAAAAATATGTACATTACATTTTGCTTATTTTCATA
TAAAAGGTAAGACAGAGTTTGCAAAGCATTTGTGGCTTTTTGTAGTTTACTTAAGCCAAAATGTGTTTTTTTCCCCTTGATAGCTTCGCT
AATATTTTAAACAGTCCTGTAAAAAACCAAAAAGGACTTTTTGTATAGAAAGCACTACCCTAAGCCATGAAGAACTCCATGCTTTGCTAA
CCAAGATAACTGTTTTCTCTTTGTAGAAGTTTTGTTTTTGAAATGTGTATTTCTAATTATATAAAATATTAAGAATCTTTTAAAAAAATC
TGTGAAATTAACATGCTTGTGTATAGCTTTCTAATATATATAATATTATGGTAATAGCAGAAGTTTTGTTATCTTAATAGCGGGAGGGGG
GTATATTTGTGCAGTTGCACATTTGAGTAACTATTTTCTTTCTGTTTTCTTTTACTCTGCTTACATTTTATAAGTTTAAGGTCAGCTGTC
AAAAGGATAACCTGTGGGGTTAGAACATATCACATTGCAACACCCTAAATTGTTTTTAATACATTAGCAATCTATTGGGTCAACTGACAT
CCATTGTATATACTAGTTTCTTTCATGCTATTTTTATTTTGTTTTTTGCATTTTTATCAAATGCAGGGCCCCTTTCTGATCTCACCATTT
CACCATGCATCTTGGAATTCAGTAAGTGCATATCCTAACTTGCCCATATTCTAAATCATCTGGTTGGTTTTCAGCCTAGAATTTGATACG
CTTTTTAGAAATATGCCCAGAATAGAAAAGCTATGTTGGGGCACATGTCCTGCAAATATGGCCCTAGAAACAAGTGATATGGAATTTACT
TGGTGAATAAGTTATAAATTCCCACAGAAGAAAAATGTGAAAGACTGGGTGCTAGACAAGAAGGAAGCAGGTAAAGGGATAGTTGCTTTG
TCATCCGTTTTTAATTATTTTAACTGACCCTTGACAATCTTGTCAGCAATATAGGACTGTTGAACAATCCCGGTGTGTCAGGACCCCCAA
ATGTCACTTCTGCATAAAGCATGTATGTCATCTATTTTTTCTTCAATAAAGAGATTTAATAGCCATTTCAAGAAATCCCATAAAGAACCT
CTCTATGTCCCTTTTTTTAATTTAAAAAAAATGACTCTTGTCTAATATTCGTCTATAAGGGATTAATTTTCAGACCCTTTAATAAGTGAG
TGCCATAAGAAAGTCAATATATATTGTTTAAAAGATATTTCAGTCTAGGAAAGATTTTCCTTCTCTTGGAATGTGAAGATCTGTCGATTC
ATCTCCAATCATATGCATTGACATACACAGCAAAGAAGATATAGGCAGTAATATCAACACTGCTATATCATGTGTAGGACATTTCTTATC
CATTTTTTCTCTTTTACTTGCATAGTTGCTATGTGTTTCTCATTGTAAAAGGCTGCCGCTGGGTGGCAGAAGCCAAGAGACCTTATTAAC
TAGGCTATATTTTTCTTAACTTGATCTGAAATCCACAATTAGACCACAATGCACCTTTGGTTGTATCCATAAAGGATGCTAGCCTGCCTT
GTACTAATGTTTTATATATTAAAAAAAAAAAATCTATCAACCATTTCATATATATCCCACTACTCAAGGTATCCATGGAACATGAAAGAA
TAACATTTATGCAGAGGAAAAACAAAAACATCCCTGAAAATATACACACTCATACACACACACGCACAGGGGAATAAAATAAGAAAATCA
TTTTCCTCACCATAGACTTGATCCCATCCTTACAACCCATCCTTCTAACTTGATGTGTATAAAATATGCAAACATTTCACAAATGTTCTT
TGTCATTTCAAAATACTTTAGTATATCAATATCAGTAGATACCAGTGGGTGGGAAAGGGTCATTACATGAAAATATGAAGAAATAGCCAT
ATTAGTTTTTTAACCTGCAATTTGCCTCAGCAACAAAGAAAAAGTGAATTTTTAATGCTGAAGATAAAGTAAGCTAAAGTACCAGCAGAA
GCCTTGGCTATTTATAGCAGTTCTGACAATAGTTTTATAAGAACATGAAGAGAACAGAATCACTTGAAAATGGATGCCAGTCATCTCTTG
TTCCCACTACTGAATTCTTATAAAGTGGTGGCAAGATAGGGAAGGGATAATCTGAGAATTTTTAAAAGATGATTTAATGAGAAGAAGCAC
AATTTTGATTTTGATGAGTCACTTTCTGTAAACAATCTTGGTCTATCTTTACCCTTATACCTTATCTGTAATTTACCATTTATTGTATTT
GCAAAGCTAGTATGGTTTTTAATCACAGTAAATCCTTTGTATTCCAGACTTTAGGGCAGAGCCCTGAGGGAGTATTATTTTACATAACCC
GTCCTAGAGTAACATTTTAGGCAACATTCTTCATTGCAAGTAAAAGATCCATAAGTGGCATTTTACACGGCTGCGAGTATTGTTATATCT
AATCCTATTTTAAAAGATTTTTGGTAATATGAAGCTTGAATACTGGTAACAGTGATGCAATATACGCAAGCTGCACAACCTGTATATTGT
ATGCATTGCTGCGTGGAGGCTGTTTATTTCAACCTTTTTAAAAATTGTGTTTTTTAGTAAAATGGCTTATTTTTTCCCAAAGGTGGAATT
TAGCATTTTGTAATGATGAATATAAAAATACCTGTCATCCCCAGATCATTTAAAAGTTAACTAAAGTGAGAATGAAAAAACAAAATTCCA
AGACACTTTTTAAAAGAATGTCTGCCCTCACACACTTTTATGGATTTGTTTTTCTTACATACCCATCTTTTAACTTAGAGATAGCATTTT
TTGCCCTCTTTATTTTGTTGTTTGTTTCTCCAGAGAGTAAACGCTTTGTAGTTCTTTCTTTAAAAAACATTTTTTTTAAAGAAGAAGAAG
CCACTTGAACCCTCAATAAAGGCTGTTGCCTAAGCATGGCATACTTCATCTGTTCTCATTTGTGCCATCTGCCGTGATGTCGTCACTTTT
ATGGCGTTAATTTCCTGCCACTACAGATCTTTTGAAGATTGCTGGAATACTGGTGTCTGTTAGAATGCTTCAGACTACAGATGTAATTAA
AGGCTTTTCTTAATATGTTTTAACCAAAGATGTGGAGCAATCCAAGCCACATATCTTCTACATCAAATTTTTCCATTTTGGTTATTTTCA
TAATCTGGTATTGCATTTTGCCTTCCCTGTTCATACCTCAAATTGATTCATACCTCAGTTTAATTCAGAGAGGTCAGTTAAGTGACGGAT
TCTGTTGTGGTTTGAATGCAGTACCAGTGTTCTCTTCGAGCAAAGTAGACCTGGGTCACTGTAGGCATAGGACTTGGATTGCTTCAGATG
GTTTGCTGTATCATTTTTCTTCTTTTTCTTTTCCTGGGGACTTGTTTCCATTAAATGAGAGTAATTAAAATCGCTTGTAAATGAGGGCAT
ACAAGCATTTGCAACAAATATTCAAATAGAGGCTCACAGCGGCATAAGCTGGACTTTGTCGCCACTAGATGACAAGATGTTATAACTAAG
TTAAACCACATCTGTGTATCTCAAGGGACTTAATTCAGCTGTCTGTAGTGAATAAAAGTGGGAAATTTTCAAAAGTTTCTCCTGCTGGAA
ATAAGGTATAATTTGTATTTTGCAGACAATTCAGTAAAGTTACTGGCTTTCTTAGTGATGCAGTGTCCGTGGTGCATTTTTTTAAATTAA

>In-frame_TNPO1_ENST00000454282_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_5802nt
GAATGTTCCCGCCGCGGGCTCCGCCCCCCGGCCAATCGGACCGGCGCTCGGTGAAGCCCAGATTCTCTTTGTTCCGCAGCCATTTCAGGC
CCCGGACAGGAGGCAGTGCCGCTTCGGCCGAAGGCCCGAGCGCCCGAGGCGTCTGGGATGGTGTGGGACCGGACGTTGAGAAAGAAGGGC
CTTAATGGCTGTGACAGCCCAGACCCCGATGCGGACGATTCCGCATTGAACAAGAAAGAAAACAAAGGCTGTGAAAGCCCCGATCCCGAC
TCCTCTTATGCACTCACCCCACGCACTGAAGAAAAATACAAAAAAATTAATGAAGAATTTGATAATATGATCAAGAGTCATAAAATTCCT
GCTGTTCCACCTCCCAACTTCGAGATGCCAGTCTCCATCCCAGTGTCCAGCCACAACAGTTTGGTGTACAGCAACCCTGTCAGCTCACTG
GGAAACCCCAACCTATTGCCACTGGCTCACCCTTCTCTGCAGAGGAATAGTATGTCTCCTGGTGTAACACATCGACCTCCAAGTGCAGGT
AACACAGGTGGTCTGATGGGTGGAGACCTCACGTCTGGTGCAGGCACCAGTGCAGGGAACGGGTATGGCAATCCCCGAAACTCACCAGGT
CTGCTGGTCTCACCTGGTAACTTGAACAAGAATATGCAAGCAAAATCTCCTCCCCCAATGAATTTAGGAATGAATAACCGTAAACCAGAT
CTCCGAGTTCTTATTCCACCAGGCAGCAAGAATACGATGCCATCAGTGAATCAAAGGATAAATAACTCCCAGTCGGCTCAGTCATTGGCT
ACCCCAGTGGTTTCCGTAGCAACTCCTACTTTACCAGGACAAGGAATGGGAGGATATCCATCAGCCATTTCAACAACATATGGTACCGAG
TACTCTCTGAGTAGTGCAGACCTGTCATCTCTGTCTGGGTTTAACACCGCCAGCGCTCTTCACCTTGGTTCAGTAACTGGCTGGCAACAG
CAACACCTACATAACATGCCACCATCTGCCCTCAGTCAGTTGGGAGCTTGCACTAGCACTCATTTATCTCAGAGTTCAAATCTCTCCCTG
CCTTCTACTCAAAGCCTCAACATCAAGTCAGAACCTGTTTCTCCTCCTAGAGACCGTACCACCACCCCTTCGAGATACCCACAACACACG
CGCCACGAGGCGGGGAGATCTCCTGTTGACAGCTTGAGCAGCTGTAGCAGTTCGTACGACGGGAGCGACCGAGAGGATCACCGGAACGAA
TTCCACTCCCCCATTGGACTCACCAGACCTTCGCCGGACGAAAGGGAAAGTCCCTCAGTCAAGCGCATGCGACTTTCTGAAGGATGGGCA
ACATGATCAGATTATTACTTACTAGTTTTTTTTTTTTTCTTGCAGTGTGTGTGTGTGCTATACCTTAATGGGGAAGGGGGGTCGATATGC
ATTATATGTGCCGTGTGTGGAAAAAAAAAAAGTCAGGTACTCTGTTTTGTAAAAGTACTTTTAAATTGCCTCAGTGATACAGTATAAAGA
TAAACAGAAATGCTGAGATAAGCTTAGCACTTGAGTTGTACAACAGAACACTTGTACAAAATAGATTTTAAGGCTAACTTCTTTTCACTG
TTGTGCTCCTTTGCAAAATGTATGTTACAATAGATAGTGTCATGTTGCAGGTTCAACGTTATTTACATGTAAATAGACAAAAGGAAACAT
TTGCCAAAAGCGGCAGATCTTTACTGAAAGAGAGAGCAGCTGTTATGCAACATATAGAAAAATGTATAGATGCTTGGACAGACCCGGTAA
TGGGTGGCCATTGGTAAATGTTAGGAACACACCAGGTCACCTGACATCCCAAGAATGCTCACAAACCTGCAGGCATATCATTGGCGTATG
GCACTCATTAAAAAGGATCAGAGACCATTAAAAGAGGACCATACCTATTAAAAAAAAATGTGGAGTTGGAGGGCTAACATATTTAATTAA
ATAAATAAATAAATCTGGGTCTGCATCTCTTATTAAATAAAAATATAAAAATATGTACATTACATTTTGCTTATTTTCATATAAAAGGTA
AGACAGAGTTTGCAAAGCATTTGTGGCTTTTTGTAGTTTACTTAAGCCAAAATGTGTTTTTTTCCCCTTGATAGCTTCGCTAATATTTTA
AACAGTCCTGTAAAAAACCAAAAAGGACTTTTTGTATAGAAAGCACTACCCTAAGCCATGAAGAACTCCATGCTTTGCTAACCAAGATAA
CTGTTTTCTCTTTGTAGAAGTTTTGTTTTTGAAATGTGTATTTCTAATTATATAAAATATTAAGAATCTTTTAAAAAAATCTGTGAAATT
AACATGCTTGTGTATAGCTTTCTAATATATATAATATTATGGTAATAGCAGAAGTTTTGTTATCTTAATAGCGGGAGGGGGGTATATTTG
TGCAGTTGCACATTTGAGTAACTATTTTCTTTCTGTTTTCTTTTACTCTGCTTACATTTTATAAGTTTAAGGTCAGCTGTCAAAAGGATA
ACCTGTGGGGTTAGAACATATCACATTGCAACACCCTAAATTGTTTTTAATACATTAGCAATCTATTGGGTCAACTGACATCCATTGTAT
ATACTAGTTTCTTTCATGCTATTTTTATTTTGTTTTTTGCATTTTTATCAAATGCAGGGCCCCTTTCTGATCTCACCATTTCACCATGCA
TCTTGGAATTCAGTAAGTGCATATCCTAACTTGCCCATATTCTAAATCATCTGGTTGGTTTTCAGCCTAGAATTTGATACGCTTTTTAGA
AATATGCCCAGAATAGAAAAGCTATGTTGGGGCACATGTCCTGCAAATATGGCCCTAGAAACAAGTGATATGGAATTTACTTGGTGAATA
AGTTATAAATTCCCACAGAAGAAAAATGTGAAAGACTGGGTGCTAGACAAGAAGGAAGCAGGTAAAGGGATAGTTGCTTTGTCATCCGTT
TTTAATTATTTTAACTGACCCTTGACAATCTTGTCAGCAATATAGGACTGTTGAACAATCCCGGTGTGTCAGGACCCCCAAATGTCACTT
CTGCATAAAGCATGTATGTCATCTATTTTTTCTTCAATAAAGAGATTTAATAGCCATTTCAAGAAATCCCATAAAGAACCTCTCTATGTC
CCTTTTTTTAATTTAAAAAAAATGACTCTTGTCTAATATTCGTCTATAAGGGATTAATTTTCAGACCCTTTAATAAGTGAGTGCCATAAG
AAAGTCAATATATATTGTTTAAAAGATATTTCAGTCTAGGAAAGATTTTCCTTCTCTTGGAATGTGAAGATCTGTCGATTCATCTCCAAT
CATATGCATTGACATACACAGCAAAGAAGATATAGGCAGTAATATCAACACTGCTATATCATGTGTAGGACATTTCTTATCCATTTTTTC
TCTTTTACTTGCATAGTTGCTATGTGTTTCTCATTGTAAAAGGCTGCCGCTGGGTGGCAGAAGCCAAGAGACCTTATTAACTAGGCTATA
TTTTTCTTAACTTGATCTGAAATCCACAATTAGACCACAATGCACCTTTGGTTGTATCCATAAAGGATGCTAGCCTGCCTTGTACTAATG
TTTTATATATTAAAAAAAAAAAATCTATCAACCATTTCATATATATCCCACTACTCAAGGTATCCATGGAACATGAAAGAATAACATTTA
TGCAGAGGAAAAACAAAAACATCCCTGAAAATATACACACTCATACACACACACGCACAGGGGAATAAAATAAGAAAATCATTTTCCTCA
CCATAGACTTGATCCCATCCTTACAACCCATCCTTCTAACTTGATGTGTATAAAATATGCAAACATTTCACAAATGTTCTTTGTCATTTC
AAAATACTTTAGTATATCAATATCAGTAGATACCAGTGGGTGGGAAAGGGTCATTACATGAAAATATGAAGAAATAGCCATATTAGTTTT
TTAACCTGCAATTTGCCTCAGCAACAAAGAAAAAGTGAATTTTTAATGCTGAAGATAAAGTAAGCTAAAGTACCAGCAGAAGCCTTGGCT
ATTTATAGCAGTTCTGACAATAGTTTTATAAGAACATGAAGAGAACAGAATCACTTGAAAATGGATGCCAGTCATCTCTTGTTCCCACTA
CTGAATTCTTATAAAGTGGTGGCAAGATAGGGAAGGGATAATCTGAGAATTTTTAAAAGATGATTTAATGAGAAGAAGCACAATTTTGAT
TTTGATGAGTCACTTTCTGTAAACAATCTTGGTCTATCTTTACCCTTATACCTTATCTGTAATTTACCATTTATTGTATTTGCAAAGCTA
GTATGGTTTTTAATCACAGTAAATCCTTTGTATTCCAGACTTTAGGGCAGAGCCCTGAGGGAGTATTATTTTACATAACCCGTCCTAGAG
TAACATTTTAGGCAACATTCTTCATTGCAAGTAAAAGATCCATAAGTGGCATTTTACACGGCTGCGAGTATTGTTATATCTAATCCTATT
TTAAAAGATTTTTGGTAATATGAAGCTTGAATACTGGTAACAGTGATGCAATATACGCAAGCTGCACAACCTGTATATTGTATGCATTGC
TGCGTGGAGGCTGTTTATTTCAACCTTTTTAAAAATTGTGTTTTTTAGTAAAATGGCTTATTTTTTCCCAAAGGTGGAATTTAGCATTTT
GTAATGATGAATATAAAAATACCTGTCATCCCCAGATCATTTAAAAGTTAACTAAAGTGAGAATGAAAAAACAAAATTCCAAGACACTTT
TTAAAAGAATGTCTGCCCTCACACACTTTTATGGATTTGTTTTTCTTACATACCCATCTTTTAACTTAGAGATAGCATTTTTTGCCCTCT
TTATTTTGTTGTTTGTTTCTCCAGAGAGTAAACGCTTTGTAGTTCTTTCTTTAAAAAACATTTTTTTTAAAGAAGAAGAAGCCACTTGAA
CCCTCAATAAAGGCTGTTGCCTAAGCATGGCATACTTCATCTGTTCTCATTTGTGCCATCTGCCGTGATGTCGTCACTTTTATGGCGTTA
ATTTCCTGCCACTACAGATCTTTTGAAGATTGCTGGAATACTGGTGTCTGTTAGAATGCTTCAGACTACAGATGTAATTAAAGGCTTTTC
TTAATATGTTTTAACCAAAGATGTGGAGCAATCCAAGCCACATATCTTCTACATCAAATTTTTCCATTTTGGTTATTTTCATAATCTGGT
ATTGCATTTTGCCTTCCCTGTTCATACCTCAAATTGATTCATACCTCAGTTTAATTCAGAGAGGTCAGTTAAGTGACGGATTCTGTTGTG
GTTTGAATGCAGTACCAGTGTTCTCTTCGAGCAAAGTAGACCTGGGTCACTGTAGGCATAGGACTTGGATTGCTTCAGATGGTTTGCTGT
ATCATTTTTCTTCTTTTTCTTTTCCTGGGGACTTGTTTCCATTAAATGAGAGTAATTAAAATCGCTTGTAAATGAGGGCATACAAGCATT
TGCAACAAATATTCAAATAGAGGCTCACAGCGGCATAAGCTGGACTTTGTCGCCACTAGATGACAAGATGTTATAACTAAGTTAAACCAC
ATCTGTGTATCTCAAGGGACTTAATTCAGCTGTCTGTAGTGAATAAAAGTGGGAAATTTTCAAAAGTTTCTCCTGCTGGAAATAAGGTAT
AATTTGTATTTTGCAGACAATTCAGTAAAGTTACTGGCTTTCTTAGTGATGCAGTGTCCGTGGTGCATTTTTTTAAATTAATGTTTTGCT

>In-frame_TNPO1_ENST00000523768_chr5_72112579_+_MEF2C_ENST00000340208_chr5_88057145_-_5721nt
ATTTCAGGCCCCGGACAGGAGGCAGTGCCGCTTCGGCCGAAGGCCCGAGCGCCCGAGGCGTCTGGGATGGTGTGGGACCGGACGTTGAGA
AAGAAGGGCCTTAATGGCTGTGACAGCCCAGACCCCGATGCGGACGATTCCGCATTGAACAAGAAAGAAAACAAAGGCTGTGAAAGCCCC
GATCCCGACTCCTCTTATGCACTCACCCCACGCACTGAAGAAAAATACAAAAAAATTAATGAAGAATTTGATAATATGATCAAGAGTCAT
AAAATTCCTGCTGTTCCACCTCCCAACTTCGAGATGCCAGTCTCCATCCCAGTGTCCAGCCACAACAGTTTGGTGTACAGCAACCCTGTC
AGCTCACTGGGAAACCCCAACCTATTGCCACTGGCTCACCCTTCTCTGCAGAGGAATAGTATGTCTCCTGGTGTAACACATCGACCTCCA
AGTGCAGGTAACACAGGTGGTCTGATGGGTGGAGACCTCACGTCTGGTGCAGGCACCAGTGCAGGGAACGGGTATGGCAATCCCCGAAAC
TCACCAGGTCTGCTGGTCTCACCTGGTAACTTGAACAAGAATATGCAAGCAAAATCTCCTCCCCCAATGAATTTAGGAATGAATAACCGT
AAACCAGATCTCCGAGTTCTTATTCCACCAGGCAGCAAGAATACGATGCCATCAGTGAATCAAAGGATAAATAACTCCCAGTCGGCTCAG
TCATTGGCTACCCCAGTGGTTTCCGTAGCAACTCCTACTTTACCAGGACAAGGAATGGGAGGATATCCATCAGCCATTTCAACAACATAT
GGTACCGAGTACTCTCTGAGTAGTGCAGACCTGTCATCTCTGTCTGGGTTTAACACCGCCAGCGCTCTTCACCTTGGTTCAGTAACTGGC
TGGCAACAGCAACACCTACATAACATGCCACCATCTGCCCTCAGTCAGTTGGGAGCTTGCACTAGCACTCATTTATCTCAGAGTTCAAAT
CTCTCCCTGCCTTCTACTCAAAGCCTCAACATCAAGTCAGAACCTGTTTCTCCTCCTAGAGACCGTACCACCACCCCTTCGAGATACCCA
CAACACACGCGCCACGAGGCGGGGAGATCTCCTGTTGACAGCTTGAGCAGCTGTAGCAGTTCGTACGACGGGAGCGACCGAGAGGATCAC
CGGAACGAATTCCACTCCCCCATTGGACTCACCAGACCTTCGCCGGACGAAAGGGAAAGTCCCTCAGTCAAGCGCATGCGACTTTCTGAA
GGATGGGCAACATGATCAGATTATTACTTACTAGTTTTTTTTTTTTTCTTGCAGTGTGTGTGTGTGCTATACCTTAATGGGGAAGGGGGG
TCGATATGCATTATATGTGCCGTGTGTGGAAAAAAAAAAAGTCAGGTACTCTGTTTTGTAAAAGTACTTTTAAATTGCCTCAGTGATACA
GTATAAAGATAAACAGAAATGCTGAGATAAGCTTAGCACTTGAGTTGTACAACAGAACACTTGTACAAAATAGATTTTAAGGCTAACTTC
TTTTCACTGTTGTGCTCCTTTGCAAAATGTATGTTACAATAGATAGTGTCATGTTGCAGGTTCAACGTTATTTACATGTAAATAGACAAA
AGGAAACATTTGCCAAAAGCGGCAGATCTTTACTGAAAGAGAGAGCAGCTGTTATGCAACATATAGAAAAATGTATAGATGCTTGGACAG
ACCCGGTAATGGGTGGCCATTGGTAAATGTTAGGAACACACCAGGTCACCTGACATCCCAAGAATGCTCACAAACCTGCAGGCATATCAT
TGGCGTATGGCACTCATTAAAAAGGATCAGAGACCATTAAAAGAGGACCATACCTATTAAAAAAAAATGTGGAGTTGGAGGGCTAACATA
TTTAATTAAATAAATAAATAAATCTGGGTCTGCATCTCTTATTAAATAAAAATATAAAAATATGTACATTACATTTTGCTTATTTTCATA
TAAAAGGTAAGACAGAGTTTGCAAAGCATTTGTGGCTTTTTGTAGTTTACTTAAGCCAAAATGTGTTTTTTTCCCCTTGATAGCTTCGCT
AATATTTTAAACAGTCCTGTAAAAAACCAAAAAGGACTTTTTGTATAGAAAGCACTACCCTAAGCCATGAAGAACTCCATGCTTTGCTAA
CCAAGATAACTGTTTTCTCTTTGTAGAAGTTTTGTTTTTGAAATGTGTATTTCTAATTATATAAAATATTAAGAATCTTTTAAAAAAATC
TGTGAAATTAACATGCTTGTGTATAGCTTTCTAATATATATAATATTATGGTAATAGCAGAAGTTTTGTTATCTTAATAGCGGGAGGGGG
GTATATTTGTGCAGTTGCACATTTGAGTAACTATTTTCTTTCTGTTTTCTTTTACTCTGCTTACATTTTATAAGTTTAAGGTCAGCTGTC
AAAAGGATAACCTGTGGGGTTAGAACATATCACATTGCAACACCCTAAATTGTTTTTAATACATTAGCAATCTATTGGGTCAACTGACAT
CCATTGTATATACTAGTTTCTTTCATGCTATTTTTATTTTGTTTTTTGCATTTTTATCAAATGCAGGGCCCCTTTCTGATCTCACCATTT
CACCATGCATCTTGGAATTCAGTAAGTGCATATCCTAACTTGCCCATATTCTAAATCATCTGGTTGGTTTTCAGCCTAGAATTTGATACG
CTTTTTAGAAATATGCCCAGAATAGAAAAGCTATGTTGGGGCACATGTCCTGCAAATATGGCCCTAGAAACAAGTGATATGGAATTTACT
TGGTGAATAAGTTATAAATTCCCACAGAAGAAAAATGTGAAAGACTGGGTGCTAGACAAGAAGGAAGCAGGTAAAGGGATAGTTGCTTTG
TCATCCGTTTTTAATTATTTTAACTGACCCTTGACAATCTTGTCAGCAATATAGGACTGTTGAACAATCCCGGTGTGTCAGGACCCCCAA
ATGTCACTTCTGCATAAAGCATGTATGTCATCTATTTTTTCTTCAATAAAGAGATTTAATAGCCATTTCAAGAAATCCCATAAAGAACCT
CTCTATGTCCCTTTTTTTAATTTAAAAAAAATGACTCTTGTCTAATATTCGTCTATAAGGGATTAATTTTCAGACCCTTTAATAAGTGAG
TGCCATAAGAAAGTCAATATATATTGTTTAAAAGATATTTCAGTCTAGGAAAGATTTTCCTTCTCTTGGAATGTGAAGATCTGTCGATTC
ATCTCCAATCATATGCATTGACATACACAGCAAAGAAGATATAGGCAGTAATATCAACACTGCTATATCATGTGTAGGACATTTCTTATC
CATTTTTTCTCTTTTACTTGCATAGTTGCTATGTGTTTCTCATTGTAAAAGGCTGCCGCTGGGTGGCAGAAGCCAAGAGACCTTATTAAC
TAGGCTATATTTTTCTTAACTTGATCTGAAATCCACAATTAGACCACAATGCACCTTTGGTTGTATCCATAAAGGATGCTAGCCTGCCTT
GTACTAATGTTTTATATATTAAAAAAAAAAAATCTATCAACCATTTCATATATATCCCACTACTCAAGGTATCCATGGAACATGAAAGAA
TAACATTTATGCAGAGGAAAAACAAAAACATCCCTGAAAATATACACACTCATACACACACACGCACAGGGGAATAAAATAAGAAAATCA
TTTTCCTCACCATAGACTTGATCCCATCCTTACAACCCATCCTTCTAACTTGATGTGTATAAAATATGCAAACATTTCACAAATGTTCTT
TGTCATTTCAAAATACTTTAGTATATCAATATCAGTAGATACCAGTGGGTGGGAAAGGGTCATTACATGAAAATATGAAGAAATAGCCAT
ATTAGTTTTTTAACCTGCAATTTGCCTCAGCAACAAAGAAAAAGTGAATTTTTAATGCTGAAGATAAAGTAAGCTAAAGTACCAGCAGAA
GCCTTGGCTATTTATAGCAGTTCTGACAATAGTTTTATAAGAACATGAAGAGAACAGAATCACTTGAAAATGGATGCCAGTCATCTCTTG
TTCCCACTACTGAATTCTTATAAAGTGGTGGCAAGATAGGGAAGGGATAATCTGAGAATTTTTAAAAGATGATTTAATGAGAAGAAGCAC
AATTTTGATTTTGATGAGTCACTTTCTGTAAACAATCTTGGTCTATCTTTACCCTTATACCTTATCTGTAATTTACCATTTATTGTATTT
GCAAAGCTAGTATGGTTTTTAATCACAGTAAATCCTTTGTATTCCAGACTTTAGGGCAGAGCCCTGAGGGAGTATTATTTTACATAACCC
GTCCTAGAGTAACATTTTAGGCAACATTCTTCATTGCAAGTAAAAGATCCATAAGTGGCATTTTACACGGCTGCGAGTATTGTTATATCT
AATCCTATTTTAAAAGATTTTTGGTAATATGAAGCTTGAATACTGGTAACAGTGATGCAATATACGCAAGCTGCACAACCTGTATATTGT
ATGCATTGCTGCGTGGAGGCTGTTTATTTCAACCTTTTTAAAAATTGTGTTTTTTAGTAAAATGGCTTATTTTTTCCCAAAGGTGGAATT
TAGCATTTTGTAATGATGAATATAAAAATACCTGTCATCCCCAGATCATTTAAAAGTTAACTAAAGTGAGAATGAAAAAACAAAATTCCA
AGACACTTTTTAAAAGAATGTCTGCCCTCACACACTTTTATGGATTTGTTTTTCTTACATACCCATCTTTTAACTTAGAGATAGCATTTT
TTGCCCTCTTTATTTTGTTGTTTGTTTCTCCAGAGAGTAAACGCTTTGTAGTTCTTTCTTTAAAAAACATTTTTTTTAAAGAAGAAGAAG
CCACTTGAACCCTCAATAAAGGCTGTTGCCTAAGCATGGCATACTTCATCTGTTCTCATTTGTGCCATCTGCCGTGATGTCGTCACTTTT
ATGGCGTTAATTTCCTGCCACTACAGATCTTTTGAAGATTGCTGGAATACTGGTGTCTGTTAGAATGCTTCAGACTACAGATGTAATTAA
AGGCTTTTCTTAATATGTTTTAACCAAAGATGTGGAGCAATCCAAGCCACATATCTTCTACATCAAATTTTTCCATTTTGGTTATTTTCA
TAATCTGGTATTGCATTTTGCCTTCCCTGTTCATACCTCAAATTGATTCATACCTCAGTTTAATTCAGAGAGGTCAGTTAAGTGACGGAT
TCTGTTGTGGTTTGAATGCAGTACCAGTGTTCTCTTCGAGCAAAGTAGACCTGGGTCACTGTAGGCATAGGACTTGGATTGCTTCAGATG
GTTTGCTGTATCATTTTTCTTCTTTTTCTTTTCCTGGGGACTTGTTTCCATTAAATGAGAGTAATTAAAATCGCTTGTAAATGAGGGCAT
ACAAGCATTTGCAACAAATATTCAAATAGAGGCTCACAGCGGCATAAGCTGGACTTTGTCGCCACTAGATGACAAGATGTTATAACTAAG
TTAAACCACATCTGTGTATCTCAAGGGACTTAATTCAGCTGTCTGTAGTGAATAAAAGTGGGAAATTTTCAAAAGTTTCTCCTGCTGGAA
ATAAGGTATAATTTGTATTTTGCAGACAATTCAGTAAAGTTACTGGCTTTCTTAGTGATGCAGTGTCCGTGGTGCATTTTTTTAAATTAA


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FusionGenePPI for TNPO1_MEF2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNPO1RGPD5, SRP19, RPL23A, RAN, NUP98, PABPN1, TCEA2, CD4, MME, HDAC5, SIRT7, NXF1, NDN, IPO5, VPS16, TNPO3, WRAP53, SNRPA, NOTCH1, CA9, LRRK2, NFATC2, ITGA4, SOX2, EGFR, IPO4, IPO7, IREB2, PPP2CA, IPO9, PPP3CA, RRM1, VBP1, TXNRD1, PHKG2, CUL7, OBSL1, CCDC8, CD274, VSIG2, TUSC5, HTR6, IPO8, RANBP6, BYSL, GAR1, TUBA4A, TUBB3, NTRK1, STIL, ERBB2, XRCC3, AKAP5, NUP153, TMEM63B, ENTHD2, MBOAT1, SUCO, CDC5L, SIGLECL1, TMA16, PTPRA, PTPRE, PTPRN, STOM, TRIM25, G3BP1, BRCA1MEF2CHDAC4, EP300, SP1, SOX18, SMAD2, TEAD1, TWIST2, MYOD1, MYOG, MAPK7, EPAS1, MAPK14, SPTBN1, YWHAZ, HDAC9, COPS5, SIRT1, HDAC7, NCOA2, IFRD1, HDAC5, ASCL1, PLA2G12A, UBE2I, SKP2, MEF2A, MEF2C, MEF2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNPO1_MEF2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNPO1_MEF2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMEF2CC0004352Autistic Disorder1CTD_human
TgeneMEF2CC0014544Epilepsy1CTD_human;HPO
TgeneMEF2CC0038220Status Epilepticus1CTD_human
TgeneMEF2CC0038273Stereotypic Movement Disorder1CTD_human;HPO
TgeneMEF2CC1510586Autism Spectrum Disorders1CTD_human;HPO
TgeneMEF2CC3714756Intellectual Disability1CTD_human