	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 38926

FusionGeneSummary for TNNT1_TNNT1

Fusion gene summary

Fusion gene information	Fusion gene name: TNNT1_TNNT1
	Fusion gene ID: 38926
		Hgene	Tgene
	Gene symbol	TNNT1	TNNT1
	Gene ID	7138	7138
	Gene name	troponin T1, slow skeletal type	troponin T1, slow skeletal type
	Synonyms	ANM\|NEM5\|STNT\|TNT\|TNTS	ANM\|NEM5\|STNT\|TNT\|TNTS
	Cytomap	19q13.42	19q13.42
	Type of gene	protein-coding	protein-coding
	Description	troponin T, slow skeletal muscleslow skeletal muscle troponin Ttroponin T type 1 (skeletal, slow)troponin-T1, skeletal, slow	troponin T, slow skeletal muscleslow skeletal muscle troponin Ttroponin T type 1 (skeletal, slow)troponin-T1, skeletal, slow
	Modification date	20180523	20180523
	UniProtAcc	P13805	P13805
	Ensembl transtripts involved in fusion gene	ENST00000587758, ENST00000588426, ENST00000356783, ENST00000291901, ENST00000536926, ENST00000588981, ENST00000587465, ENST00000585321, ENST00000592920,	ENST00000587758, ENST00000588426, ENST00000356783, ENST00000291901, ENST00000536926, ENST00000588981, ENST00000587465, ENST00000585321, ENST00000592920,
Fusion gene scores	* DoF score	3 X 3 X 2=18	7 X 4 X 5=140
	# samples	3	7
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TNNT1 [Title/Abstract] AND TNNT1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNNT1	GO:0045932	negative regulation of muscle contraction	18032382
Tgene	TNNT1	GO:0045932	negative regulation of muscle contraction	18032382

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE962861	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000587758	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587758	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587758	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587758	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587758	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587758	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587758	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000587758	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000587758	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588426	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000588426	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000588426	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000356783	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000356783	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000356783	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000291901	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000291901	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000291901	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000536926	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000536926	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000536926	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000588981	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000588981	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000588981	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000587465	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000587465	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000587465	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000585321	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000585321	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000585321	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000587758	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000588426	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000356783	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000291901	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000536926	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000588981	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-3UTR	ENST00000592920	ENST00000587465	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000592920	ENST00000585321	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+
intron-intron	ENST00000592920	ENST00000592920	TNNT1	chr19	55648486	-	TNNT1	chr19	55644231	+

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FusionProtFeatures for TNNT1_TNNT1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TNNT1 P13805	TNNT1 P13805
Troponin T is the tropomyosin-binding subunit oftroponin, the thin filament regulatory complex which conferscalcium-sensitivity to striated muscle actomyosin ATPase activity.	Troponin T is the tropomyosin-binding subunit oftroponin, the thin filament regulatory complex which conferscalcium-sensitivity to striated muscle actomyosin ATPase activity.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TNNT1_TNNT1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNNT1_TNNT1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TNNT1_TNNT1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TNNT1_TNNT1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 38926

FusionGeneSummary for TNNT1_TNNT1

FusionProtFeatures for TNNT1_TNNT1

FusionGeneSequence for TNNT1_TNNT1

FusionGenePPI for TNNT1_TNNT1

RelatedDrugs for TNNT1_TNNT1

RelatedDiseases for TNNT1_TNNT1