![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 38933 |
FusionGeneSummary for TNPO1_IKBKB |
![]() |
Fusion gene information | Fusion gene name: TNPO1_IKBKB | Fusion gene ID: 38933 | Hgene | Tgene | Gene symbol | TNPO1 | IKBKB | Gene ID | 3842 | 3551 |
Gene name | transportin 1 | inhibitor of nuclear factor kappa B kinase subunit beta | |
Synonyms | IPO2|KPNB2|MIP|MIP1|TRN | IKK-beta|IKK2|IKKB|IMD15|NFKBIKB | |
Cytomap | 5q13.2 | 8p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | transportin-1M9 region interaction proteinimportin 2importin beta 2karyopherin (importin) beta 2karyopherin beta-2 | inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betaIKK-Binhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase beta | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92973 | O14920 | |
Ensembl transtripts involved in fusion gene | ENST00000337273, ENST00000454282, ENST00000447967, ENST00000523768, ENST00000513944, ENST00000506351, | ENST00000520810, ENST00000416505, ENST00000519735, ENST00000520835, ENST00000379708, ENST00000518983, ENST00000522147, ENST00000522785, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 8 X 7 X 3=168 |
# samples | 8 | 10 | |
** MAII score | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNPO1 [Title/Abstract] AND IKBKB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IKBKB | GO:0006468 | protein phosphorylation | 15084260|20434986 |
Tgene | IKBKB | GO:0018105 | peptidyl-serine phosphorylation | 21399639 |
Tgene | IKBKB | GO:0042325 | regulation of phosphorylation | 26212789 |
Tgene | IKBKB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055|23453807 |
Tgene | IKBKB | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15790681 |
Tgene | IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | HM245392 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000337273 | ENST00000520810 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000337273 | ENST00000416505 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000337273 | ENST00000519735 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000337273 | ENST00000520835 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000337273 | ENST00000379708 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000337273 | ENST00000518983 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000337273 | ENST00000522147 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000337273 | ENST00000522785 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000454282 | ENST00000520810 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000454282 | ENST00000416505 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000454282 | ENST00000519735 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000454282 | ENST00000520835 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000454282 | ENST00000379708 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000454282 | ENST00000518983 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000454282 | ENST00000522147 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000454282 | ENST00000522785 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000447967 | ENST00000520810 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000447967 | ENST00000416505 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000447967 | ENST00000519735 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000447967 | ENST00000520835 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000447967 | ENST00000379708 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000447967 | ENST00000518983 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000447967 | ENST00000522147 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000447967 | ENST00000522785 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000523768 | ENST00000520810 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000523768 | ENST00000416505 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000523768 | ENST00000519735 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000523768 | ENST00000520835 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000523768 | ENST00000379708 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000523768 | ENST00000518983 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000523768 | ENST00000522147 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000523768 | ENST00000522785 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-5UTR | ENST00000513944 | ENST00000520810 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-5UTR | ENST00000513944 | ENST00000416505 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-5UTR | ENST00000513944 | ENST00000519735 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-intron | ENST00000513944 | ENST00000520835 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-5UTR | ENST00000513944 | ENST00000379708 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-5UTR | ENST00000513944 | ENST00000518983 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-5UTR | ENST00000513944 | ENST00000522147 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
3UTR-intron | ENST00000513944 | ENST00000522785 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000506351 | ENST00000520810 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000506351 | ENST00000416505 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000506351 | ENST00000519735 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000506351 | ENST00000520835 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000506351 | ENST00000379708 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000506351 | ENST00000518983 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-5UTR | ENST00000506351 | ENST00000522147 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
5CDS-intron | ENST00000506351 | ENST00000522785 | TNPO1 | chr5 | 72147146 | + | IKBKB | chr8 | 42129599 | + |
Top |
FusionProtFeatures for TNPO1_IKBKB |
![]() |
Hgene | Tgene |
TNPO1 | IKBKB |
Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates (PubMed:24753571). Is thought to mediatedocking of the importin/substrate complex to the nuclear porecomplex (NPC) through binding to nucleoporin and the complex issubsequently translocated through the pore by an energy requiring,Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region ofthe heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2and mediates their nuclear import. Appears also to be involved inhnRNP A1/A2 nuclear export. Mediates the nuclear import ofribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-likeimport receptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (Bysimilarity). Mediates nuclear import of ADAR/ADAR1 isoform 1 andisoform 5 in a RanGTP-dependent manner (PubMed:19124606,PubMed:24753571). {ECO:0000250|UniProtKB:Q8BFY9,ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606,ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:8986607,ECO:0000269|PubMed:9687515}. (Microbial infection) In case of HIV-1 infection, bindsand mediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:16704975}. | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimulisuch as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. Acts as part of the canonicalIKK complex in the conventional pathway of NF-kappa-B activationand phosphorylates inhibitors of NF-kappa-B on 2 critical serineresidues. These modifications allow polyubiquitination of theinhibitors and subsequent degradation by the proteasome. In turn,free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response,growth control, or protection against apoptosis. In addition tothe NF-kappa-B inhibitors, phosphorylates several other componentsof the signaling pathway including NEMO/IKBKG, NF-kappa-B subunitsRELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.IKK-related kinase phosphorylations may prevent the overproductionof inflammatory mediators since they exert a negative regulationon canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor.Also phosphorylates other substrates including NCOA3, BCL10 andIRS1. Within the nucleus, acts as an adapter protein for NFKBIAdegradation in UV-induced NF-kappa-B activation.{ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:15084260,ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809,ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986,ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TNPO1_IKBKB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TNPO1_IKBKB |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNPO1 | RGPD5, SRP19, RPL23A, RAN, NUP98, PABPN1, TCEA2, CD4, MME, HDAC5, SIRT7, NXF1, NDN, IPO5, VPS16, TNPO3, WRAP53, SNRPA, NOTCH1, CA9, LRRK2, NFATC2, ITGA4, SOX2, EGFR, IPO4, IPO7, IREB2, PPP2CA, IPO9, PPP3CA, RRM1, VBP1, TXNRD1, PHKG2, CUL7, OBSL1, CCDC8, CD274, VSIG2, TUSC5, HTR6, IPO8, RANBP6, BYSL, GAR1, TUBA4A, TUBB3, NTRK1, STIL, ERBB2, XRCC3, AKAP5, NUP153, TMEM63B, ENTHD2, MBOAT1, SUCO, CDC5L, SIGLECL1, TMA16, PTPRA, PTPRE, PTPRN, STOM, TRIM25, G3BP1, BRCA1 | IKBKB | TRPC4AP, PPM1B, NFKB1, BTRC, MAP3K13, PRDX3, IRS1, PRKCQ, CHUK, IKBKG, CDC37, PRKDC, TNFRSF1A, TRAF2, CTNNB1, IRAK1, NFKBIA, FANCA, MAP3K11, EIF2AK2, CASP8, NCOA3, IKBKAP, TNFAIP3, MAP3K14, TRAF3IP2, NFKBIB, IKBKB, MAP3K1, MAP3K7, CUEDC2, PPP1CA, PPP1R15A, RELA, AKT1, TNF, PRKCA, PRKCI, PRKCD, DUSP1, TP53, KEAP1, CUL3, HTT, COPS3, COPS4, COPS5, COPS7A, CUL1, JUN, ERC1, TRIM21, HNRNPU, TRIM40, FKBP4, FKBP5, PYGL, CSNK2B, MAPK14, NLRX1, PLK1, MUC1, TP63, HOMER3, IKBKE, NEDD4L, RIPK1, PELI1, TRAF6, USP4, BRAP, BCL10, TNIP2, SRC, PPP2R3C, NLRP2, HSP90AA1, EGLN3, TRIM27, TP73, TRAPPC9, FAF1, PPP2CA, MEOX2, CDKN2A, TRAF1, FOXO3, STAP2, CSF2RA, CSF2RB, TSC1, CREBBP, NAA20, BCL2, DPP4, TAB1, PRKCE, HSPB1, PYCARD, NLRC5, TAB2, AURKA, TPX2, NGFR, SASH1, TFAP2C, FLNC, ROCK1, MTOR, RPTOR, RICTOR, PPARG, SHARPIN, DHCR24, RAN, SLC25A13, SLC25A22, CD40, MAVS, BIRC3, HSP90AB1, CLTC, PRKCB, STK26, COMMD7, MACROD1, LATS2, GLI1, ITCH, USP18, TWIST1, SMN1, KLHL21, TAB3, PSG1, UBC, MALT1, HIF1A, EPAS1, TNIK, IFIT5 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TNPO1_IKBKB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IKBKB | O14920 | DB00244 | Mesalazine | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved |
Tgene | IKBKB | O14920 | DB00795 | Sulfasalazine | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved |
Tgene | IKBKB | O14920 | DB00995 | Auranofin | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|investigational |
Tgene | IKBKB | O14920 | DB01169 | Arsenic trioxide | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|investigational |
Tgene | IKBKB | O14920 | DB06151 | Acetylcysteine | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|investigational |
Tgene | IKBKB | O14920 | DB00945 | Acetylsalicylic acid | Inhibitor of nuclear factor kappa-B kinase subunit beta | small molecule | approved|vet_approved |
Top |
RelatedDiseases for TNPO1_IKBKB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |