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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38933

FusionGeneSummary for TNPO1_IKBKB

check button Fusion gene summary
Fusion gene informationFusion gene name: TNPO1_IKBKB
Fusion gene ID: 38933
HgeneTgene
Gene symbol

TNPO1

IKBKB

Gene ID

3842

3551

Gene nametransportin 1inhibitor of nuclear factor kappa B kinase subunit beta
SynonymsIPO2|KPNB2|MIP|MIP1|TRNIKK-beta|IKK2|IKKB|IMD15|NFKBIKB
Cytomap

5q13.2

8p11.21

Type of geneprotein-codingprotein-coding
Descriptiontransportin-1M9 region interaction proteinimportin 2importin beta 2karyopherin (importin) beta 2karyopherin beta-2inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betaIKK-Binhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase beta
Modification date2018052320180523
UniProtAcc

Q92973

O14920

Ensembl transtripts involved in fusion geneENST00000337273, ENST00000454282, 
ENST00000447967, ENST00000523768, 
ENST00000513944, ENST00000506351, 
ENST00000520810, ENST00000416505, 
ENST00000519735, ENST00000520835, 
ENST00000379708, ENST00000518983, 
ENST00000522147, ENST00000522785, 
Fusion gene scores* DoF score7 X 6 X 6=2528 X 7 X 3=168
# samples 810
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/168*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNPO1 [Title/Abstract] AND IKBKB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIKBKB

GO:0006468

protein phosphorylation

15084260|20434986

TgeneIKBKB

GO:0018105

peptidyl-serine phosphorylation

21399639

TgeneIKBKB

GO:0042325

regulation of phosphorylation

26212789

TgeneIKBKB

GO:0045944

positive regulation of transcription by RNA polymerase II

23091055|23453807

TgeneIKBKB

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15790681

TgeneIKBKB

GO:0071356

cellular response to tumor necrosis factor

23091055


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1HM245392TNPO1chr5

72147146

+IKBKBchr8

42129599

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337273ENST00000520810TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000337273ENST00000416505TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000337273ENST00000519735TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000337273ENST00000520835TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000337273ENST00000379708TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000337273ENST00000518983TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000337273ENST00000522147TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000337273ENST00000522785TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000454282ENST00000520810TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000454282ENST00000416505TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000454282ENST00000519735TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000454282ENST00000520835TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000454282ENST00000379708TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000454282ENST00000518983TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000454282ENST00000522147TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000454282ENST00000522785TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000447967ENST00000520810TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000447967ENST00000416505TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000447967ENST00000519735TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000447967ENST00000520835TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000447967ENST00000379708TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000447967ENST00000518983TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000447967ENST00000522147TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000447967ENST00000522785TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000523768ENST00000520810TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000523768ENST00000416505TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000523768ENST00000519735TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000523768ENST00000520835TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000523768ENST00000379708TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000523768ENST00000518983TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000523768ENST00000522147TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000523768ENST00000522785TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-5UTRENST00000513944ENST00000520810TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-5UTRENST00000513944ENST00000416505TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-5UTRENST00000513944ENST00000519735TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-intronENST00000513944ENST00000520835TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-5UTRENST00000513944ENST00000379708TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-5UTRENST00000513944ENST00000518983TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-5UTRENST00000513944ENST00000522147TNPO1chr5

72147146

+IKBKBchr8

42129599

+
3UTR-intronENST00000513944ENST00000522785TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000506351ENST00000520810TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000506351ENST00000416505TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000506351ENST00000519735TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000506351ENST00000520835TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000506351ENST00000379708TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000506351ENST00000518983TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-5UTRENST00000506351ENST00000522147TNPO1chr5

72147146

+IKBKBchr8

42129599

+
5CDS-intronENST00000506351ENST00000522785TNPO1chr5

72147146

+IKBKBchr8

42129599

+

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FusionProtFeatures for TNPO1_IKBKB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNPO1

Q92973

IKBKB

O14920

Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates (PubMed:24753571). Is thought to mediatedocking of the importin/substrate complex to the nuclear porecomplex (NPC) through binding to nucleoporin and the complex issubsequently translocated through the pore by an energy requiring,Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region ofthe heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2and mediates their nuclear import. Appears also to be involved inhnRNP A1/A2 nuclear export. Mediates the nuclear import ofribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-likeimport receptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (Bysimilarity). Mediates nuclear import of ADAR/ADAR1 isoform 1 andisoform 5 in a RanGTP-dependent manner (PubMed:19124606,PubMed:24753571). {ECO:0000250|UniProtKB:Q8BFY9,ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606,ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:8986607,ECO:0000269|PubMed:9687515}. (Microbial infection) In case of HIV-1 infection, bindsand mediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:16704975}. Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimulisuch as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. Acts as part of the canonicalIKK complex in the conventional pathway of NF-kappa-B activationand phosphorylates inhibitors of NF-kappa-B on 2 critical serineresidues. These modifications allow polyubiquitination of theinhibitors and subsequent degradation by the proteasome. In turn,free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response,growth control, or protection against apoptosis. In addition tothe NF-kappa-B inhibitors, phosphorylates several other componentsof the signaling pathway including NEMO/IKBKG, NF-kappa-B subunitsRELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.IKK-related kinase phosphorylations may prevent the overproductionof inflammatory mediators since they exert a negative regulationon canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor.Also phosphorylates other substrates including NCOA3, BCL10 andIRS1. Within the nucleus, acts as an adapter protein for NFKBIAdegradation in UV-induced NF-kappa-B activation.{ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:15084260,ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809,ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986,ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNPO1_IKBKB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNPO1_IKBKB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNPO1RGPD5, SRP19, RPL23A, RAN, NUP98, PABPN1, TCEA2, CD4, MME, HDAC5, SIRT7, NXF1, NDN, IPO5, VPS16, TNPO3, WRAP53, SNRPA, NOTCH1, CA9, LRRK2, NFATC2, ITGA4, SOX2, EGFR, IPO4, IPO7, IREB2, PPP2CA, IPO9, PPP3CA, RRM1, VBP1, TXNRD1, PHKG2, CUL7, OBSL1, CCDC8, CD274, VSIG2, TUSC5, HTR6, IPO8, RANBP6, BYSL, GAR1, TUBA4A, TUBB3, NTRK1, STIL, ERBB2, XRCC3, AKAP5, NUP153, TMEM63B, ENTHD2, MBOAT1, SUCO, CDC5L, SIGLECL1, TMA16, PTPRA, PTPRE, PTPRN, STOM, TRIM25, G3BP1, BRCA1IKBKBTRPC4AP, PPM1B, NFKB1, BTRC, MAP3K13, PRDX3, IRS1, PRKCQ, CHUK, IKBKG, CDC37, PRKDC, TNFRSF1A, TRAF2, CTNNB1, IRAK1, NFKBIA, FANCA, MAP3K11, EIF2AK2, CASP8, NCOA3, IKBKAP, TNFAIP3, MAP3K14, TRAF3IP2, NFKBIB, IKBKB, MAP3K1, MAP3K7, CUEDC2, PPP1CA, PPP1R15A, RELA, AKT1, TNF, PRKCA, PRKCI, PRKCD, DUSP1, TP53, KEAP1, CUL3, HTT, COPS3, COPS4, COPS5, COPS7A, CUL1, JUN, ERC1, TRIM21, HNRNPU, TRIM40, FKBP4, FKBP5, PYGL, CSNK2B, MAPK14, NLRX1, PLK1, MUC1, TP63, HOMER3, IKBKE, NEDD4L, RIPK1, PELI1, TRAF6, USP4, BRAP, BCL10, TNIP2, SRC, PPP2R3C, NLRP2, HSP90AA1, EGLN3, TRIM27, TP73, TRAPPC9, FAF1, PPP2CA, MEOX2, CDKN2A, TRAF1, FOXO3, STAP2, CSF2RA, CSF2RB, TSC1, CREBBP, NAA20, BCL2, DPP4, TAB1, PRKCE, HSPB1, PYCARD, NLRC5, TAB2, AURKA, TPX2, NGFR, SASH1, TFAP2C, FLNC, ROCK1, MTOR, RPTOR, RICTOR, PPARG, SHARPIN, DHCR24, RAN, SLC25A13, SLC25A22, CD40, MAVS, BIRC3, HSP90AB1, CLTC, PRKCB, STK26, COMMD7, MACROD1, LATS2, GLI1, ITCH, USP18, TWIST1, SMN1, KLHL21, TAB3, PSG1, UBC, MALT1, HIF1A, EPAS1, TNIK, IFIT5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNPO1_IKBKB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIKBKBO14920DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved
TgeneIKBKBO14920DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved
TgeneIKBKBO14920DB00995AuranofinInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|investigational
TgeneIKBKBO14920DB01169Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|investigational
TgeneIKBKBO14920DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|investigational
TgeneIKBKBO14920DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betasmall moleculeapproved|vet_approved

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RelatedDiseases for TNPO1_IKBKB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource